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arXiv 2020年

作者： Law, Jeffrey N. Akers, Kyle Tasnina, Nure Della Santina, Catherine M. Deutsch, Shay Kshirsagar, Meghana Klein-Seetharaman, Judith Crovella, Mark Rajagopalan, Padmavathy Kasif, Simon Murali, T.M. Interdisciplinary Ph.D. Program in Genetics Bioinformatics and Computational Biology BlacksburgVA United States Department of Computer Science Virginia Tech BlacksburgVA United States Department of Biomedical Engineering Boston University BostonMA United States Department of Mathematics University of California Los AngelesCA United States AI for Good Lab Microsoft RedmondWA United States Department of Chemistry Colorado School of Mines GoldenCO United States Department of Computer Science Boston University BostonMA United States Department of Chemical Engineering Virginia Tech BlacksburgVA United States

Background: Network propagation has been widely used for nearly 20 years to predict gene functions and phenotypes. Despite the popularity of this approach, little attention has been paid to the question of provenance tracing in this context, e.g., determining how much any experimental observation in the input contributes to the score of every prediction. Results: We design a network propagation framework with two novel components and apply it to predict human proteins that directly or indirectly interact with SARS-CoV-2 proteins. First, we trace the provenance of each prediction to its experimentally validated sources, which in our case are human proteins experimentally determined to interact with viral proteins. Second, we design a technique that helps to reduce the manual adjustment of parameters by users. We find that for every top-ranking prediction, the highest contribution to its score arises from a direct neighbor in a human protein-protein interaction network. We further analyze these results to develop functional insights on SARS-CoV-2 that expand on known biology such as the connection between endoplasmic reticulum stress, HSPA5, and anti-clotting agents. Conclusions: We examine how our provenance tracing method can be generalized to a broad class of network-based algorithms. We provide a useful resource for the SARS-CoV-2 community that implicates many previously undocumented proteins with putative functional relationships to viral infection. This resource includes potential drugs that can be opportunistically repositioned to target these proteins. We also discuss how our overall framework can be extended to other, newly-emerging viruses. © 2020, CC BY-NC-SA.

关键词： SARS

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Phase-change metal ink with pH-controlled chemical sintering for versatile and scalable fabrication of variable stiffness electronics

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science advances 2025年第22期11卷 eadv4921页

作者： Simok Lee Gun-Hee Lee Inho Kang Woojin Jeon Semin Kim Yejin Ahn Choong Yeon Kim Do A Kwon Michael D Dickey Steve Park Seongjun Park Jae-Woong Jeong School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. Medical Research Center Seoul National University Seoul 03080 Republic of Korea. Departments of Cogno-Mechatronics Engineering and Optics and Mechatronics Engineering Pusan National University Busan 46241 Republic of Korea. Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Information and Electronics Research Institute Daejeon 34141 Republic of Korea. Research Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Chemical and Biomolecular Engineering North Carolina State University (NCSU) Raleigh NC 27606 USA. Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Institute for NanoCentury Daejeon 34141 Republic of Korea. Department of Biomedical Sciences College of Medicine Seoul National University Seoul 03080 Republic of Korea. School of Transdisciplinary Innovations Seoul National University Seoul 03080 Republic of Korea. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea. Department of Transdisciplinary Medicine Seoul National University Hospital Seoul 03080 Republic of Korea. KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea.

Variable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft electronics in a single system through dynamic mechanical modulation. While gallium's high modulus tuning ratio and rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, high surface tension, and unintended phase transitions during processing pose substantial challenges. Here, we introduce STiffness-Adjustable temperature-Responsive ink (STAR ink), a chemically sinterable gallium composite electronic ink designed to overcome these obstacles. STAR ink enables high-resolution (~50 micrometers) circuit patterning, large-scale batch fabrication, and three-dimensional structure coating at room temperature. Through pH-controlled chemical sintering, STAR ink-based TES exhibits exceptional mechanical tunability (tuning ratio: 1465) and electrical conductivity (2.27 × 10 siemens per meter). Demonstrated applications-from multilayered variable stiffness printed circuit boards (PCBs) matching standard PCBs' complexity to body-temperature responsive neural probe-underscore STAR ink's potential for reconfigurable electronics across consumer electronics and biomedical devices.

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Author Correction: Reconciliation of energy use disparities in brick production in India

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Nature Sustainability 2023年 1715页

作者： Kushal Tibrewal Chandra Venkataraman Harish Phuleria Anurag Gupta Pradnya Lokhande Veena Joshi Sameer Maithel Anand Damle Shahadev Rabha Binoy K. Saikia Sayantee Roy Gazala Habib Shubham Rathi Anubha Goel Sakshi Ahlawat Tuhin Kumar Mandal M. Azharuddin Hashmi Asif Qureshi Abisheg Dhandapani Jawed Iqbal Sandeep Devaliya Ramya Sunder Raman Yang Lian Govindan Pandithurai Sudheer Kumar Kuppili M. Shiva Nagendra Sauryadeep Mukherjee Abhijit Chatterjee Tanveer Ahmad Najar Arshid Jehangir Jitender Singh Baerbel Sinha Interdisciplinary Program in Climate Studies Indian Institute of Technology Bombay Mumbai India Pune Maharashtra India Greentech Knowledge Solutions Pvt. Ltd. New Delhi India De Boer Damle (India) Pvt. Ltd. Pune Maharashtra India Coal and Energy Division CSIR-North East Institute of Science and Technology Jorhat India Department of Civil Engineering Indian Institute of Technology Delhi Hauz Khas New Delhi India Department of Civil Engineering Indian Institute of Technology Kanpur Kanpur India Center on Global Change Environmental Sciences and Biomedical Metrology Division CSIR-National Physical Laboratory New Delhi India Department of Civil Engineering Indian Institute of Technology Hyderabad Hyderabad India Civil and Environmental Engineering Birla Institute of Technology Ranchi India Earth and Environmental Sciences Indian Institute of Science Education and Research Bhopal Bhopal India Indian Institute of Tropical Meteorology Pune Pune India Department of Civil Engineering Indian Institute of Technology Madras Chennai India Department of Environmental Sciences Bose Institute Kolkata India Department of Environmental Science University of Kashmir Srinagar Jammu and Kashmir India Department of Earth and Environmental Sciences Indian Institute of Science Education and Research Mohali Punjab India

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Spatiotemporal Control of Morphogen Delivery to Pattern Stem Cell Differentiation in Three-Dimensional Hydrogels

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Current Protocols in Stem Cell Biology 2019年第1期51卷 e97页

作者： Balikov, Daniel A. Lippmann, Ethan S. Bellan, Leon M. Department of Mechanical Engineering Vanderbilt University Nashville TN United States Interdisciplinary Materials Science Program Vanderbilt University Nashville TN United States Department of Biomedical Engineering Vanderbilt University Nashville TN United States Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville TN United States

Morphogens are biological molecules that alter cellular identity and behavior across both space and time. During embryonic development, morphogen spatial localization can be confined to small volumes in a single tissue or permeate throughout an entire organism, and the temporal effects of morphogens can range from fractions of a second to several days. In most cases, morphogens are presented as a gradient to adjacent cells within tissues to pattern cell fate. As such, to appropriately model development and build representative multicellular architectures in vitro, it is vital to recapitulate these gradients during stem cell differentiation. However, the ability to control morphogen presentation within in vitro systems remains challenging. Here, we describe an innovative platform using channels patterned within thick, three-dimensional hydrogels that deliver multiple morphogens to embedded cells, thereby demonstrating exquisite control over both spatial and temporal variations in morphogen presentation. This generalizable approach should have broad utility for researchers interested in patterning in vitro tissue structures. © 2019 by John Wiley & Sons, Inc. © 2019 John Wiley & Sons, Inc.

关键词： differentiation gradient hydrogel morphogen stem cell tissue engineering

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Corrigendum to "Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology" [Biomed. Pharmacother. 172 (2024) 1-14/116226]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 181卷 117686页

作者： Yunkwon Nam Ritu Prajapati Sujin Kim Soo Jung Shin Da Yeon Cheong Yong Ho Park Hyun Ha Park Danyou Lim Yoojeong Yoon Gyudo Lee Hyun Ah Jung Insu Park Dong-Hyun Kim Jae Sue Choi Minho Moon Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Department of Biochemistry College of Medicine Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Department of Biotechnology and Bioinformatics Korea University Sejong 30019 Republic of Korea Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong 30019 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Department of Food Science and Human Nutrition Chonbuk National University Jeonju 54896 Republic of Korea. Department of Biomedical Engineering Konyang University Daejeon 35365 Republic of Korea. Electronic address: insupark@konyang.ac.kr. Departments of Pharmacology and Advanced Translational Medicine School of Medicine Konkuk University Seoul 05029 Republic of Korea. Electronic address: mose79@kku.ac.kr. Department of Food and Life Science Pukyong National University Busan 48513 Republic of Korea. Electronic address: choijs@pknu.ac.kr. Research Institute for Dementia Science Konyang University 158 Gwanjeodong-ro Seo-gu Daejeon 35365 Republic of Korea. Electronic address: hominmoon@konyang.ac.kr.

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High Affinity to Skeleton Rare Earth Doped Nanoparticles for Near-Infrared Ⅱ Imaging

High Affinity to Skeleton Rare Earth Doped Nanoparticles for...

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第十一届全国化学生物学学术会议

作者：和树庆 Changfeng Wu Junle Qu Zhen Cheng 南方科技大学 Academy for Advanced Interdisciplinary Studies and Department of Biomedical Engineering Southern University of Science and Technology(SUSTech) Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University Molecular Imaging Program at Stanford(MIPS) Bio-X Programand Department of RadiologyCanary Center at Stanford for Cancer Early DetectionStanford University

As a newly non-invasive emerging modality,NIR-Ⅱ fluorescence imaging(1000-1700 nm) has many advantages over conventional visible and NIR-I imaging(700-900 nm).[1-5] Unfortunately,few NIR-Ⅱ fluorophores are suitable for bone ***,we report an NIR-Ⅱ fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles(RENPs@DSPE-mPEG),which shows inherent affinity to bone without linking any targeting ligands,and thus it provides an alternative non-invasive and non-radiation strategy for skeletal system mapping and bone diseases ***,within NIR-Ⅱ window,imaging at longer wavelength(1345 nm) provides higher resolution and signal-to-noise ratio than that imaging at 1064 nm,even though quantum yield at 1064 nm is 2-fold higher than that at 1345 nm.[2] Besides bone imaging,RENPs@DSPE-mPEG show imaging application in blood vessel and lymph ***,RENPs@DSPE-mPEG can be internalized by circulating white blood *** finding may open a window to increase efficient nanoparticle delivery in the fields such as immunotherapy and improve the diagnostic and therapeutic efficacy of cancer-targeted nanoparticles in clinical applications.

关键词： NIR-Ⅱ imaging NIR-Ⅱa imaging Bone imaging Rare earth doped nanoparticles Thrombus

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Inside Back Cover: Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches (Angew. Chem. Int. Ed. 52/2021)

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Angewandte Chemie International Edition 2021年第52期60卷

作者： Yanrong He Dr. Shu Zhang Dr. Hari Krishna Bisoyi Jinghui Qiao Hong Chen JingJing Gao Prof. Jinbao Guo Prof. Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Education College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Institute of Advanced Materials School of Chemistry and Chemical Engineering Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast University Nanjing 211189 China Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State University Kent Ohio 44242 USA

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Innenrücktitelbild: Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches (Angew. Chem. 52/2021)

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Angewandte Chemie 2021年第52期133卷

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Irradiation-Wavelength Directing Circularly Polarized Luminescence in Self-Organized Helical Superstructures Enabled by Hydrogen-Bonded Chiral Fluorescent Molecular Switches

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Angewandte Chemie 2021年第52期133卷

Two light-driven chiral fluorescent molecular switches, ( R , S , R )-switch 1 and ( R , S , R )-switch 2 , are prepared by means of hydrogen-bonded (H-bonded) assembly of a photoresponsive ( S ) chiral fluorescent molecule, respectively with a cyano substitution at different positions as an H-bond acceptor and an opposite ( R ) chiral molecule as an H-bond donor. The resulting two switches exhibit tunable and reversible Z / E photoisomerization irradiated with 450 nm blue and 365 nm UV light. When doped into an achiral liquid crystal, both switches are found to be able to form a CPL tunable luminescent helical superstructure. In contrast to the tunable CPL characteristics of the system incorporating switch 2 , exposure of the system incorporating switch 1 to 365 nm and 450 nm radiation can lead to controllable different photostationary CPL behavior, including switching-off and polarization inversion. In addition, optical information coding is demonstrated using the system containing switch 1 .

关键词： circularly polarized luminescence handedness inversion hydrogen-bonded chiral fluorescent switch luminescent helical superstructures

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The application of an extracellular vesicle-based biosensor in early diagnosis and prediction of chemoresponsiveness in ovarian cancer

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Cancer Letters 2024年 581卷 216533-216533页

作者： Tsang, Benjamin K. Asare-Werehene, Meshach Hunter, Rob Gerber, Emma Reunov, Arkadiy Brine, Isaiah Chang, Chia-Yu Chang, Chia-Ching Shieh, Dar-Bin Burger, Dylan Anis, Hanan Departments of Obstetrics & Gynecology and Cellular & Molecular Medicine Centre for Infection Immunity and Inflammation Interdisciplinary School of Health Sciences University of Ottawa Ottawa ON K1N 6N5 Canada Chronic Disease Program Ottawa Hospital Research Institute The Ottawa Hospital Ottawa ON K1Y 4E9 Canada Department of Biology St. Francis Xavier University 2320 Notre Dame Avenue Antigonish NS B2G 2W5 Canada School of Electrical Engineering and Computer Science Ottawa-Carleton Institute for Biomedical Engineering University of Ottawa Ottawa ON K1N 6N5 Canada Department of Biological Science and Department of Electrophysics Technology Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B) National Yang Ming Chiao Tung University Hsinchu 30068 Taiwan Institute of Basic Medical Science Institute of Oral Medicine and Department of Stomatology Advanced Optoelectronic Technology Center and Center for Micro/Nano Science and Technology National Cheng Kung University Hospital National Cheng Kung University Tainan 704 Taiwan Institute of Physics Academia Sinica Taipei 10529 Taiwan

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