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GmBSK1-GmGSK1-GmBES1.5 regulatory module controls heat tolerance in soybean

Journal of Advanced Research 2024年 73卷 187-198页

作者： Hou, Ze-Hao Gao, Yuan Zheng, Jia-Cheng Zhao, Meng-Jie Liu, Ying Cui, Xiao-Yu Li, Zhi-Yong Wei, Ji-Tong Yu, Tai-Fei Zheng, Lei Jiao, Yuan-Chen Yang, Shu-Hui Hao, Jia-Min Chen, Jun Zhou, Yong-Bin Chen, Ming Qiu, Lijuan Ma, You-Zhi Xu, Zhao-Shi State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop Sciences Chinese Academy of Agricultural Sciences (CAAS) Beijing 100081 China Anhui Science and Technology University College of Agronomy Fengyang 233100 China College of Agriculture and Forestry Sciences Linyi University Linyi 276000 China SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology Shenzhen 518055 China National Nanfan Research Institute (Sanya) Chinese Academy of Agricultural Sciences/Seed Industry Laboratory Sanya 572024 China

Introduction: Heat stress poses a severe threat to the growth and production of soybean (Glycine max). Brassinosteroids (BRs) actively participate in plant responses to abiotic stresses, however, the role of BR signaling pathway genes in response to heat stress in soybean remains poorly understood. Objectives: In this study, we investigate the regulatory mechanisms of GmBSK1 and GmBES1.5 in response to heat stress and the physiological characteristics and yield performance under heat stress conditions. Methods: Transgenic technology and CRISPR/Cas9 technology were used to generated GmBSK1-OE, GmBES1.5-OE and gmbsk1 transgenic soybean plants, and transcriptome analysis, LUC activity assay and EMSA assay were carried out to elucidate the potential molecular mechanism underlying GmBSK1-GmBES1.5-mediated heat stress tolerance in soybean. Results: CRISPR/Cas9-generated gmbsk1 knockout mutants exhibited increased sensitivity to heat stress due to a reduction in their ability to scavenge reactive oxygen species (ROS). The expression of GmBES1.5 was up-regulated in GmBSK1-OE plants under heat stress conditions, and it directly binds to the E-box motif present in the promoters of abiotic stress-related genes, thereby enhancing heat stress tolerance in soybean plants. Furthermore, we identified an interaction between GmGSK1 and GmBES1.5, while GmGSK1 inhibits the transcriptional activity of GmBES1.5. Interestingly, the interaction between GmBSK1 and GmGSK1 promotes the localization of GmGSK1 to the plasma membrane and releases the transcriptional activity of GmBES1.5. Conclusion: Our findings suggest that both GmBSK1 and GmBES1.5 play crucial roles in conferring heat stress tolerance, highlighting a potential strategy for breeding heat-tolerant soybean crops involving the regulatory module consisting of GmBSK1-GmGSK1-GmBES1.5. © 2024

关键词： BR signaling pathway Heat stress Regulation mechanism ROS Soybean

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Cryptanalysis of BAKSHEESH Block Cipher 20th

Cryptanalysis of BAKSHEESH Block Cipher

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20th International Conference on Information Security and Cryptology, Inscrypt 2024

作者： Xu, Shengyuan Chen, Siwei Feng, Xiutao Xiang, Zejun Zeng, Xiangyong Department of Fundamental Courses Shandong University of Science and Technology Shandong Taian China School of Cyber Science and Technology Hubei University Hubei Wuhan China Key Laboratory of Mathematics Mechanization Academy of Mathematics and Systems Science Beijing China Faculty of Mathematics and Statistics Hubei Key Laboratory of Applied Mathematics Hubei University Hubei Wuhan China Key Laboratory of Intelligent Sensing System and Security Ministry of Education Hubei University Hubei Wuhan China

ISBN: (纸本)9789819647330

BAKSHEESH is a lightweight block cipher following up the well-known cipher GIFT-128, which uses a 4-bit SBox that has a non-trivial Linear Structure (LS). Also, the Sbox requires a low number of AND gates that makes BAKSHEESH stronger to resist the side channel attacks compared to GIFT-128. In this paper, we give the first third-party security analysis of BAKSHEESH from the traditional attacks perspective: integral, differential and linear attacks. Firstly, we propose a framework for integral attacks based on the properties of BAKSHEESH ’s Sbox and its inverse. By this, we achieve the 9- and 10-round practical key-recovery attacks, and give a 15-round theoretical attack. Secondly, we re-evaluate the security bound against differential cryptanalysis, correcting two errors from the original paper and presenting a key-recovery attack for 19 rounds. At last, for linear cryptanalysis, we develop an automated model for key-recovery attacks and then demonstrate a key-recovery attack for 21 rounds. We stress that our attacks cannot threaten the full-round BAKSHEESH, but give a deep understanding on its security. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： BAKSHEESH key-recovery Attacks Lightweight Block Cipher Security Evaluation

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Cu single sites on BO2 as thyroid peroxidase mimicking for iodotyrosine coupling and pharmaceutical assess

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science Bulletin 2025年第10期70卷 1611-1618页

作者： Hu, Lijun Li, Ruimin Chen, Chengjie Jia, Xiangkun Li, Xiaotong Jiao, Lei Zhu, Chengzhou Lu, Xiaoquan Zhai, Yanling Guo, Shaojun Institute of Molecular Metrology College of Chemistry and Chemical Engineering Qingdao University Qingdao266071 China School of Materials Science and Engineering Peking University Beijing100871 China Key Laboratory of Water Security and Water Environment Protection in Plateau Intersection Ministry of Education Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou730070 China National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensing Technology and Health College of Chemistry Central China Normal University Wuhan430079 China

Designing three-dimensional (3D) catalytic sites in single-atom catalysts (SACs) that mimic thyroid peroxidase (TPO) function for achieving iodotyrosine coupling, although highly desirable for the synthesis of thyroid hormones, poses a great challenge. Herein, we design and synthesize a class of SACs with 3D catalytic centers composed of Cu-N5 as catalytic sites and BO2 as binding sites (BO2/CuN5C) for mimicking TPO in activating H2O2 to facilitate tyrosine iodination and conjugation for producing thyroid hormones. We demonstrate that the as-prepared BO2/CuN5C not only provides binding sites for H2O2 through hydrogen bond interactions but also possesses catalytic sites to promote an alternative O–O heterolysis process. BO2/CuN5C with TPO-like catalytic centers can produce 3,3′,5-triiodothyronine and D-thyroxine with 2.4-fold and 11.1-fold improvements relative to those of CuN5C. Besides, the assessment of 2-mercapto-1-methylimidazole and 6-propyl-2-thiouracil in vitro investigations of antithyroid drugs corresponds well with the European Thyroid Association guidelines and therefore can provide clinical medication guidance to prevent toxic reactions. Overall, this work unlocks an approach to precisely simulate the natural enzyme active site for amino acid coupling and pharmaceutical assessment. © 2025 science China Press

关键词： Hydrogen bonds

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analysis of atmospheric optical turbulence to plateau atmosphere using HAP model 6

Analysis of atmospheric optical turbulence to plateau atmosp...

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6th Conference on Frontiers in Optical Imaging and technology: Novel Technologies in Optical Systems

作者： Hu, Zhiyuan Shao, Shiyong Tang, Pei Mu, Yuan Hu, Xiaodan Wu, Xiaoqing Zhou, Liangping Science Island Branch of Graduate School University of Science and Technology of China Hefei230026 China Key Laboratory of Atmospheric Optics Anhui Institute of Optics and Fine Mechanics Hfips Chinese Academy of Sciences Hefei230031 China Beijing Aviation Meteorological Institute Beijing100085 China

ISBN: (数字)9781510679672

ISBN: (纸本)9781510679665

The distribution of optical turbulence with height over the plateau is one of the most important points for laser propagation in the atmosphere. The simultaneous measurement of optical turbulence at three layers (2m, 5m and 10m) was carried out on Plateau with sand-grass underlying surface. The measured refraction index structure constant at 2m and local sunrise and sunset times were used to verify the applicability of the HAP model. The index of the HAP model and its diurnal variation are re-fitted by the measured refraction index structure constant. Compared with the traditional model, the average correlation coefficient and root mean square error are increased from 0.893, 0.796, 0.263 and 0.286 to 0.899, 0.816, 0.158 and 0.243, respectively. It is improved that the applicability of the new HAP model to plateau atmosphere. The new HAP model provides a new reference for the evaluation of the turbulence effect for plateau laser atmospheric transmission. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

关键词： Mean square error

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Kinematics Modeling and analysis for Mobile Manipulator

Kinematics Modeling and Analysis for Mobile Manipulator

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International Conference on Guidance, Navigation and Control, ICGNC 2022

作者： Gao, Xiaoshan Yan, Liang Ren, Mengtong Che, Honglei School of Automation Science and Electrical Engineering Beihang University Beijing100191 China Ningbo Institute of Technology Beihang University Ningbo315800 China School of Future Aerospace Technology/Shen Yuan Honors College Beihang University Beijing China Beijing Key Laboratory of Metro Fire and Passenger Transportation Safety China Academy of Safety Science and Technology Beijing100029 China

ISBN: (纸本)9789811966125

Mobile manipulators integrate with the mobility of mobile platforms and the manipulation of the multi-degree of freedom manipulators, and have the superiority as large workspace, flexibility and intelligence, etc. According to the configuration of the mobile manipulator, the differential-drive mobile platform movement is converted to virtual joints, i.e., prismatic and revolute joints, together with the multi-degree of freedom manipulator, the mobile manipulator can be built as 2P7R joint configuration, which realizes the whole forward kinematics modeling of mobile platform and multi-joint manipulator, and thus overcoming the traditional divide and conquer modeling method. The analytical modeling of the whole forward kinematics for the mobile manipulator is verified through the Robotics Toolbox. Besides, the workspace of mobile manipulator is analyzed as well, which provides an important reference for high dimensional motion planning and motion control of the mobile manipulators. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Manipulators

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Drop and Align: Fusing Pathology and Genomics via Graph Learning for Cancer Survival Prediction 22

Drop and Align: Fusing Pathology and Genomics via Graph Lear...

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22nd IEEE International Symposium on Biomedical Imaging, ISBI 2025

作者： Zhang, Zeyu Zhao, Yuanshen Duan, Jingxian Liu, Yaou Liang, Dong Li, Zhi-Cheng Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing China Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China Chinese Academy of Sciences The Key Laboratory of Biomedical Imaging Science and System Shenzhen China

ISBN: (纸本)9798331520526

Pathological image and genomic data have been widely explored in cancer survival analysis. However, due to the instability of gene sequencing and the randomness of tumor tissue sampling, it remains challenging to extract robust feature representation from each modality. Besides, the high semantic heterogeneity also adds an extra burden to the integration of tissue morphological feature and genomic expression information. In this paper, we propose the node Dropping and feature Alignment based Graph (DAGraph), a unified pathology-genomics fusion framework that utilizes graph neural network to model the spatial organization of pathological image and correlation information of genomics data. Notably, we propose to randomly drop nodes in pathological graph and genomic graph. Then we introduce an intra-modal consistency loss to guide the model to extract robust and general feature via minimizing the feature discrepancy between the original and modified graph in each modality. Additionally, an inter-modal alignment loss is also adopted to reduce the feature heterogeneity and contribute to more sufficient multi-modal fusion. Transformer-based fusion layer is utilized to integrate feature embedding of both modalities. Experiments on low-grade gliomas (LGG) dataset collected from The Cancer Genome Atlas (TCGA) demonstrate the robustness and effectiveness of the proposed method. © 2025 IEEE.

关键词： Gene encoding

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Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis

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Journal of Pharmaceutical analysis 2024年第8期14卷 1140-1157页

作者： Weilun Cheng Wanqi Mi Shiyuan Wang Xinran Wang Hui Jiang Jing Chen Kaiyue Yang Wenqi Jiang Jun Ye Baoliang Guo Yunpeng Zhang Department of General Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin150001China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin150081China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Breast cancer remains a leading cause of mortality in women ***-negative breast cancer(TNBC)is a particularly aggressive subtype characterized by rapid progression,poor prognosis,and lack of clear therapeutic *** the clinic,delineation of tumor heterogeneity and development of effective drugs continue to pose considerable *** the scope of our study,high heterogeneity inherent to breast cancer was uncovered based on the landscape constructed from both tumor and healthy breast tissue ***,TNBC exhibited significant specificity regarding cell proliferation,differentiation,and disease *** associations between tumor grade,prognosis,and TNBC oncogenes were established via pseudotime trajectory ***,we further performed comprehensive characterization of the TNBC microenvironment.A crucial epithelial subcluster,E8,was identified as highly malignant and strongly associated with tumor cell proliferation in ***,epithelial-mesenchymal transition(EMT)-associated fibroblast and M2 macrophage subclusters exerted an influence on E8 through cellular interactions,contributing to tumor *** genes in these three cluster cells could therefore serve as potential therapeutic targets for *** collective findings provided valuable insights that assisted in the screening of a series of therapeutic drugs,such as *** further confirmed the anti-cancer effect of pelitinib in an orthotopic 4T1 tumor-bearing mouse ***,our study sheds light on the unique characteristics of TNBC at single-cell resolution and the crucial cell types associated with tumor cell proliferation that may serve as potent tools in the development of effective anti-cancer drugs.

关键词： Triple-negative breast cancer Single-cell RNA sequencing Epithelial-mesenchymal transition Macrophage polarization Therapeutic drugs Bioinformatics

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Yangshan A-Type Granites in the Lower Yangtze River Belt Formed by Ridge Subduction:Radiogenic Ca and Nd Isotopic Constraints

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Journal of Earth science 2022年第3期33卷 581-590页

作者： Jianghao Bai Mingxing Ling Xiaoyong Yang Fang Liu Huangling Gu Zebin Luo Xiaoyan Jiang Zhaofeng Zhang State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China International Research Center for Planetary Science College of Earth SciencesChengdu University of TechnologyChengdu 610059China School of City and Environment Hunan University of TechnologyZhuzhou 412007China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China

The Early Cretaceous aluminous A-type granites in the Lower Yangtze River belt(LYRB)can provide important insights into the Mesozoic magmatism in eastern China,but their origin remains highly *** this study,radiogenic Ca-Nd isotopic analysis was performed for syenite porphyry and alkali-feldspar granite porphyry of the Yangshan pluton,a typical aluminous A-type granitic intrusion in the LYRB,to constrain its source and geodynamic *** results show thatε_(Ca)(126 Ma),ε_(Nd)(126 Ma)and K/Ca_(source) of the syenite porphyry range from-0.24 to+0.96,-7.2 to-6.0,and 0.31 to 1.26,*** corresponding values for the alkali-feldspar granite porphyry range from 0.26 to 0.84,-8.0 to-6.1,and 0.79 to 1.08,*** mixing modeling indicates that they were originated from the same sources with different proportion,namely,a mixing of 50%to 75%Neoproterozoic crust and 50%to 25%asthenospheric *** with previous works,we propose that the Early Cretaceous subduction of the ridge between the Pacific and Izanagi plates was responsible for the formation of the aluminous A-type granites in the LYRB.

关键词： Lower Yangtze River belt(LYRB) aluminous A-type granite Yangshan pluton radiogenic Ca-Nd isotopes ridge subduction geochemistry

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Promising graphdiyne-based nanomaterials for environmental pollutant control

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science China Materials 2024年第11期67卷 3456-3467页

作者： Chuanqi Pan Qianli He Chaofan Li College of Environmental Engineering Henan University of TechnologyZhengzhou 450001China 2 Institute of ChemistryHenan Academy of SciencesZhengzhou 450002China Institute of Quality Standard and Testing Technology for Agro-Products Chinese Academy of Agricultural Sciencesand Key Laboratory of Agro-Food Safety and Quality Ministry of Agriculture and Rural AffairsBeijing 100081China Henan Academy of Sciences Zhengzhou 450046China

ABSTRACT Environmental pollutants,including gas phase pollutants,liquid organic pollutants,heavy metal ions,and pathogenic bacteria,pose a serious threat to our ecological environment and human *** addressing these pollutants has become one of the most urgent ***(GDY),as an emerging carbon material for environmental remediation,has unique acetylene bonds and abundant pore *** unique carbon atomic structure of sp/sp2 hybrid endows it with tunable electronic structure and outstanding physical and chemical *** review summarizes the practical applications of GDY-based nanomaterials in the context of environmental pollution control,including carbon monoxide(CO)oxidation,ozone(O_(3))decomposition,heavy metal ion detection and adsorption,organic pollutant degradation,and bacterial ***,the structure-performance relationship of GDYbased nanomaterials is analyzed,and the issues and challenges in the field of environmental remediation of GDY-based materials are indicated.

关键词： graphdiyne CO oxidation O_(3) decomposition heavy metal ion detection and adsorption organic pollutant degradation bacterial inactivation

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The 2022 report of synergetic roadmap on carbon neutrality and clean air for China:Accelerating transition in key sectors

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Environmental science and Ecotechnology 2024年第3期19卷 4-18页

作者： Yu Lei Zhicong Yin Xi Lu Qiang Zhang Jicheng Gong Bofeng Cai Cilan Cai Qimin Chai Huopo Chen Renjie Chen Shi Chen Wenhui Chen Jing Cheng Xiyuan Chi Hancheng Dai Xiangzhao Feng Guannan Geng Jianlin Hu Shan Hu Cunrui Huang Tiantian Li Wei Li Xiaomei Li Jun Liu Xin Liu Zhu Liu Jinghui Ma Yue Qin Dan Tong Xuhui Wang Xuying Wang Rui Wu Qingyang Xiao Yang Xie Xiaolong Xu Tao Xue Haipeng Yu Da Zhang Ning Zhang Shaohui Zhang Shaojun Zhang Xian Zhang Xin Zhang Zengkai Zhang Bo Zheng Yixuan Zheng Jian Zhou Tong Zhu Jinnan Wang Kebin He Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental PlanningBeijing100041China Center for Carbon Neutrality Chinese Academy of Environmental PlanningBeijing100041China Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing210044China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China Ministry of Education Key Laboratory for Earth System Modelling Department of Earth System ScienceTsinghua UniversityBeijing100084China State Key Joint Laboratory for Environment Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and HealthPeking UniversityBeijing100871China National Center for Climate Change Strategy and International CooperationBeijing100035China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China School of Public Health Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of HealthFudan UniversityShanghai200032China School of Economics and Management Beijing University of Chemical TechnologyBeijing100029China Department of Earth System Science University of CaliforniaIrvineCA92697USA National Meteorological Center China Meteorological AdministrationBeijing100081China College of Environmental Sciences and Engineering Peking UniversityBeijing100871China Policy Research Center for Environment and Economy Ministry of Ecology and Environment of the People's Republic of ChinaBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring

China is now confronting the intertwined challenges of air pollution and climate *** the high synergies between air pollution abatement and climate change mitigation,the Chinese government is actively promoting synergetic control of these two *** Synergetic Roadmap project was launched in 2021 to track and analyze the progress of synergetic control in China by developing and monitoring key *** Synergetic Roadmap 2022 report is the first annual update,featuring 20 indicators across five aspects:synergetic governance system and practices,progress in structural transition,air pollution and associated weather-climate interactions,sources,sinks,and mitigation pathway of atmospheric composition,and health impacts and benefits of coordinated *** to the comprehensive review presented in the 2021 report,the Synergetic Roadmap 2022 report places particular emphasis on progress in 2021 with highlights on actions in key sectors and the relevant *** milestones include the proportion of non-fossil power generation capacity surpassing coal-fired capacity for the first time,a decline in the production of crude steel and cement after years of growth,and the surging penetration of electric ***,in 2022,China issued the first national policy that synergizes abatements of pollution and carbon emissions,marking a new era for China's pollution-carbon *** changes highlight China's efforts to reshape its energy,economic,and transportation structures to meet the demand for synergetic control and sustainable ***,the country has witnessed a slowdown in carbon emission growth,improved air quality,and increased health benefits in recent years.

关键词： Synergetic roadmap Carbon neutrality Clean air

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