检索结果-内蒙古大学图书馆

Dopaminergic and serotoninergic neurotoxicity of lanthanide phosphate (TbPO4) in developing zebrafish

Chemosphere 2023年第1期340卷

作者： Chen, Siying Wang, Xiaohong Ye, Xiaolin Qin, Yingju Wang, Haiqing Liang, Zhenda Zhu, Lishan Zhou, Li Martyniuk, Christopher J. Yan, Bing Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of Education Guangzhou University Guangzhou510006 China Center for Environmental and Human Toxicology Department of Physiological Sciences College of Veterinary Medicine UF Genetics Institute Interdisciplinary Program in Biomedical Sciences in Neuroscience University of Florida GainesvilleFL32611 United States School of Environmental Science and Engineering Shandong University Shandong Jinan250100 China

Rare earth elements (REEs) are exploited for global use in manufacturing. Such activities result in their release into the environment and the transformation into more stable phosphate deposition. The objective of this study was to evaluate molecular and behavioral changes of zebrafish exposed to the synthesized terbium phosphate (TbPO4) at concentrations of 10, 20, and 50 mg/L and to determine its potential for neurotoxicity. Metabolomics related to neurotransmitters, and assessment of transcripts and proteins were conducted to uncover the molecular mechanisms underlying TbPO4 with emphasis on neurotransmitter systems. Exposure to 20 mg/L TbPO4 induced larval hyperactivity and perturbed the cholinergic system in zebrafish. Based on metabolomics related to neurotransmitters, dopamine (DA), serotonin (5-HT), and many of their precursors and metabolites were decreased in abundance by TbPO4. In addition, the expression levels of transcripts related to the synthesis, transport, receptor binding, and metabolism of DA and 5-HT were analyzed at the mRNA and protein levels. Transcript and protein levels for tyrosine hydroxylase (TH), the rate-limiting enzyme for DA synthesis, were down-regulated in larval fish. Monoamine oxidase (MAO), an enzyme that catabolizes monoamines DA and 5-HT, was also reduced in mRNA abundance. We hypothesize that DA synthesis and monoamine metabolism are associated with behavioral alterations. This study elucidates putative mechanisms and exposure risks to wildlife and humans by characterizing phosphatic REE-induced neurotoxicity in developing zebrafish. © 2023 Elsevier Ltd

关键词： Rare earth elements

来源：评论

学校读者我要写书评

暂无评论

Numerical Evaluation of Low-Head Inverted Cross-Flow Turbine Design Methodology: A Comprehensive Study

SSRN

引用

SSRN 2023年

作者： Ha, Hojin Ham, Sangwoo Ehsan, Adeeb Lee, Jeong Wan Interdisciplinary Program in Biohealth-Machinery Convergence Engineering Kangwon National University 1 Kangwondaehak-gil Gangwon-do Chuncheon-si24341 Korea Republic of Division of Mechanical & Biomedical Mechatronics and Materials Science and Engineering Kangwon National University 1 Kangwondaehak-gil Gangwon-do Chuncheon-si24341 Korea Republic of Kangwon Institute of Inclusive Technology Kangwon National University 1 Kangwondaehak-gil Gangwon-do Chuncheon-si24341 Korea Republic of

In this study, we aim to address the challenges of micro-hydropower generation in low-head environments. The authors reviewed and assessed various factors affecting the feasibility of micro-hydro systems, such as geographical constraints, construction costs, and grid connectivity. To overcome the limitations of conventional hydro turbines in such conditions, the authors proposed a novel cross-flow turbine. Initially, they designed and analyzed an inverted cross-flow turbine based on design rules established by previous researchers and performed numerical analyses. Four steps parametric studies were conducted to achieved optimum turbine values, such as runner diameter ratio and the number of blades, considering the maximum efficiency point from the previous step. The best efficiency point of the optimized design turbine was 72.92 % at a runner rotational speed of 170 RPM with a 0.75 runner diameter ratio and 35 blades. To validate the optimized design, the authors compared it with the initial design using hill charts and numerical values obtained from parametric studies. Overall, this research demonstrates the usefulness of computational fluid dynamics simulations and parametric studies in optimizing the design of an inverted cross-flow turbine under low head conditions. © 2023, The Authors. All rights reserved.

关键词： Computational fluid dynamics

来源：评论

学校读者我要写书评

暂无评论

Effective Falls Detection Method using Two Tri-axial Accelerometers

Effective Falls Detection Method using Two Tri-axial Acceler...

引用

2012 International Conference on Biomaterial and Bioengineering(ICBB 2012)

作者： Gye-Rok Jeon Young-Jae Kim Ah-Young Jeon Sang-hoon Lee Jae-hyung Kim Min-Seok Kim Seong-Ho Lee Ji-Hyun Kim Dept.of Biomedical Engineering School of MedicinePusan National Univ. Dept.of Anesthesia and Pain Medicine Busan Paik Hospital College of Medicine Inje University Dept.of Interdisciplinary Program in Biomedical Engineering Graduated School Pusan National University Dept.of Computer Simulation Inje Univ. Dept.of Honours Specialization in Medical Science University of Western Ontario Dept.of Anesthesiology Samsung Changwon Hospital School of MedicineSungkyun Kwan Univ. Dept.of Anesthesia and Pain Medicine School of MedicinePusan Natl.Univ.

Falls detection systems have been developed in recent years because falls are detrimental events that can have a devastating effect on health of the elderly population. Current fall detecting methods mainly employ accelerometer to discriminate falls from activities of daily living（ADL）. However, this makes it difficult to distinguish real falls from certain fall-like activities such as jogging and jumping. In this paper, an accurate fall detection system was implemented using two tri-axial accelerometers. By attaching the accelerometers on the chest and the abdomen, our system can effectively differentiate between falls and non-fall *** Diff and Sumiff parameter resulted in falls detection rate of 100%, respectively.

关键词： Falls Accelerometer Activity of daily living DiffZ Sum diffZ

来源：评论

学校读者我要写书评

暂无评论

Complexity Analysis based on Parietal Fuzzy Entropy to Facilitate ADHD Diagnosis in Young Children

Complexity Analysis based on Parietal Fuzzy Entropy to Facil...

引用

Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： I-Wen Huang Yu-Ci Jheng I-Chun Chen Li-Wei Ko Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan Institute of Electrical and Control Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan International Program in Interdisciplinary Neuroscience College of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Department of Physical Medicine and Rehabilitation Ton-Yen General Hospital Hsinchu Taiwan Drug Development and Value Creation Research Center Kaohsiung Medical University Kaohsiung Taiwan

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

Attention deficit hyperactivity disorder (ADHD) is the most common condition affecting the development of neurons in children. Therefore, early and accurate diagnosis of ADHD in young children is of paramount importance. In this study, the 8-channel wireless wearable EEG measurement device was employed to record EEG data from 30 children diagnosed with ADHD and 30 typical development (TD) young children aged 4-7 years. The data was collected both during rest and while the children performed a Kiddie Continuous Performance Test (K-CPT). We extract relative power spectral density (PSD) unaffected by factors like skull resistance and thickness. Additionally, a range of complex entropy values based on the time domain were extracted. These included sample entropy (SaEn), permutation entropy (PeEn), singular value decomposition entropy (SvdEn), and fuzzy entropy (FuEn). We compare the performance of k-Nearest Neighbors (kNN), Support Vector Machine (SVM), and XGBoost, and utilized the sequential forward selection (SFS) feature selection method in the wrapper approach. Through this process, the study identified the most effective EEG data segments and feature subsets. The findings indicated that using a combination of resting and K-CPT EEG data yielded greater discriminability. Notably, the study found that extracting beta power from the right occipital lobe along with fuzzy entropy from the parietal lobe resulted in optimal accuracy of 90% in distinguishing between children with ADHD and TD children. These outcomes highlight the potential of relative PSD and complexity metrics to support the clinical diagnosis of early ADHD. Furthermore, these metrics may contain unique neurobiomarkers that could be valuable for devising early intervention strategies.

关键词： Support vector machines Performance evaluation Pediatrics Accuracy Aging Feature extraction Entropy Electroencephalography Complexity theory Time-domain analysis

来源：评论

学校读者我要写书评

暂无评论

Dopaminergic and Serotoninergic Neurotoxicity of Lanthanide Phosphate (Tbpo4) in Developing Zebrafish

SSRN

引用

SSRN 2023年

作者： Chen, Siying Wang, Xiaohong Ye, Xiaolin Qin, Yingju Wang, Haiqing Liang, Zhenda Zhu, Lishan Zhou, Li Martyniuk, Christopher J. Yan, Bing Institute of Environ. Res. at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of Education Guangzhou University Guangzhou510006 China Center for Environmental and Human Toxicology Department of Physiological Sciences College of Veterinary Medicine UF Genetics Institute Interdisciplinary Program in Biomedical Sciences in Neuroscience University of Florida GainesvilleFL32611 United States School of Environmental Science and Engineering Shandong University Shandong Jinan250100 China

Rare earth elements (REEs) are exploited for global use in manufacturing. Such activities result in their release into the environment and the transformation into more stable phosphate deposition. The objective of this study was to evaluate molecular and behavioral changes of zebrafish exposed to the synthesized terbium phosphate (TbPO4) at concentrations of 10, 20, and 50 mg/L and to determine its potential for neurotoxicity. Metabolomic profiling and assessment of transcripts and proteins were conducted to uncover the molecular mechanisms underlying TbPO4 with emphasis on neurotransmitter systems. Exposure to 20 mg/L TbPO4 induced larval hyperactivity and perturbed the cholinergic system in zebrafish. Based on metabolomics, dopamine (DA), serotonin (5-HT), and many of their precursors and metabolites were decreased in abundance by TbPO4. In addition, the expression levels of transcripts related to the synthesis, transport, receptor binding, and metabolism of DA and 5-HT were analyzed at the mRNA and protein levels. Transcript and protein levels for tyrosine hydroxylase (TH), the rate-limiting enzyme for DA synthesis, were down-regulated in larval fish. Monoamine oxidase (MAO), an enzyme that catabolizes monoamines DA and 5-HT, also reduced mRNA abundance. We hypothesize that DA synthesis and monoamine metabolism are associated with behavioral alterations. In addition, a mechanism for the disruption of neurotransmitter systems by TbPO4 may be the apoptosis of neurons. This study elucidates putative mechanisms and exposure risks to wildlife and humans by characterizing phosphatic REE-induced neurotoxicity in developing zebrafish. © 2023, The Authors. All rights reserved.

关键词： Rare earth elements

来源：评论

学校读者我要写书评

暂无评论

Interpretable network propagation with application to expanding the repertoire of human proteins that interact with SARS-CoV-2

arXiv

引用

arXiv 2020年

作者： Law, Jeffrey N. Akers, Kyle Tasnina, Nure Della Santina, Catherine M. Deutsch, Shay Kshirsagar, Meghana Klein-Seetharaman, Judith Crovella, Mark Rajagopalan, Padmavathy Kasif, Simon Murali, T.M. Interdisciplinary Ph.D. Program in Genetics Bioinformatics and Computational Biology BlacksburgVA United States Department of Computer Science Virginia Tech BlacksburgVA United States Department of Biomedical Engineering Boston University BostonMA United States Department of Mathematics University of California Los AngelesCA United States AI for Good Lab Microsoft RedmondWA United States Department of Chemistry Colorado School of Mines GoldenCO United States Department of Computer Science Boston University BostonMA United States Department of Chemical Engineering Virginia Tech BlacksburgVA United States

Background: Network propagation has been widely used for nearly 20 years to predict gene functions and phenotypes. Despite the popularity of this approach, little attention has been paid to the question of provenance tracing in this context, e.g., determining how much any experimental observation in the input contributes to the score of every prediction. Results: We design a network propagation framework with two novel components and apply it to predict human proteins that directly or indirectly interact with SARS-CoV-2 proteins. First, we trace the provenance of each prediction to its experimentally validated sources, which in our case are human proteins experimentally determined to interact with viral proteins. Second, we design a technique that helps to reduce the manual adjustment of parameters by users. We find that for every top-ranking prediction, the highest contribution to its score arises from a direct neighbor in a human protein-protein interaction network. We further analyze these results to develop functional insights on SARS-CoV-2 that expand on known biology such as the connection between endoplasmic reticulum stress, HSPA5, and anti-clotting agents. Conclusions: We examine how our provenance tracing method can be generalized to a broad class of network-based algorithms. We provide a useful resource for the SARS-CoV-2 community that implicates many previously undocumented proteins with putative functional relationships to viral infection. This resource includes potential drugs that can be opportunistically repositioned to target these proteins. We also discuss how our overall framework can be extended to other, newly-emerging viruses. © 2020, CC BY-NC-SA.

关键词： SARS

来源：评论

学校读者我要写书评

暂无评论

Author Correction: SARS-CoV-2 infection engenders heterogeneous ribonucleoprotein interactions to impede translation elongation in the lungs

引用

EXPERIMENTAL AND MOLECULAR MEDICINE 2023年第12期55卷 2609-2609页

作者： Kim, Junsoo Youn, Daehwa Choi, Seunghoon Lee, Youn Woo Sumberzul, Dulguun Yoon, Jeongeun Lee, Hanju Bae, Jong Woo Noh, Hyuna On, Dain Hong, Seung-Min An, Se-Hee Jang, Hui Jeong Kim, Seo Yeon Kim, Young Been Hwang, Ji-Yeon Lee, Hyo-Jung Kim, Hong Bin Park, Jun Won Yun, Jun-Won Shin, Jeon-Soo Seo, Jun-Young Nam, Ki Taek Choi, Kang-Seuk Lee, Ho-Young Chang, Hyeshik Seong, Je Kyung Cho, Jun Center for RNA Research Institute for Basic Science (IBS) Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioinformatics Seoul National University Seoul Republic of Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea Korea Mouse Phenotyping Center (KMPC) Seoul National University Seoul Republic of Korea Laboratory of Developmental Biology and Genomics Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam Republic of Korea School of Biological Sciences Seoul National University Seoul Republic of Korea Laboratory of Avian Diseases Research Institute for Veterinary Science and BK 21 PLUS Program for Creative Veterinary Science Research College of Veterinary Medicine Seoul National University Seoul Republic of Korea Preclinical Research Center Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Periodontology Section of Dentistry Seoul National University Bundang Hospital Seongnam Republic of Korea Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea Division of Biomedical Convergence College of Biomedical Science Kangwon National University ChunCheon Republic of Korea Laboratory of Veterinary Toxicology College of Veterinary Medicine Seoul National University Seoul Republic of Korea Severance Biomedical Science Institute Graduate School of Medical Science Brain Korea 21 Project Yonsei University College of Medicine Seoul Republic of Korea Department of Nuclear Medicine Seoul National University College of Medicine Seoul Republic of Korea Interdisciplinary Program and BIO MAX Institute Seoul National University

来源：评论

学校读者我要写书评

暂无评论

Inorganic Ions Activate Lineage-Specific Gene Regulatory Networks to Drive Stem Cells Differentiation

SSRN

引用

SSRN 2023年

作者： Kersey, Anna L. Gaharwar, Akhilesh K. Singh, Irtisha Department of Biomedical Engineering College of Engineering Texas A&M University College StationTX77843 United States Department of Cell Biology and Genetics College of Medicine Texas A&M University College StationTX77843 United States Interdisciplinary Program in Genetics Texas A&M University College StationTX77843 United States Center for Remote Health Technologies and Systems Texas A&M University College StationTX77843 United States Department of Material Science and Engineering Dwight Look College of Engineering Texas A&M University College StationTX77843 United States

Ions released from inorganic biomaterials play a vital role in defining cell identity. However, the effect of inorganic ions on cellular functions has yet to be investigated at the transcriptomic level, representing a critical knowledge gap in the development of next-generation of bioactive materials. To address this gap, we investigated the impact of various inorganic ions including silver, copper, titanium, and platinum on human stem cells. Our finding showed that silver and copper induce osteogenic and chondrogenic differentiation respectively, through enrichment of ion-dependent signaling pathways. Specifically, silver effectively induced Wnt and MAPK signaling, which are vital for osteogenesis. On the other hand, copper specifically stimulated TGFβ signaling, while suppressing JAK-STAT signaling, thereby promoting chondrogenesis. In contrast, platinum, tantalum, and titanium ions didn't stimulate regenerative responses. Titanium displayed minimal gene expression changes, demonstrating its relative inertness, while platinum and tantalum induced oxidative stress. These findings are further supported by gene and protein level validation using traditional techniques. Together, our findings highlight the potential of inorganic biomaterials in revolutionizing tissue regeneration strategies, which currently rely largely on growth factors and small molecule therapeutics. © 2023, The Authors. All rights reserved.

关键词： Stem cells

来源：评论

学校读者我要写书评

暂无评论

Statistical Power Analysis for Designing Bulk, Single-Cell, and Spatial Transcriptomics Experiments: Review, Tutorial, and Perspectives

arXiv

引用

arXiv 2023年

作者： Jeon, Hyeongseon Xie, Juan Jeon, Yeseul Jung, Kyeong Joo Gupta, Arkobrato Chang, Won Chung, Dongjun Department of Biomedical Informatics The Ohio State University ColumbusOH United States Pelotonia Institute for Immuno-Oncology The James Comprehensive Cancer Center The Ohio State University ColumbusOH43210 United States The Interdisciplinary PhD program in Biostatistics The Ohio State University ColumbusOH United States Department of Statistics and Data Science Yonsei University Seoul Korea Republic of Department of Applied Statistics Yonsei University Seoul Korea Republic of Department of Computer Science and Engineering The Ohio State University ColumbusOH United States Division of Statistics and Data Science University of Cincinnati CincinnatiOH United States

Gene expression profiling technologies have been used in various applications such as cancer biology. The development of gene expression profiling has expanded the scope of target discovery in transcriptomic studies, and each technology produces data with distinct characteristics. In order to guarantee biologically meaningful findings using transcriptomic experiments, it is important to consider various experimental factors in a systematic way through statistical power analysis. In this paper, we review and discuss the power analysis for three types of gene expression profiling technologies from a practical standpoint, including bulk RNA-seq, single-cell RNA-seq, and high-throughput spatial transcriptomics. Specifically, we describe the existing power analysis tools for each research objective for each of the bulk RNA-seq and scRNA-seq experiments, along with recommendations. On the other hand, since there are no power analysis tools for high-throughput spatial transcriptomics at this point, we instead investigate the factors that can influence power analysis. © 2023, CC BY-NC-ND.

关键词： RNA

来源：评论

学校读者我要写书评

暂无评论

Zwitterionic modified and freeze-thaw reinforced foldable hydrogel as intraocular lens for posterior capsule opacification prevention

引用

Biomaterials 2024年 309卷 122593-122593页

作者： Yang, Cheng-Jui Huang, Wei-Lun Yang, Yu Kuan, Chen-Hsiang Tseng, Ching-Li Wang, Tzu-Wei Department of Materials Science and Engineering National Tsing Hua University Hsinchu Taiwan Department of Ophthalmology National Taiwan University Hospital Hsin-Cchu Branch Hsinchu Taiwan Interdisciplinary Program of Life Science and Medicine National Tsing Hua University Hsinchu Taiwan Division of Plastic Surgery Department of Surgery National Taiwan University Hospital Taipei Taiwan Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University Taipei Taiwan

Posterior capsule opacification (PCO) is a predominant postoperative complication, often leading to visual impairment due to the aberrant proliferation and adhesion of lens epithelial cells (LECs) and protein precipitates subsequent to intraocular lens (IOL) implantation. To address this clinical issue, a foldable and antifouling sharp-edged IOL implant based on naturally-derived cellulose hydrogel is synthesized. The mechanical strength and transparency of the hydrogel is enhanced via repeated freeze-thaw (FT) cycles. The incorporated zwitterionic modifications can remarkably prevent the incidence of PCO by exhibiting proteins repulsion and cell anti-adhesion properties. The graft of dopamine onto both the haptic and the periphery of the posterior surface ensures the adhesion of the hydrogel to the posterior capsule and impedes the migration of LECs without compromising transparency. In in vivo study, the zwitterionic modified foldable hydrogel exhibits uveal and capsular biocompatibility synchronously with no signs of inflammatory response and prevent PCO formation, better than that of commercialized and PEG-modified IOL. With foldability, endurability, antifouling effect, and adhesive to posterior capsule, the reported hydrogel featuring heterogeneous surface design displays great potential to eradicate PCO and attain post-operative efficacy after cataract surgery. © 2024 Elsevier Ltd

关键词： Hydrogels

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：