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Textured Asymmetric Membrane Electrode Assemblies of Piezoelectric Phosphorene and Ti_(3)C_(2)T_(x)MXene Heterostructures for Enhanced Electrochemical Stability and Kinetics in LIBs

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Nano-Micro Letters 2024年第4期16卷 394-414页

作者： Yihui Li Juan Xie Ruofei Wang Shugang Min Zewen Xu Yangjian Ding Pengcheng Su Xingmin Zhang Liyu Wei Jing‑Feng Li Zhaoqiang Chu Jingyu Sun Cheng Huang Volta and DiPole Materials Labs College of EnergySoochow Institute for Energy and Materials InnovationS(SIEMIS)Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceKey Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical IndustrySoochow UniversitySuzhou 215006People’s Republic of China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013People’s Republic of China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001People’s Republic of China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204People’s Republic of China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084People’s Republic of China High Density Materials Technology Center for Flexible Hybrid Electronics Suzhou Institute of Electronic Functional Materials TechnologySuzhou Industrial Technology Research InstituteSuzhou 215151People’s Republic of China Institute of Advanced Materials and Institute of Membrane Science and Technology Jiangsu National Synergistic Innovation Center for Advanced MaterialsSuzhou Laboratory and Nanjing Tech UniversityNanjing 211816People’s Republic of China

Black phosphorus with a superior theoretical capacity(2596 mAh g^(-1))and high conductivity is regarded as one of the powerful candidates for lithium-ion battery(LIB)anode materials,whereas the severe volume expansion and sluggish kinetics still impede its applications in *** contrast,the exfoliated two-dimensional phosphorene owns negligible volume variation,and its intrinsic piezoelectricity is considered to be beneficial to the Li-ion transfer kinetics,while its positive influence has not been discussed ***,a phosphorene/MXene heterostructure-textured nanopiezocomposite is proposed with even phosphorene distribution and enhanced piezo-electrochemical coupling as an applicable free-standing asymmetric membrane electrode beyond the skin effect for enhanced Li-ion *** experimental and simulation analysis reveals that the embedded phosphorene nanosheets not only provide abundant active sites for Li-ions,but also endow the nanocomposite with favorable piezoelectricity,thus promoting the Li-ion transfer kinetics by generating the piezoelectric field serving as an extra *** waltzing with the MXene framework,the optimized electrode exhibits enhanced kinetics and stability,achieving stable cycling performances for 1,000 cycles at 2 A g^(-1),and delivering a high reversible capacity of 524 m Ah g^(-1)at-20℃,indicating the positive influence of the structural merits of self-assembled nanopiezocomposites on promoting stability and kinetics.

关键词： Phosphorene Nanopiezocomposite Piezo-electrochemical coupling Membrane electrode assembly Lithium-ion storage

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Finite Element Method-Based Safety Assessment of a Gas Pipeline with Bulge Defect 6

Finite Element Method-Based Safety Assessment of a Gas Pipel...

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2024 6th International Conference on Advanced Materials and Ecological Environment, AMEE 2024

作者： Xiang, Zhi Tang, Xiatao Liu, Quanbing Chen, Yin Wang, Zhongyan Li, Jintao Zhejiang Academy of Special Equipment Science Zhejiang Hangzhou310020 China Key Laboratory of Special Equipment Safety Testing Technology of Zhejiang Province Zhejiang Hangzhou310020 China Zhejiang Provincial Natural Gas Development Co. Ltd. Zhejiang Hangzhou310051 China

A safety assessment was conducted on a natural gas pipeline tee section containing a bulge defect. Geometric data of the bulge were sampled to establish a finite element model of the defective pipe section for stress analysis, which was compared to a defect-free model. The load-bearing capacity of the defective section was predicted using conventional design and analytical design methods, respectively. The results showed that under the design pressure, the maximum stress in the defective section was 71% of the allowable stress, indicating a safe stress level. The bulge did not increase local stresses, suggesting a limited impact on the load-bearing capacity. The defective section could withstand pressures exceeding the design pressure, with the analytical design method yielding a significantly higher predicted value. © Published under licence by IOP Publishing Ltd.

关键词： Natural gas pipelines

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Cell division factor ZapE regulates Pseudomonas aeruginosa biofilm formation by impacting the pqs quorum sensing system

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mLife 2023年第1期2卷 28-42页

作者： Xi Liu Minlu Jia Jing Wang Hang Cheng Zhao Cai Zhaoxiao Yu Yang Liu Luyan ZMa Lianhui Zhang Yingdan Zhang Liang Yang State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijingChina Key University Laboratory of Metabolism and Health of Guangdong School of MedicineSouthern University of Science and TechnologyShenzhenChina Guangdong Province Key Laboratory of Microbial Signals and Disease Control Integrative Microbiology Research CenterSouth China Agricultural UniversityGuangzhouChina Medical Research Center Southern University of Science and Technology HospitalShenzhenChina Shenzhen Third People's Hospital National Clinical Research Center for Infectious DiseaseThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhenChina

Pseudomonas aeruginosa is one of the leading nosocomial pathogens that causes both severe acute and chronic *** strong capacity of *** to form biofilms can dramatically increase its antibiotic resistance and lead to treatment *** biofilm resident bacterial cells display distinct gene expression profiles and phenotypes compared to their free-living *** the genetic determinants of biofilm formation is crucial for the development of antibiofilm *** this study,a highthroughput transposon-insertion site sequencing(Tn-seq)approach was employed to identify novel *** biofilm genetic *** analyzing the novel biofilm regulatory genes,we found that the cell division factor ZapE(PA4438)controls the *** pqs quorum sensing *** ΔzapE mutant lost fitness against the wild-type PAO1 strain in biofilms and its production of 2-heptyl-3-hydroxy-4(1H)-quinolone(PQS)had been *** biochemical analysis showed that ZapE interacts with PqsH,which encodes the synthase that converts 2-heptyl-4-quinolone(HHQ)to *** addition,site-directed mutagenesis of the ATPase active site of ZapE(K72A)abolished the positive regulation of ZapE on PQS *** ZapE is highly conserved among the Pseudomonas group,our study suggests that it is a potential drug target for the control of Pseudomonas infections.

关键词： biofilm Pseudomonas aeruginosa Pseudomonas quinolone signal transposon‐insertion site sequencing(Tn‐seq) ZapE

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In silico off-target profiling for enhanced drug safety assessment

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2927-2941页

作者： Jin Liu Yike Gui Jingxin Rao Jingjing Sun Gang Wang Qun Ren Ning Qu Buying Niu Zhiyi Chene Xia Sheng Yitian Wang Mingyue Zheng Xutong Li College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Nanjing University of Chinese Medicine Nanjing 210023China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyHangzhou 330106China

Ensuring drug safety in the early stages of drug development is crucial to avoid costly failures in subsequent ***,the economic burden associated with detecting drug off-targets and potential side effects through in vitro safety screening and animal testing is *** off-target interactions,along with the adverse drug reactions they induce,are significant factors affecting drug *** assess the liability of candidate drugs,we developed an artificial intelligence model for the precise prediction of compound off-target interactions,leveraging multi-task graph neural *** outcomes of off-target predictions can serve as representations for compounds,enabling the differentiation of drugs under various ATC codes and the classification of compound ***,the predicted off-target profiles are employed in adverse drug reaction(ADR)enrichment analysis,facilitating the inference of potential ADRs for a *** the withdrawn drug Pergolide as an example,we elucidate the mechanisms underlying ADRs at the target level,contributing to the exploration of the potential clinical relevance of newly predicted off-target ***,our work facilitates the early assessment of compound safety/toxicity based on off-target identification,deduces potential ADRs of drugs,and ultimately promotes the secure development of drugs.

关键词： Drug safety Off-target prediction Adverse drug reactions Toxicity Molecular representation Artificial intelligence

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Process risk prioritization of metalorganic chemical vapor deposition device 32nd

Process risk prioritization of metalorganic chemical vapor d...

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32nd European Safety and Reliability Conference, ESREL 2022

作者： Liu, Xuan Meng, Huixing Yao, Weizhen Liu, Xianglin Zhang, Chao State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing100081 China Key Laboratory of Semiconductor Materials Science Institute of Semiconductors Chinese Academy of Sciences Beijing100083 China Beijing CASIntruments Semiconductor Technology Co. Ltd. Beijing100192 China Environmental Engineering Department Sinopec Engineering Incorporation Beijing100101 China

ISBN: (纸本)9789811851834

The metal-organic chemical vapor deposition (MOCVD) device is indispensable in the semiconductor manufacturing industry. The process risk prioritization is beneficial to secure the safe operations of MOCVD. To find out the weakness of the device, the hazard and operability (HAZOP) study can be used to assess the process risk of MOCVD. In this paper, to identify the crucial components and associated hazards, we introduce a hybrid method by integrating HAZOP and the interval analytical hierarchy process (IAHP) to prioritize the hazards for decision-makers. Firstly, we employ HAZOP to identify the failure causes and consequences of deviations. Then we conduct IAHP to prioritize the risk of MOCVD to identify the priority for the hazards with the same risk priority number (RPN). The combination valve section before the reactor of MOCVD is analyzed as the case study. The obtained results from the HAZOP analysis can support the lifecycle risk management of MOCVD. © 2022 ESREL2022 Organizers. Published by Research Publishing, Singapore.

关键词： Metallorganic chemical vapor deposition

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Generation mechanism and motion behavior of sliver defect in single crystal Ni-based superalloy

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Journal of Materials science & technology 2023年第6期137卷 232-246页

作者： Huxiang Xia Yanhong Yang Qiushui Feng Qingyan Xu Hongbiao Dong Baicheng Liu Key Laboratory for Advanced Materials Processing Technology(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing100084China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Engineering University of LeicesterLeicesterLE17RHUnited Kingdom

Sliver is a common but easily neglected defect in single crystal Ni-based superalloy *** date,there is still no unified viewpoint on its formation mechanism and generation *** this work,the orientation discontinuity and motion behavior of sliver defects were studied through experiments and numerical *** ultrathin wedge-shaped specimen containing the grain boundary of the sliver and the matrix was prepared at the initial position of the sliver defect for the observation of equal thick-ness *** discontinuity of equal thickness fringes on both sides of the grain boundary was ob-served through a transmission electron microscope,which directly confirms the abrupt change in the orientation between the sliver and matrix from the *** crystal lattices at the smooth area and the bulging area of the grain boundary were found to have unusually different *** irregular lattice arrangement at the bulging area shows that the grain boundary has experienced high-stress *** results of sliver orientation deviation with a further composition analysis show the micro protuberance of the mold shell has a noticeable inductive effect on the sliver ***,a self-developed three-dimensional phase-field simulation model coupled with the spatial topology algorithm is established to simulate the orientation deflection behavior and orientation devia-tion threshold of fractured *** simulation results indicated that there is an upper limit of the cross-section solid fraction at the fracture position for the motion of the fractured *** the cross-section solid fraction at the fracture position is higher than this upper limit,it will be difficult to produce large deviation slivers due to the structural limitation of surrounding *** upper limit does not change with the solidification temperature gradient.

关键词： Single crystal Ni-based superalloys Directional solidification Sliver defect Phase-field simulation

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An ARF24-ZmArf2 module influences kernel size in different maize haplotypes

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Journal of Integrative Plant Biology 2023年第7期65卷 1767-1781页

作者： Jie Gao Long Zhang Haonan Du Yongbin Dong Sihan Zhen Chen Wang Qilei Wang Jingyu Yang Paifeng Zhang Xu Zheng Yuling Li State Key Laboratory of Wheat and Maize Crop Science Henan Maize Engineering Technology Joint CenterCollege of Agronomyand Center for Crop Genome EngineeringLongzi Lake CampusHenan Agricultural UniversityZhengzhou 450046China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Members of the ADP-ribosylation factor family,which are GTP-binding proteins, are involved in metabolite transport, cell division, and *** there has been a significant amount of research on small GTP-binding proteins, their roles and functions in regulating maize kernel size remain elusive. Here, we identified Zm Arf2 as a maize ADPribosylation factor-like family member that is highly conserved during evolution. Maize zmarf2 mutants showed a characteristic smaller kernel size. Conversely, ZmArf2 overexpression increased maize kernel size. Furthermore, heterologous expression of Zm Arf2 dramatically elevated Arabidopsis and yeast growth by promoting cell division. Using expression quantitative trait loci(e QTL) analysis, we determined that Zm Arf2 expression levels in various lines were mainly associated with variation at the gene locus. The promoters of Zm Arf2 genes could be divided into two types, p S and p L, that were significantly associated with both Zm Arf2 expression levels and kernel size. In yeast-one-hybrid screening, maize Auxin Response Factor 24(ARF24) is directly bound to the Zm Arf2 promoter region and negatively regulated Zm Arf2 ***, the p S and p L promoter types each contained an ARF24 binding element: an auxin response element(AuxRE) in p S and an auxin response region(Aux RR) in p L, respectively. ARF24binding affinity to Aux RR was much higher compared with Aux RE. Overall, our results establish that the small G-protein Zm Arf2 positively regulates maize kernel size and reveals the mechanism of its expression regulation.

关键词： ARF24 auxin response maize kernel ZmArf2

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Interface-induced Berry-curvature dipole and second-order nonlinear Hall effect in two-dimensional Fe5GeTe2

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Physical Review Applied 2024年第2期21卷 024044-024044页

作者： Jinrui Zhong Huimin Peng Xiaocui Wang Qi Feng Yuqing Hu Qiuli Li Yongkai Li Wei Jiang Zhiwei Wang Junxi Duan Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) School of Physics Beijing Institute of Technology Beijing 100086 China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems Beijing Institute of Technology Beijing 100081 China Material Science Center Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314011 China

The second-order nonlinear Hall effect (NLHE), driven by the Berry-curvature dipole (BCD), quantum metrics, and disorder-related mechanisms, have potential in energy harvesting and signal doubling. However, for a large class of known materials, in which inversion symmetry is preserved, the BCD and NLHE are strictly zero. Here, we report that, by interface modulation through AlxO3-assisted exfoliation, a strong NLHE is generated in few-layer Fe5GeTe2, in which both the BCD and disorder-related contributions are in principle prohibited due to its R3¯m lattice symmetry. Scaling analysis indicates the existence of a large BCD reaching Λ≈150nm. The negative results from Fe5GeTe2 devices on SiO2 substrates confirm that the interface between Fe5GeTe2 and AlxO3 is responsible for the observed NLHE, revealing an interface-induced BCD, which has never been reported before. Our study provides a feasible way to generate NLHE in materials with inversion symmetry, expanding the material family for NLHE research and inspiring potential applications due to the advantages in mass production.

关键词： Anomalous Hall effect Geometric & topological phases Topological Hall effect Transport phenomena 2-dimensional systems Ferromagnets Topological materials Van der Waals systems

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Natural Graphene Plasmonic Nano-Resonators for Highly Active Surface-Enhanced Raman Scattering Platforms

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Energy & Environmental Materials 2023年第5期6卷 269-280页

作者： Xiaoqiang Feng Zhiduo Liu Guanglin Zhang Shan Zhang Shuiping Huang Zhengyi He Genwang Wei Siwei Yang Yangguang Zhu Caichao Ye Cheng-Te Lin Guqiao Ding Gang Wang Department of Microelectronic Science and Engineering School of Physical Science andNingbo UniversityNingbo 315211China State Key Laboratory of Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Academy for Advanced Interdisciplinary Studies&Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China

Highly sensitive and uniform three-dimensional(3D)hybrid heterogeneous structures for use in surface-enhanced Raman scattering(SERS)experiments were fabricated by sequentially decorating high-quality,ultra-clean,graphene quantum dots(GQDs)and Ag nanoparticles(Ag-NPs)onto ***-difference time-domain calculations and scanning Kelvin probe microscopy were used to verify that the Ag-NPs/GQDs/3D-graphene system facilitates substantial electromagnetic enhancement(due to the occurrence of two kinds of"gaps"between the Ag-NPs that form 3D"hot spots")and additional chemical enhancement(in detecting someπ-conjugated molecules).The SERS mechanism was explored in further detail via experimental analysis and confirmed by performing theoretical *** large surface area of the 3D substrate(due to the large specific surface areas of the GQDs and 3D-graphene)results in a better enrichment effect which helps produce lower detection *** particular,the detection limits obtained using the Ag-NPs/GQDs/3D-graphene platform can reach 10^(-11)M for rhodamine 6G,10^(-10)M for methylene blue and dopamine,and 10^(-7)M for tetramethylthiuram disulfide and methyl parathion in apple juice(these are superior to most of the results reported using graphene-based SERS substrates).In summary,the 3D-platform Ag-NPs/GQDs/3D-graphene/Si shows outstanding SERS *** therefore has excellent application prospects in biochemical molecular detection and food safety monitoring.

关键词： Ag-NPs/GQDs/3D-graphene chemical enhancement dopamine Electromagnetic enhancement

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Tu-Xian Decoction ameliorates diabetic cognitive impairment by inhibiting DAPK-1

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Chinese Journal of Natural Medicines 2023年第12期21卷 950-960页

作者： WANG Danyang YAN Bin WANG An SUN Qing PANG Junyi CUI Yangming TIAN Guoqing Department of Traditional Chinese Medicine Peking Union Medical College HospitalBeijing 100730China Chinese Academy of Mediucal Sciences&Peking Union Medical College Beijing 100730China Department of Pathology Peking Union Medical College HospitalState Key Laboratory of Complex Severe and Rare DiseaseMolecular Pathology Research CenterBeijing 100730China Animal Research Laboratory Platform Peking Union Medical College Hospitalthe National Science and Technology Key Infrastructure on Translational MedicineBeijing 100730China

Tu-Xian decoction(TXD),a traditional Chinese medicine(TCM)formula,has been frequently administered to manage diabetic cognitive impairment(DCI).Despite its widespread use,the mechanisms underlying TXD’s protective effects on DCI have yet to be fully *** a significant regulator in neurodegenerative conditions,death-associated protein kinase-1(DAPK-1)serves as a focus for understanding the action of *** study was designed to whether TXD mediates its beneficial outcomes by inhibiting *** this end,a diabetic model was established using Sprague-Dawley(SD)rats through a high-fat,high-sugar(HFHS)diet regimen,followed by streptozotocin(STZ)*** experimental cohort was stratified into six groups:Control,Diabetic,TC-DAPK6,high-dose TXD,medium-dose TXD,and low-dose TXD *** a 12-week treatment period,various assessments—including blood glucose levels,body weight measurements,Morris water maze(MWM)testing for cognitive function,brain magnetic resonance imaging(MRI),and histological analyses using hematoxylin-eosin(H&E),and Nissl staining—were *** expression in the hippocampus was quantified through Western blotting *** results revealed that TXD significantly improved spatial learning and memory abilities,and preserved hippocampal structure in diabetic ***,TXD administration led to a down-regulation of proteins indicative of neurological damage and suppressed DAPK-1 activity within the hippocampal *** results underscore TXD's potential in mitigating DCI via DAPK-1 inhibition,positioning it as a viable therapeutic candidate for addressing this *** investigation into TXD's molecular mechanisms may elucidate new pathways for the treatment of DCI.

关键词： Tu-Xian decoction Traditional Chinese medicine Diabetes complications Diabetic cognitive impairment Death associated protein kinase-1

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