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11th International Conference on Smart Homes and Health Telematics, ICOST 2013

作者： Assad, Danielle Aline Barata Elui, Valéria Meirelles Carril Fortulan, Carlos Alberto Graduate Program in Bioengineering Inter FMRP/ EESC/ IQSC University of São Paulo Worker Av St-carlense 400 San-Carlos São Paulo Brazil

ISBN: (纸本)9783642394690

A removable support bar without structural modification of the environment, was developed. Assistive technology (AT) is a multidisciplinary science that combines knowledge of health professionals and the exact sciences area. This study is based in the methods of engineering product design and its relation to the development of resources. This paper aims to present the development process of a removable support bar that is easy to use, requiring no technical knowledge and no change the constitution of the walls and floors in the houses. Based on the methodology design the study was divided into five stages: informational (questionnaire with closed questions and an essay from the target population for use of the bar);conceptual (technical specifications, design, standards, solutions and decisions);preliminary design (design and drawing fully bar, and prototype (project preparation and design of the bar, prototyping and evaluation), validation (validation of the prototype). As the results, the support bar have been developed with seven parts for assembly in several configurations that can attend the populations needs in terms of available room: the parts are: base, tube, tee, elbow, elbow 30o.;elbow 60o. and elbow-tee. Volunteer's priority are to employ it in the bathrooms and bedrooms. The attachment configuration has small height (0,90 m) and is glued with thermo wax resin that is easy to assemble, and fixation, is removable causing no damage to the floor surface and is secure. © 2013 Springer-Verlag Berlin Heidelberg.

关键词： Floors

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Accuracy assessment of different finger placements for cardiopulmonary resuscitation on infants

Accuracy assessment of different finger placements for cardi...

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IEEE EMBS International Conference on Information Technology Applications in Biomedicine (ITAB)

作者： Jiheum Park Chiyul Yoon Jae Yun Jung Do Kyun Kim Young Ho Kwak Jung Chan Lee Hee Chan Kim Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul Korea Department of Emergency Medicine Seoul National University Hospital Seoul Korea Department of Emergency Medicine Seoul National University Hospital Seoul 110-744 Korea Department of Emergency Medicine Seoul National University College of Medicine Seoul Korea Department of Biomedical Engineering Seoul National University Hospital Seoul Korea

ISBN: (纸本)9781479921324

The assessment of cardiopulmonary resuscitation (CPR) is important for training as well as CPR related research to validate new method or to confirm efficacy of existing one. Infant CPR, in particular, has been received great attention due to its controversy over appropriateness of or superiority between two different methods, two-finger (TF) and two-thumb (TT) CPR, suggested by the resuscitation council. Accordingly, the development of assessment tool that is capable of reliably investigating different CPR techniques has become critical. One of the most challenging task in the infant CPR is to provide consistent and accurate finger placement throughout the performance. Here, we suggest a new method to measure accuracy of the finger placement for both TF and TT CPR using manikin-integrated digital measuring system developed in the previous study. Center of forces of force sensitive resistance sensors used for assessing different finger placements were measured in each compression and scattered on 2D plane to quantitatively and qualitatively probe the finger position. The appearance of the scattered data turned out to be significantly different depending on the performance capability. In the comparison between beginners and experts, stdY and meanDist were significant parameters differentiating these two groups for both techniques, meaning beginners are poor at providing consistent forces along y direction and targeting a specific region while relatively good at balancing in x direction.

关键词： Sensors Pediatrics Thumb Force Accuracy Correlation

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55.1:Distinguished Paper: Motion Artifacts on 240Hz OLED Stereoscopic 3D Displays

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SID Symposium Digest of Technical Papers 2014年第1期45卷

作者： Paul Johnson Joohwan Kim David M. Hoffman Andres Vargas Martin S. Banks UC Berkeley – UCSF Graduate Program in Bioengineering University of California Berkeley Vision Science Program 360 Minor Hall Berkeley CA USA Samsung Display Americas Lab San Jose CA USA

We examined the visibility of motion artifacts—judder, motion blur, and edge banding—on a Samsung 240Hz stereoscopic 3D (S3D) OLED display. We determined the relative contributions of the frame rate of the content, update rate of the panel, duty cycle, and flash number. We compared the visibility of artifacts on the Samsung display with those on a 60Hz S3D LCD. Short duty cycles and low flash numbers reduce the visibility of motion artifacts.

关键词： OLED stereoscopic 3D motion perception motion sampling frame rate

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Statistical appearance modeling of whole-body bone shape and density

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Journal of Orthopaedic Translation 2014年第4期2卷 246-247页

作者： Bennett K. Ng Louise Marquino Viva W. Tai Caitlin Sheets Kathleen Mulligan Timothy F. Cootes John A. Shepherd University of California Berkeley–University of California San Francisco Graduate Program in Bioengineering San Francisco California United States of America Department of Radiology and Biomedical Imaging University of California San Francisco United States of America Division of Endocrinology and Metabolism Department of Medicine University of California San Francisco United States of America Clinical and Translational Science Institute University of California San Francisco United States of America Centre for Imaging Sciences Institute of Population Health The University of Manchester Manchester United Kingdom

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25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts

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BMC NEUROSCIENCE 2016年第1期17卷 1-112页

作者： [Anonymous] Computational Neurobiology Laboratory The Salk Institute for Biological Studies San Diego USA UNIC CNRS Gif sur Yvette France The European Institute for Theoretical Neuroscience (EITN) Paris France ATR Computational Neuroscience Laboratories Kyoto Japan Krembil Research Institute University Health Network Toronto Canada Department of Physiology University of Toronto Toronto Canada Department of Medicine (Neurology) University of Toronto Toronto Canada Department of Physics University of New Hampshire Durham USA Department of Neurophysiology Nencki Institute of Experimental Biology Warsaw Poland Department of Theory Wigner Research Centre for Physics of the Hungarian Academy of Sciences Budapest Hungary Department of Mathematical Sciences KAIST Daejoen Republic of Korea Department of Mathematics University of Houston Houston USA Department of Biochemistry & Cell Biology and Institute of Biosciences and Bioengineering Rice University Houston USA Department of Biology and Biochemistry University of Houston Houston USA Grupo de Neurocomputación Biológica Dpto. de Ingeniería Informática Escuela Politécnica Superior Universidad Autónoma de Madrid Madrid Spain Department of Biological Sciences University of Southern California Los Angeles USA Center for Neuroscience Korea Institute of Science and Technology Seoul South Korea Department of Neurology Albert Einstein College of Medicine Bronx USA Center for Neuroscience KIST Seoul South Korea Department of Neuroscience University of Science and Technology Daejon South Korea Systems Neuroscience Group QIMR Berghofer Medical Research Institute Herston Australia Department of Psychology Yonsei University Seoul South Korea Department of Psychiatry Kyung Hee University Hospital at Gangdong Seoul South Korea Department of Psychiatry Veterans Administration Boston Healthcare System and Harvard Medical School Brockton USA Department of Electrical and Electronic Engineering The University of Melbourne Parkvil

A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling of propagating waves in visual cortex Alain Destexhe A3 Dynamics and biomarkers of mental disorders Mitsuo Kawato F1 Precise recruitment of spiking output at theta frequencies requires dendritic h-channels in multi-compartment models of oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods in reconstruction of current sources from extracellular potentials for single cells and the whole brains Daniel K. Wójcik, Chaitanya Chintaluri, Dorottya Cserpán, Zoltán Somogyvári F3 The synchronized periods depend on intracellular transcriptional repression mechanisms in circadian clocks. Jae Kyoung Kim, Zachary P. Kilpatrick, Matthew R. Bennett, Kresimir Josić O1 Assessing irregularity and coordination of spiking-bursting rhythms in central pattern generators Irene Elices, David Arroyo, Rafael Levi, Francisco B. Rodriguez, Pablo Varona O2 Regulation of top-down processing by cortically-projecting parvalbumin positive neurons in basal forebrain Eunjin Hwang, Bowon Kim, Hio-Been Han, Tae Kim, James T. McKenna, Ritchie E. Brown, Robert W. McCarley, Jee Hyun Choi O3 Modeling auditory stream segregation, build-up and bistability James Rankin, Pamela Osborn Popp, John Rinzel O4 Strong competition between tonotopic neural ensembles explains pitch-related dynamics of auditory cortex evoked fields Alejandro Tabas, André Rupp, Emili Balaguer-Ballester O5 A simple model of retinal response to multi-electrode stimulation Matias I. Maturana, David B. Grayden, Shaun L. Cloherty, Tatiana Kameneva, Michael R. Ibbotson, Hamish Meffin O6 Noise correlations in V4 area correlate with behavioral performance in visual discrimination task Veronika Koren, Timm Lochmann, Valentin Dragoi, Klaus Obermayer O7 Input-location dependent gain modulation in cerebellar nucleus neurons Maria Psarrou, Maria Schilstra, Neil Davey, Benjamin Torben-Ni

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Engineering Microorganisms for Biomedical and Energy Applications

Engineering Microorganisms for Biomedical and Energy Applica...

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第八届全国微全分析系统学术会议、第三届全国微纳尺度生物分离分析学术会议暨第五届国际微化学与微系统学术会议

作者： I-Ming Hsing Danhui Cheng Department of Chemical and Biomolecular Engineering the Hong Kong University of Science and TechnologyHong Kong SARChina Division of Biomedical Engineering and Bioengineering Graduate Programthe Hong Kong University of Science and Technology Division of Biomedical Engineering and Bioengineering Graduate Program the Hong Kong University of Science and Technology

The availability of technologies to rapidly synthesize and decode genetic sequences has provided new applications for recombinant DNA technology and genetic engineering developed in early *** new genetic engineering approach,also coined as synthetic biology by many scientists,often involves engineering of microorganism through expression of heterologous gene segments in the microbial *** ability to engineer microorganisms empowered with tailor-made characteristics has provided exciting opportunities in different areas of *** instance,drug synthesis and novel drug delivery methods based on engineered bacteria strains have been extensively studied in biomedical ***,various synthetic biology approaches have been proposed to construct novel metabolic pathways in order to achieve higher yield in bioenergy & biofuel production,such as in ethanol fermentation,hydrogen production and bioelectricity generation through a microbial fuel *** this plenary presentation,we will start with an overview of this very exciting technology (*** biology),followed by a detailed discussion of two related projects in my *** the first part,we utilized yeast display technology for developing a new cell-based immunoassay *** the second one,we engineered photosynthetic bacteria to rewire its indigenous electron transfer pathway in pursuit of converting solar energy to ***,for the interests of our microfluidic community,some thoughts and opportunities of studying and utilizing engineered microorganisms in a microfluidic platform will be discussed.

关键词： Synthetic Biology Genetic Engineering Yeast Surface Display Photosynthetic Bacteria

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2-D thresholding of the connectivity map following the multiple sequence alignments of diverse datasets

2-D thresholding of the connectivity map following the multi...

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10th IASTED International Conference on Biomedical Engineering, BioMed 2013

作者： Doǧan, Tunca Karaçali, Bilge Biotechnology and Bioengineering Graduate Program Izmir Institute of Technology Dokuz Eylül University Izmir Turkey Electrical and Electronics Engineering Department Izmir Institute of Technology Dokuz Eylül University Izmir Turkey Institute of Health Sciences Dokuz Eylül University Izmir Turkey

ISBN: (纸本)9780889869530

Multiple sequence alignment (MSA) is a widely used method to uncover the relationships between the biomolecular sequences. One essential prerequisite to apply this procedure is to have a considerable amount of similarity between the test sequences. It's usually not possible to obtain reliable results from the multiple alignments of large and diverse datasets. Here we propose a method to obtain sequence clusters of significant intragroup similarities and make sense out of the multiple alignments containing remote sequences. This is achieved by thresholding the pairwise connectivity map over 2 parameters. The first one is the inferred pairwise evolutionary distances and the second parameter is the number of gapless positions on the pairwise comparisons of the alignment. Threshold curves are generated regarding the statistical parameter values obtained from a shuffled dataset and probability distribution techniques are employed to select an optimum threshold curve that eliminate as much of the unreliable connectivities while keeping the reliable ones. We applied the method on a large and diverse dataset composed of nearly 18000 human proteins and measured the biological relevance of the recovered connectivities. Our precision measure (0.981) was nearly 20% higher than the one for the connectivities left after a classical thresholding procedure displaying a significant improvement. Finally we employed the method for the functional clustering of protein sequences in a gold standard dataset. We have also measured the performance, obtaining a higher F-measure (0.882) compared to a conventional clustering operation (0.827).

关键词： Probability distributions

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Single cell western blotting

Single cell western blotting

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17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

作者： Hughes, Alex J. Spelke, Dawn P. Xu, Zhuchen Schaffer, David V. Herr, Amy E. Department of Bioengineering University of California UC Berkeley Berkeley CA United States UC Berkeley-UCSF Graduate Program in Bioengineering UC Berkeley Berkeley CA United States Department of Chemical Engineering UC Berkeley Berkeley CA United States Helen Wills Neuroscience Institute UC Berkeley Berkeley CA United States California Institute for Quantitative Biosciences UC Berkeley Berkeley CA United States

Understanding protein-mediated cell signaling and differentiation processes requires capturing response heterogeneity for single cells in large populations. We report single-cell western blots on standard microscope s... 详细信息

ISBN: (纸本)9781632666246

关键词： Proteins

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26th Annual Computational Neuroscience Meeting (CNS*2017) of the Organization for Computational Neuroscience Antwerp, Belgium, July 15-20, 2017

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BMC NEUROSCIENCE 2017年第SUPPL 1期18卷 59-59页

作者： [Anonymous] Indiana University Purdue University Indianapolis Indianapolis IN 46032 USA Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis IN 46032 USA Department of Mathematics East Carolina University Greenville NC 27858 USA Jülich Supercomputing Centre Forschungszentrum Jülich 52425 Jülich Germany Future Systems Swiss National Supercomputing Centre 8092 Zurich Switzerland User Engagement and Support Swiss National Supercomputing Centre 6900 Lugano Switzerland Institut de Neurosciences des Systèmes Aix Marseille Univ 13005 Marseille France Simulation Lab Neuroscience Forschungszentrum Jülich Jülich Germany Department of Experimental Psychology Ghent University 9000 Ghent Belgium Donders Center for Cognitive Neuroimaging Radboud University 6525HR Nijmegen The Netherlands Department of Electrical Computer and Energy Engineering University of Colorado Boulder CO 80309 USA Department of Neurosurgery Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Neurology Johns Hopkins School of Medicine Baltimore MD 21287 USA Department of Otolaryngology Johns Hopkins School of Medicine Baltimore MD 21287 USA INSERM U968 Paris France Sorbonne Universités UPMC University Paris 06 UMR_S 968 Institut de la Vision Paris France CNRS UMR_7210 Paris France Department of Computer Architecture and Technology University of Granada (CITIC) Granada Spain Sorbonne Universités UPMC Univ Paris 06 INSERM CNRS Institut de la Vision Paris France Department of Adaptive Machine Systems Osaka University Osaka Japan Department of Computer Science University of Cergy-Pontoise Cergy-Pontoise France Department of Physics and Astronomy College of Charleston Charleston SC 29424 USA School of Physics Faculty of Science University of Sydney Sydney NSW 2006 Australia Center of Excellence for Integrative Brain Function Australian Research Council Sydney Australia Max Planck Institute for Human Cognitive and Brain Sciences Saxony Lei

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Center of Pressure Velocity Autocorrelation as a New Measure of Postural Control During Quiet Stance

Center of Pressure Velocity Autocorrelation as a New Measure...

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International IEEE/EMBS Conference on Neural Engineering

作者： Manuel E. Hernandez Cory Stevenson Joseph Snider Howard Poizner Institute for Neural Computation University of California Institute for Neural Computation and Department of Bioengineering University of California Institute for Neural Computation and Graduate Program in Neurosciences University of California

ISBN: (纸本)9781467319676

Falls are a significant cause of mortality and serious injury in older adults and particularly in people with neurological disorders. The ability to maintain balance and postural control is commonly evaluated using center of pressure (COP) data collected with a force platform. Recent methods such as the Stabilogram Diffusion Analysis (SDA) have examined the stochastic characteristics of the COP but require numerous, long duration trials for reliable measures. To further our understanding of the underlying dynamical processes in postural control, we propose a new conceptual framework for studying human postural control using the COP velocity autocorrelation function (COP-VAF), and compare its results to SDA. Five healthy young participants were studied under quiet standing conditions with either eyes open or closed. COP trajectories were analyzed using both traditional postur-ographic measures, SDA, and the COP-VAF. It is shown that the COP-VAF leads to repeatable, physiologically meaningful measures that can distinguish postural control differences with and without vision in healthy individuals. More specifically, visual feedback was found to significantly decrease the peak COP velocity autocorrelation value and magnitude of the first minimum, while increasing the diffusion coefficient. This result is interpreted as an indication that visual input serves to rapidly eliminate any oscillatory motion in quiet stance and utilizes a smaller potential field to maintain balance. In contrast to SDA, COP-VAF measures provide a more concise and reliable measure of postural control (intraclass coefficient correlation (ICC) = 0.23-0.87 vs. 0.05-0.91 in COP-VAF vs. SDA measures, respectively). This work suggests that we can further extend our understanding of the underlying mechanisms behind postural control in quiet stance using the COP-VAF and may apply this analysis in quantifying future neurorehabilitative interventions aimed at improving balance.

关键词： CARD16 gene Center of pressure oscillating movements Standing Orders Serious Injury potential field Autocorrelation conceptual framework

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