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Abstracts for the 6th Congress of Asian Sleep Research Society

Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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3B-1 Noninvasive Insulin Delivery in Large Pigs (> 100 lbs) Using the Lightweight Cymbal Array

3B-1 Noninvasive Insulin Delivery in Large Pigs (> 100 lbs) ...

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IEEE Symposium (IUS) Ultrasonics

作者： E.-J. Park J. Werner N. B. Smith Department of Bioengineering Pennsylvania State University University Park PA USA Animal Resource Program Pennsylvania State University University Park PA USA Graduate Program in Acoustics Pennsylvania State University University Park PA USA

Use of needles for multiple injections of drugs, such as insulin for diabetes, can be painful. As a result, prescribed drug noncompliance can results in severe medical complications. In previous studies, ultrasound mediated transdermal drug delivery has shown a promising potential as a method for noninvasive drug administration. Yet for prospective human application, a milestone to a practical clinical device of this research requires that the efficacy of the cymbal array be demonstrated on animals larger than rats and rabbits. Larger and possessing a blood volume similar to humans, pig is an appropriate animal model for further experimentation in evaluating the practicability of this ultrasound device. Six Yorkshire pigs (100-140 lbs) were divided into two groups. As the control (n = 3), the first group did not receive any ultrasound exposure with the insulin. The second group (n = 3) was treated with ultrasound and insulin at 20 kHz with an I sptp = 100 mW/cm 2 at a 20% duty cycle for 60 minutes. With the pigs in lateral recumbency after anesthesia, the ultrasound transducer with insulin was placed on the axillary area of the pig. At the beginning and every 15 minutes up to 90 minutes, the blood glucose level was determined using a glucose monitoring system. To compare the results of individual animals, the change of blood glucose level was normalized to each animal's initial glucose value at the start of the experiment. Although each animal had a different initial glucose level, the mean and standard error for the six animals was 146plusmn13 mg/dl (Figure 1). For the control group, the blood glucose level increased to 31plusmn21 mg/dl compared to the initial baseline over the 90 minute experiment. However for the ultrasound with insulin treated group, the glucose level decreased to -72plusmn5 mg/dl at 60 minutes (p < 0.05) and continued to decreased to -91plusmn23 mg/dl in 90 minutes (p < 0.05). Results demonstrate a promising pre-clinical outcome for the low p

关键词： Insulin Optical arrays Ultrasonic imaging Sugar Animals Blood Drugs Humans Diabetes Needles

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Cooperative university/industry development of a freshman 'introduction to ECE design' course

Cooperative university/industry development of a freshman 'i...

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114th Annual ASEE Conference and Exposition, 2007

作者： Williams, Douglas Butera, Robert Uluagac, Selcuk Clark, Matthew Deck, Andy Torba, Michael Trahan, Steven Georgia Institute of Technology United States Undergraduate Affairs School of Electrical and Computer Engineering Georgia Tech. Georgia Department of Electrical and Computer Engineering Interdisciplinary Bioengineering Graduate Program Georgia Tech. United States Georgia Tech. School of Electrical and Computer Engineering United States National Instruments National Instruments Austin TX United States

Faculty members from Georgia Tech's School of Electrical and Computer Engineering (ECE) have worked jointly with engineers from National Instruments (NI) to develop a new freshman engineering course. This course is entitled 'Introduction to ECE Design' and is constructed around the use of the LEGO MINDSTORMS NXT robotics system. NI partnered with LEGO to jointly develop the programming software for the MINDSTORMS NXT, and their engineers are uniquely positioned to provide insight into the use and functionality of these kits. NI engineers have not only provided technical support but have also conceived and designed most of the laboratories for the course. This course addresses the diverse objectives of providing students with a systems-level design experience at the beginning of their academic programs and introducing them to a broad range of ECE disciplines. A primary goal is to enable students to make better-informed decisions when choosing whether or not to major in electrical engineering or computer engineering. © American Society for Engineering Education, 2007.

关键词： Systems engineering

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Electrochemistry based Real-Time Polymerase Chain Reaction (PCR) for Point of Care Applications

Electrochemistry based Real-Time Polymerase Chain Reaction (...

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The Eleventh International & The First Sino-Japan Bilateral Symposium on Electroanalytical Chemistry (11th ISEC & 1st SJBSEC)第十一届国际电分析化学学术会议暨第一届中日双边电分析化学学术会议

作者： I-Ming HSING Thomas Ming Hung LEE Department of Chemical Engineering and Bioengineering Graduate Program Hong Kong University of Science and TechnologyKowloonHong Kong SARChina Department of Health Technology and InformaticsThe Hong Kong Polytechnic University

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Electrochemistry based Real-Time Polymerase Chain Reaction (PCR) for Point of Care Applications

Electrochemistry based Real-Time Polymerase Chain Reaction (...

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The Eleventh International and the First Sino-Japan Bilateral Symposium on Electroanalytical Chemistry

作者： I-Ming HSING Thomas Ming Hung LEE Department of Chemical Engineering and Bioengineering Graduate Program Hong Kong University of Science and Technology Kowloon Hong Kong SAR China Department of Health Technology and Informatics The Hong Kong Polytechnic University

Nucleic acid based analysis has an important role to play in many critical applications such as medical diagnostics,environmental monitoring and food safety *** the available analytical tools,real time polymerase chain reaction(PCR)has been widely adopted as a viable technique for rapid detection and quantification of trace nucleic acid analytes[1].One challenge to

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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

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Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

A graphical abstract is available for this content

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9F-4 Rectangular Cymbal Arrays for Ultrasonic Transdermal Insulin Delivery

9F-4 Rectangular Cymbal Arrays for Ultrasonic Transdermal In...

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IEEE Symposium (IUS) Ultrasonics

作者： J. Luis E.-J. Park R. J. Meyer Jr. N. B. Smith Graduate Program in Acoustics Pennsylvania State University University Park PA USA Department of Bioengineering Pennsylvania State University University Park PA USA Applied Research Laboratory Pennsylvania State University University Park PA USA

Studies have shown that ultrasound mediated transdermal drug delivery offers a promising potential for needle-less insulin delivery for diabetes treatment. Arrays of cymbal transducers have been shown to be effective in delivering therapeutic levels of insulin to decrease hyperglycemic glucose levels in rats, rabbits and pigs. To improve delivery efficiency of the cymbal arrays, an increase in the spatial intensity field without increasing the size the device or Isptp was desired. A 3 times 1 rectangular cymbal array was designed for this purpose. Rectangular cymbals maximized packing density and allowed the flexural cap resonance and the ceramic length mode resonance frequencies to be designed closer in frequency. Bringing the cap and ceramic resonances closer together increased the transmitting power and improved the electrical efficiency. By using higher order modes excited in the cap while operating at the first ceramic resonance frequency, the intensity spatial area was increased compared to the circular array. With a similar intensity (I sptp ap 50 mW/cm ), our goal was to determine if the 3 times 1 rectangular cymbal array could perform significantly better than the 3 times 3 circular array for blood glucose reduction in hyperglycemic rabbits. Nine New Zealand White rabbit (ap 4.0 kg) experiments were performed in three groups: control (n = 3) and ultrasound exposure with the 3 times 3 circular cymbal array (n = 3) or 3 times 1 rectangular cymbal array (n = 3). The rabbits were anesthetized and their thigh area was shaved for the exposure. A water tight reservoir which held the insulin was fastened between the rabbit's thigh and the ultrasound arrays. At the beginning of the experiment and every 15 minutes for 90 minutes, 0.3 ml of blood was collected from the ear vein to determine the glucose level (mg/dl) using a glucose monitoring system. For comparison between individual rabbits, the change in the blood glucose level was normalized to their initial basel

关键词： Insulin Sugar Rabbits Blood Resonance Ultrasonic imaging Ceramics Ultrasonic transducer arrays Drug delivery Resonant frequency

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The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell

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Journal of Inclusion Phenomena and Macrocyclic Chemistry 2007年第3-4期58卷 205-219页

作者： Nagasaki, Takeshi Shinkai, Seiji Department of Applied Chemistry and Bioengineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku. Osaka 558-8585 Japan SORST Program Japan Science and Technology Corporation Kawaguchi. Saitama 332-0012 Japan Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan Center for Future Chemistry Kyushu University Fukuoka 819-0395 Japan

Since the first generation of molecular machines including photoresponsive crown ethers and its analogues was reported by Shinkai et al., a huge number of molecular machines exhibiting dynamic chemical and physical functions have been designed and developed. On the other hand, non-viral vectors are desired to possess conflicting properties to associate with DNA until reaching the nucleus as their final destination and dissociate from DNA there. In other words, non-viral vectors should work as a sort of molecular machinery. To overcome this dilemma, recently, much attention is focused on the development of the intelligent vectors, also called as "stimuli responsive vectors' working as molecular machines. In this review, stimulus responsive gene delivery systems in which some structural factors and/or physiological properties are regulated in response to extracellular signals such as redox, pH, ultrasound, light, temperature, etc. are introduced as a new generation of non-viral vectors. These extracellular signals such as ultrasound, light, and temperature can be potent stimuli capable of site-, timing-, and duration-specific gene expression. © Springer Science+Business Media B.V. 2007.

关键词： Ultrasonics

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Regulation of vascular smooth muscle cells and mesenchymal stem cells by mechanical strain

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MCB Molecular and Cellular Biomechanics 2006年第1期3卷 21-34页

作者： Kurpinski, Kyle Park, Jennifer Thakar, Rahul G. Li, Song Department of Bioengineering University of California at Berkeley Berkeley CA United States Joint Graduate Program in Bioengineering UC Berkeley Berkeley CA United States Joint Graduate Program in Bioengineering UC San Francisco San Francisco CA United States

Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to generate SMCs to construct tissue-engineered vascular grafts for blood vessel replacements. In this review, we will focus on the effects of mechanical strain on SMCs and MSCs, e.g., cell phenotype, cell morphology, cytoskeleton organization, gene expression, signal transduction and receptor activation. We will compare the responses of SMCs and MSCs to equiaxial strain, uniaxial strain and mechanical strain in three-dimensional culture. Understanding the hemodynamic regulation of SMC and MSC functions will provide a basis for the development of new vascular therapies and for the construction of tissue-engineered vascular, grafts. Copyright © 2006 Tech Science Press.

关键词： Muscle

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Improved optical design for fast scanning RMA

Improved optical design for fast scanning RMA

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Biomedical Topical Meeting, BIO 2006

作者： Chen, Nan Guang Liu, Linbo Division of Bioengineering National University of Singapore Singapore 117576 Singapore Graduate Program in Bioengineering National University of Singapore Singapore 117597 Singapore Department of Electrical and Computer Engineering National University of Singapore Singapore 117576 Singapore

We have developed a double-pass rotary mirror array for fast scanning optical delay line with improved optical coupling. Such a device is ideal for real-time optical coherence tomography. © 2006 Optical Society o... 详细信息

ISBN: (纸本)1557528071

关键词： Optical design

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