A miniaturized tissue equivalent proportional counter (mini-TEPC) cannot accommodate an internal alpha source for calibration. Instead, electron and proton edges on Monte Carlo (MC)-generated lineal energy spectra can...
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We propose a method based on blind deconvolution to calibrate the spatially-varying point spread functions of a coded-aperture microscope system. From easy-to-acquire measurements of unstructured fluorescent beads, we...
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This paper presents a microfluidic device for the rapid identification of high-affinity anti-tumor T cells. This device consists of a polymethyl methacrylate (PMMA) microchannel containing a dense array of circular mi...
This paper presents a microfluidic device for the rapid identification of high-affinity anti-tumor T cells. This device consists of a polymethyl methacrylate (PMMA) microchannel containing a dense array of circular microwells fabricated using a unique CO 2 laser etching process. Using this device, OT-I T cells and LLC-OVA tumor cells were incubated within microwells to identify high-affinity T cells in <1 hour, which is significantly faster than existing T cell screening methods (requiring weeks/months) while being simpler to operate without requiring sophisticated instrumentation. Furthermore, this method is compatible with adherent and nonadherent tumor cells, making it a versatile platform for T cell-tumor cell interaction studies and T cell screening.
State-of-the-art intracortical neuroprostheses currently enable communication at 60+ words per minute for anarthric individuals by training on over 10K sentences to account for phoneme variability in different word co...
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ISBN:
(数字)9798350371499
ISBN:
(纸本)9798350371505
State-of-the-art intracortical neuroprostheses currently enable communication at 60+ words per minute for anarthric individuals by training on over 10K sentences to account for phoneme variability in different word contexts. There is limited understanding about whether this performance can be maintained in decoding naturalistic speech with 40K+ word vocabularies across elicited, spontaneous, and conversational speech contexts. We introduce a vocal-unit-level generalization test to explicitly evaluate neural decoder performance with an expanded and more diverse behavioral repertoire. Tested on neural decoders modeling zebra finch vocalization, an analog to human vocal production, we compare three decoders with different input types: spike trains, neural factors, and firing rates. The factors and rates are latent neural features inferred using trained Latent Factor Analysis via Dynamical Systems (LFADS) models that capture the population neural dynamics during vocal production. While the conventional random holdout generalization error measure is similar for all three decoders, factor- and rate-based decoders outperform spike-based decoders when testing vocal-unit-holdout generalization error. These results suggest the later models better adapt to flexible vocalization inference when trained with partial observation of data variation, motivating further exploration of decoders incorporating latent neural and vocalization dynamics.
Introduction: The therapeutic success of total hip arthroplasty (THA) is unquestionable. However, in young patients, it is still a controversial topic, not because of the results obtained, but because of the presumed ...
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Introduction: The therapeutic success of total hip arthroplasty (THA) is unquestionable. However, in young patients, it is still a controversial topic, not because of the results obtained, but because of the presumed need for revision of the prosthetics components in the future. Objectives: The present work performs a retrospective study of patients who underwent THA surgery in the past, in which the femoral head was transferred to the iliac for use in future revisions of total hip arthroplasty (autograft), and describes the proposed technique. Methods: The research reviewed 27 patients operated on using the femoral head autograft technique for the ipsilateral iliac in total hip arthroplasty, performed from 1996 to 2005;the study considered medical records, X-rays and CT scan images, and photographs taken at the time of surgery. Results: To date, only two revisions of total hip arthroplasty have been performed, in which the patients have benefited from the technique of autografting of the femoral head. No case evolved with infection or any other type of complication. All inserted grafts are consolidated and integrated with the iliac. Conclusion: The autograft technique is cheap, simple and reproducible, making available large amounts of bone for use in future revisions of total hip arthroplasty in young patients.
The development of bioinks for bone tissue engineering (BTE) requires a precise balance of printability, stability and bioactivity to ensure cell viability while supporting cell attachment, proliferation and osteogeni...
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Electrical stimulation is a powerful tool for targeted neurorehabilitation, and recent work in adaptive stimulation where stimulation can be adjusted in real-time has shown promise in improving stimulation outcomes an...
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One of the emerging strategies in constructing the artificial ovary is the concern of remaining malignant cells in cryopreserved ovarian tissue, impeding fertility preservation after chemotherapy. The extracellular ma...
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Most brain surgeries aim to completely resection a tumor. However, the arrangement of blood vessels around brain tumors is often complex. Moreover, the tumors and blood vessels have similar colors, making it difficult...
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A major challenge in designing proteins de novo to bind user-defined ligands with high affinity is finding backbones structures into which a new binding site geometry can be engineered with high precision. Recent adva...
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