This paper presents the results of an on-going investigation into the use of an anthropomorphic robotic manipulator with three degrees of freedom (two DOF shoulder joint and one DOF elbow joint) for rehabilitation of ...
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This paper presents the results of an on-going investigation into the use of an anthropomorphic robotic manipulator with three degrees of freedom (two DOF shoulder joint and one DOF elbow joint) for rehabilitation of a human upper arm. The reduction to three DOF for this manipulator allows for a simpler project, leading to a lower cost of production and maintenance: important factors for its intended wide-spread use in financially restricted areas, e.g., the state of Goiás, Brazil. The project focuses on determining the variations observed for a class of trajectories known as functional movements. These functional movements are trajectories realized when a limb is used for a given function, e.g., combing the hair. In this present paper we use three functional movements: hair combing, bringing a cup to one's mouth and a waving movement. We describe how these functional movements are acquired from test subjects and compared in computer simulations to the equivalent functional movements of our proposed reduced-order anthropomorphic manipulator. Our research indicates that the errors incurred in using a reduced-order shoulder joint are well within the observed variation in the functional movements of human subjects, when compared among different subjects and also between similar functional movements of any one given human subject. Despite the limitations, the proposed manipulator would be viable for rehabilitation of patients in early phases of a stroke, at lower cost of production.
In this paper, the preliminary investigation for application of capacitive electroencephalogram (EEG) measurement for brain-computer interface (BCI) is described. EEG was obtained by active electrodes that very high i...
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In this paper, the preliminary investigation for application of capacitive electroencephalogram (EEG) measurement for brain-computer interface (BCI) is described. EEG was obtained by active electrodes that very high input impedance pre-amplifier circuit was mounted on the electrodes. This method enabled EEG measurements through hair without direct contact with scalp and conductive gel applications. The presented electrode was attached to the normal usual baseball cap for nonintrusive daily or long-term use. Subject wore electrode installed baseball cap and EEG signal was measured under experimental BCI paradigms such as alpha wave, steady-state visual evoked potential, P300, auditory steady-state response and motor imagery. The results showed that further studies are still required to apply capacitive sensing methods to clinical neurosciences, however, it can be concluded that steady of the art capacitive electrode technology can be used for engineering applications using current popular BCI paradigms.
＜正＞Objective:To examine theindependent association ofbody shape（total volume,trunk volume,and trunk to leg volume ratio）tofracture risk. Methods:We performed a cross-sectional study of the NHANES 1999-2004 survey...
＜正＞Objective:To examine theindependent association ofbody shape（total volume,trunk volume,and trunk to leg volume ratio）tofracture risk. Methods:We performed a cross-sectional study of the NHANES 1999-2004 survey data downloaded from the study *** individualshad both a valid dual-energy Xray absorptiometry（DXA） scan and known fracture status. The body shape measureswere derived using DXA whole
We introduce a 'hands free' proteomic tool with the potential to radically transform the status quo of cancer protein bi-omarker validation. Here, we focus on a challenging and broadly relevant target in this ...
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ISBN:
(纸本)9781618395955
We introduce a 'hands free' proteomic tool with the potential to radically transform the status quo of cancer protein bi-omarker validation. Here, we focus on a challenging and broadly relevant target in this analyte class - the prostate cancer marker prostate-specific antigen (PSA). We introduce light-activatable, volume accessible polyacrylamide separation gels (LAVAgels) that capture electrophoretically separated PSA isoforms within a highly multiplexed (16-channel) microfluidic assay format. The 3D LAVAgel matrix offers unprecedented target capture duty, with capture efficiencies greater than 100fold higher than for existing surface chemistries. Our optofluidic separations strategy harnesses tremendous micro/nanoscale transport advantages to yield unmatched speed and efficiency - major barriers to realizing high-throughput proteomics.
Ultrasound-guided biopsy procedure for prostate cancer diagnosis,which is the current gold standard,involves quasi-random sampling of prostate tissue without any functional *** this study,we discuss the possibility to...
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Ultrasound-guided biopsy procedure for prostate cancer diagnosis,which is the current gold standard,involves quasi-random sampling of prostate tissue without any functional *** this study,we discuss the possibility to augment the detection of prostate cancer using a dual-modality optical approach,which can be coupled with the current needle biopsy *** techniques are light reflectance spectroscopy(LRS)that uses a broadband light source and a CCD array spectrometer,and auto-fluorescence lifetime measurement(AFLM)that uses a custom-designed,time-correlated single photon counting(TCSPC)*** LRS and AFLM were employed sequentially in this study to measure cancer tissue along with control tissue on a rat prostate tumor *** an excitation wavelength of 447 nm,we investigated auto-fluorescence decay curves at the emission wavelengths of 532,562,632 and 684 nm for in vivo and ex vivo *** results show that auto-fluorescence lifetimes at all measured emission wavelengths differ between control and cancerous tissues with 100% specificity and ***,absolute values of hemoglobin derivatives and scattering coe±cient were quantified using in vivo *** part of study also demonstrates that light scattering and absorption are significantly different between the control and cancerous ***,the study demonstrates that both LRS and AFLM may provide several intrinsic biomarkers for in vivo detection of prostate cancer.
Human tear film fluid offers tremendous potential as a non-invasive diagnostic fluid. However, the use of tear fluid in diagnostic medicine is limited owing to non-standardized collection methodologies and low volume ...
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Zero-valent iron particles were prepared by wet reduction chemistry assisted with ultrasonic treatment. Such prepared particles have uniform size, exhibit crystalline structure and show strong pararnagnetic property. ...
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Zero-valent iron particles were prepared by wet reduction chemistry assisted with ultrasonic treatment. Such prepared particles have uniform size, exhibit crystalline structure and show strong pararnagnetic property. Their surface modification by coating poly（N-vinyl-2-pyrrolidone） （PVP） was investigated. The resulting Fe（0）-PVP particles were monodispersed and possessed enhancing magnetization saturation. Those synthesis conditions to control the particle size and distribution were exploited.
A low-dose CT simulation technique is presented which might allow for a virtual ultra-low-dose trial in CT colonography without requiring raw sinogram data. A virtual sinogram is generated by performing the line integ...
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Western blotting readily identifies specific proteins amidst complex biological backgrounds [1, 2]. Nevertheless, immunob-lotting suffers from tremendous labor-intensive and time-intensive requirements [3]. The slab-g...
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ISBN:
(纸本)9781618395955
Western blotting readily identifies specific proteins amidst complex biological backgrounds [1, 2]. Nevertheless, immunob-lotting suffers from tremendous labor-intensive and time-intensive requirements [3]. The slab-gel assays require 1-2 days for completion with multiple hands-on "blotting" steps and yield semi-quantitative information. Recently, our group has introduced new approaches for completing Western blotting. The microfluidic integration strategies introduced and used allow rapid results reporting, full assay automation, and limited sample consumption (1-10 uL). Our integration strategies use spatial, temporal, and spatiotemporal modulation of separation mechanisms in fully electrophoretic systems. The present study reports on recapitulation of immunoaffinity in previously sized proteins, using novel in-transit electrophoretic removal of SDS from SDS-protein complexes. Early results show both the length- and timescales for protein 'renaturation' are compatible with on-chip operation. Further, substantial binding affinity is recapitulated using this streamlined and promising approach.
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