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The 4th ASRS Congress

作者： Jung-Su Oh Jin Woo Seo Byunghun Choi Do-Un Jeong Kwang-Suk Park Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Department of Psychiatry and Behavioral Science Seoul National University College of Medicine and Division of Sleep Studies Seoul National University Hospital Department of Biomedical Engineering Seoul National University College of Medicine Seoul Republic of Korea

The quantity and quality of human sleep draw more attention as the society becomes more sophisticated. The unique and common method for evaluating human sleep is polysomnography (PSG) and it generates sleep architecture with functional variables. Sleep stages are nonuniform constituents of sleep architecture and each 30-second epoch should be scored accu-

关键词： EOG EMG Sleep Stage Scoring by EEG Spectral Information Based on Fuzzy Clustering Only Fuzzy

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Fluorescence resonance energy transfer detection of mouse immunoglobulin G and Octamer-4 on protein nanoarray

Fluorescence resonance energy transfer detection of mouse im...

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IEEE/ICME International Conference on Complex Medical engineering, CME

作者： Phat. L. Tran Yee Tchao Jeong-Yeol Yoon Biomedical Engineering Graduate Interdisciplinary Program University of Arizona Tucson Tucson AZ USA Department of Veterinary Science and Microbiology University of Arizona Tucson Tucson AZ USA Department of Agricultural and Biosystems Engineering and Biomedical Engineering Graduate Interdisciplinary Program University of Arizona Tucson Tucson AZ USA

An alternative approach for fabricating a protein array at nanoscale (<100 nm) is suggested with a capability of characterization and/or localization of multiple components on a nanoarray. Basically, fluorescent micro- and nanospheres each conjugated with different proteins are size-dependently self-assembled (SDSA) onto these nanometer wells that were created on the polymethyl methacrylate (PMMA) substrate by electron beam lithography (EBL). Particles of different diameters are added serially, and electrostatically attached to the corresponding wells through electrostatic attraction between the carboxylic groups of the spheres and p-doped silicon substrate underneath the PMMA layer. Target detection utilizes fluorescence resonance energy transfer (FRET) from fluorescent beads to target (mouse immunoglobulin G = mIgG or Octamer-4 = Oct4) and its antibody bound on the beads. The 180 nm blue beads are conjugated with mIgG to capture anti-mIgG-FITC. The 50 nm green and 100 nm yellow-green beads are conjugated with anti-Oct4 to capture Oct4 peptides; where the secondary anti-Oct4 tagged with phycoerythrin via F(ab)2 fragment is then added to function as an indicator of Oct4 detection. These protein-conjugated particles are added serially from the largest to the smallest and the particles are successfully self-assembled to the respective nanometer wells to achieve size-dependent self-assembly. FRET signals are detected through fluorescence and confocal microscopes, and further confirmed by Fluorolog3 spectrofluorometer. Therefore, SDSA is a valuable approach for the fabrication of multiple components array; and FRET is a useful biorecognition technique for the detection of mIgG, Oct4 or other targets of interest.

关键词： Fluorescence Resonance Energy exchange Mice Proteins Self-assembly Immune system Electron beams Lithography Electrostatics

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Characterization of the complete mitochondrial genome ofBothrocara hollandi(Perciformes: Zoarcidae)

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Mitochondrial DNA Part B 2019年第1期4卷 523-524页

作者： Nack-Keun Kim Sapto Andriyono Jobaidul Alam Sung-Tae Kim Kyung Mi Jung Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty Universitas Airlangga Surabaya Indonesia Dokdo Fisheries Research Center National Institute of Fisheries Science Pohang Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The full mitogenome ofBothrocara hollandiwas determined by high-throughput sequencing (HTS) platform. The genome was 16,732 bp in length, which included 13 protein-coding genes, 22 tRNAs, two ribosomal RNAs (12S and 16S), and a control region (D-Loop). The overall composition of G + C in the mitogenome was 45.90%, which was lower than A + T contents (54.10%). Except for COX1 (GTG), the other twelve protein-coding genes begin with typical start codon, ATG. The incomplete stop codon (TA − or T–) was identified in five genes, including COXI, COXII, COXIII, ND3, and ND4. The phylogenetic analysis with the currently reported mitogenome sequences showed thatB. hollandiwas most closely related toLycodes tanakae, suggesting that additional mitogenome sequences in genusBothrocaraare required for its clear evolutional relationship.

关键词： High-throughput sequencing Bothrocara hollandi mitogenome phylogenetic eelpout

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PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

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Sleep apnea detection by slope analysis

Sleep apnea detection by slope analysis

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3rd IASTED International Conference on Medical engineering 2005

作者： Han, Jonghee Shin, Hongbeom Jeong, Do-Un Park, Kwangsuk Department of Biomedical Engineering College of Medicine and Hospital Seoul National University Seoul Korea Republic of Interdisciplinary Program College of Medicine and Hospital Seoul National University Seoul Korea Republic of Department of Psychiatry and Behavioral Science College of Medicine and Hospital Seoul National University Seoul Korea Republic of

ISBN: (纸本)0889864780

Detection of sleep apnea is the one of the major tasks in sleep medicine. Various methods have been applied to detect sleep apnea by analyzing different bio-signals. This paper introduces an innovative algorithm that analyze slope of nasal airflow signal in polysomnography. In this study, slope is obtained by the moving average of an absolute differentiation of a signal with 3.8 seconds' time window followed by segmentation of 1 second. Apnea threshold is determined by 10% of the slope of normal breathing. If segments having slope below apnea threshold appear for 10 consecutive segments, those segments are marked as apnea. The presented algorithm analyzed polysomnography records from 13 subjects and detected 2500 apnea events. Performance of presented algorithm was evaluated by comparing its results against the sleep specialist's manual scoring on same records. The overall agreement rate between the two was 95.36% (κ=0.86). In considering its simplicity and lower computational load, the presented algorithm is robust and useful.

关键词： Sleep research

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Recent advances in molecularly imprinted polymers toward biomedical healthcare devices

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Biosensors and Bioelectronics 2025年

作者： Youngjun Seo Yonghwan Kim Jaeheung Kim Hyo Gi Jung Jae Won Jang Hyunji Kim Kyo Seon Hwang Dongtak Lee Sang Won Lee Jeong Hoon Lee Dae Sung Yoon School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Bioengineering & Nano-bioengineering Research Center for Bio Materials and Process Development Incheon National University Incheon 22012 Republic of Korea Division of Bioengineering Incheon National University Incheon 22012 Republic of Korea Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA KU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea Department of Integrative Energy Engineering College of Engineering Korea University Seoul 02841 Republic of Korea Astrion Inc Seoul 02841 Republic of Korea

Following the increase in the global aging population, the importance of monitoring various disease-related biomarkers at an early stage has increased to ensure the health of the elderly. In an aging society, point-of-care (POC) systems are needed to care for elderly people who have physical and mental disorders. In light of the increasing prominence of POC systems, there is a growing effort to address the limitations associated with conventional receptors in wearable devices by substituting them with molecularly imprinted polymer (MIP). MIPs are well-known synthetic receptors engineered with specific binding cavities based on the "lock and key" principle. They could be synthesized in various configurations depending on specific types of monomers and templates. Compared to conventional receptors such as antibodies and aptamers, MIPs exhibit outstanding advantages, including good stability, cost-effectiveness, ease of synthesis, reusability, and broad applicability. These advantages have led to their extensive application in biomedical healthcare devices. This review summarizes a comparative analysis of sensors utilized for the detection of disease-specific biomarkers through diverse MIP applications and methodologies. Furthermore, we evaluated recent advancements in the miniaturization of MIPs and their integration with wearable biomedical devices for comprehensive healthcare monitoring applications. Finally, we delineated the existing limitations that need to be surmounted for the effective implementation of MIP-based biomedical devices and outlined future objectives for the enhancement of wearable and wireless biomedical healthcare monitoring devices.

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The molecular characterization of complete mitochondrial genome of spotted snakehead fish,Channa punctata(Bloch 1793)

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Mitochondrial DNA Part B 2019年第1期4卷 547-548页

作者： Md. Jobaidul Alam Sapto Andriyono Sinar Pagi Sektiana Md. Mofizur Rahman Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Fisheries Ministry of Fisheries and Livestock Dhaka Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaFisheries and Marine Faculty Universitas Airlangga Surabaya East Java Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaAquaculture Technology Study Program Sekolah Tinggi Perikanan Jakarta Indonesia Department of Marine Biology Pukyong National University Busan Republic of KoreaDepartment of Fisheries and Marine Science Noakhali Science and Technology University Sonapur Noakhali Bangladesh Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome of spotted snakehead fish,Channa punctata(Bloch 1793) was determined by MiSeq platform. The genome was 16,409 bp in length, in which canonical 13 protein-coding genes, 22 tRNAs, 2 rRNAs, and a control region (D-Loop) were encoded. Relatively higher overall A + T contents (53.70%) was identified compared with G + C contents (46.30%). Among 13 protein-coding genes, only one unusual start condon (GTG) was identified in COX1, whereas six genes includingCOXII,COXIII,NAD2,NAD3,NAD4, andCytbwere ended with the incomplete stop codons (TA-/T–). Based on the currently identified mitogenomes of Channa fish species,C. punctatawas most closely related toChanna gachuawith 82% sequence identity.

关键词： Next generation sequencing Channa punctata mitochondrial genome phylogeny snakehead fish

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Correction: Recent progress in DNA data storage based on high-throughput DNA synthesis

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biomedical engineering letters 2024年第5期14卷 1147-1152页

作者： Seokwoo Jo Haewon Shin Sung-Yune Joe David Baek Chaewon Park Honggu Chun Department of Biomedical Engineering Korea University 466 Hana Science Hall Seoul 02841 Korea. Interdisciplinary Program in Precision Public Health Korea University 466 Hana Science Hall Seoul 02841 Korea.

[This corrects the article DOI: 10.1007/s13534-024-00386-z.].

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Correction to: N‑doped carbon nanospheres as selective fluorescent probes for mercury detection in contaminated aqueous media: chemistry, fluorescence probing, cell line patterning, and liver tissue interaction

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Environmental science and pollution research international 2025年第20期32卷 2025 May 6页

作者： Soheil Sojdeh Ali Banitalebi Dehkordi Alireza Badiei Ali Zarrabi Pooyan Makvandi Milad Ashrafizadeh Mohammad Reza Saeb Eder C Lima Mohammad Rabiee Mohsen Asadnia Thomas J Webster Navid Rabiee School of Chemistry College of Science University of Tehran P.O. Box Tehran 14155‑6455 Iran. Department of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Istanbul Turkey. Centre for Materials Interfaces Istituto Italiano Di Tecnologia 56025 Pisa Italy. Sabanci University Orta Mahalle Üniversite Caddesi No. 27 Orhanlı Tuzla 34956 Istanbul Turkey. Department of Polymer Technology Gdańsk University of Technology G. Narutowicza 11/12 80‑233 Gdańsk Poland. Institute of Chemistry Federal University of Rio Grande Do Sul (UFRGS) Av. Bento Goncalves 9500 Postal Box 15003 Porto Alegre ZIP 91501‑970 Brazil. profederlima@***. Biomaterials Group Department of Biomedical Engineering Amirkabir University of Technology Tehran Iran. School of Engineering Macquarie University New South Wales Sydney 2109 Australia. School of Health Sciences and Biomedical Engineering Hebei University of Technology Tijian 300130 China. School of Engineering Saveetha University Chennai 602105 India. Interdisciplinary Laboratory for Advanced Materials (LIMAV) Materials Science and Engineering Graduate Program Federal University of Piaui Teresina 64049‑550 Brazil. Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth 6150 Australia.

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Development of A Remotely-Accessible Digital Polysomnography Using TCP/IP

Development of A Remotely-Accessible Digital Polysomnography...

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The 4th ASRS Congress

作者： Jin Woo Seo Byunghun Choi Kwang Suk Park Do-Un Jeong Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Interdisciplinary Program-Biomedical Engineering Major Graduate School Seoul National University Department of Biomedical Engineering Seoul National University College of Medicine Department of Psychiatry and Behavioral Science Seoul National University College of Medicine and Division of Sleep Studies Seoul National University Hospital Seoul Republic of Korea

Despite that conventional polysomnography(PSG) is a very strong diagnostic tool for sleep disorders, there are some limitations. Among them, temporal and spatial limitations are very significant. They could be overcome by remotely-accessible digital PSG. We developed a digital PSG system for tele-monitoring patients overnight on physiological signals and behavior. The

关键词： Development of A Remotely-Accessible Digital Polysomnography Using TCP/IP

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