检索结果-内蒙古大学图书馆

Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Trent J. Bradberry Jose L. Contreras-Vidal Feng Rong Fischell Department of Bioengineering University of Maryland College Park MD USA Department of Kinesiology Fischell Department of Bioengineering and Graduate Program in Neuroscience and Cognitive Science University of Maryland College Park MD USA National Institute on Deafness and other Communication Disorders Bethesda MD USA Graduate Program in Neuroscience and Cognitive Science University of Maryland College Park MD USA

The ability to decode kinematics of intended movement from neural activity is essential for the development of prosthetic devices, such as artificial arms, that can aid motor-disabled persons. To date, most of the progress in the development of neuromotor prostheses has been obtained by decoding neural activity acquired through invasive means, such as microelectrode arrays seated into motor cortical tissue. In this study, we demonstrate the feasibility of decoding both hand position and velocity from non-invasive magnetoencephalographic signals during a center-out drawing task in familiar and novel environments. The mean correlation coefficients between measured and decoded kinematics ranged from 0.27–0.61 for the horizontal dimension of movement and 0.06–0.58 for the vertical dimension. Our results indicate that non-invasive neuroimaging signals may contain sufficient kinematic information for controlling neuromotor prostheses.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Polymers for tissue engineering

引用

作者： He, Wei Feng, Yu Ma, Zuwei Ramakrishna, Seeram Graduate Program in Bioengineering Centre for Life Sciences #05-01 28 Medical Drive Singapore 117456 Singapore Department of Orthopedics Medical School University of Massachusetts 55 Lake Avenue North Worcester MA 01605 United States Department of Mechanical Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117576 Singapore

ISBN: (纸本)9780841239661

Recently it has been the main trend for the application of polymer materials in the interdisciplinary tissue engineering area. Polymer materials have shown their versatility and played main roles in constructing tissue engineering scaffolds. This book chapter briefly reviews the materials requirements for tissue engineering application, and focus on polymer materials including both natural and synthetic polymers. The frequently used and newly developed fabrication technologies for constructing tissue engineering scaffolds are described. Some surface modification/functionalization approaches to the tissue engineering scaffolds are also discussed. Recent advances for the development of polymer scaffolds in skin, cartilage, blood vessel, and nerve tissue engineering are also summarized. © 2008 American Chemical Society.

关键词： Tissue

来源：评论

学校读者我要写书评

暂无评论

*** inhibition strategies offered against cariogenic biofilm challenge;Studies performed using an oral biofilm reactor

*** inhibition strategies offered against cariogenic biofilm...

引用

第四届中日口腔医学大会(The Fourth Sino-Japanese Conference on Stomatology)

作者： MATIN Khairul KITASAKO Yuichi NIKAIDO Toru OTSUKI Masayuki HANAWA Takao TA GAMI Junji OKADA Ayako GYO Mariko ANJUM Aita DANESHMEHR Leila HAYATI Fahimeh SHIDA Kanako UCHIDA Ryoichiro TANAKA Yuta Cariology and Operative Dentistry Department of Restorative Sciences Tokyo Medical and Dental University(TMDU) Tokyo Japan 3 Support Program for Improving Graduate School Education TMDU Tokyo Japan Cariology and Operative Dentistry Department of Restorative Sciences Tokyo Medical and Dental University(TMDU) Tokyo Japan Cariology and Operative Dentistry Department of Restorative Sciences Tokyo Medical and Dental University(TMDU) Tokyo Japan Support Program for Improving Graduate School Education TMDU Tokyo Japan Institute of Biomaterials and Bioengineering TMDU Japan Cariology and Operative Dentistry Department of Restorative Sciences Tokyo Medical and Dental University(TMDU) Tokyo Japan Department of Oral Health National Institute of Public Health Saitama Japan

来源：评论

学校读者我要写书评

暂无评论

Perfusion culture improves the maintenance of cultured liver tissue slices

Perfusion culture improves the maintenance of cultured liver...

引用

作者： Schumacher, Karl Khong, Yuet-Mei Chang, Shi Ni, Jun Sun, Wanxin Yu, Hanry Institute of Bioengineering and Nanotechnology A STAR Singapore Singapore Graduate Program in Bioengineering NUS Graduate School of Integrative Science and Engineering National University of Singapore Singapore Singapore Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR The Nanos 31 Biopolis Way Singapore 138669 Singapore

Cultured precision-cut liver tissue slices are useful for studying the metabolism and toxicity of xenobiotics in liver. They may also be used to investigate the behavior of and interaction between different cell types in an intact histo-architectere. Because cultured liver tissues undergo a loss of function and morphology because of their separation from the blood supply, we investigated changes in key protein marker expressions in parenchymal and non-parenchymal cells, as well as in the extracellular matrix (ECM) at different time points. We also compared conventional culture methods such as static and dynamic cultures with perfusion culture, which allows a continuous exchange of the culture medium. In conventional culture methods, the expression of vimentin and collagen type IV decreased after 5 h in the non-parenchymal cells and the ECM, respectively, whereas the hepatocyte nuclear factor 4 alpha (HNF4α) staining in the hepatocytes remained constant. In perfusion culture, on the other hand, vimentin, collagen type IV, and HNF4α staining were clearly detectable after 5 h. The histo-architecture obtained from perfusion culture was also more compact than those obtained from conventional culture methods. After 24 h, only the perfusion cultured sample retained protein marker expression in all components of the liver tissue. Our results suggest that, to develop improved culture techniques for liver slices, changes at the early time-points should be taken into consideration. Our results also show that culture techniques that enable a continuous exchange of the culture medium seem to be superior to static or dynamic cultures in terms of maintaining the protein expression and the histo-architecture. © Mary Ann Liebert, Inc.

关键词： Cell culture

来源：评论

学校读者我要写书评

暂无评论

Nanofibrous modification on ultra-thin poly(e-caprolactone) membrane via electrospinning

引用

Materials Science and Engineering C 2007年第2期27卷 325-332页

作者： Chen, F. Lee, C.N Teoh, S.H Graduate Program in Bioengineering National University of Singapore Singapore Department of Cardiac Thoracic and Vascular Surgery National University Hospital Singapore Department of Mechanical Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117576 Singapore

Poly(e-caprolactone) (PCL) is a favorable material for tissue engineering. PCL was successfully fabricated into less than 10 μm thin membranes using a 2-roll-heated-mill and biaxial stretching process. However, PCL is known for its poor cellular adhesion and surface modifications are needed for any tissue engineering applications. This paper reports on a novel surface modification technique of the PCL membrane by coating with electrospun nanofibers. The purpose was to mimic the architecture of the natural extracellular matrix and create nanotopography for enhanced cellular attachment. The surfaces were characterized by scanning electron microscopy (SEM), water contact angle and atomic force microscopy. The results showed that uniform nanofibrous topology were successfully achieved on the surface of the PCL membrane, with increased roughness (more than 17 times) and surface area. This nanofibrous topology induced capillary effects after sodium hydroxide (NaOH) treatment, causing the water contact angle to drop to almost zero. Scratch tests revealed a strong interaction of PCL nanofiber coating on the PCL membrane. AlamarBlue assay indicated that 3T3 fibroblast cells proliferated well on the nanofibrous membrane. Confocal Laser Scanning Microscope revealed better cell attachment onto the nanofibrous membranes than the untreated membranes. Results from SEM showed that the cells' spindle-shaped morphology on the NaOH-treated fibrous surface was evident while they remained in isolated spherical shaped entities in the non-treated fibrous surfaces. © 2006 Elsevier B.V. All rights reserved.

关键词： Polymeric membranes

来源：评论

学校读者我要写书评

暂无评论

Characterization of smooth muscle cells on poly(Ε-caprolactone) films

引用

Materials Science and Engineering C 2007年第2期27卷 309-312页

作者： Chong, M.S.K. Lee, C.N. Teoh, S.H. Graduate Program in Bioengineering National University of Singapore Singapore Singapore Department of Cardiac Thoracic and Vascular Surgery National University Hospital Singapore Singapore Centre for Biomedical Materials Applications and Techn Department of Mechanical Engineering 9 Engineering Drive 1 Singapore 117576 Singapore

Bioresorbable vascular grafts can be used for direct implantation. Over time, the grafts will degrade and be replaced by natural tissue. In this study, the potential application of biaxially drawn poly(Ε-caprolactone) (PCL) films for the design of vascular grafts was examined. PCL films were first modified to enhance cell physiological response to the surface. Two methods of surface modification were studied: surface hydrolysis by immersion in sodium hydroxide, and immobilization of collagen onto PCL film surface. Tensile tests indicate that immersion in sodium hydroxide results in a significant drop in ultimate tensile strength, whereas collagen-immobilized films remained uncompromised. Human coronary artery smooth muscle cells were cultured on the different surfaces, and it was demonstrated that collagen-immobilized films elicited the most favorable response from the cultured cells. This indicates the potential for collagen-immobilized PCL films for vascular tissue engineering applications. © 2006 Elsevier B.V. All rights reserved.

关键词： Muscle

来源：评论

学校读者我要写书评

暂无评论

Noninvasive insulin delivery in large pigs (>100 lbs) using the lightweight cymbal array

Noninvasive insulin delivery in large pigs (>100 lbs) using ...

引用

2007 IEEE Ultrasonics Symposium, IUS

作者： Park, Eun-Joo Werner, Jacob Smith, Nadine Barrie Department of Bioengineering Pennsylvania State University University Park PA 16802 United States Animal Resource Program Pennsylvania State University University Park PA 16802 United States Graduate Program in Acoustics Pennsylvania State University University Park PA 16802 United States

ISBN: (纸本)1424413834

Use of needles for multiple injections of drugs, such as insulin for diabetes, can be painful. As a result, prescribed drug noncompliance can results in severe medical complications. In previous studies, ultrasound mediated transdermal drug delivery has shown a promising potential as a method for noninvasive drug administration. Yet for prospective human application, a milestone to a practical clinical device of this research requires that the efficacy of the cymbal array be demonstrated on animals larger than rats and rabbits. Larger and possessing a blood volume similar to humans, pig is an appropriate animal model for further experimentation in evaluating the practicability of this ultrasound device. Six Yorkshire pigs (100 - 140 lbs) were divided into two groups. As the control (n = 3), the first group did not receive any ultrasound exposure with the insulin. The second group (n = 3) was treated with ultrasound and insulin at 20 kHz with an Isptp = 100 mW/cm2 at a 20% duty cycle for 60 minutes. With the pigs in lateral recumbency after anesthesia, the ultrasound transducer with insulin was placed on the axillary area of the pig. At the beginning and every 15 minutes up to 90 minutes, the blood glucose level was determined using a glucose monitoring system. To compare the results of individual animals, the change of blood glucose level was normalized to each animal's initial glucose value at the start of the experiment. Although each animal had a different initial glucose level, the mean and standard error for the six animals was 146 ±13 mg/dl (Figure 1). For the control group, the blood glucose level increased to 31 ±21 mg/dl compared to the initial baseline over the 90 minute experiment. However for the ultrasound with insulin treated group, the glucose level decreased to -72 ±5 mg/dl at 60 minutes (p

关键词： Insulin

来源：评论

学校读者我要写书评

暂无评论

Computational modelling of chemotaxis in cooperative phenomena in bacterial populations

引用

BMC Systems Biology 2007年第1期1卷 1-2页

作者： Vinayak Doraiswamy Martin Buist Andrew Goryachev Graduate Program in Bioengineering National University of Singapore Singapore Division of Bioengineering National University of Singapore Singapore Centre for Integrative Systems Biology University of Edinburgh Edinburgh Scotland UK

来源：评论

学校读者我要写书评

暂无评论

Nonlinear Transmembrane Current Response of Micro Elelectroporation for Human Cancer Cells

Nonlinear Transmembrane Current Response of Micro Elelectrop...

引用

IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

作者： Huiqi He Donald C. Chang Yi-Kuen Lee Bioengineering Graduate Program Hong Kong University of Science and Technology Hong Kong China Department of Biology Hong Kong University of Science and Technology Hong Kong China Bioengineering Graduate Program Hong Kong University of Science and Technology Kowloon Hong Kong China

This paper presents a method to quantify the nonlinear electric current responses of electroporation (EP) on microchips for human cancer cells. Micro EP chips with three dimensional gold electrodes were fabricated with a modified electroplating process. Electrochemical impedance spectroscopy (EIS) was carried out with an electrochemistry analyzer on micro EP chips and a nonlinear equivalent circuit model was proposed to describe the dynamic response of the whole system. Using such a method, micro EP current was isolated from undesired leakage current to study the corresponding nano electropore dynamics under different input voltages. In addition, the EP efficiency results from electric measurements were confirmed by studies using fluorescence microscopy.

关键词： Humans Cancer Nonlinear dynamical systems Gold Electrodes Electrochemical impedance spectroscopy Equivalent circuits Leakage current Voltage Electric variables measurement

来源：评论

学校读者我要写书评

暂无评论

Rectangular cymbal arrays for ultrasonic transdermal insulin delivery

Rectangular cymbal arrays for ultrasonic transdermal insulin...

引用

2007 IEEE Ultrasonics Symposium, IUS

作者： Luis, Joseph Park, Eun-Joo Meyer Jr., Richard J. Smith, Nadine Barrie Graduate Program in Acoustics Pennsylvania State University University Park PA 16802 United States Department of Bioengineering Pennsylvania State University University Park PA 16802 United States Applied Research Laboratory Pennsylvania State University University Park PA 16802 United States

ISBN: (纸本)1424413834

Studies have shown that ultrasound mediated transdermal drug delivery offers a promising potential for needle-less insulin delivery for diabetes treatment. Arrays of cymbal transducers have been shown to be effective in delivering therapeutic levels of insulin to decrease hyperglycemic glucose levels in rats, rabbits and pigs. To improve delivery efficiency of the cymbal arrays, an increase in the spatial intensity field without increasing the size the device or Isptp was desired. A 3 × 1 rectangular cymbal array was designed for this purpose. Rectangular cymbals maximized packing density and allowed the flexural cap resonance and the ceramic length mode resonance frequencies to be designed closer in frequency. Bringing the cap and ceramic resonances closer together increased the transmitting power and improved the electrical efficiency. By using higher order modes excited in the cap while operating at the first ceramic resonance frequency, the intensity spatial area was increased compared to the circular array. With a similar intensity (I sptp ≈ 50 mW/cm2), our goal was to determine if the 3 × 1 rectangular cymbal array could perform significantly better than the 3 × 3 circular array for blood glucose reduction in hyperglycemic rabbits. Nine New Zealand White rabbit (≈ 4.0 kg) experiments were performed in three groups: control (n = 3) and ultrasound exposure with the 3 × 3 circular cymbal array (n = 3) or 3 × 1 rectangular cymbal array (n = 3). The rabbits were anesthetized and their thigh area was shaved for the exposure. A water tight reservoir which held the insulin was fastened between the rabbit's thigh and the ultrasound arrays. At the beginning of the experiment and every 15 minutes for 90 minutes, 0.3 ml of blood was collected from the ear vein to determine the glucose level (mg/dl) using a glucose monitoring system. For comparison between individual rabbits, the change in the blood glucose level was normalized to their initial baseline value. For the cont

关键词： Ultrasonics

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：