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Inside Cover: Nonplanar Butterfly-Shaped π-Expanded Pyrrolopyrroles (Chem. Eur. J. 46/2016)

Chemistry – A European Journal 2016年第46期22卷 16326-16326页

作者： Maciej Krzeszewski Takuya Kodama Eli M. Espinoza Prof. Dr. Valentine I. Vullev Prof. Dr. Takashi Kubo Prof. Dr. Daniel T. Gryko Institute of Organic Chemistry Polish Academy of Sciences Kasprzaka 44–52 01-224 Warsaw Poland Department of Bioengineering Department of Biochemistry Department of Chemistry and Materials Science and Engineering Program University of California Riverside California 92521 USA Graduate School of Science Osaka University Toyonaka Osaka 560-0043 Japan

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Chemical shift separation with controlled aliasing for hyperpolarized 13C metabolic imaging

Chemical shift separation with controlled aliasing for hyper...

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作者： Shin, Peter J. Larson, Peder E.Z. Uecker, Martin Reed, Galen D. Kerr, Adam B. Tropp, James Ohliger, Michael A. Nelson, Sarah J. Pauly, John M. Lustig, Michael Vigneron, Daniel B. Department of Radiology and Biomedical Imaging University of California at San Francisco 1700 4th Street San FranciscoCA94158 United States UC Berkeley - UCSF Graduate Program in Bioengineering CA United States Department of Electrical Engineering and Computer Sciences University of California at Berkeley BerkeleyCA United States Magnetic Resonance Systems Research Laboratory Department of Electrical Engineering Stanford University StanfordCA United States General Electric Healthcare FremontCA United States

Purpose A chemical shift separation technique for hyperpolarized 13C metabolic imaging with high spatial and temporal resolution was developed. Specifically, a fast three-dimensional pulse sequence and a reconstruction method were implemented to acquire signals from multiple 13C species simultaneously with subsequent separation into individual images. Theory and Methods A stack of flyback echo-planar imaging readouts and a set of multiband excitation radiofrequency pulses were designed to spatially modulate aliasing patterns of the acquired metabolite images, which translated the chemical shift separation problem into parallel imaging reconstruction problem. An eight-channel coil array was used for data acquisition and a parallel imaging method based on nonlinear inversion was developed to separate the aliased images. Results Simultaneous acquisitions of pyruvate and lactate in a phantom study and in vivo rat experiments were performed. The results demonstrated successful separation of the metabolite distributions into individual images having high spatial resolution. Conclusion This method demonstrated the ability to provide accelerated metabolite imaging in hyperpolarized 13C MR using multichannel coils, tailored readout, and specialized RF pulses. © 2014 Wiley Periodicals, Inc.

关键词： Separation

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Design and Synthesis of Nanoparticle Contrast Agents for Spectral (color) X-Ray Imaging

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MRS Online Proceedings Library (OPL) 2015年第1期1719卷 mrsf14-1719-c05-08-mrsf14-1719-c05-08页

作者： Prakash D. Nallathamby Tracie L. Mcginnity Lisa E. Cole Margaret E. Best Tracy Vargo-Gogola Ryan K. Roeder Department of Aerospace & Mechanical Engineering University of Notre Dame Mishawaka IN United States. Bioengineering Graduate Program University of Notre Dame Notre Dame IN United States. Harper Cancer Research Institute University of Notre Dame Notre Dame IN United States. Department of Biochemistry and Molecular Biology Indiana University Medical School South Bend IN United States.

Computed tomography (CT) is an important tool in clinical diagnostic imaging enabling three-dimensional anatomic imaging at high spatial resolution with short scan times. However, X-ray attenuation differences in physiological fluids and soft tissues are relatively small, requiring the use of contrast agents to achieve sufficient imaging contrast. Recent advances in energy-sensitive X-ray detectors have made spectral (color) CT commercially feasible by unmixing the energy-dependent attenuation profile of different materials and will potentially enable molecular imaging in CT. In order to leverage these capabilities for diagnostic imaging, we are developing a spectral library of nanoparticle contrast agents with K-shell absorption edges spaced at least 10 keV apart. The objective of this study was to demonstrate the ability of spectral CT to simultaneously detect up to three different contrast agents and unmixed their signals to create color images. Gadolinium oxide (Gd), hafnium oxide (Hf) and gold (Au) were chosen due to exhibiting K-edges spaced 10-20 keV apart. Core-shell nanoparticles of each composition were synthesized by various methods to have a core diameter of 15-20 nm and were coated with a silica shell at least 2-4 nm in thickness to create a common platform for surface functionalization. The contrast agents were imaged in a soft tissue equivalent phantom using source-side method for spectral CT imaging. The source-side approach utilized monochromatic synchrotron radiation at the Argonne National Laboratory which, while not clinically applicable, served as a gold standard due to providing the highest spectral resolution. The nanoparticles designed for this study have broad applications in biomedical imaging due to their modular assembly, potential for enabling multi-modal detection, and surface functionalization with biomolecules (e.g., antibodies, peptides or enzymes) for active targeting.

关键词： x-ray tomography nanoscale optical

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Rapid fabrication method for plastic microfluidic devices with embedded microelectrodes and its application to electroporation and cell lysis on chip 18

Rapid fabrication method for plastic microfluidic devices wi...

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18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

作者： Paredes, Jacobo Chooljian, Marc Fink, Kathryn D. Liepmann, Dorian CEIT and Tecnun University of Navarra Spain CIC MicroGUNE Spain UC Berkeley San Francisco Graduate Program in Bioengineering United States Department of Bioengineering UC Berkeley United States Berkeley Sensors and Actuators Center United States

ISBN: (纸本)9780979806476

Methods of fabricating microfluidic devices that are scalable, simple, and inexpensive are necessary to ease the transition of microfluidics from an academic to an industrial discipline. Here we present a method for rapid prototyping of microfluidic devices with embedded electrodes in plastic based on electroplating and hot embossing techniques. We then discuss its applicability to electroporation and lysis, two of many potential applications that could benefit from this manufacturing method. © 14CBMS.

关键词： Fabrication

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Galvanotactic control of collective cell migration in epithelial monolayers (vol 13, pg 409, 2014)

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NATURE MATERIALS 2014年第5期13卷 530-530页

作者： Cohen, Daniel J. Nelson, W. James Maharbiz, Michel M. Joint Graduate Program in Bioengineering University of California at Berkeley Berkeley California 94720 USA Department of Biology Molelcular Cellular Physiology Stanford University Stanford California 94305 USA Department of Electrical Engineering Computer Science University of California at Berkeley Berkeley California 94720 USA

Many normal and pathological biological processes involve the migration of epithelial cell sheets. This arises from complex emergent behaviour resulting from the interplay between cellular signalling networks and the forces that physically couple the cells. Here, we demonstrate that collective migration of an epithelium can be interactively guided by applying electric fields that bias the underlying signalling networks. We show that complex, spatiotemporal cues are locally interpreted by the epithelium, resulting in rapid, coordinated responses such as a collective U-turn, divergent migration, and unchecked migration against an obstacle. We observed that the degree of external control depends on the size and shape of the cell population, and on the existence of physical coupling between cells. Together, our results offer design and engineering principles for the rational manipulation of the collective behaviour and material properties of a tissue.

关键词： CELL migration EPITHELIUM EPITHELIAL cells CELL populations SPATIOTEMPORAL processes

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Motion artifacts on 240Hz OLED stereoscopic 3D displays

Motion artifacts on 240Hz OLED stereoscopic 3D displays

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2014 SID International Symposium

作者： Johnson, Paul Kim, Joohwan Hoffman, David M. Vargas, Andres Banks, Martin S. UC Berkeley - UCSF Graduate Program in Bioengineering United States University of California Berkeley Vision Science Program 360 Minor Hall Berkeley CA United States Samsung Display Americas Lab San Jose CA United States

We examined the visibility of motion artifacts-judder, motion blur, and edge banding-on a Samsung 240Hz stereoscopic 3D (S3D) OLED display. We determined the relative contributions of the frame rate of the content, update rate of the panel, duty cycle, and flash number. We compared the visibility of artifacts on the Samsung display with those on a 60Hz S3D LCD. Short duty cycles and low flash numbers reduce the visibility of motion artifacts. © 2014 SID.

关键词： Visibility

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4-dimensional, multiphase, steady-state imaging with contrast enhancement (MUSIC) in the heart;a feasibility study in children

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Journal of Cardiovascular Magnetic Resonance 2015年第SUPPL 1期17卷 Q131-Q131页

作者： Fei Han Stanislas Rapacchi Sarah N Khan Ihab Ayad Isidro Salusky Adam Plotnik Simon Gabriel Paul J Finn Peng Hu Radiological Sciences David Geffen School of Medicine at UCLA Los Angeles CA USA Department of Bioengineering University of California Los Angeles Los Angeles CA USA Department of Anesthesiology David Geffen School of Medicine at UCLA Los Angeles CA USA Department of Pediatrics David Geffen School of Medicine at UCLA Los Angeles CA USA Biomedical Physics Inter-Departmental Graduate Program University of California Los Angeles Los Angeles CA USA

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Integrated microfluidic phenotyping of tumor-derived exosomes 18

Integrated microfluidic phenotyping of tumor-derived exosome...

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18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

作者： He, Mei Godwin, Andrew K. Zeng, Y. Department of Biological and Agricultural Engineering Kansas State University United States Pathology and Laboratory Medicine KU Medical Center KU Cancer Center United States Department of Chemistry Bioengineering Graduate Program University of Kansas United States

ISBN: (纸本)9780979806476

We report on a microfluidic approach to streamline the exosome analysis pipeline via integrating immunoisolation and targeted proteomic analysis of exosomes. This method enables quantitative exosomal biomarker analysis directly from minimally invasive amount of plasma samples (30 μL) within ∼100 min, with markedly improved detection sensitivity. We demonstrated phenotyping of exosome subpopulations by targeting common exosomal and tumor-specific markers and multiparameter analyses of intravesicular biomarkers in a selected subpopulation. We were able to assess the total expression and phosphorylation level of IGF-1R by probing circulating exosomes in non-small cell lung cancer patients, as a non-invasive alternative to conventional biopsy. © 14CBMS.

关键词： Biomarkers

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Rapid on-chip molecular profiling of circulating exosomes for early detection of ovarian cancer 18

Rapid on-chip molecular profiling of circulating exosomes fo...

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18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

作者： He, Mei Zhao, Zheng Godwin, Andrew K. Zeng, Yong Department of Biological and Agricultural Engineering Kansas State University United States Pathology and Laboratory Medicine KU Medical Center KU Cancer Center United States Department of Chemistry Bioengineering Graduate Program University of Kansas United States

ISBN: (纸本)9780979806476

Exosome enriched with a group of tumor antigens is a promising alternative for reliable diagnosis of ovarian cancer (OvCa) from simple blood draw. However, the tedious and lengthy protocols for exosome isolation presents serious technical barrier. For overcoming the technical limitations, we developed a simple microfluidic-based approach for integration of rapid isolation with molecular marker profiling of exosomes directly from OvCa plasma. The rapid on-chip mixing and selective isolation of OvCa derived exosomes was completed within 30 mins. We demonstrated the detection of CA125 expression on the EpCAM+ exosomes from OvCa plasma, which showed significantly higher levels than healthy controls. © 14CBMS.

关键词： Microfluidics

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Ballistocardiography for Nonintrusive Sleep Structure Estimation

Ballistocardiography for Nonintrusive Sleep Structure Estima...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Kwang Suk Park Su Hwan Hwang Da Woon Jung Hee Nam Yoon Won Kyu Lee Department of Biomedical Engineering Seoul National University Interdisciplinary Program of Bioengineering Graduate School Seoul National University

ISBN: (纸本)9781424479276

Based on the its nonintrusive characteristics, ballistocardiography (BCG) has applied in the estimation of sleep structure without attaching any sensors to the subject's body. Loadcell or polyvinylidenefluoride (PVDF) film sensors are installed on the mattress for the monitoring of BCG. BCG peak was detected and heart rate variability parameters are derived. Parameters representing sleep structure and quality are estimated using these parameters. Sleep efficiency, four stages of sleep structure and sleep onset latency are estimated and results are compared with the results derived from polysomnographic recording.

关键词： Sleep apnea Heart rate Estimation Electrocardiography Biomedical monitoring Blood pressure

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