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Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9-11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada Abstracts

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JOURNAL OF SPINAL CORD MEDICINE 2017年第6期40卷 813-869页

作者： [Anonymous] a NET Team Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. fo Neural Engineering and Therapeutic Team Lyndhurst Centre Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. c Rick Hansen Institute Vancouver BC Canada. ev Rick Hansen Institute Vancouver BC Canada. fc Stan Cassidy Hospital University of New Brunswick Fredericton NB Canada. fd Dalhousie University Halifax NS Canada. e University of Saskatchewan Saskatoon SK Canada. aa University of Calgary Calgary AB Canada. y Dalhousie University Halifax NS Canada. fa Health Sciences Centre Winnipeg MB Canada. fb University of Manitoba Winnipeg MB Canada. h University of Alberta Edmonton AB Canada. i Universite Laval Quebe c City QC Canada. bd Rick Hansen Institute Vancouver BC Canada. fz Clinician Investigator Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Medicine Division of Physical Medicine and Rehabilitation University of Toronto. v University of Toront o Toronto ON Canada. n Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto ON Canada. o Toronto Rehabilitation Institute - University Health Network Toronto ON Canada. ga Clinical Scientist Lyndhurst Centre Toronto Rehabilitation Institute University Health Network and Assistant Professor Department of Physical Therapy University of Toronto. dx Department of Electrical and Computer Engineering University of Toronto Toronto ON Canada. fm Lawson Health Research Institute London ON Canada. r Parkwood Institute London ON Canada. bi Parkwood Institute London ON Canada. s University of British Columbia Vancouver BC Canada. t Simon Fraser University Burnaby BC Canada. u DeltaQuest Foundation Concord MA USA. z Institut national d'excellence en santé et en services sociaux (INESSS) Quebec City QC Ca

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROscience 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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SU-E-T-717: Surface Coating for Prevention of Metallic Seed Migration in Tissues

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Medical Physics 2015年第6PART23期42卷 3501-3502页

作者： H Lee W Lee J Park Y Choy S Ye Program in Biomedical Radiation Sciences Department of Transdisciplinary Studies Graduate School of Convergence Science and Technology Seoul National University Seoul Korea Interdisciplinary Program in Bioengineering Seoul National University College of Engineering Seoul Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul Korea Department of Radiation Oncology Seoul National University Hospital Seoul Korea

Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, we propose a potential strategy to use of a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, non-radioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and X-ray photoelectron spectroscopy, the surface of the polydopamine-coated and non-coated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in-vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than non-coated seeds. From the in-vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the non-coated seed. This difference was increased with a greater length of time after implantation. Conclusion: We suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.

关键词： Tissues Brachytherapy Dosimetry Metallic coatings Scanning electron microscopy Biocompatibility Image guided radiation therapy Medical imaging X-ray photoelectron spectroscopy

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Correction: Liquid-capped encoded microcapsules for multiplex assays

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Lab on a chip 2017年第4期17卷 738页

作者： Younghoon Song Yunjin Jeong Taehong Kwon Daewon Lee Dong Yoon Oh Tae-Joon Park Junhoi Kim Jiyun Kim Sunghoon Kwon Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 151-742 Republic of Korea. skwon@snu.ac.kr and Department of Electrical and Computer Science Seoul National University Seoul 151-742 Republic of Korea. Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 151-742 Republic of Korea. skwon@snu.ac.kr and Interdisciplinary Program of Bioengineering Seoul National University Seoul 151-742 Republic of Korea. Nano Systems Institute Seoul National University Seoul 151-742 Republic of Korea. Department of Materials Science and Engineering Ulsan National Institute of Science and Technology Ulsan 44919 Republic of Korea. Institutes of Entrepreneurial BioConvergence Seoul National University Seoul 151-742 Republic of Korea. skwon@snu.ac.kr and Department of Electrical and Computer Science Seoul National University Seoul 151-742 Republic of Korea and Interdisciplinary Program of Bioengineering Seoul National University Seoul 151-742 Republic of Korea and Nano Systems Institute Seoul National University Seoul 151-742 Republic of Korea and Seoul National University Hospital Biomedical Research Institute Seoul National University Hospital Seoul 151-742 Republic of Korea and Quantamatrix Inc. Seoul 151-742 Republic of Korea.

Correction for 'Liquid-capped encoded microcapsules for multiplex assays' by Younghoon Song et al., Lab Chip, 2017, DOI: .

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Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Abstracts

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FLUIDS AND BARRIERS OF THE CNS 2017年第SUPPL 2期14卷 27-27页

作者： [Anonymous] The Jerzy Kukuczka Academy of Physical Education Katowice Poland The Institute of Animal Physiology and Food Research Polish Academy of Sciences Olsztyn Poland University of Miami Miami FL USA Institute of Pharmaceutical Science King’s College London London United Kingdom Department of Ophthalmology and Molecular and Integrative Physiology The University of Michigan Ann Arbor MI USA Department of Internal Medicine and Cardiology The University of Michigan Ann Arbor MI USA School of Medicine Department of Cellular and Molecular Medicine Koc University Istanbul Turkey Department of Cellular and Molecular Medicine Medical Faculty Koc University Istanbul Turkey Department of Neuroscience School of Medicine Koc University Istanbul Turkey Department of Neuroscience Medical Faculty Koc University Istanbul Turkey Department of Laboratory Animals Science Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey Department of Neuroscience Aziz Sancar Experimental Medicine Research Institute Istanbul University Istanbul Turkey School of Medicine Koc University Istanbul Turkey Department of Forensic Science Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Histology and Embryology School of Medicine Koc University Istanbul Turkey Department of Histology and Embryology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey Department of Physiology School of Medicine Koc University Istanbul Turkey Theodor Kocher Institute University of Bern Bern Switzerland Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich Zurich Switzerland Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Zurich Center of Integrative Human Physiology University of Zurich Zurich Switzerland Institute for Veterinary Physiology and Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland Institute of Veterinary Physiology Univer

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Label-free Imaging of Membrane Potential via Stimulated Raman Scattering

Label-free Imaging of Membrane Potential via Stimulated Rama...

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2015年中国生物医学工程联合学术年会

作者： Bin Liu Hyeon Jeong Lee Delong Zhang Chien-Sheng Liao Na Ji Yuanqin Xia Ji-Xin Cheng National Key Laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHa Interdisciplinary Life Science Program Purdue UniversityWest LafayetteIndiana 47907United States Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIndiana 47907United States Janelia Research Campus Howard Hughes Medical InstituteAshburnVirginia 20147United States National Key Laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHa Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIndiana 47907United States

Hyperspectral stimulated Raman scattering microscopy is deployed to measure single-membrane vibrational spectrum as a function of membrane *** erythrocyte ghost as a model,quantitative correlation between transmembrane potential and Raman spectral profile was ***,the ratio between the area under Raman band at~2930 cm-1 and that at~2850 cm-1 increased by~2.6 times when the potential across the erythrocyte ghost membrane varied from +10 mV to-10 mV.

关键词： Membrane potential stimulated Raman scattering Raman spectroscopy

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A problem-action relation extraction based on causality patterns of clinical events in discharge summaries 14

A problem-action relation extraction based on causality patt...

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23rd ACM International Conference on Information and Knowledge Management, CIKM 2014

作者： Seol, Jae-Wook Jo, Seung-Hyeon Yi, Wangjin Choi, Jinwook Lee, Kyung-Soon Dept. of Computer Science and Engineering CAIIT Chonbuk National University Korea Republic of Interdisciplinary Program of Bioengineering College of Engineering Seoul National University Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781450325981

Medical knowledge extraction has great potential to improve the treatment quality of hospitals. In this paper, we propose a clinical problem-action relation extraction method. It is based on clinical semantic units and event causality patterns in order to present a chronological view of a patient's problem and a physician's action. Based on our observation, a clinical semantic unit is defined as a conceptual medical knowledge for a problem and/or action. Since a clinical event is a basic concept of the problem-action relation, events are detected from clinical texts based on conditional random fields. A clinical semantic unit is segmented from a sentence based on time expressions and inherent structure of events. Then, a clinical semantic unit is classified into a problem and/or action relation based on event causality features in support vector machines. The experimental result on Korean medical collection shows 78.8% in F-measure when given the answer of clinical events. This result shows that the proposed method is effective for extracting clinical problem-action relations.

关键词： Semantics

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Bone Remodeling: Theranostic Bioabsorbable Bone Fixation Plate with Drug‐Layered Double Hydroxide Nanohybrids (Adv. Healthcare Mater. 21/2016)

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Advanced Healthcare Materials 2016年第21期5卷

作者： Myung Hun Kim Woojune Hur Goeun Choi Hye Sook Min Tae Hyun Choi Young Bin Choy Jin‐Ho Choy Center for Intelligent Nano‐Bio Materials (CINBM) Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Plastic and Reconstructive Surgery Institute of Human‐Environment Interface Biology College of Medicine Seoul National University Seoul 03080 Republic of Korea Department of Preventive Medicine Graduate School of Public Health Seoul National University Seoul 08826 Korea Institute of Medical and Biological Engineering Medical Research Center and Department of Biomedical Engineering College of Medicine Seoul National University Seoul 03080 Republic of Korea

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Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

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Nature communications 2019年第1期10卷 2956页

作者： Lohith Madireddy Kicheol Kim Xiaoming Jia Adam Santaniello Stacy J. Caillier Bruce A. C. Cree Roland Henry Stephen L. Hauser Jorge R. Oksenberg Sergio E. Baranzini Nikolaos A. Patsopoulos Philip De Jager Chris Cotsapas Matthew R. Lincoln David A. Hafler Steffan D. Bos Hanne F. Harbo Tone Berge Elisabeth G. Celius Ashley Beecham Jacob McCauley Margaret A. Pericak-Vance Till F. M. Andlauer Christiane Gasperi Bernhard Hemmer Lisa F. Barcellos Luisa Bernardinelli Filippo Martinelli-Boneschi David R. Booth Graeme J. Stewart Farren Briggs Jonathan Haines Manuel Comabella Giancarlo Comi Federica Esposito Sandra D’Alfonso Katrina Dedham Pierre Duquette Efthimios Dardiotis Bertrand Fontaine An Goris Bénédicte Dubois Pierre-Antoine Gourraud Georgios Hadjigeorgiou Clive Hawkins Seema Kalra Rogier Hintzen Dana Horakova Noriko Isobe Jun-ichi Kira Michael Khalil Ingrid Kockum Tomas Olsson Christina M. Lill Felix Luessi Frauke Zipp Roland Martin Annette Oturai Aarno Palotie Janna Saarela Adrian Ivinson Bruce V. Taylor Alastair Compston Stephen Sawcer Weill Institute for Neurosciences Department of Neurology University of California San Francisco San Francisco CA 94158 USA Bakar Institute for Computational Health Science. University of California San Francisco San Francisco CA 94158 USA Systems Biology and Computer Science Program Ann Romney Center for Neurological Diseases Department of Neurology and Division of Genetics Department of Medicine Brigham & Women’s Hospital Harvard Medical School Boston MA 02115 USA Broad Institute of Harvard University and Massachusetts Institute of Technology Cambridge MA 02142 USA Department of Neurology Center for Translational and Computational Neuroimmunology and Multiple Sclerosis Center Columbia University Medical Center New York NY 10032 USA Departments of Neurology Yale School of Medicine 300 George St New Haven CT 06511 USA Department of Genetics Yale School of Medicine 300 George St New Haven CT 06511 USA Institute of Clinical Medicine University of Oslo Oslo 0318 Norway Department of Neurology Oslo University Hospital Oslo 0424 Norway Department of Mechanical Electronics and Chemical Engineering Oslo Metropolitan University Oslo 0167 Norway Institute of Health and Society University of Oslo Oslo 0318 Norway John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine Miami FL 33136 USA Dr. John T. Macdonald Foundation Department of Human Genetics University of Miami Miller School of Medicine Miami FL 33136 USA Department of Neurology Klinikum rechts der Isar School of Medicine Technical University of Munich 81675 Munich Germany Munich Cluster for Systems Neurology (SyNergy) 81377 Munich Germany Division of Epidemiology School of Public HealthUniversity of California 324 Stanley Hall MC#3220 Berkeley CA 94720 USA Section of Biostatistics Neurophyisiology and Psychiatry Unit of medical and genomic statistics Universita of Pavia Pavia 27100 Italy Department of Biomedical Sciences for Health Univers

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Leveraging wikipedia and context features for clinical event extraction from mixed-language discharge summary

Lecture Notes in Computer Science (including subseries Lectu...

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Lecture Notes in Computer science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2014年 8870卷 302-313页

作者： Jeong, Kwang-Yong Yi, Wangjin Seol, Jae-Wook Choi, Jinwook Lee, Kyung-Soon Dept. of Computer Science & Engineering CAIIT Chonbuk National University Korea Republic of Interdisciplinary Program of Bioengineering Seoul National University Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

Unstructured clinical texts contain patients’ disease related narratives, but it is required elaborate work to mine the kind of information. Especially for the classification of semantic types of a clinical term, implementations of domain knowledge from resources such as the Unified Medical Language System (UMLS) are essential. The UMLS has a limitation in dealing with other languages. In this paper, we leverage Wikipedia as well as UMLS for clinical event extraction, especially from clinical narratives written in mixed-language. Semantic features for clinical terms are extracted based on semantic networks of hierarchical categories in Wikipedia. Semantic types for Korean clinical terms are detected by using translation links and semantic networks in Wikipedia. An additional remarkable feature is a controlled vocabulary of clue words which can be contextual evidence to determine clinical semantic types of a word. The experimental result on 150 discharge summaries written in English and Korean showed 75.9% in F1-measure. This result shows that the proposed features are effective for clinical event extraction. © Springer International Publishing Switzerland 2014.

关键词： Domain Knowledge

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