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9th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2005

作者： Hung, Lung-Hsin Hsieh, Albert Tsung-Hsi Portney, Nate Lee, Abraham Philip Department of Biomedical Engineering Interdisciplinary Materials Science and Engineering Program University of California at Irvine 204 Rockwell Engineering Center Irvine CA 92697 United States Department of Chemical and Environmental Engineering Department University of California at Riverside United States Department of Biomedical Engineering Mechanical and Aerospace Engineering University of California at Irvine United States

ISBN: (纸本)0974361119

This paper presents an integrated microfluidic device for the generation of poly (lactideco- glycolide) (PLGA) nanospheres with protein coating. The chip utilizes the microfluidic droplet reactor technique [1] and PLGA salting-out [2] approach to provide high consistency and efficiency. The size of generated PLGA nanospheres was in the 300nm range;and the coating amount is 1 μg of bovine serum albumin (BSA) per 1mg PLGA nanospheres. Compared to conventional methods, the microfluidic generation of nanospheres reported here has the advantages of continuous synthesis process, tuneable process condition, and small droplet/particle dispersion. Copyright © 2005 by the Transducer Research Foundation, Inc.

关键词： Solvent extraction

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Bioinspired MXene-Based Soft Actuators Exhibiting Angle-Independent Structural Color

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Nano-Micro Letters 2023年第1期15卷 1-13页

作者： Pan Xue Yuanhao Chen Yiyi Xu Cristian Valenzuela Xuan Zhang Hari Krishna Bisoyi Xiao Yang Ling Wang Xinhua Xu Quan Li School of Materials Science and Engineering Tianjin UniversityTianjin 300350People’s Republic of China Institute of Advanced Materials School of Chemistry and Chemical EngineeringTech Key Laboratory for Biomedical ResearchSoutheast Universityand Jiangsu Province HiNanjing 211189People’s Republic of China Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOH 44242USA

In nature,many living organisms exhibiting unique structural coloration and soft-bodied actuation have inspired scientists to develop advanced structural colored soft actuators toward biomimetic soft ***,it is challenging to simultaneously biomimic the angle-independent structural color and shape-morphing capabilities found in the plum-throated cotinga flying ***,we report biomimetic MXene-based soft actuators with angle-independent structural color that are fabricated through controlled self-assembly of colloidal SiO_(2) nanoparticles onto highly aligned MXene films followed by vacuum-assisted infiltration of polyvinylidene fluoride into the *** resulting soft actuators are found to exhibit brilliant,angle-independent structural color,as well as ultrafast actuation and recovery speeds(a maximum curvature of 0.52 mm−1 can be achieved within 1.16 s,and a recovery time of~0.24 s)in response to acetone *** proof-of-concept illustrations,structural colored soft actuators are applied to demonstrate a blue gripper-like bird’s claw that can capture the target,artificial green tendrils that can twine around tree branches,and an artificial multicolored butterfly that can flutter its wings upon cyclic exposure to acetone *** strategy is expected to offer new insights into the development of biomimetic multifunctional soft actuators for somatosensory soft robotics and next-generation intelligent machines.

关键词： Bioinspired soft actuator Angle-independent structural color MXene liquid crystals Soft robotics

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The mitochondrial genome data of the Capsicum annuum cv. Dempsey (Solanaceae)

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Data in Brief 2025年 60卷

作者： Seona Yun Junseong Bae Jeongbin Park Hyeran Kim Institute of Life Sciences Kangwon National University Chuncheon Republic of Korea Interdisciplinary Program of Genomic Data Science Pusan National University Yangsan Republic of Korea Graduate School of Medical AI Pusan National University Yangsan Republic of Korea School of Biomedical Convergence Engineering Pusan National University Yangsan Republic of Korea Department of Biological Sciences Kangwon National University Chuncheon Republic of Korea

Capsicum annuum L. (1753), commonly known as pepper, holds significant economic value as one of the globally cultivated horticultural crops. This study presents the mitochondrial genome of the sweet pepper C. annuum cv. Dempsey, assembled using Illumina NovaSeq data. The circular mitogenome is 577,453 base pairs (bp) in length and includes 36 protein-coding genes, three ribosomal RNA genes, and 43 transfer RNA genes. Phylogenetic analysis reveals that C. annuum is not monophyletic, with C. annuum cv. Dempsey identified as a sister to the hot pepper C. annuum cv. Jeju. This study provides as a valuable resource for comparative analyses of pepper mitogenomes, enhancing our understanding of the evolution and adaptive mechanisms of pepper species.

关键词： Capsicum annuum Sweet pepper Cultivar dempsey Mitogenome Phylogeny

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A problem-action relation extraction based on causality patterns of clinical events in discharge summaries 14

A problem-action relation extraction based on causality patt...

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23rd ACM International Conference on Information and Knowledge Management, CIKM 2014

作者： Seol, Jae-Wook Jo, Seung-Hyeon Yi, Wangjin Choi, Jinwook Lee, Kyung-Soon Dept. of Computer Science and Engineering CAIIT Chonbuk National University Korea Republic of Interdisciplinary Program of Bioengineering College of Engineering Seoul National University Korea Republic of Dept. of Biomedical Engineering College of Medicine Seoul National University Korea Republic of

ISBN: (纸本)9781450325981

Medical knowledge extraction has great potential to improve the treatment quality of hospitals. In this paper, we propose a clinical problem-action relation extraction method. It is based on clinical semantic units and event causality patterns in order to present a chronological view of a patient's problem and a physician's action. Based on our observation, a clinical semantic unit is defined as a conceptual medical knowledge for a problem and/or action. Since a clinical event is a basic concept of the problem-action relation, events are detected from clinical texts based on conditional random fields. A clinical semantic unit is segmented from a sentence based on time expressions and inherent structure of events. Then, a clinical semantic unit is classified into a problem and/or action relation based on event causality features in support vector machines. The experimental result on Korean medical collection shows 78.8% in F-measure when given the answer of clinical events. This result shows that the proposed method is effective for extracting clinical problem-action relations.

关键词： Semantics

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Evaluation of three mattress designs for capacitive ecg measurement from conductive textiles on bed

Evaluation of three mattress designs for capacitive ecg meas...

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10th IASTED International Conference on biomedical engineering, BioMed 2013

作者： Lee, Hongji Lee, Seungmin Park, Kwangsuk Interdisciplinary Program of Bioengineering Seoul National University Seoul 110-799 Korea Republic of Department of Biomedical Engineering College of Health Science Korea University Seoul 136-703 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul 110-799 Korea Republic of

ISBN: (纸本)9780889869530

In this paper, we developed three designs depending on the shape of electrode array for unconstrained electrocardiogram (ECG) measurement and tested the systems in practical and numerical terms. Conductive textiles and polyurethane form were used to make electrodes for comfortable ECG measurement. A total of three experiments were conducted to compare each design with a conventional ECG system by error rates of heart rate variability parameters, and to test the effects of capacitive ECG measurement depending on the thickness of cotton cloth inserted between a subject and textile electrodes, in cases of textiles with laminating or without laminating process. The overall results showed that the general type of horizontal array had the best performance in numerical side even though other designs were modified for reflection of heart axis or better contact in practical aspect. The maximum possible thickness for ECG measurement was about 2 mm on conductive textile and about 1.5 mm on the textile laminated by non-conductive material. Therefore, in terms of durability, the system is possible to apply enough in real life and we can use this system for algorithm of arrhythmias detection, OSA detection and sleep stages.

关键词： Electrocardiograms

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Using a Recurrent Neural Network Model for Classification of Tweets Conveyed Influenza-related Information 1

Using a Recurrent Neural Network Model for Classification of...

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1st International Workshop on Digital Disease Detection using Social Media, DDDSM 2017, co-located with the 8th International Joint Conference on Natural Language Processing, IJCNLP 2017

作者： Wang, Chen-Kai Singh, Onkar Tang, Zhao-Li Dai, Hong-Jie Graduate Institute of Biomedical Informatics Taipei Medical University Taipei Taiwan Bioinformatics Program Taiwan International Graduate Program Institute of Information Science Academia Sinica Taipei Taiwan Institute of Biomedical Informatics National Yang-Ming University Taipei Taiwan Department of Computer Science and Information Engineering National Taitung University Taitung Taiwan Interdisciplinary Program of Green and Information Technology National Taitung University Taitung Taiwan

ISBN: (纸本)9781948087070

Traditional disease surveillance systems depend on outpatient reporting and virological test results released by hospitals. These data have valid and accurate information about emerging outbreaks but it's often not timely. In recent years the exponential growth of users getting connected to social media provides immense knowledge about epidemics by sharing related information. Social media can now flag more immediate concerns related to outbreaks in real time. In this paper we apply the long short-term memory recurrent neural network (RNN) architecture to classify tweets conveyed influenza-related information and compare its performance with baseline algorithms including support vector machine (SVM), decision tree, naive Bayes, simple logistics, and naive Bayes multinomial. The developed RNN model achieved an F-score of 0.845 on the MedWeb task test set, which outperforms the F-score of SVM without applying the synthetic minority oversampling technique by 0.08. The F-score of the RNN model is within 1% of the highest score achieved by SVM with oversampling technique. © 2017 AFNLP

关键词： Support vector machines

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Serum proteomic approach to identifying differentially expressed proteins in effusive feline infectious peritonitis

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Scientific Reports 2025年第1期15卷 1-12页

作者： Wassamon Moyadee Jatuporn Rattanasrisomporn Sittiruk Roytrakul Janthima Jaresitthikunchai Narumon Phaonakrop Kiattawee Choowongkomon Sekkarin Ploypetch Natthasit Tansakul Amonpun Rattanasrisomporn Graduate Program in Animal Health and Biomedical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency Pathum Thani Thailand Department of Biochemistry Faculty of Science Kasetsart University Bangkok Thailand Department of Clinical Sciences and Public Health Faculty of Veterinary Science Mahidol University Nakhon Pathom Thailand Department of Pharmacology Faculty of Veterinary Medicine Kasetsart University Bangkok Thailand Interdisciplinary of Genetic Engineering and Bioinformatics Graduate School Kasetsart University Bangkok Thailand

Feline infectious peritonitis (FIP) is a lethal, viral-induced immune-mediated disease that remains a challenge for diagnosis and treatment in cats. Proteomic profiling, which analyzes the protein content of biological samples, offers the potential to identify novel biomarkers that could improve the diagnosis and management of FIP. This study aims to assess the serum proteome and identify proteins that differentiate healthy cats from cats diagnosed with effusive FIP using liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). A total of 30 cats diagnosed with effusive FIP and 27 clinically normal cats were enrolled. Twenty-three proteins were significantly (p< 0.01, ≥ fivefold change in abundance) differentially expressed between cats with effusive FIP and controls. Among these, the P2X purinoceptor, DNA topoisomerase, Notch receptor 2, and cadherin-17 were identified as key proteins of interest in cats with effusive FIP. Our findings suggest that these differentially expressed proteins could serve as potential diagnostic biomarkers and therapeutic targets for FIP. However, further studies are needed to validate these findings and explore their potential applications.

关键词： Biomarkers Cats Coronavirus Feline infectious peritonitis Proteomics Serum

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Nanomaterials-based flexible and stretchable bioelectronics

Nanomaterials-based flexible and stretchable bioelectronics

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作者： Song, Jun-Kyul Do, Kyungsik Koo, Ja Hoon Son, Donghee Kim, Dae-Hyeong School of Chemical and Biological Engineering Seoul National University Korea Republic of Interdisciplinary Program for Bioengineering Seoul National University Korea Republic of Biomedical Research Institute Korea Institute of Science and Technology Korea Republic of Seoul National University Korea Republic of

Conventional silicon-based electronics have faced challenges in the realization of soft bioelectronics, such as wearable and implantable integrated devices, which necessitate electrically and mechanically interactive biotic-abiotic interfacing without disturbing the daily life of the user or posing biocompatibility issues. Recently, much effort has been directed at overcoming the mechanical limitations of conventional rigid electronics by replacement of bulky, thick, and rigid electronic materials with biocompatible, soft, and nanoscale electronic materials, which exhibit intrinsic mechanical deformability as well as superior electrical properties. Recent advances in the synthesis of unconventional nanomaterials, surface functionalization methods, and integrated device fabrication techniques have resulted in further improvements in the performance of nanomaterials-based soft bioelectronics. Numerous studies have focused on the biological, electrical, and mechanical analyses of heterogeneous nanomaterial-biosystem interfaces as well as the development of efficient integration processes of soft nanomaterials into devices. In this article, we summarize the latest advances and future prospects in nanomaterials synthesis, processing, and integration strategies for flexible and stretchable bioelectronics, and their application to wearable and implantable devices. © Materials Research Society 2019.

关键词： Flexible electronics

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Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer

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Nature Communications 2025年第1期16卷 1-11页

作者： Hyeonyeob Seo Gun-Hee Lee Dong-Yeong Kim Kum Seok Nam Jiwoo Park Yeonzu Son Semin Kim Congqi Yang Seongjun Park Joonhee Won Hyunjun Kim Steve Park Jae-Young Bae Seung-Kyun Kang Jiheong Kang Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Departments of Cogno-Mechatronics Engineering Pusan National University Busan Republic of Korea Departments of Optics and Mechatronics Engineering Pusan National University Busan Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea Medical Research Center Seoul National University Seoul Republic of Korea Department of Biomedical Sciences College of Medicine Seoul National University Seoul Republic of Korea School of Transdisciplinary Innovations Seoul National University Seoul Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul Republic of Korea Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea KAIST Institute for NanoCentury Daejeon Republic of Korea Department of Materials Science and Engineering Seoul National University Seoul Republic of Korea Department of Chemistry Seoul National University Seoul Republic of Korea

Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conventional packaging process involves multiple steps that increase in complexity as the number of circuit layers multiply. In this study, we introduce a self-packaged stretchable printed circuit board enabled by the in situ phase separation of liquid metal particles (LMPs) within various polymer matrices during solution-based printing processes. The ligand-bound LMPs (LB-LMPs), engineered to inhibit oxide growth, undergo in situ sintering, prompting vertical phase separation. This synthesis strategy not only achieves high initial conductivity of the LMPs but also encapsulates them within the polymer matrix, preventing leakage and providing electrical insulation. Our method enables multi-layer circuit printing, eliminating the need for additional activation and packaging processes. Furthermore, by integrating conductive materials into packaging layers for selective electrical conductivity, vertical interconnect accesses and conductive pads can be formed, enabling large-scale, stretchable, and leakage-free multi-layer electrical circuits and bio-interfaces.

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Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

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Bioactive Materials 2024年第10期40卷 306-317页

作者： Rachel H.Koh Junhee Kim Jeong-Uk Kim Seunghyun L.Kim Arun Kumar Rajendran Seunghun SLee Heesoo Lee Joo Hyun Kim Ji Hoon Jeong Yongsung Hwang Jong Woo Bae Nathaniel S.Hwang School of Chemical and Biological Engineering Institute of Chemical ProcessesSeoul National UniversitySeoul08826South Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826South Korea Department of Biomedical Engineering Dongguk UniversitySeoul10326South Korea Soonchunhyang Institute of Medi-bio Science(SIMS) Soonchunhyang UniversityCheonan31151South Korea Department of Integrated Biomedical Science Soonchunhyang UniversityAsan31538South Korea Department of Orthopaedic Surgery Konkuk University Chungju HospitalKonkuk University School of MedicineChungju27376South Korea BioMAX Institute Seoul National UniversitySeoul08826South Korea

Osteochondral tissue is a highly specialized and complex tissue composed of articular cartilage and subchondral bone that are separated by a calcified cartilage *** or gradient scaffolds,often in conjunction with stem cells and growth factors,have been developed to mimic the respective layers for osteochondral defect *** this study,we designed a hyaline cartilage-hypertrophic cartilage bilayer graft(RGD/RGDW)with ***,we demonstrated that RGD peptide-modified chondroitin sulfate cryogel(RGD group)is chondro-conductive and capable of hyaline cartilage ***,we incorporated whitlockite(WH),a Mg^(2+)-containing calcium phosphate,into RGD cryogel(RGDW group)to induce chondrocyte hypertrophy and form collagen X-rich hypertrophic *** is the first study to use WH to produce hypertrophic ***-laden RGDW cryogel exhibited significantly upregulated expression of hypertrophy markers in vitro and formed ectopic hypertrophic cartilage in vivo,which mineralized into calcified cartilage in bone ***,RGD cryogel and RGDW cryogel were combined into bilayer(RGD/RGDW group)and implanted into rabbit osteochondral defect,where RGD layer supports hyaline cartilage regeneration and bioceramic-containing RGDW layer promotes calcified cartilage *** the RGD group(monolayer)formed hyaline-like neotissue that extends into the subchondral bone,the RGD/RGDW group(bilayer)regenerated hyaline cartilage tissue confined to its respective layer and promoted osseointegration for integrative defect repair.

关键词： Bioceramic Whitlockite Bilayer scaffold Chondrocyte hypertrophy Osteochondral defect repair

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