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Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis

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World Journal of Gastroenterology 2018年第38期24卷 4341-4355页

作者： Natalia Schneider Nunes Saejeong Kim Maggie Sundby Parwathy Chandran Scott Robert Burks Ana Helena Paz Joseph Alan Frank Frank Laboratory Radiology and Imaging Sciences Clinical Center National Institutes of Health Gastroenterology and Hepatology Sciences Graduate Program Universidade Federal do Rio Grande do Sul National Institute of Biomedical Imaging and Bioengineering National Institutes of Health

AIM To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium(DSS)-induced acute *** Acute colitis was induced in C57 BL/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and blood in the stool, while spleens and colons were harvested on day 8. A time course analysis was performed in mice ingesting 3% DSS, which included colon proteomics through multiplex assay, colon histological scoring by a blinded investigator, and immune response through flow cytometry or immunohistochemistry of the spleen, mesenteric lymph node and *** Progressive worsening of clinical colitis was observed with increasing DSS from 1% to 3%. In mice ingesting 3% DSS, colon shortening and increase in proinflammatory factors starting at day 3 was observed, with increased spleen weights at day 6 and day 8. This coincided with cellular infiltration in the colon from day 2 to day 8, with progressive accumulation of macrophages F4/80^+, T helper CD4^+(Th), T cytotoxic CD8^+(Tcyt) and T regulatory CD25^+(Treg) cells, and progressive changes in colonic pathology including destruction of crypts, loss of goblet cells and depletion of the epithelial barrier. Starting on day 4, mesenteric lymph node and/or spleen presented with lower levels of Treg, Th and Tcyt cells, suggesting an immune cell tropism to the gut. CONCLUSION These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS.

关键词： Ulcerative colitis Dextran sulfate sodium Proteomics Inflammatory bowel diseases Inflammation

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Towards optimal design of patient isolation units in emergency rooms to prevent airborne virus transmission: From computational fluid dynamics to data-driven modeling

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Computers in Biology and Medicine 2024年 173卷 108309-108309页

作者： Lee, Jong Hyeon Shim, Jae Woo Lim, Min Hyuk Baek, Changhoon Jeon, Byoungjun Cho, Minwoo Park, Sungwoo Choi, Dong Hyun Kim, Byeong Soo Yoon, Dan Kim, Young Gyun Cho, Seung Yeon Lee, Kyung-Min Yeo, Myoung-Souk Zo, Hangman Shin, Sang Do Kim, Sungwan Interdisciplinary Program in Bioengineering Graduate School Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of 50 UNIST-gil Eonyang-eup Ulju-gun Ulsan Korea Republic of 50 UNIST-gil Eonyang-eup Ulju-gun Ulsan Korea Republic of Department of Transdisciplinary Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Innovative Medical Technology Research Institute Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Medical Research Center Seoul National University 103 Daehak-ro Jongno-gu Seoul Korea Republic of Office of Hospital Information Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Biomedical Engineering Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of International Vaccine Institute 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Department of Architecture and Architectural Engineering Seoul National University College of Engineering 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Laboratory of Emergency Medical Services Biomedical Research Institute Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Emergency Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul Korea Republic of Department of Emergency Medicine Seoul National University College of Medicine 103 Daehak-ro Jongno-gu Seoul Korea Republic of Institute of Bioengineering Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of Artificial Intelligence Institute Seoul National University 1 Gwanak-ro Gwanak-gu Seoul Korea Republic of

Background: Patient isolation units (PIUs) can be an effective method for effective infection control. Computational fluid dynamics (CFD) is commonly used for PIU design;however, optimizing this design requires extensive computational resources. Our study aims to provide data-driven models to determine the PIU settings, thereby promoting a more rapid design process. Method: Using CFD simulations, we evaluated various PIU parameters and room conditions to assess the impact of PIU installation on ventilation and isolation. We investigated particle dispersion from coughing subjects and airflow patterns. Machine-learning models were trained using CFD simulation data to estimate the performance and identify significant parameters. Results: Physical isolation alone was insufficient to prevent the dispersion of smaller particles. However, a properly installed fan filter unit (FFU) generally enhanced the effectiveness of physical isolation. Ventilation and isolation performance under various conditions were predicted with a mean absolute percentage error of within 13%. The position of the FFU was found to be the most important factor affecting the PIU performance. Conclusion: Data-driven modeling based on CFD simulations can expedite the PIU design process by offering predictive capabilities and clarifying important performance factors. Reducing the time required to design a PIU is critical when a rapid response is required. © 2024 Elsevier Ltd

关键词： COVID-19

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An artificial neural network for hand movement classification using surface electromyography 12

An artificial neural network for hand movement classificatio...

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12th International Conference on Bio-Inspired Systems and Signal Processing, BIOSIGNALS 2019 - Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019

作者： Viana, Paulo L. Fujii, Victoria S. Lima, Larissa M. Ouriques, Gabriel L. Oliveira, Gustavo C. Varoto, Renato Cliquet, Alberto Department of Electrical and Computer Engineering Trabalhador São-Carlense Avenue 400 São Carlos Brazil University of São Paulo Interunits Graduate Program in Bioengineering Trabalhador São-Carlense Avenue 400 São Carlos Brazil Department of Orthopedics and Traumatology University of Campinas Cidade Universitária Zeferino Vaz Campinas Brazil

ISBN: (纸本)9789897583537

In this paper we present the development of an artificial neural network that uses surface EMG data from two forearm muscles to classify hand movements and gestures. We trained our network to classify three different sets of movements, using EMG data from six healthy subjects. We were able to achieve hit rates of above 99% in the training sets and hit rates of above 85% in all three test sets, with a maximum of 88.8% for the second movement set. Advantages of the proposed method include small number of electrodes, reduced complexity, computational cost and response time. Copyright © 2019 by SCITEPRESS - Science and Technology Publications, Lda. All rights reserved.

关键词： Neural networks

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Recent advances in spying on cell signaling with fluorescent biosensors

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Current Opinion in Cell Biology 2025年 95卷

作者： Qian-yi Zhang Sohum Mehta Jin Zhang Department of Pharmacology University of California 9500 Gilman Drive La Jolla San Diego CA 92093 USA Biomedical Sciences Graduate Program University of California 9500 Gilman Drive La Jolla San Diego CA 92093 USA Moores Cancer Center University of California La Jolla San Diego CA USA Department of Chemistry & Biochemistry University of California 9500 Gilman Drive La Jolla San Diego CA 92093 USA Shu Chien - Gene Lay Department of Bioengineering University of California 9500 Gilman Drive La Jolla San Diego CA 92093 USA

Cells routinely orchestrate the activities of diverse biochemical pathways to sustain cellular function and proliferation, as exemplified by their ability to faithfully convert extracellular signals into specific intracellular responses. The dynamic nature of intracellular signaling calls for appropriate tools to capture these complex molecular events. Recent advances in genetically encoded biosensor engineering are revolutionizing our ability to dissect the molecular mechanisms regulating signaling activities with unprecedented resolution. Here, we present a timely update on novel biosensor designs and highlight recent applications where biosensor imaging yielded breakthrough insights into the spatiotemporal dynamics of GPCR signaling and cell cycle regulation.

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Author Correction: Dynamical flexible inference of nonlinear latent factors and structures in neural population activity

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Nature biomedical engineering 2025年第2期9卷 283页

作者： Hamidreza Abbaspourazad Eray Erturk Bijan Pesaran Maryam M Shanechi Ming Hsieh Department of Electrical and Computer Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. Departments of Neurosurgery Neuroscience and Bioengineering University of Pennsylvania Philadelphia PA USA. Ming Hsieh Department of Electrical and Computer Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. shanechi@usc.edu. Thomas Lord Department of Computer Science Alfred E. Mann Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los Angeles CA USA. shanechi@usc.edu.

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Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway

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Nature chemical biology 2024年 2024 Nov 8页

作者： Jordan J Baker Jie Shi Shangying Wang Elena M Mujica Simone Bianco Sara Capponi John E Dueber Department of Bioengineering University of California Berkeley CA USA. UC Berkeley and UCSF Joint Graduate Program in Bioengineering University of California Berkeley CA USA. NSF Center for Cellular Construction University of California San Francisco CA USA. Department of Functional Genomics and Cellular Engineering IBM Almaden Research Center San Jose CA USA. Bay Area Institute of Science Altos Labs Redwood City CA USA. NSF Center for Cellular Construction University of California San Francisco CA USA. sara.capponi@***. Department of Functional Genomics and Cellular Engineering IBM Almaden Research Center San Jose CA USA. sara.capponi@***. Department of Bioengineering University of California Berkeley CA USA. jdueber@berkeley.edu. NSF Center for Cellular Construction University of California San Francisco CA USA. jdueber@berkeley.edu. Biological Systems and Engineering Division Lawrence Berkeley National Laboratory Berkeley CA USA. jdueber@berkeley.edu.

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Assessment of functional mobility in a child with total blindness and another with low vision using an inertial sensor: Case report

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Gait & Posture 2022年 97卷 S400-S401页

作者： de Toledo, R. Roberta Carneiro da Silva Cardoso, D. Carvalho Nascimento, M. da Mata da Silva, J. Gomes Cordeiro, L. Barbosa Fonseca, D. Rosana Pedro Duarte, N. de Almeida Carvalho Parreira, R. Borges Cimolin, V. Galli, M. Oliveira, C. Evangelical University of Goiás- UniEVANGÉLICA - Anápolis -Goiás- Brazil Postgraduate Program Anápolis Brazil Evangelical University of Goiás- UniEVANGÉLICA - Anápolis -Goiás- Brazil Graduate Course in Physiotherapy Anápolis Brazil Faculdade de ciências médicas de São Paulo- Santa casa São Paulo Brazil Instituto Politecnico di Milano Department of Electronic- Information and Bioengineering- Politecnico di Milan Milano Italy Instituto Politecnico di Milano Department of Electronic- Information and Bioengineering Milano Italy

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Controlled Release of Bone Morphogenetic Protein-2 Improves Motor Function after Traumatic Brain Injury in a Rat Model

SSRN

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SSRN 2025年

作者： Townsend, Jakob M. Deng, Jasmine Z. Barbay, Scott Andrews, Brian T. Nudo, Randolph J. Detamore, Michael S. C. Wayne McIlwraith Translational Medicine Institute Colorado State University Fort CollinsCO80523 United States School of Biomedical Engineering Colorado State University Fort CollinsCO80523 United States Bioengineering Graduate Program University of Kansas LawrenceKS66045 United States Department of Physical Medicine and Rehabilitation University of Kansas Medical Center Kansas CityKS66103 United States Department of Otolaryngology University of Iowa Medical Center Iowa CityIA52245 United States Department of Mechanical Engineering Colorado State University Fort CollinsCO80523 United States

Severe traumatic brain injury (TBI) is a life-threatening condition characterized by internal brain swelling and commonly treated using a two-stage surgical approach. The interval between surgeries, generally spaced weeks to months, is associated with secondary neurologic complications from leaving the brain unprotected. Hydrogels may reshape severe TBI treatment by enabling a single-stage surgical intervention, capable of being implanted at the initial surgery, remaining flexible to accommodate brain swelling, and calibrated to regenerate bone after brain swelling has subsided. The current study evaluated the use of a pentenoate-modified hyaluronic acid (PHA) polymer with thiolated devitalized tendon (TDVT) for calvarial bone regeneration in a rat TBI model. Additionally, PHA-TDVT hydrogels encapsulating microspheres containing bone morphogenetic protein-2 (BMP-2) were investigated to enhance bone regeneration. All hydrogel precursor formulations exhibited sufficient yield stress for surgical placement. The addition of TDVT to the crosslinked hydrogels increased the average compressive modulus. In vitro cell studies revealed that the PHA-TDVT hydrogel with the highest concentration of BMP-2 microspheres (i.e., PHA-TDVT+µ100) significantly improved calcium deposition and osteogenic gene expression. Minimal in vivo bone regeneration was observed for all hydrogel groups;however, BMP-2 microsphere addition fortuitously reduced motor skill impairment and brain atrophy. The PHA-TDVT+µ100 group had 2.8 times greater reach index and 2.3 times lower brain atrophy values compared to the negative control (p © 2025, The Authors. All rights reserved.

关键词： Transplantation (surgical)

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Plasmonic bacteria on a nanoporous mirror via hydrodynamic trapping for rapid identification of waterborne pathogens

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Light(Science & Applications) 2018年第1期7卷 359-367页

作者： Keumrai Whang Jong-Hwan Lee Yonghee Shin Wooju Lee Young Wan Kim Dongchoul Kim Luke P.Lee Taewook Kang Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Korea Berkeley Sensor and Actuator Center Departments of BioengineeringElectrical Engineering and Computer ScienceBiophysics Graduate ProgramUniversity of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Mechanical Engineering Sogang UniversitySeoul 04107Korea

A rapid,precise method for identifying waterborne pathogens is critically needed for effective disinfection and better ***,conventional methods,such as culture-based counting,generally suffer from slow detection times and low ***,we developed a rapid detection method for tracing waterborne pathogens by an innovative optofluidic platform,a plasmonic bacteria on a nanoporous mirror,that allows effective hydrodynamic cell trapping,enrichment of pathogens,and optical signal *** designed and simulated the integrated optofluidic platform to maximize the enrichment of the bacteria and to align bacteria on the nanopores and plasmonic mirror via hydrodynamic cell *** nanoparticles are self-assembled to form antenna arrays on the surface of bacteria,such as Escherichia coli and Pseudomonas aeruginosa,by replacing citrate with hydroxylamine hydrochloride in order to amplify the signal of the plasmonic optical *** to the synergistic contributions of focused light via the nanopore geometry,self-assembled nanoplasmonic optical antennas on the surface of bacteria,and plasmonic mirror,we obtain a sensitivity of detecting *** as low as 102 cells/ml via surface-enhanced Raman *** believe that our label-free strategy via an integrated optofluidic platform will pave the way for the rapid,precise identification of various pathogens.

关键词： mirror trapping precise

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Author Correction: Autophagy restricts Mycobacterium tuberculosis during acute infection in mice

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Nature microbiology 2024年第7期9卷 1899页

作者： Guillaume R Golovkine Allison W Roberts Huntly M Morrison Rafael Rivera-Lugo Rita M McCall Hannah Nilsson Nicholas E Garelis Teresa Repasy Michael Cronce Jonathan Budzik Erik Van Dis Lauren M Popov Gabriel Mitchell Reena Zalpuri Danielle Jorgens Jeffery S Cox Department of Molecular and Cell Biology University of California Berkeley CA USA. Evotec Toulouse France. Department of Plant & Microbial Biology University of California Berkeley CA USA. Bio-Rad Laboratories Seattle WA USA. Department of Bioengineering University of California Berkeley CA USA. UC Berkeley-UCSF Graduate program in Bioengineering Berkeley CA USA. Department of Medicine University of California San Francisco CA USA. Department of Immunology University of Washington School of Medicine Seattle WA USA. Novome Biotechnologies San Francisco CA USA. Open Innovation @ NITD Novartis Institute for Tropical Diseases Emeryville CA USA. Electron Microscope Laboratory University of California Berkeley CA USA. Department of Molecular and Cell Biology University of California Berkeley CA USA. jeff.cox@berkeley.edu.

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