Morphogens are biological molecules that alter cellular identity and behavior across both space and time. During embryonic development, morphogen spatial localization can be confined to small volumes in a single tissu...
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As a newly non-invasive emerging modality,NIR-Ⅱ fluorescence imaging(1000-1700 nm) has many advantages over conventional visible and NIR-I imaging(700-900 nm).[1-5] Unfortunately,few NIR-Ⅱ fluorophores are suitable ...
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As a newly non-invasive emerging modality,NIR-Ⅱ fluorescence imaging(1000-1700 nm) has many advantages over conventional visible and NIR-I imaging(700-900 nm).[1-5] Unfortunately,few NIR-Ⅱ fluorophores are suitable for bone ***,we report an NIR-Ⅱ fluorophore based on DSPE-mPEG encapsulated rare earth doped nanoparticles(RENPs@DSPE-mPEG),which shows inherent affinity to bone without linking any targeting ligands,and thus it provides an alternative non-invasive and non-radiation strategy for skeletal system mapping and bone diseases ***,within NIR-Ⅱ window,imaging at longer wavelength(1345 nm) provides higher resolution and signal-to-noise ratio than that imaging at 1064 nm,even though quantum yield at 1064 nm is 2-fold higher than that at 1345 nm.[2] Besides bone imaging,RENPs@DSPE-mPEG show imaging application in blood vessel and lymph ***,RENPs@DSPE-mPEG can be internalized by circulating white blood *** finding may open a window to increase efficient nanoparticle delivery in the fields such as immunotherapy and improve the diagnostic and therapeutic efficacy of cancer-targeted nanoparticles in clinical applications.
Two light-driven chiral fluorescent molecular switches, ( R , S , R )-switch 1 and ( R , S , R )-switch 2 , are prepared by means of hydrogen-bonded (H-bonded) assembly of a photoresponsive ( S ) chiral fluorescent mo...
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Two light-driven chiral fluorescent molecular switches, ( R , S , R )-switch 1 and ( R , S , R )-switch 2 , are prepared by means of hydrogen-bonded (H-bonded) assembly of a photoresponsive ( S ) chiral fluorescent molecule, respectively with a cyano substitution at different positions as an H-bond acceptor and an opposite ( R ) chiral molecule as an H-bond donor. The resulting two switches exhibit tunable and reversible Z / E photoisomerization irradiated with 450 nm blue and 365 nm UV light. When doped into an achiral liquid crystal, both switches are found to be able to form a CPL tunable luminescent helical superstructure. In contrast to the tunable CPL characteristics of the system incorporating switch 2 , exposure of the system incorporating switch 1 to 365 nm and 450 nm radiation can lead to controllable different photostationary CPL behavior, including switching-off and polarization inversion. In addition, optical information coding is demonstrated using the system containing switch 1 .
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