This paper presents a 0D model for the pulsatile pediatric Ventricular Assist Device (pVAD), as well as its characterization and test results obtained by using an experimental hydraulic system that provides operationa...
This paper presents a 0D model for the pulsatile pediatric Ventricular Assist Device (pVAD), as well as its characterization and test results obtained by using an experimental hydraulic system that provides operational conditions close to the physiological conditions observed in pediatric patients. The measurements of the physical quantities used in characterization of the pVAD have been obtained by using the LabVIEW platform. The air chamber pressure signal is used to model the pneumatic actuation system behaviour, whereas the pressure-volume relationship inside the blood chamber is applied to model the pVAD compliance. The set of test and validation results demonstrated the correctness of the proposed model.
Electrospinning is one of the most effective approaches to fabricate tissue-engineered scaffolds composed of nano-to sub-microscale fibers that simulate a native extracellular ***,one major concern about electrospun s...
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Electrospinning is one of the most effective approaches to fabricate tissue-engineered scaffolds composed of nano-to sub-microscale fibers that simulate a native extracellular ***,one major concern about electrospun scaffolds for tissue repair and regeneration is that their small pores defined by densely compacted fibers markedly hinder cell infiltration and tissue *** address this problem,researchers have developed and investigated various methods of manipulating scaffold structures to increase pore size or loosen the *** methods involve the use of physical treatments,such as salt leaching,gas foaming and custom-made collectors,and combined techniques to obtain electrospun scaffolds with loose fibrous structures and large *** article provides a summary of these motivating electrospinning techniques to enhance cell infiltration of electrospun scaffolds,which may inspire new electrospinning techniques and their new biomedical applications.
This paper presents a virtual reality(VR) control system for a robotic endoscope holder for minimally invasive surgery (MIS). The system features a three degree of freedom(DOF) robotic endoscope holder, virtual realit...
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ISBN:
(纸本)9781509015740;9781509015733
This paper presents a virtual reality(VR) control system for a robotic endoscope holder for minimally invasive surgery (MIS). The system features a three degree of freedom(DOF) robotic endoscope holder, virtual reality head mounted display and a control system that allows robot to follow headset movement. The headset display is aligned with endoscope camera view thus creating a full presence effect for a surgeon. The video from endoscope is streamed to the virtual reality head mounted display after image processing in a computer. During surgery, the proposed control system generates commands to the robot based on the headset's positioning data. After the desired camera motion direction is estimated, the robotic endoscope holder receives motion commands through serial interface. The proposed virtual reality robot control system is implemented in Unity. The system has been tested in the laboratory environment through a set of motion tests and achieved a response latency of 2s. The proposed system is able to restore the surgeon's perceptual capability of the operation space that is highly restricted in MIS and provide highly intuitive endoscope robot control.
Captive wildlife are a unique set of animals, whose diverse host–microbe symbioses are underexplored. Compared to their wild counterparts they are particularly susceptible to a variety of diseases, many of which have...
In this study, we present a 4-channel intracortical glassy carbon (GC) microelectrode array on a flexible substrate for the simultaneous in vivo neural activity recording and dopamine (DA) concentration measurement at...
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A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and live-cell microscopy. Guid...
A robust and reproducible method for culturing monolayers of adherent and well-spread primary islet cells on glass coverslips is required for detailed imaging studies by super-resolution and live-cell microscopy. Guided by an observation that dispersed islet cells spread and adhere well on glass surfaces in neuronal co-culture and form a monolayer of connected cells, we demonstrate that in the absence of neurons, well-defined surface coatings combined with components of neuronal culture media collectively support robust attachment and growth of primary human or rat islet cells as monolayers on glass surfaces. The islet cell monolayer cultures on glass stably maintain distinct mono-hormonal insulin+, glucagon+, somatostatin+ and PP+ cells and glucose-responsive synchronized calcium signaling as well as expression of the transcription factors Pdx-1 and NKX-6.1 in beta cells. This technical advance enabled detailed observation of sub-cellular processes in primary human and rat beta cells by super-resolution microscopy. The protocol is envisaged to have broad applicability to sophisticated analyses of pancreatic islet cells that reveal new biological insights, as demonstrated by the identification of an in vitro protocol that markedly increases proliferation of primary beta cells and is associated with a reduction in ciliated, ostensibly proliferation-suppressed beta cells.
Hemodynamic activities in the prefrontal cortex are investigated during noxious thermal stimulation over the right Forearm, right TMJ, and left Forearm. Robustness of prefrontal hemodynamic responses during noxious th...
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The molecular mechanism of transmembrane proton translocation in rotary motor ATPases is not fully understood. Here, we report the 3.5-Å resolution cryoEM structure of the lipid nanodisc-reconstituted Vo proton c...
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We present here a browser-based application for visualizing patterns of connectivity in 3D stacked data matrices with large numbers of pairwise relations. Visualizing a connectivity matrix, looking for trends and patt...
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