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Scientific World Journal 2025年第1期2025卷 9466270页

作者： Floriano, Juliana Ferreira Rodrigues, Daniel Ohara, Rie Almeida, Nara Lígia Martins Lara, Vanessa Soares Sartorelli, Patricia Graeff, Carlos Frederico de Oliveira Grecco, Simone dos Santos González, Alejandra Hortencia Miranda D’Alpino, Paulo Henrique Perlatti Imperial College London National Heart and Lung Institute imperial.ac.uk GBR London United Kingdom Botucatu Medical School São Paulo State University (UNESP) São Paulo unesp.br BRA Botucatu Brazil Bioengineering and Biomaterials Group School of Pharmaceutical Sciences São Paulo State University (UNESP) unesp.br BRA Araraquara São Paulo Brazil Biotechnology and Innovation in Health Program Universidade Anhanguera de São Paulo (UNIAN) São Paulo BRA Brazil Brazil Department of Health Management Fundação Nacional de Gestão de Saúde São Paulo Brazil Undergraduate Program Medical School Universidade Nove de Julho Bauru São Paulo Brazil Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo (USP) São Paulo usp.br BRA Bauru Brazil Department of Chemistry Institute of Environmental Chemical and Pharmaceutical Sciences Federal University of São Paulo São Paulo unifesp.br BRA Diadema Brazil Department of Physics School of Sciences POSMAT-Post-Graduate Program in Materials Science and Technology São Paulo State University (UNESP) São Paulo Bauru Brazil Department of Research and Development (RD) and Innovation Center Triplet Biotechnology Solutions Inc Bauru São Paulo Brazil Post-Graduate Program in Dentistry Uniderp Anhanguera University Mato Grosso do Sul Campo Grande Brazil Post-Graduate Program in Integrated Dental Sciences University of Cuiabá (UNIC) Mato Grosso do Sul Cuiabá Brazil Department of Physics School of Sciences São Paulo State University (UNESP) São Paulo unesp.br BRA Bauru Brazil

Chronic wounds have a significant impact on patients’ quality of life, necessitating the management of pain, infection, bleeding, and emotional challenges. Debridement, which involves the removal of nonviable tissue, is crucial for promoting wound healing. In addition to surgical methods, cost-effective alternatives such as local solutions and ointments with biological properties have been explored. The use of natural compounds with anti-inflammatory, antibacterial, and collagen-synthesizing abilities holds promise for wound healing. This in vitro and in vivo preclinical study aimed to assess the safety and effectiveness of a wound healing ointment containing bioactive ingredients derived from medicinal plants (extracts, essential oils, and vegetable oils). The chemical composition of the ointment was characterized using Fourier transform infrared (FTIR) spectroscopy to gain insights into its synergistic action. Preclinical tests were conducted following standardized protocols. FTIR analysis revealed similarities between the product’s spectrum and that of bioactive compounds. The in vitro tests demonstrated that all formulations of the ointment induced no cell death, DNA damage, or acute toxicity in cell cultures (p < 0.05). No lethal dose was observed, indicating the safety of the ointment at all concentrations. The ointment also stimulated a notably more organized, significantly higher collagen production compared to control groups (p < 0.05). In vivo preclinical analyses also demonstrated no adverse responses being effective in the healing process compared to the control group (silver sulfadiazine) in terms of wound contraction and ulcer re-epithelization (p < 0.05). Significantly higher means of wound contraction were observed in the groups treated with the bioactive-containing ointment when compared to both the positive control group (sulfadiazine) and the control untreated groups (p < 0.05). The regenerative ointment exhibited excellent biocompatibility and bi

关键词： biocompatibility chronic wounds natural compounds preclinical tests wound care

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Epileptogenic Foci Time Varying Source Loca1ization Using Source Affine Image Reconstruction (SAFFIRE) Algorithm

Epileptogenic Foci Time Varying Source Loca1ization Using So...

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2019 IEEE Jordan International Joint Conference on Electrical Engineering and Information Technology, JEEIT 2019

作者： Al-Momani, Sajedah Mir, Hasan S. Al-Nashash, Hasan Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Electrical Engineering Biosciences and Bioengineering Research Institute American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781538679425

This paper presents the performance of the Source Affine Image reconstruction algorithm (SAFFIRE) on an epileptogemc foci time-varying source localization. This algorithm is based on the recursive implementation of the mimmum mean squared error (MMSE) estimator. The SAFFIRE algorithm is applied on a synthetic EEG signal originated from different sources' scenarios. The simulation results show how the algorithm is able to localize and track the sources as they vary with time with a high resolution even if the sources are located close to each other. © 2019 IEEE.

关键词： Inverse problems

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Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

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Nature Communications 2024年第1期15卷 2187页

作者： Turner, Mackenzie E. Blum, Kevin M. Watanabe, Tatsuya Schwarz, Erica L. Nabavinia, Mahboubeh Leland, Joseph T. Villarreal, Delaney J. Schwartzman, William E. Chou, Ting-Heng Baker, Peter B. Matsumura, Goki Krishnamurthy, Rajesh Yates, Andrew R. Hor, Kan N. Humphrey, Jay D. Marsden, Alison L. Stacy, Mitchel R. Shinoka, Toshiharu Breuer, Christopher K. Center for Regenerative Medicine Research Institute at Nationwide Children’s Hospital Columbus OH United States Molecular Cellular and Developmental Biology Graduate Program The Ohio State University Columbus OH United States The Ohio State University College of Medicine Columbus OH United States Department of Biomedical Engineering Yale University New Haven CT United States Biomedical Sciences Graduate Program The Ohio State University College of Medicine Columbus OH United States Department of Exercise and Health Science National Taipei University of Nursing and Health Sciences Taipei City Taiwan Pathology Department at Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Medical Safety Management Tokyo Women’s Medical University Tokyo Japan Department of Radiology Nationwide Children’s Hospital and The Ohio State University Columbus OH United States Department of Pediatrics The Ohio State University College of Medicine Columbus OH United States The Heart Center Nationwide Children’s Hospital Columbus OH United States Departments of Pediatrics and Bioengineering Stanford University Stanford CA United States Department of Surgery The Ohio State University College of Medicine Columbus OH United States Interdisciplinary Biophysics Graduate Program The Ohio State University Columbus OH United States Department of Cardiothoracic Surgery Nationwide Children’s Hospital Columbus OH United States Department of Surgery Nationwide Children’s Hospital Columbus OH United States

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p < 0.001) and animal models (p < 0.0001). Further assessments of graft compliance reveal that tissue-engineered vascular grafts maintain greater compliance (p < 0.0001) and distensibility (p < 0.001) than polytetrafluoroethylene grafts. These properties improve graft hemodynamic performance, as validated through computational fluid dynamics simulations. We demonstrate the promise of tissue engineered vascular grafts, remaining compliant and distensible while resisting long-term calcification, to enhance the long-term success of congenital heart surgeries. © The Author(s) 2024.

关键词： Translational research Cardiac device therapy Cardiovascular models

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Artifact Removal in tACS-EEG Recordings: A Combined Methodology Based on the Empirical Wavelet Transform*

Artifact Removal in tACS-EEG Recordings: A Combined Methodol...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Xuanteng Yan Marie-Hélène Boudrias Georgios D. Mitsis Graduate Program in Biological and Biomedical Engineering McGill University Montréal Canada School of Physical & Occupational Therapy McGill University Montréal Canada Department of Bioengineering McGill University Montréal Canada

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation technique that modulates brain activity, which yields promise for achieving desired behavioral outcomes in different contexts. Combining tACS with electroencephalography (EEG) allows for the monitoring of the real-time effects of stimulation. However, the EEG signal recorded with simultaneous tACS is largely contaminated by stimulation-induced artifacts. In this work, we examine the combination of the empirical wavelet transform (EWT) with three blind source separation (BSS) methods: principal component analysis (PCA), multiset canonical correlation analysis (MCCA) and independent vector analysis (IVA), aiming to remove artifacts in tACS-contaminated EEG recordings. Using simulated data, we show that EWT followed by IVA achieves the best performance. Using experimental data, we show that BSS combined with EWT performs better compared to standard BSS methodology in terms of preserving useful information while eliminating artifacts.

关键词： Electroencephalography Tensile stress Principal component analysis Correlation Time series analysis Wavelet transforms

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Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

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Bone Research 2019年第4期7卷 354-370页

作者： Courtney MMazur Jonathon JWoo Cristal SYee Aaron JFields Claire Acevedo Karsyn NBailey Serra Kaya Tristan WFowler Jeffrey CLotz Alexis Dang Alfred CKuo Thomas PVail Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley-UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA San Francisco Veterans Affairs Medical Center San FranciscoCA 94121USA

Osteoarthritis(OA),long considered a primary disorder of articular cartilage,is commonly associated with subchondral bone ***,the cellular mechanisms responsible for changes to subchondral bone in OA,and the extent to which these changes are drivers of or a secondary reaction to cartilage degeneration,remain *** knee joints from human patients with end-stage OA,we found evidence of profound defects in osteocyte *** of osteocyte perilacunar/canalicular remodeling(PLR)was most severe in the medial compartment of OA subchondral bone,with lower protease expression,diminished canalicular networks,and disorganized and hypermineralized extracellular *** a step toward evaluating the causality of PLR suppression in OA,we ablated the PLR enzyme MMP13 in osteocytes while leaving chondrocytic MMP13 intact,using Cre recombinase driven by the 9.6-kb DMP1 *** only did osteocytic MMP13 deficiency suppress PLR in cortical and subchondral bone,but it also compromised *** in the absence of injury,osteocytic MMP13 deficiency was sufficient to reduce cartilage proteoglycan content,change chondrocyte production of collagen II,aggrecan,and MMP13,and increase the incidence of cartilage lesions,consistent with early ***,in humans and mice,defects in PLR coincide with cartilage ***-derived MMP13 emerges as a critical regulator of cartilage homeostasis,likely via its effects on ***,these findings implicate osteocytes in bone-cartilage crosstalk in the joint and suggest a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis.

关键词： MMP13 homeostasis likely

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Single-Cell and Bulk RNA Sequencing Analysis of Adult Patients with Acute Myeloid Leukemia to Identify Potential for Transferability of Pediatric Trivalent CAR-T Approaches

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Transplantation and Cellular Therapy 2025年第2期31卷 S203-S203页

作者： Seir, Gabriel E, BS Bubb, Quenton Rashawn, MPhil, PhD Salzman, Gabriel, MD, PhD Czechowicz, Agnieszka, MD, PhD Zhang, Tian Y, MD, PhD Kennedy, Vanessa E, MD Department of Bioengineering Stanford University Stanford CA Stem Cell Biology and Regenerative Medicine Graduate Program Medical Scientist Training Program Stanford University Stanford CA Hematology and Medical Oncology Fellowship Program Stanford Health Care Stanford California Stanford University Stanford CA Department of Pediatrics； Division of Hematology Oncology Stem Cell Transplantation and Regenerative Medicine Stanford University School of Medicine Stanford CA Department of Medicine Division of Hematology Stanford University Stanford CA Division of Blood and Marrow Transplantation & Cellular Therapy Stanford University Stanford CA

IntroductionChimeric antigen receptor (CAR) T-cells have shown success in B-cell malignancies but have yet to extend to acute myeloid leukemia (AML) due to disease heterogeneity hindering targeting with mono or even bivalent CARs. Our group previously engineered a trivalent CAR targeting the KIT, MPL, and FLT3 hematopoietic receptors based on bulk and single-cell (SC) RNA-seq analysis from pediatric AML samples showing specificity of these targets to stem-like compartments and potent activity in xenograft murine models. We investigated if this approach could extend to adult AML. MethodsWe used data from The Cancer Genome Atlas (TCGA) (n = 173) and BEAT AML (n = 395) to analyze bulk expression of KIT, MPL and FLT3 across AML genetic subtypes. We used a published dataset of newly diagnosed AML (van Galen et al, 2019; n = 16) to analyze SC expression by cell type and differentiation state (assessed via CytoTRACE). Data analysis was conducted via Seurat. ResultsAt the bulk-RNA level, at least one of KIT, MPL, or FLT3 was expressed in >85% of patients in both cohorts. A high proportion of tumors with ELN adverse-risk disease had expression ≥1 of the putative targets, at 84.4% (n=45) and 90.0% (n=148) for TCGA and BEAT AML, respectively. Notably, 100% (n=5) and 88.0% (n=25) of TP53-mutant tumors and 91.9% (n=37) and 91.1% (n=202) of poor cytogenetic tumors had ≥1 gene expressed. Triple-negative tumors were rare, at 13.8% and 14.6%. Of these triple-negative tumors, no single genetic subtype was over-represented, and most were intermediate-risk disease. Expression of any combination of KIT, MPL, and FLT3, was not associated with overall survival in either dataset. SC RNA-seq analysis showed KIT was highly expressed, largely confined to immature blasts with high differentiation potential (CytoTRACE score close to 1). Further, differential expression of FLT3 was observed among most leukemic cells, some expression in non-malignant myeloid cells, and minimal expression in lymph

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Motor crosslinking augments elasticity in active nematics

arXiv

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arXiv 2023年

作者： Redford, Steven A. Colen, Jonathan Shivers, Jordan L. Zemsky, Sasha Molaei, Mehdi Floyd, Carlos Ruijgrok, Paul V. Vitelli, Vincenzo Bryant, Zev Dinner, Aaron R. Gardel, Margaret L. The Graduate Program in Biophysical Sciences University of Chicago ChicagoIL60637 United States Institute for Biophysical Dynamics University of Chicago ChicagoIL60637 United States Department of Physics University of Chicago ChicagoIL60637 United States James Franck Institute University of Chicago ChicagoIL60637 United States Department of Chemistry University of Chicago ChicagoIL60637 United States Department of Bioengineering Stanford University StanfordCA94305 United States Pritzker School of Molecular Engineering The University of Chicago ChicagoIL60637 United States Department of Structural Biology Stanford University School of Medicine StanfordCA94305 United States

In active materials, uncoordinated internal stresses lead to emergent long-range flows. An understanding of how the behavior of active materials depends on mesoscopic (hydrodynamic) parameters is developing, but there remains a gap in knowledge concerning how hydrodynamic parameters depend on the properties of microscopic elements. In this work, we combine experiments and multiscale modeling to relate the structure and dynamics of active nematics composed of biopolymer filaments and molecular motors to their microscopic properties, in particular motor processivity, speed, and valency. We show that crosslinking of filaments by both motors and passive crosslinkers not only augments the contributions to nematic elasticity from excluded volume effects but dominates them. By altering motor kinetics we show that a competition between motor speed and crosslinking results in a nonmonotonic dependence of nematic flow on motor speed. By modulating passive filament crosslinking we show that energy transfer into nematic flow is in large part dictated by crosslinking. Thus motor proteins both generate activity and contribute to nematic elasticity. Our results provide new insights for rationally engineering active materials. © 2023, CC BY.

关键词： Elasticity

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Linking physical phenotype to drug resistance: Single-cell mechanical measurements of acute promyelocytic Leukemia 23

Linking physical phenotype to drug resistance: Single-cell m...

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

作者： Li, Brian L. Maslan, Annie M. Streets, Aaron M. Sohn, Lydia L. UC Berkeley UCSF Graduate Program in Bioengineering Berkeley and San Francisco United States UC Berkeley Center for Computational Biology Berkeley United States UC Berkeley Biophysics Graduate Group Berkeley United States UC Berkeley Department of Mechanical Engineering Berkeley United States

ISBN: (纸本)9781733419000

Mechanical testing of cancer cells has established that certain pathophysiological phenotypes are strongly associated with abnormal cell mechanics. We used a microfluidic platform previously developed in our laboratory to perform rapid mechanical phenotyping of acute promyelocytic leukemia (APL) cells. These measurements revealed that drug-resistant APL cells exhibit more solid-like viscoelastic behavior compared to drug-responsive cells and that this mechanical difference could be due to chromatin condensation. Our work demonstrates that single-cell mechanical phenotyping could serve to predict drug-resistance in APL. © 2019 CBMS-0001.

关键词： Mechanical testing

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Physical properties of 25 years old Sentang (Azadirachta excelsa) planted at Gurun, Kedah

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AIP Conference Proceedings 2022年第1期2454卷

作者： Andi Hermawan Shaharlina Abd Rasid Syazrol Omar Mohd Afifi Shuhaimin 1Forest Resource Technology Program Faculty of Bioengineering and Technology Universiti Malaysia Kelantan Kelantan Malaysia 2Forest Resource Technology Centre of Post Graduate Studies Universiti Malaysia Kelantan Pengkalan Chepa Malaysia

To meet the local and international market’s timber demands, Azadirachta excelsa, a native tree locally known as a Sentang, has been listed among the potential fast-growing species to be planted for forest plantation establishment in the mid -1990s by the Malaysian government. Understanding wood properties is well known as crucial for the industry to use it as a raw material properly. Because of the underrepresented and limited accessible data on the tree’s qualities, the species’ potential has been determined. The physical properties of the 25-year-old Sentang tree planted in Gurun, Kedah, Malaysia, were discussed in this paper. The impact of radial growth rates on moisture content, density, and shrinkage from the pith to the bark at the stump, DBH, middle, and top of the trees is investigated in this paper. As a result, three trees were cut and classed as slow, average, or fast-growing. The results were as follows. From the pith to the bark, the green MC of all classed trees continues to diminish. The density, on the other hand, did not follow the same pattern; however, fast-growing trees have lower densities than slower-growing trees at the bottom, DBH, middle, and top of the trees. Tangential, radial, and longitudinal shrinkage appeared to reduce as tree height climbed, then increase again at the trees’ tops.

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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine and Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 South Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 South Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 South Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 South Korea

Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties;however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy. © 2025

关键词： Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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