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Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells

Curcumin suppresses doxorubicin-induced epithelial-mesenchym...

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作者： Chen, Wei-Chih Lai, Ying-An Lin, Ying-Chao Ma, Jui-Wen Huang, Li-Fen Yang, Ning-Sun Ho, Chi-Tang Kuo, Sheng-Chu Way, Tzong-Der Ph.D. Program for Cancer Biology and Drug Discovery College of Medicine China Medical University Taichung 40402 Taiwan Department of Biological Science and Technology College of Life Sciences China Medical University Taichung 40402 Taiwan Division of Neurosurgery Buddhist Tzu Chi General Hospital Taichung Branch Taichung 427 Taiwan Institute of Biochemistry College of Life Science National Chung Hsing University Taichung 402 Taiwan Graduate School of Biotechnology and Bioengineering Yuan Ze University Taoyuan 320 Taiwan Agricultural Biotechnology Research Center Academia Sinica Taipei 115 Taiwan Department of Food Science Rutgers State University of New Jersey New Brunswick NJ 08901 United States Graduate Institute of Pharmaceutical Chemistry College of Pharmacy China Medical University Taichung 40402 Taiwan Department of Health and Nutrition Biotechnology College of Health Science Asia University Taichung 413 Taiwan

Triple-negative breast cancer (TNBC) is defined by a lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER 2). Therefore, targeted therapy agents may not be used, and therapy is largely limited to chemotherapy. Doxorubicin treatment consequently acquires undesired malignance characteristics [i.e., epithelial-mesenchymal transition (EMT) and multi-drug resistance]. Our results illustrated that doxorubicin triggered EMT and resulted in the acquisition of a mesenchymal phenotype in TNBC cells. Moreover, we found that transforming growth factor-β (TGF-β) and PI3K/AKT signaling pathways were acquired for doxorubicin-induced EMT. Interestingly, we found that curcumin suppressed doxorubicin-induced EMT. Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression. We also found that curcumin inhibited doxorubicin-induced EMT by inhibiting the TGF-β and PI3K/AKT signaling pathways. Moreover, curcumin enhanced the antiproliferative effects of doxorubicin in TNBC cells. In summary, our results suggest that doxorubicin in combination with curcumin may be a potential therapy for TNBC. © 2013 American Chemical Society.

关键词： Chemotherapy

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High spatial and temporal resolution dynamic contrast-enhanced magnetic resonance angiography (CE-MRA) using compressed sensing with magnitude image subtraction

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Journal of Cardiovascular Magnetic Resonance 2013年第SUPPL 1期15卷 E82-E82页

作者： Stanislas Rapacchi Fei Han Yutaka Natsuaki Randall M Kroeker Adam N Plotnik Evan Lehrman James Sayre Gerhard Laub J Paul Finn Peng Hu Deparment of Radiological Sciences University of California Los Angeles Los Angeles CA USA Department of Bioengineering David Geffen School of Medicine University of California Los Angeles Los Angeles CA USA Siemens Healthcare Los Angeles CA USA Department of Biostatistics School of Public Health University of California Los Angeles Los Angeles CA USA Biomedical Physics Inter-Departmental Graduate Program University of California Los Angeles Los Angeles CA USA

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Metabolomics and Network Biology for sensitive monitoring of how growth environment changes affect the physiology of industrial-scale perfusion cultures

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IFAC Proceedings Volumes 2013年第31期46卷 227-232页

作者： S.I. Vernardis C.T. Goudar M.I. Klapa Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering Foundation for Research and Technology-Hellas Patras GR- 265 04 Greece Cell Culture Development Global Biological Development Bayer HealthCare 800 Dwight Way Berkeley CA 94710 Interdepartmental Graduate Program in “Informatics in Life Sciences” Medical School University of Patras Greece & Current Address: Cell Science and Technology AMGEN Inc. Thousand Oaks CA 91320 USA Secondary Affiliation: Depts of Chemical & Biomolecular Eng and Bioengineering University of Maryland College Park MD 20742 USA

Metabolomic analysis can indeed enhance the prime variable dataset for the monitoring of perfusion cultures by providing a higher resolution view of the metabolic state. Metabolic profiles can capture physiological state shifts over the course of the perfusion cultures and indicate a metabolic “signature” of the phase transitions, which is not observable from prime variable data. Notably, metabolomics provides orthogonal (to prime variables) evidence that all cultures follow this same metabolic state shift with cell age, independently of bioreactor scale. Additionally, this analysis can increase the information content of process development experiments by helping better understand the impact of changes in bioreactor operating conditions on cell physiology. In this context, metabolic profiling could be integrated into the monitoring of cell physiology in perfusion cultures.

关键词： industrial cell culture engineering GC-MS metabolomics perfusion cultures multivariate statistical analysis metabolic network reconstruction growth environmental variations

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Estimation of sleep onset latency based on the correlation between blood pressure and heart beat interval

Estimation of sleep onset latency based on the correlation b...

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IEEE-EMBS International Conference on Biomedical and Health Informatics, BHI 2012. In Conj. with the 8th Int. Symp.on Medical Devices and Biosensors and the 7th Int. Symp. on Biomedical and Health Engineering

作者： Jung, Da Woon Chung, Gih Sung Hwang, Su Hwan Park, Kwang Suk Interdisciplinary Program of Bioengineering Seoul National University Graduate School Seoul 100 799 Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Seoul 100 799 Korea Republic of

ISBN: (纸本)9781457721779

Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the correlation between blood pressure (BP) and heart beat interval (HBI). This approach facilitates less intrusive finding of SOL as compared with currently using polysomnographic method. We hypothesized that the arterial baroreflex, one kind of reflex mechanism to regulate BP, takes a role of maintaining sleep's toning-down effect on BP. At the time of transition from full wakefulness to sleep, the toning-down effect starts to drop the BP and the arterial baroreflex is activated to maintain lowered BP by leading to increase in HBI for the elevated BP. Consequently, there is a great contribution of arterial baroreflex to HBI control. With a quantitative evaluation of the contribution, we tried to estimate SOL. For six healthy subjects (27.5 ± 3.15 years), the mean absolute error (MAE) was 0.3 ± 0.42 minutes. We expect our method can be applicable to non-intrusive and automatic SOL estimation system by not using electroencephalogram (EEG) sensors. © 2012 IEEE.

关键词： Blood pressure

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Measurement of brain activations to examine gender-specific risk decision making using functional near infrared spectroscopy (fNIRS)

Measurement of brain activations to examine gender-specific ...

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Biomedical Optics, BIOMED 2012

作者： Li, Lin Lin, Zi-Jing Cazzell, Mary Liu, Hanli Department of Bioengineering Joint Graduate Program b/w Univ. of Texas Southwestern Medical University of Texas Arlington TX 76019 United States College of Nursing University of Texas at Arlington Arlington TX 76019 United States

We utilized fNIRS to examine gender differences in brain activation at the prefrontal cortex of forty healthy adults while performing the Balloon Analogue Risk Task (BART). It shows promises of fNIRS to study risk dec... 详细信息

ISBN: (纸本)9781557529428

关键词： Chemical activation

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Appendicular DXA BMC and Lean Mass Strongly Associated to Hip Fracture Risk

Appendicular DXA BMC and Lean Mass Strongly Associated to Hi...

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第六届国际骨质疏松及骨矿盐疾病学术会议

作者： John A Shepherd Serghei Malkov Kathleen Peters Jane Cauley Steve Cummings Tamara Harris Rachel Murphy Suzanne Satterfield Marjolien Visser Joseph Wilson Joseph Zmuda Peggy Cawthon Department of Radiology & Biomedical Imaging University of California San FranciscoUSA UC Berkeley-UCSF Graduate Program in Bioengineering California Pacific Medical Center Department of Epidemiology Graduate School of Public HealthUniversity of PittsburghPittsburghPennsylvaniaUSA UC Berkeley-UCSF Graduate Program in Bioengineering San FranciscoCA USA

Objective We aimto determine the utility of quantifying DXA-derived surrogates of CT measures including thigh cross-sectional muscle area(CSA) and muscle attenuation. Methods We used a retrospective case-cohort study design using data from the HealthAging and Body Composition(HealthABC) *** were 111 participants that had a hip fracture during the 8.7-year study period.A cohortof 212 non-fracture participants wasrandomly selected

关键词： DXA Appendicular DXA BMC and Lean Mass Strongly Associated to Hip Fracture Risk BMC

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The effect of Cytochalasin D on F-actin behavior of single-cell electroendocytosis using multi-chamber micro cell chip

The effect of Cytochalasin D on F-actin behavior of single-c...

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7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012

作者： Lin, Ran Chang, Donald. C. Lee, Yi-Kuen Bioengineering Graduate Program HKUST Kowloon Hong Kong Dept. of Mechanical Engineering HKUST Kowloon Hong Kong Division of Life Science HKUST Kowloon Hong Kong Joint KAUST-HKUST Micro/Nanofluidics Laboratory HKUST Clear Water Bay Kowloon Hong Kong

ISBN: (纸本)9781467311243

Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytochalasin D (CD) on the actin-filaments (F-Actin) behavior of single-cell EED. The CD concentration (CCD) can control the depolymerization of F-actin. A multi-chamber micro cell chip was fabricated to study the EED under different conditions. Large-scale single-cell data demonstrated EED highly depends on both electric field and CCD. © 2012 IEEE.

关键词： Electric fields

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Polymer translocation in solid-state nanopores: Dependence of scaling behavior on pore dimensions and applied voltage

Polymer translocation in solid-state nanopores: Dependence o...

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作者： Edmonds, Christopher M. Hudiono, Yeny C. Ahmadi, Amir G. Hesketh, Peter J. Nair, Sankar Interdisciplinary Bioengineering Graduate Program Georgia Institute of Technology Atlanta GA 30332 United States School of Chemical Biomolecular Engineering Georgia Institute of Technology Atlanta GA 30332 United States Woodruff School of Mechanical Engineering Georgia Institute of Technology Atlanta GA 30332 United States

We investigate unforced and forced translocation of a Rouse polymer (in the absence of hydrodynamic interactions) through a silicon nitride nanopore by three-dimensional Langevin dynamics simulations, as a function of pore dimensions and applied voltage. Our nanopore model consists of an atomistically detailed nanopore constructed using the crystal structure of β-Si 3N4. We also use realistic parameters in our simulation models rather than traditional dimensionless quantities. When the polymer length is much larger than the pore length, we find the translocation time versus chain length scales as τ ∼ N2+v for the unforced case and as τ ∼ N(1+2v)/(1+v) for the forced case. Our results agree with theoretical predictions which indicate that memory effects and tension on the polymer chain play an important role during the translocation process. We also find that the scaling exponents are highly dependent on the applied voltage (force). When the length of the polymer is on the order of the length of the pore, we do not find a continuous scaling law, but rather scaling exponents that increase as the length of the polymer increases. Finally, we investigate the scaling behavior of translocation time versus applied voltage for different polymer and pore lengths. For long pores, we obtain the theoretical scaling law of τ ∼ 1/Vα, where α 1 for all voltages and polymer lengths. For short pores, we find that α decreases for very large voltages andor small polymer lengths, indicating that the value of α = 1 is not universal. The results of our simulations are discussed in the context of experimental measurements made under different conditions and with differing pore geometries. © 2012 American Institute of Physics.

关键词： Nanopores

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Diffuse optical tomography to study ischemic stroke in preclinical rat models

Diffuse optical tomography to study ischemic stroke in precl...

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Biomedical Optics, BIOMED 2012

作者： Lin, Zi-Jing Ren, Ming Li, Lin Yang, Shaohua Liu, Hanli Department of Bioengineering Joint Graduate Program b/w Univ. of Texas Southwestern Medical University of Texas TX 76019 United States Department of Pharmacology and Neuroscience Institute for Aging and Alzheimer's Disease Research University of North Texas Health Science Center Fort Worth TX 76107 United States

We investigated hyper-acute cerebral ischemia using diffuse optical tomography with the depth compensation algorithm (DCA) in pre-clinical rat models. Results suggest that this methodology has a great potential to mon... 详细信息

ISBN: (纸本)9781557529428

关键词： Rats

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The effect of Cytochalasin D on F-Actin behavior of single-cell electroendocytosis using multi-chamber micro cell chip

The effect of Cytochalasin D on F-Actin behavior of single-c...

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IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Ran Lin Donald. C. Chang Yi-Kuen Lee Bioengineering Graduate Program HKUST Hong Kong China Division of Life Science HKUST Hong Kong China Hong Kong University of Science and Technology Kowloon HK

Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytochalasin D (CD) on the actin-filaments (F-Actin) behavior of single-cell EED. The CD concentration (C CD ) can control the depolymerization of F-actin. A multi-chamber micro cell chip was fabricated to study the EED under different conditions. Large-scale single-cell data demonstrated EED highly depends on both electric field and C CD .

关键词： Nanoelectromechanical systems Fluorescence Gold Polymers

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