Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the corr...
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We utilized fNIRS to examine gender differences in brain activation at the prefrontal cortex of forty healthy adults while performing the Balloon Analogue Risk Task (BART). It shows promises of fNIRS to study risk dec...
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Objective We aimto determine the utility of quantifying DXA-derived surrogates of CT measures including thigh cross-sectional muscle area(CSA) and muscle attenuation. Methods We used a retrospective case-cohort study ...
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Objective We aimto determine the utility of quantifying DXA-derived surrogates of CT measures including thigh cross-sectional muscle area(CSA) and muscle attenuation. Methods We used a retrospective case-cohort study design using data from the HealthAging and Body Composition(HealthABC) *** were 111 participants that had a hip fracture during the 8.7-year study period.A cohortof 212 non-fracture participants wasrandomly selected
Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytoch...
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We investigate unforced and forced translocation of a Rouse polymer (in the absence of hydrodynamic interactions) through a silicon nitride nanopore by three-dimensional Langevin dynamics simulations, as a function of...
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We investigated hyper-acute cerebral ischemia using diffuse optical tomography with the depth compensation algorithm (DCA) in pre-clinical rat models. Results suggest that this methodology has a great potential to mon...
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Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytoch...
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Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytochalasin D (CD) on the actin-filaments (F-Actin) behavior of single-cell EED. The CD concentration (C CD ) can control the depolymerization of F-actin. A multi-chamber micro cell chip was fabricated to study the EED under different conditions. Large-scale single-cell data demonstrated EED highly depends on both electric field and C CD .
The adaptive immune system produces a large and diverse set of antibodies,each with an individual evolutionary and clonal *** so called " antibody repertoire" protects each individual against insults such as...
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The adaptive immune system produces a large and diverse set of antibodies,each with an individual evolutionary and clonal *** so called " antibody repertoire" protects each individual against insults such as infection and cancer,and responds to vaccination with B cell proliferation in response to the antigenic *** and antigen-specific FACSbased analysis have given us much insight on how the immune system generates the complex and diverse immune response required to protect the body from the wide variety of potential ***,these methods have not been sufficient to make global and unbiased
Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the corr...
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Sleep onset latency (SOL) provides an objective assessment of sleepiness and it also clinically useful as a sleep deprivation diagnostic tool. In this study, we suggest a new approach to estimate SOL based on the correlation between blood pressure (BP) and heart beat interval (HBI). This approach facilitates less intrusive finding of SOL as compared with currently using polysomnographic method. We hypothesized that the arterial baroreflex, one kind of reflex mechanism to regulate BP, takes a role of maintaining sleep's toning-down effect on BP. At the time of transition from full wakefulness to sleep, the toning-down effect starts to drop the BP and the arterial baroreflex is activated to maintain lowered BP by leading to increase in HBI for the elevated BP. Consequently, there is a great contribution of arterial baroreflex to HBI control. With a quantitative evaluation of the contribution, we tried to estimate SOL. For six healthy subjects (27.5 ± 3.15 years), the mean absolute error (MAE) was 0.3 ± 0.42 minutes. We expect our method can be applicable to non-intrusive and automatic SOL estimation system by not using electroencephalogram (EEG) sensors.
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