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26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

作者： Roychowdhury, Sayan Mahmud, Samreen T. Puleri, Daniel F. Lai, Andre Rex, Rachel Li, Brian Sohn, Lydia L. Randles, Amanda Department of Biomedical Engineering Duke University United States UC Berkeley-UC San Francisco Graduate Program in Bioengineering University of California Berkeley United States Department of Mechanical Engineering University of California Berkeley United States

ISBN: (纸本)9781733419048

Microfluidics can be used to characterize individual cells in a population based on their mechanical traits. In this work, we digitally replicate the microfluidic device developed by Li et al. [1] and perform simulations of a representative AP-1060 cell. We show that the numerical model is able to recover whole-cell deformability index, a metric used to quantify the resistance of cells to compressive deformation, within 3% of the experimental average. These results pave the way for future studies which utilize experimental and computational approaches to optimize geometric design parameters, complement signal analysis, and enhance the acquisition of mechanical information. © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： Fluid structure interaction

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Intelligent reflux and suction detection system for ventricular assist devices: in silico study

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Research on Biomedical Engineering 2025年第1期41卷 1-23页

作者： Santos, Bruno J. Cestari, Idágene A. Biomedical Engineering Graduate Program Polythecnic School of Engineering University of Sao Paulo Av. Prof. Luciano Gualberto Travessa 3 nº380 Sao Paulo05508-010 Brazil Department of Information Technology of Universidade São Judas Tadeu Rua Taquari nº546 Sao Paulo03166-000 Brazil Faculdade de Medicina Bioengineering Division - Heart Institute Hospital das Clinicas HCFMUSP Universidade de Sao Paulo LIM Bioengenharia Sao Paulo Sao Paulo Brazil

Introduction: Left ventricular assist devices (LVADs) serve both as a bridge to transplantation and as destination therapy for the treatment of congestive heart failure (CHF). However, the inability of the existing control strategies to automatically adapt LVAD flow according to hemodynamic changes can significantly impact patient survival and quality of life. Physiological control strategies for LVAD show promising results, with reflux and suction detection (RSD) increasing device safety. Methods: This study presents in silico results of an RSD system based on measurements of inlet and outlet pressures in continuous-flow LVAD. Two strategies were used to investigate control feasibility, safety, and adjustments to nonlinear variations and comprehensively assess the system’s state considering a structured algorithm (SA) and ensembles of AI models (eAIm): K-nearest neighbors (KNN), support vector machine (SVM), and artificial neural network (ANN). Results: The SA submodule achieved an accuracy of 99.66% in suction detection but showed limitations in reflux events, with 80.04% accuracy and an F1-Score of 70.4%. The KNN and SVM models demonstrated performance exceeding 96% for both events, exhibiting more excellent stability than the SA submodule. The ANN excelled with low variability and an RMSE of 0.07 in R1, though its suction accuracy (96.7%) was slightly lower than for reflux (99.48%). The KNN was the most effective model, achieving 99.66% accuracy in suction and 98.44% in reflux. The SVM also produced competitive results but with variability across evaluations. The eAIm model showed satisfactory precision (97.78% for suction and 97.14% for reflux), with variations depending on the scenario. The eAIm is recommended for optimization in precision-critical situations. Discussion: These strategies are designed to fulfill the proposal’s feasibility, flexibility, and safety requirements. They address the challenges of achieving consistent reproduction using an SA and the

关键词： Left ventricular assist devices

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Cartilage targeting cationic peptide carriers display deep cartilage penetration and retention in a rabbit model of post-traumatic osteoarthritis

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Osteoarthritis and Cartilage 2025年第6期33卷 721-734页

作者： Boyer, Timothy L. Chao, Olivia Hakim, Bill Childress, Luke Meslier, Quentin A. Iyengar, Suhasini M. Ondrechen, Mary Jo Porter, Ryan M. Bajpayee, Ambika G. Department of Bioengineering Northeastern University Boston MA United States Department of Biochemistry Northeastern University Boston MA United States Graduate Program for Interdisciplinary Biomedical Sciences UAMS Little Rock AR United States Department of Chemistry and Chemical Biology Northeastern University Boston MA United States Department of Internal Medicine UAMS Little Rock AR United States Department of Orthopaedic Surgery UAMS Little Rock AR United States

Objective: Drug delivery to cartilage is limited by its complex architecture and avascularity. Cationic peptide carriers (CPCs) have previously been optimized for improved cartilage transport and retention of drugs in vitro. In this study, we evaluated the kinetics, stability, and immunogenicity of CPCs after a single intra-articular injection using a rabbit knee injury model. Design: New Zealand White rabbits were administered a single dose of Cy5-labeled CPCs in knees receiving anterior cruciate ligament transection (ACLT) or Sham surgery. CPC biodistribution and retention within joint tissues and synovial fluid were evaluated 1 and 7 days after administration, and extra-articular kinetics were assessed in serum. Histology, immunohistochemistry, and reverse transcription quantitative polymerase chain reaction were performed to assess synovitis and protease activity. Proteolytic analysis of CPCs in the presence of arthritic enzymes was evaluated using synovial fluid size-exclusion filtration, Fluorescence Resonance Energy Transfer analysis, and computational molecular docking. Results: CPCs penetrated the full depth of sulfated glycosaminoglycan (sGAG)-rich tissues, notably cartilage, and were retained through the latest timepoint measured (one week) in both Sham and ACLT knees. Compared to ACLT, Sham knees had greater joint retention at Day 1 (1.6-fold) and Day 7 (1.8-fold). CPC intra-tissue concentration strongly correlated with tissue sGAG density, which did not considerably differ between surgical conditions at these timepoints. However, CPCs exhibited elevated vascular clearance and proteolytic fragmentation in inflammatory conditions. CPCs did not increase macrophage abundance, cytokine expression, or alter tissue morphology. Conclusion: CPCs target the deep layers of cartilage, even in inflamed joints, and can be utilized to substantially improve intra-joint bioavailability of therapeutics. © 2025 Osteoarthritis Research Society International

关键词： Cartilage penetration Cationic carriers Charge-based drug delivery Post-traumatic osteoarthritis Rabbit

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SwiftMedSAM: An Ultra-lightweight Prompt-Based Universal Medical Image Segmentation Model for Highly Constrained Environments

SwiftMedSAM: An Ultra-lightweight Prompt-Based Universal Med...

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International Challenge on Segment Anything in Medical Images on Laptop held in conjunction with the IEEE/CVF Conference on Computer Vision and Pattern Recognition, CVPR 2024

作者： Kong, Youngbin Kim, Kwangtai Jeong, Seoi Lee, Kyu Eun Kong, Hyoun-Joong Interdisciplinary Program in Bioengineering Graduate School Seoul National University Seoul Korea Republic of Department of Transdisciplinary Medicine Seoul National University Hospital Seoul Korea Republic of Department of Surgery Seoul National University Hospital and College of Medicine Seoul Korea Republic of Department of Medicine Seoul National University College of Medicine Seoul Korea Republic of Innovative Medical Technology Research Institute Seoul National University Hospital Seoul Korea Republic of Interdisciplinary Program of Medical Informatics Seoul National University College of Medicine Seoul Korea Republic of

ISBN: (纸本)9783031818530

Medical image segmentation is a crucial step for accurate diagnosis and treatment planning, as it provides quantitative information about anatomical structures and pathological lesions in various clinical scenarios. However, the existing methodologies have limitations in terms of their generalizability and computational efficiency. In this study, we propose SwiftMedSAM, an ultra-lightweight prompt-based general model, to enable efficient medical image segmentation even in resource-constrained environments. Based on LiteMedSAM, we significantly reduced the model size and computational complexity through the hyperparameter optimization of the image encoder and mask decoder components. SwiftMedSAM showed remarkable performance across various imaging modalities enabling real-time inference in resource-limited computing environments. It achieved a validation score of 0.75 demonstrating that SwiftMedSAM outperformed the existing methodologies in terms of the trade-off between accuracy and efficiency. Owing to its unprecedented generalizability and low computational cost, SwiftMedSAM is expected to enable high-quality medical image analysis in resource-constrained settings, thereby contributing to advancements in precision medicine and telemedicine. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Medical imaging

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Nanoconfinement effect of nanoporous carbon electrodes for ionic liquid-based aluminum metal anode

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Journal of Energy Chemistry 2022年第11期31卷 121-127,I0005页

作者： Juhee Yoon Seongbak Moon Son Ha Hyung-Kyu Lim Hyoung-Joon Jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheon 22212South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841South Korea Division of Chemical Engineering and Bioengineering Kangwon National UniversityGangwon-do 24341South Korea Department of Integrative Energy Engineering Korea UniversitySeoul 02841South Korea

Rechargeable aluminum batteries(RABs),which use earth-abundant and high-volumetric-capacity metal anodes(8040 m Ah cm-3),have great potential as next-generation power sources because they use cheaper resources to deliver higher energies,compared to current lithium ion ***,the mechanism of charge delivery in the newly developed,ionic liquid-based electrolytic system for RABs differs from that in conventional organic ***,targeted research efforts are required to address the large overpotentials and cycling decay encountered in the ionic liquid-based electrolytic *** this study,a nanoporous carbon(NPC)electrode with well-developed nanopores is used to develop a high-performance aluminum *** negatively charged nanopores can provide quenched dynamics of electrolyte molecules in the aluminum deposition process,resulting in an increased collision *** fast chemical equilibrium of anionic species induced by the facilitated anionic collisions leads to more favorable reduction reactions that form aluminum *** nanoconfinement effect causes separated nucleation and growth of aluminum nanoparticles in the multiple confined nanopores,leading to higher coulombic efficiencies and more stable cycling performance compared with macroporous carbon black and 2D stainless steel electrodes.

关键词： Nanoconfinement effect Nanoporous carbon Ionic liquid electrolyte Metal anode Aluminum batteries Multivalent batteries

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Technical artifacts in droplet-microfluidics-based single-nuclei RNA-sequencing 25

Technical artifacts in droplet-microfluidics-based single-nu...

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25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Gupta, Anushka Streets, Aaron UC Berkeley-UC San Francisco Graduate Program in Bioengineering BerkeleyCA United States Chan Zuckerberg Biohub San FranciscoCA United States

ISBN: (纸本)9781733419031

Droplet microfluidic platforms have recently become a powerful tool for sequencing the transcriptomes of single nuclei in a ultrahigh-throughput format. However, single-nuclei RNA-sequencing (snRNA-seq) introduces severe sources of technical noise and transcript detection bias which distorts true biological heterogeneity. In this work, we performed a comparative study between droplet-based single-cell RNA-sequencing (scRNA-seq) and snRNA-seq on human preadipocytes to identify and characterize primary sources of technical artifacts associated with snRNA-seq, and propose strategies to account for these artifacts. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

关键词： RNA

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Development of an Application to Assess Quality of Life 27th

Development of an Application to Assess Quality of Life

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27th Brazilian Congress on Biomedical Engineering, CBEB 2020

作者： Oliveira, D.S. Santos, W.S. Ribeiro, L.M. Oliveira, G.S. Magalhães, D.S.F. Frade-Barros, A.F. Brazil University Bioengineering Department Rua A 208 Novo Jaçanã São Paulo Itabuna-Bahia Brazil Nutrition Department UniFTC Itabuna Brazil Graduate Program in Computational Modelling in Science and Technology State University of Santa Cruz Ilhéus Brazil

ISBN: (纸本)9783030706005

Quality of life (QOL) is how the individual perceives himself as having an impact on his physical-emotional integrity, functional capacity, and self-esteem. Quality of life assessment tools can be generic or specific. Generics evaluate various aspects of quality of life and health status, and can be useful for patients, regardless of disease or condition, and can also be used for healthy individuals. The Medical questionnaire Outcomes Study 36 (SF-36) is one of the main instruments used to assess the health-related quality of life. This study aimed to develop the first application software (APP) for assessing the quality of life in Portuguese. This is an experimental study, of analytical, observational, and transversal nature that seeks associations or correlations between variables of interest. The application was developed on the Unity Engine to facilitate port for Android and its graphical interface. The Sarcvida app contemplates the SF-36 questionnaire and the SARC-F+CC. The application has undergone structural and functional tests and the next step is the evaluation of the app by health professionals. Sarcvida app is composed of SF-36 QOL questionnaire, SARC-F+CC, and D-score. The application proved to be functional, corresponding to initial research expectations for the project. The app presented usability and functionality for the evaluation of QOL in the tests to which it has been submitted so far. In Brazil there are no applications composed of SF-36 QOL questionnaire, SARC-F+CC, and the D-score, therefore, this study is innovative, presenting the first Portuguese version available in the app. Besides, mobile technology developed here is a tool to help monitor patients by contributing health professionals in possible interventions for health promotion. © 2022, Springer Nature Switzerland AG.

关键词： Application programs

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Biomass-Based Discrete Furan Oligomers as Materials for Electrochromic Devices

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ACS Sustainable Chemistry and Engineering 2024年第1期12卷 459-469页

作者： Atayde, Eduardo C. Fong, Guan-Lun Yeh, Jyun-Yi Matsagar, Babasaheb M. Wang, Yu-Cheng Chen, De-Chian Peng, Chi-How Li, Yi-Pei Yamauchi, Yusuke Ho, Kuo-Chuan Wu, Kevin C.-W. Molecular Science and Technology Program Taiwan International Graduate Program (TIGP-MST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan Department of Chemistry National Tsing Hua University No. 101 Sec. 2 Kuang-Fu Road Hsinchu 30013 Taiwan Department of Chemical Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan Sustainable Chemical Science and Technology Program Taiwan International Graduate Program (TIGP-SCST) Academia Sinica No. 128 Sec. 2 Academia Road Taipei 11529 Taiwan School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN) The University of Queensl Brisbane 4072 QLD Australia Department of Materials Process Engineering Graduate School of Engineering Nagoya University Nagoya 464-8603 Japan Institute of Polymer Science and Engineering National Taiwan University No.1 Sec. 4 Roosevelt Rd. Taipei 10617 Taiwan Department of Chemical Engineering and Materials Science Yuan Ze University No. 135 Yuandong Rd. Taoyuan 320 Taiwan

Electrochromic devices (ECDs) are materials that can undergo reversible changes in transmittance when exposed to different applied potentials. While many conjugated heterocyclic oligomers, such as oligothiophenes, have been developed for this purpose, there is no reported study on the use of discrete oligomeric furans as ECD materials. In this work, we introduce a furan trimer that can be utilized as a discrete electrochromic material, which transitions from light yellow to red and has a very high coloration efficiency of 1940 cm²/C at 507 nm. We propose that the reversible π-stack formation of the oligomer radical cations is behind this phenomenon, as evidenced by both experimental and computational results. The derivability of this oligomer from biomass and its facile synthesis make it an interesting alternative for other existing organic electrochromic materials. © 2023 American Chemical Society

关键词： electrochromism furan oligomer hydroxyalkylation−alkylation reaction solvatochromism π-stacks

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In vivo Detection of NO using Photonic Microring Resonators

In vivo Detection of NO using Photonic Microring Resonators

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CLEO: Science and Innovations, S and I 2022

作者： Hassan, Sakib Zhao, Xuan Schreib, Christian C. Duret, Guillaume Veiseh, Omid Robinson, Jacob T. Electrical & Computer Engineering Rice University HoustonTX77005 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Bioengineering Rice University HoustonTX77005 United States

Here we show how photonic microring resonators enable real-time detection of Nitric Oxide (NO) in vivo, which is critical for physiological monitoring particularly during the wound healing process. © Optica Publi... 详细信息

ISBN: (纸本)9781557528209

关键词： Nitric oxide

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Sweet–Bitter Taste Interactions in Binary Mixtures of Sweeteners: Relationship of Taste Receptor Activities with Sensory Perception

SSRN

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SSRN 2024年

作者： Choi, Yoonha Wong, RunRou Cha, Yeon Kyung Park, Tai Hyun Kim, Yuri Chung, Seo-Jin Department of Nutritional Science and Food Management Ewha Womans University Seoul03760 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Graduate Program in System Health Science and Engineering Ewha Womans University Seoul03760 Korea Republic of

Combining several low-calorie sweeteners in a food is a common strategy for reducing caloric sweeteners. The effects of binary sweetener mixtures on sweetness enhancement and sweet–bitter taste receptor interactions, specifically sensory perception and receptor activity, were investigated. Acesulfame K or saccharin was mixed with allulose, aspartame, erythritol, fructose, glucose, or sucrose to match a target sucrose sweetness. The effects of the mixtures on sweet and bitter taste receptors (expressed in HEK-293 cells) and sensory taste intensities were evaluated. Sweetness was enhanced in limited cases at the taste receptor level. Several monosaccharides reduced the bitter taste receptor activity triggered by acesulfame K or saccharin. The sweetness of acesulfame K and saccharin combined with any of the six sweeteners was perceptually enhanced, correlating with a reduction in their inherent bitterness. This finding suggested that sweetness perception likely increased because of the ability of monosaccharides to diminish bitter receptor activation by high-potency sweeteners. © 2024, The Authors. All rights reserved.

关键词： Binary mixtures

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