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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Il-hyung Shin Jaepyeong Cha Gyeong Woo Cheon Choonghee Lee Seung Yup Lee Hyung-Jin Yoon Hee Chan Kim Interdisciplinary Program Biomedical Engineering Major Graduate School Seoul National University Department of Electrical and Computer Engineering Johns Hopkins University Interdisciplinary Program Bioengineering Major Graduate School Seoul National University Department of Biomedical Engineering University of Michigan Department of Biomedical Engineering College of Medicine Seoul National University

ISBN: (纸本)9781424479276

This paper presents an automatic stress-relieving music recommendation system (ASMRS) for individual music listeners. The ASMRS uses a portable, wireless photoplethysmography module with a finger-type sensor, and a program that translates heartbeat signals from the sensor to the stress index. The sympathovagal balance index (SVI) was calculated from heart rate variability to assess the user's stress levels while listening to music. Twenty-two healthy volunteers participated in the experiment. The results have shown that the participants' SVI values are highly correlated with their prespecified music preferences. The sensitivity and specificity of the favorable music classification also improved as the number of music repetitions increased to 20 times. Based on the SVI values, the system automatically recommends favorable music lists to relieve stress for individuals.

关键词： Heart rate variability Stress Recommender systems Indexes Multiple signal classification Educational institutions Music

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Bone Remodeling: Theranostic Bioabsorbable Bone Fixation Plate with Drug‐Layered Double Hydroxide Nanohybrids (Adv. Healthcare Mater. 21/2016)

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Advanced Healthcare Materials 2016年第21期5卷

作者： Myung Hun Kim Woojune Hur Goeun Choi Hye Sook Min Tae Hyun Choi Young Bin Choy Jin‐Ho Choy Center for Intelligent Nano‐Bio Materials (CINBM) Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Plastic and Reconstructive Surgery Institute of Human‐Environment Interface Biology College of Medicine Seoul National University Seoul 03080 Republic of Korea Department of Preventive Medicine Graduate School of Public Health Seoul National University Seoul 08826 Korea Institute of Medical and Biological Engineering Medical Research Center and Department of Biomedical Engineering College of Medicine Seoul National University Seoul 03080 Republic of Korea

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Erratum to: Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model

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Journal of experimental & clinical cancer research : CR 2016年第1期35卷 96页

作者： Adel Galal El-Shemi Ahmad Mohammed Ashshi Youjin Na Yan Li Mohammed Basalamah Faisal Ahmad Al-Allaf Eonju Oh Bo-Kyeong Jung Chae-Ok Yun Department of Laboratory Medicine Faculty of Applied Medical Sciences Umm Al-Qura University PO Box 7607 Holy Makkah Saudi Arabia. dr_adel_elshemy2006@***. Department of Pharmacology Faculty of Medicine Assiut University Assiut Egypt. dr_adel_elshemy2006@***. Department of Laboratory Medicine Faculty of Applied Medical Sciences Umm Al-Qura University PO Box 7607 Holy Makkah Saudi Arabia. Department of Bioengineering College of Engineering Hanyang University 222 Wangsinmi-ro Seongdong-gu Seoul Korea. Graduate Program for Nanomedical Science Yonsei University Seoul Korea. Department of Pathology Faculty of Medicine Umm Al-Qura University Holy Makkah Saudi Arabia. Science and Technology Unit & Department of Medical Genetics Faculty of Medicine Umm Al-Qura University Holy Makkah Saudi Arabia. Department of Bioengineering College of Engineering Hanyang University 222 Wangsinmi-ro Seongdong-gu Seoul Korea. chaeok@hanyang.ac.kr.

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26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 Antwerp, Belgium. 15-20 July 2017 Abstracts

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 95-176页

作者： [Anonymous] Department of Neuroscience Yale University New Haven CT 06520 USA Department Physiology & Pharmacology SUNY Downstate Brooklyn NY 11203 USA NYU School of Engineering 6 MetroTech Center Brooklyn NY 11201 USA Departament de Matemàtica Aplicada Universitat Politècnica de Catalunya Barcelona 08028 Spain Institut de Neurobiologie de la Méditerrannée (INMED) INSERM UMR901 Aix-Marseille Univ Marseille France Center of Neural Science New York University New York NY USA Aix-Marseille Univ INSERM INS Inst Neurosci Syst Marseille France Laboratoire de Physique Théorique et Modélisation CNRS UMR 8089 Université de Cergy-Pontoise 95300 Cergy-Pontoise Cedex France Department of Mathematics and Computer Science ENSAT Abdelmalek Essaadi’s University Tangier Morocco Laboratory of Natural Computation Department of Information and Electrical Engineering and Applied Mathematics University of Salerno 84084 Fisciano SA Italy Department of Medicine University of Salerno 84083 Lancusi SA Italy Dipartimento di Fisica Università degli Studi Aldo Moro Bari and INFN Sezione Di Bari Italy Data Analysis Department Ghent University Ghent Belgium Coma Science Group University of Liège Liège Belgium Cruces Hospital and Ikerbasque Research Center Bilbao Spain BIOtech Department of Industrial Engineering University of Trento and IRCS-PAT FBK 38010 Trento Italy Department of Data Analysis Ghent University Ghent 9000 Belgium The Wellcome Trust Centre for Neuroimaging University College London London WC1N 3BG UK Department of Electronic Engineering NED University of Engineering and Technology Karachi Pakistan Blue Brain Project École Polytechnique Fédérale de Lausanne Lausanne Switzerland Departement of Mathematics Swansea University Swansea Wales UK Laboratory for Topology and Neuroscience at the Brain Mind Institute École polytechnique fédérale de Lausanne Lausanne Switzerland Institute of Mathematics University of Aberdeen Aberdeen Scotland UK Department of Integrativ

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Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion

Calibrationless parallel imaging reconstruction based on str...

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作者： Shin, Peter J. Larson, Peder E. Z. Ohliger, Michael A. Elad, Michael Pauly, John M. Vigneron, Daniel B. Lustig, Michael Department of Radiology and Biomedical Imaging University of California at San Francisco San FranciscoCA United States UC Berkeley-UCSF Graduate Program in Bioengineering CA United States Department of Electrical Engineering and Computer Science University of California at Berkeley BerkeleyCA United States Department of Computer Science Technion'Israel Institute of Technology Haifa Israel Magnetic Resonance Systems Research Laboratory Department of Electrical Engineering Stanford University StanfordCA United States

Purpose: A calibrationless parallel imaging reconstruction method, termed simultaneous autocalibrating and k-space estimation (SAKE), is presented. It is a data-driven, coil-by-coil reconstruction method that does not require a separate calibration step for estimating coil sensitivity information. Methods: In SAKE, an undersampled, multichannel dataset is structured into a single data matrix. The reconstruction is then formulated as a structured low-rank matrix completion problem. An iterative solution that implements a projection-ontosets algorithm with singular value thresholding is described. Results: Reconstruction results are demonstrated for retrospectively and prospectively undersampled, multichannel Cartesian data having no calibration signals. Additionally, non-Cartesian data reconstruction is presented. Finally, improved image quality is demonstrated by combining SAKE with wavelet-based compressed sensing. Conclusion: Because estimation of coil sensitivity information is not needed, the proposed method could potentially benefit MR applications where acquiring accurate calibration data is limiting or not possible at all. © 2013 Wiley Periodicals, Inc.

关键词： Compressed sensing

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Integrated microfluidic femtoliter array for quantitative ELISA at the attomolar level

Integrated microfluidic femtoliter array for quantitative EL...

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17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

作者： Zeng, Yong Wang, Tanyu Department of Chemistry University of Kansas United States Bioengineering Graduate Program University of Kansas United States

ISBN: (纸本)9781632666246

We report on an integrated microfluidic solid-phase ELISA platform for ultrasensitive protein detection with a wide dynamic range. Our system integrates a microwell-patterned assay chamber that can be pneumatically actuated to minimize the reaction volume, markedly improving the assay sensitivity and speed. In addition, monolithic integration of pumps and the actuatable assay chamber allows programmable fluid delivery and effective mixing. Quantitative ELISA of IGF-1R protein was demonstrated across five orders of magnitude with a LOD of 21.8 aM. Our system provides an expandable platform for combining digital and analog measurements to further advance proteomic analysis.

关键词： Proteins

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High performance polymers

High performance polymers

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Medical Plastics MiniTec 2013: Technology Advances in Plastic Materials and Processing for Medical Devices

作者： Roeder, Ryan K. Department of Aerospace and Mechanical Engineering Bioengineering Graduate Program University of Notre Dame Notre Dame IN 46556 United States

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De sign of a dual lens of a dual lens system for a micromachined system for a micromachined system for a micromachined system for a micromachined system for a micromachined system for a micromachined system for a micromachined system for a micromachined system for a micromachined optical setup optical setup optical setup

De sign of a dual lens of a dual lens system for a micromach...

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Microelectronics Technology and Devices (SBMicro)

作者： Thiago D. O. Moura Takashiro Tsukamoto Shuji Tanaka Daniel Filgueiras Davies W. de Lima Monteiro Graduate Program in Electrical Engineering PPGEE Universidade Federal de Minas Gerais Belo Horizonte Brazil Department of Bioengineering and Robotics Tohoku University Sendai Japan Mediphacos Belo Horizonte MG Brazil Department of Electrical Engineering OptMA_lab - DEE/UFMG Belo Horizonte MG Brazil

This paper presents the design of a dual-lens system capable of adjusting its focus by changing the distance between the lenses with a microfabricated supporting structure. The dimensions and displacement range were based on the needs of an accommodative intraocular lens (AIOL), but the concept can be extended to any other optical system that requires focal tuning.

关键词： Optical modulation Biomedical optical imaging Tuning Reliability Actuators Metals Radio access networks

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A programmable Acoustic Stimuli and Auditory Evoked Potential Measurement System for Objective Tinnitus Diagnosis Research

A Programmable Acoustic Stimuli and Auditory Evoked Potentia...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society

作者： Yunseo Ku Joong Woo Ahn Chiheon Kwon Myung-Whan Suh Jun Ho Lee Seung Ha Oh Hee Chan Kim Samsung Electronics Samsung Advanced Institute of Technology Suwon Korea Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul Korea Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University Hospital Seoul Department of Biomedical Engineering Seoul National University College of Medicine Seoul Korea

This paper presents the development of a single platform that records auditory evoked potential synchronized to specific acoustic stimuli of the gap prepulse inhibition method for objective tinnitus diagnosis research. The developed system enables to program various parameters of the generated acoustic stimuli. Moreover, only by simple filter modification, the developed system provides high flexibility to record not only short latency auditory brainstem response but also late latency auditory cortical response. The adaptive weighted averaging algorithm to minimize the time required for the experiment is also introduced. The results show that the proposed algorithm can reduce the number of the averaging repetitions to 70% compared with conventional ensemble averaging method.

关键词： Acoustics Acoustic measurements Noise measurement Noise Electrodes Educational institutions Animals

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FANTOM5 CAGE profiles of human and mouse samples

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Scientific Data 2017年第1期4卷 1-10页

作者： Noguchi, Shuhei Arakawa, Takahiro Fukuda, Shiro Furuno, Masaaki Hasegawa, Akira Hori, Fumi Ishikawa-Kato, Sachi Kaida, Kaoru Kaiho, Ai Kanamori-Katayama, Mutsumi Kawashima, Tsugumi Kojima, Miki Kubosaki, Atsutaka Manabe, Ri-Ichiroh Murata, Mitsuyoshi Nagao-Sato, Sayaka Nakazato, Kenichi Ninomiya, Noriko Nishiyori-Sueki, Hiromi Noma, Shohei Saijyo, Eri Saka, Akiko Sakai, Mizuho Simon, Christophe Suzuki, Naoko Tagami, Michihira Watanabe, Shoko Yoshida, Shigehiro Arner, Peter Axton, Richard A. Babina, Magda Kenneth Baillie, J. Barnett, Timothy C. Beckhouse, Anthony G. Blumenthal, Antje Bodega, Beatrice Bonetti, Alessandro Briggs, James Brombacher, Frank Carlisle, Ailsa J. Clevers, Hans C. Davis, Carrie A. Detmar, Michael Dohi, Taeko Edge, B. Albert S. Edinger, Matthias Ehrlund, Anna Ekwall, Karl Endoh, Mitsuhiro Enomoto, Hideki Eslami, Afsaneh Fagiolini, Michela Fairbairn, Lynsey Farach-Carson, Mary C. Faulkner, Geoffrey J. Ferrai, Carmelo Fisher, Malcolm E. Forrester, Lesley M. Fujita, Rie Furusawa, Jun-Ichi Geijtenbeek, Teunis B. Gingeras, Thomas Goldowitz, Daniel Guhl, Sven Guler, Reto Gustincich, Stefano Ha, Thomas J. Hamaguchi, Masahide Hara, Mitsuko Hasegawa, Yuki Herlyn, Meenhard Heutink, Peter Hitchens, Kelly J. Hume, David A. Ikawa, Tomokatsu Ishizu, Yuri Kai, Chieko Kawamoto, Hiroshi Kawamura, Yuki I. Kempfle, Judith S. Kenna, Tony J. Kere, Juha Khachigian, Levon M. Kitamura, Toshio Klein, Sarah Peter Klinken, S. Knox, Alan J. Kojima, Soichi Koseki, Haruhiko Koyasu, Shigeo Lee, Weonju Lennartsson, Andreas MacKay-Sim, Alan Mejhert, Niklas Mizuno, Yosuke Morikawa, Hiromasa Morimoto, Mitsuru Moro, Kazuyo Morris, Kelly J. Motohashi, Hozumi Mummery, Christine L. Nakachi, Yutaka Nakahara, Fumio Nakamura, Toshiyuki Nakamura, Yukio Nozaki, Tadasuke Ogishima, Soichi Ohkura, Naganari Ohno, Hiroshi Ohshima, Mitsuhiro Okada-Hatakeyama, Mariko Okazaki, Yasushi Orlando, Valerio Ovchinnikov, Dmitry A. Passier, Robert Patrikakis, Margaret Pombo, Ana Pradhan-Bhatt, Swati Qin, Xian-Yang Rehli, Michael Rizzu, Patrizia Roy, S Division of Genomic Technologies RIKEN Center for Life Science Technologies Yokohama Kanagawa 230-0045 Japan RIKEN Omics Science Center Yokohama Kanagawa 230-0045 Japan Department of Medicine Karolinska Institutet Stockholm 14186 Sweden Karolinska University Hospital Center for Metabolism and Endocrinology Stockholm 14186 Sweden Scottish Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH164UU United Kingdom Department of Dermatology and Allergy Charite University Medicine Berlin Charitéplatz 1 Berlin 10117 Germany Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh EH259RG United Kingdom Australian Infectious Diseases Research Centre University of Queensland St Lucia 4072 QLD Australia School of Chemistry and Molecular Biosciences University of Queensland St Lucia 4072 QLD Australia Bio-Rad Laboratories Pty Ltd Hercules 94547 CA United States University of Queensland Diamantina Institute University of Queensland Woolloongabba 4102 QLD Australia IRCCS Fondazione Santa Lucia Via del Fosso di Fiorano 64 Rome 00143 Italy Australian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane St Lucia 4072 QLD Australia Division of Immunology Institute of Infectious Diseases and Molecular Medicine University of Cape Town Anzio Road Observatory 7925 South Africa Immunology of Infectious Diseases Faculty of Health Sciences South African Medical Research Council University of Cape Town Anzio Road 7925 South Africa International Centre for Genetic Engineering and Biotechnology Cape Town Component Anzio Road 7925 South Africa Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Uppsalalaan 8 3584 Netherlands University Medical Centre Utrecht Postbus 85500 Utrecht 3508 Netherlands Genomics Cold Spring Harbor Laboratory Cold Spring Harbor New York 11797 NY United States Institute of Pharmaceutical Sciences ETH Zurich Vladi

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

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