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2023 2nd International Conference on Electronics and Integrated Circuit technology, EICT 2023

作者： Wang, Wei Liu, Kewen Liu, Xinjie Zhang, Zhi Cheng, Xin Bao, Qingjia Zhou, Xin Liu, Chaoyang School of Information Engineering Wuhan University of Technology Wuhan China Key Laboratory of Magnetic Resonance in Biological Systems Innovation Academy for Precision Measurement Science and Technology Wuhan430071 China University of Chinese Academy of Sciences Beijing100049 China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan430074 China

Based on the current deuterium metabolism imaging (DMI) technology analysis, a design scheme of a dual-core imaging coil suitable for a 7T MRI system is proposed. The size and structure of the shield layer are optimized. Based on the single-layer shield structure, a double-layer shield structure is proposed to improve the stability of the probe. A detuning circuit is added to the 2H transmitting and receiving coils so that they can work in time for better decoupling. According to the design scheme, the 1H/2H dual-core imaging coil was fabricated and applied to the 7T magnetic resonance system. We performed imaging experiments on D2O samples and quantitatively compared the correlation performance (SNR) of a 1H/2H dual-tuned RF coil with the same size deuterium transceiving-receiving integrated surface coil. The results verified that deuterium metabolism imaging using 1H/2H dual-tuned transmit-receiving separation MRI probe can effectively improve the signal-to-noise ratio of the target region. © Published under licence by IOP Publishing Ltd.

关键词： Probes

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Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

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中国药理学报（英文版） 2025年第2期46卷 308-325页

作者： Sha-sha Wang Ye Peng Ping-long Fan Jun-rui Ye Wen-yu Ma Qing-lin Wu Hong-yun Wang Ya-juan Tian Wen-bin He Xu Yan Zhao Zhang Shi-feng Chu Nai-hong Chen State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China School of Pharmacy Minzu University of ChinaBeijing 100081China State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia Medica & Neuroscience CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Shanxi Key Laboratory of Chinese Medicine Encephalopathy National International Joint Research Center for Molecular Chinese MedicineShanxi University of Chinese MedicineTaiyuan 030024China

Emerging evidence shows that psychological stress promotes the progression of Parkinson's disease(PD)and the onset of dyskinesia in non-PD individuals,highlighting a potential avenue for therapeutic *** previously reported that chronic restraint-induced psychological stress precipitated the onset of parkinsonism in 10-month-old transgenic mice expressing mutant human α-synuclein(αSyn)(hαSyn A53T).We refer to these as chronic stress-genetic susceptibility(CSGS)PD model *** this study we investigated whether ginsenoside Rg1,a principal compound in ginseng notable for soothing the mind,could alleviate PD deterioration induced by psychological ***-month-old transgenic hαSyn A53T mice were subjected to 4 weeks'restraint stress to simulate chronic stress conditions that worsen PD,meanwhile the mice were treated with Rg1(40 mg·kg-1·d-1,i.g.),and followed by functional magnetic resonance imaging(fMRI)and a variety of neurobehavioral *** showed that treatment with Rg1 significantly alleviated both motor and non-motor symptoms associated with *** MRI revealed that Rg1 treatment enhanced connectivity between brain regions implicated in PD,and in vivo multi-channel electrophysiological assay showed improvements in dyskinesia-related electrical *** addition,Rg1 treatment significantly attenuated the degeneration of dopaminergic neurons and reduced the pathological aggregation of αSyn in the striatum and *** revealed that Rg1 treatment selectively reduced the level of the stress-sensitive protein RTP801 in SNc under chronic stress conditions,without impacting the acute stress ***-MS/MS analysis coupled with site-directed mutation showed that Rg1 promoted the ubiquitination and subsequent degradation of RTP801 at residues K188 and K218,a process mediated by the Parkin RING2 *** αSyn A53T+;RTP801-/-mice,we confirmed the critical role of RTP801 in stress-aggravated PD and its necessity for Rg1's protective effec

关键词： Parkinson's disease(PD) psychological stress Rg1 RTP801 α-Synuclein autophagy

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Design and analysis of a Knee Exoskeleton with Self-alignment Capability 30

Design and Analysis of a Knee Exoskeleton with Self-alignmen...

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30th International Conference on Mechatronics and Machine Vision in Practice, M2VIP 2024

作者： Lu, Huijuan Su, Tingting Li, Guotao Liang, Xu Liu, Shengda Xiao, Wendong Xie, Shoulie Zhang, Jie He, Guangping North China University of Technology Department of Mechanical and Electrical Engineering Beijing100144 China Beijing University of Technology Faculty of Information Technology Beijing100124 China Chinese Academy of Sciences State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation Beijing100190 China Beijing Jiaotong University School of Automation and Intelligence Beijing100044 China University of Science and Technology School of Automation and Electrical Engineering Beijing100083 China A*Star Institute for Infocomm Research Singapore

ISBN: (纸本)9798350391916

The knee exoskeleton can assist patients for knee rehabilitation exercises. In this paper, a novel knee exoskeleton with self-alignment capability is proposed. First, the structure of the knee exoskeleton is designed, which has one active and four passive joints. The four passive joints are used to realize the self-alignment function of the knee exoskeleton. Second, the kinematic model is established and analysed. Third, simulations are conducted to validate the rotation ranges of human knee and hip joints. The simulation results demonstrate that the knee exoskeleton can meet the rehabilitation needs of the patients. © 2024 IEEE.

关键词： Exoskeleton (Robotics)

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Fracture Failure analysis of Gear Teeth 6

Fracture Failure Analysis of Gear Teeth

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2021 6th International Conference on Applied Mechanics and Structural Materials, AMSM 2021

作者： Liu, Chunjiang Ouyang, Kang Jiang, Tao Liu, Changkui AECC Beijing Institute of Aeronautical Materials Beijing100095 China Failure Analysis Center of Aviation Industry Corporation of China Beijing100095 China Beijing Key Laboratory of Aeronautical Materials Testing and Evaluation Beijing100095 China Aviation Key Laboratory of Science and Technology on Materials Testing and Evaluation Beijing100095 China Wuhu Machinery Plant Wuhu241007 China

Gears are important transmission components in the field of aviation industry. Failure cases such as fatigue fracture and fatigue spalling often occur due to poor conditions, and the status of teeth surface is usually one of the important elements for the failure cause analysis, but few have analyzed how the machining status of gear end surface affects the fracture failure. In this paper, one engagement failure of two gears was studied, and the failure phenomenon is as follows: all teeth of the driving gear fractured, two adjacent teeth of the driven gear fractured and several locations of teeth bottom cracked. According to the fracture morphology of the gear, it is judged that the driven gear fatigue-cracked firstly, and the fatigue zone is located at the lower end surface rather than the tooth bottom. Material structure, machining status of gear end surface, and the thickness of nitriding layer were inspected. In addition, the difference of the machining status between the lower and the upper end surface was analyzed. The results show that compared to the upper end surface, the lower end surface is smoother and the grinding amount is relatively larger. The residual stress tested by XRD shows that there is a residual compressive stress of about 84 MPa on the upper end surface and a residual tensile stress of about 238 MPa on the lower end surface. The tensile stress and the working stress cause the local stress level of the lower end surface of the gear to be higher than the fatigue strength, causing fatigue cracking from the lower end surface. © 2022 Institute of Physics Publishing. All rights reserved.

关键词： Tensile stress

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Unrevealing the effects of low temperature on cycling life of 21700-type cylindrical Li-ion batteries

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Journal of Energy Chemistry 2021年第9期30卷 104-110页

作者： Daozhong Hu Gang Chen Jun Tian Ning Li Lai Chen Yuefeng Su Tinglu Song Yun Lu Duanyun Cao Shi Chen Feng Wu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of Technology100081 BeijingChina Beijing Institute of Technology Chongqing Innovation Center 401120 ChongqingChina Department of Testing Technology China North Vehicle Research Institute100072 BeijingChina Experimental Center of Advanced Materials School of Materials Science and EngineeringBeijing Institute of Technology100081 BeijingChina

The low-temperature performance of Li-ion batteries(LIBs) has important impacts on their commercial applications. Besides the metallic lithium deposition, which is regarded as one of the main failure mechanisms of the LIBs at low temperatures, the synergistic effects originating from the cathode, anode, electrolyte, and separators to the batteries are still not clear. Here, the 21700-type cylindrical batteries were evaluated at a wide range of temperatures to investigate the failure mechanism of batteries. Voltage relaxation, and the post-mortem analysis combined with the electrochemical tests, unravel that the capacity degradation of batteries at low temperature is related to the lithium plating at graphite anodes,the formation of unsatisfied solid deposited/decomposed electrolyte mixture phase on the anode, the precipitation of solvent in the electrolytes and the block of separator pores, and the uneven dissolved transition metal-ions from the cathode. We hope this finding may open up a new avenue to alleviate the capacity degradation of advanced LIBs at low temperatures and shed light on the development of outstanding low-temperature LIBs via simultaneous optimization of all the components including electrodes, electrolytes and separators.

关键词： Low temperature Cycling life Lithium plating Solid deposited/decomposed electrolyte mixture phase Voltage relaxation

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The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation

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中国药理学报（英文版） 2024年第3期45卷 490-501页

作者： Shi-hao Cui Na Suo Ying Yang Xuan Wu Shi-meng Guo Xin Xie State Key Laboratory of Drug Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Drug Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Drug Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Drug Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Drug Research National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Oligodendrocytes(OLs)are glial cells that ensheath neuronal axons and form myelin in the central nervous system(CNS).OLs are differentiated from oligodendrocyte precursor cells(OPCs)during development and myelin repair,which is often insufficient in the latter case in demyelinating diseases such as multiple sclerosis(MS).Many factors have been reported to regulate OPC-to-OL differentiation,including a number of G protein-coupled receptors(GPCRs).In an effort to search pathways downstream of GPCRs that might be involved in OPC differentiation,we discover that U73122,a phosphoinositide specific phospholipase C(PI-PLC)inhibitor,dramatically promotes OPC-to-OL differentiation and myelin regeneration in experimental autoimmune encephalomyelitis ***,U73343,a close analog of U73122 which lacks PI-PLC inhibitory activity also promotes OL differentiation,while another reported PI-PLC inhibitor edelfosine does not have such effect,suggesting that U73122 and U73343 enhance OPC differentiation independent of *** the structures of U73122 and U73343 closely resemble 17β-estradiol,and both compounds do activate estrogen receptors Erα and Erβ with low efficacy and potency,further study indicates that these compounds do not act through Erα and/or Erβ to promote OPC ***-Seq and bioinformatic analysis indicate that U73122 and U73343 may regulate cholesterol *** study shows both compounds increase 14-dehydrozymostenol,a steroid reported to promote OPC differentiation,in OPC *** conclusion,the aminosteroids U73122 and U73343 promote OPC-to-OL generation and myelin formation by regulating cholesterol biosynthesis pathway.

关键词： oligodendrocyte oligodendrocyte progenitor cell differentiation remyelination U73122

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Wind-Bell Index: Towards Ultra-Fast Edge Query for Graph Databases 39

Wind-Bell Index: Towards Ultra-Fast Edge Query for Graph Dat...

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39th IEEE International Conference on Data Engineering, ICDE 2023

作者： Qiu, Rui Ming, Yi Hong, Yisen Li, Haoyu Yang, Tong Peking University School of Computer Science National Engineering Laboratory for Big Data Analysis Technology and Application Beijing China Peking University Academy for Advanced Interdisciplinary Studies China Peng Cheng Laboratory Shenzhen China

ISBN: (纸本)9798350322279

Graphs are good at presenting relational and structural information, making it powerful in the representation of various data. For the efficient storage and processing of graph-like data, graph databases have been rapidly developed and extensively studied. However, graph databases mostly use adjacency lists as their basic data structure (e.g., Neo4j), which could result in poor performance of edge due to the skewed degree distribution of *** design the Wind-Bell Index to address this problem. Wind-Bell Index is a memory-efficient index data structure, which can be attached to existing graph databases to speed up the edge. We have fully implemented our data structure in Neo4j, the most popular graph database today, and conduct theoretical and experimental analysis to evaluate the performance. Theoretical results prove the high query efficiency of our algorithm. And experimental results show that the average edge query speed is increased by hundreds of times compared with the original query interface of Neo4j. We believe that the excellent performance and scalability of Wind-Bell Index make it suitable for the application in a variety of graph databases. © 2023 IEEE.

关键词： Graph Databases

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Variability of Young Stellar Objects in the Perseus Molecular Cloud

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Research in Astronomy and Astrophysics 2023年第7期23卷 174-196页

作者： Xiao-Long Wang Min Fang Gregory J.Herczeg Yu Gao Hai-Jun Tian Xing-Yu Zhou Hong-Xin Zhang Xue-Peng Chen Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy Peking UniversityBeijing 100871China Department of Astronomy Xiamen UniversityXiamen 361005China School of Science Hangzhou Dianzi UniversityHangzhou 310018China Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

We present an analysis of 288 young stellar objects(YSOs)in the Perseus molecular cloud that have well defined g and r-band lightcurves from the Zwicky Transient *** the 288 YSOs,238 sources(83%of our working sample)are identified as variables based on the normalized peak-to-peak variability metric,with variability fraction of 92%for stars with disks and 77%for the diskless *** variables are classified into different categories using the quasiperiodicity(Q)and flux asymmetry(M)***-three variables are classified as strictly periodic objects that are well phased and can be attributed to spot modulated stellar *** also identify 22 bursters and 25 dippers,which can be attributed to accretion burst and variable extinction,*** with disks tend to have asymmetric and non-repeatable lightcurves,while the YSOs without disks tend to have(quasi)periodic *** periodic variables have the steepest change in g versus g-r,while bursters have much flatter changes than dippers in g versus *** and quasiperiodic variables display the lowest variability *** models suggest that the variability amplitudes of periodic variables correspond to changes of the spot coverage of 30%-40%,burster variables are attributed to accretion luminosity changes in the range of L_(acc)/L_(*)=0.1-0.3,and dippers are due to variable extinction with A_(V)changes in the range of 0.5-1.3 mag.

关键词： stars:variables:general stars:late-type stars:emission-line Be (stars:)starspots accretion accretion disks

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Pathogenic analysis of coxsackievirus A10 in rhesus macaques

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Virologica Sinica 2022年第4期37卷 610-618页

作者： Suqin Duan Fengmei Yang Yanyan Li Yuan Zhao Li Shi Meng Qin Quan Liu Weihua Jin Junbin Wang Lixiong Chen Wei Zhang Yongjie Li Ying Zhang Jingjing Zhang Shaohui Ma Zhanlong He Qihan Li Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research Development on Severe Infectious DiseaseKunming650118China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China

Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and *** people,particularly young children,may have different immunological responses to *** CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this *** characteristics of CV-A10 infection,replication,and shedding in humans remain *** this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in *** clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in *** inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and *** the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery *** addition,there were no significant differences between respiratory and digestive tract infected ***,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies.

关键词： Coxsackievirus A10(CV-A10) Hand Foot and mouth disease(HFMD) Non-human primate model Rhesus macaque Pathogenic analysis

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A marine gravimeter based on electromagnetic damping and its tests in the South China Sea

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Journal of Oceanology and Limnology 2023年第2期41卷 792-803页

作者： Pengfei WU Lin WU Lifeng BAO Long WANG Bo WANG Danling TANG State Key Laboratory of Geodesy and Earth’s Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China University of the Chinese Academy of Sciences Beijing 100049China Guangdong Remote Sensing Center for Marine Ecology and Environment(GDRS) Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)Guangzhou 511458China School of Geography and Information Engineering China University of GeosciencesWuhan 430074China

A new gravity sensor based on electromagnetic damping for the JMGrav marine gravimeter is *** new gravity sensor considered the advanced construction methods of the electromagnetic damping system of the *** design features of the new system are discussed and the research survey data in the South China Sea are *** simulations are applied to model the magnetic and mechanical characteristics of the system using finite element analysis and to evaluate the force distribution and the resulting damping *** performance characteristics of the system were tested on a motion simulator in laboratory,and the gravimeter was subjected to vertical accelerations of up to 100 Gal in 1-1000 *** was found that the amplitude reduction of vertical accelerations in 3-15 s is 30-45 dB,with a time lag of 2-5 s,while the effect on gravity in period greater than 600 s is less than 0.5 dB,with a time lag of less than 100 *** accelerations cause discrepancies of approximately only 1 mGal between the static value and the mean dynamic *** sea tests were conducted in September *** measurements were taken with a JMGrav marine gravimeter onboard the R/V Dongfanghong 3,and the effective survey line exceeded 2000 *** irregular accelerations with peaks up to 100 Gal yielded a reduction of approximately 40 dB in *** survey data were evaluated using ocean gravity field models and grid line *** results show that the accuracy of the gravity measurements is better than 2 mGal.

关键词： electromagnetic damping JMGrav marine gravimeter marine gravity survey

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