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2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006

作者： Koev, Stephan T. Powers, Michael A. Badilita, Vlad Yi, Hyunmin Bentley, William E. Payne, Gregory F. Rubloff, Gary W. Ghodssi, Reza Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland College Park MD 20742 University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742

ISBN: (纸本)1424402786

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different BioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these BioMEMS sensing devices. © 2006 IEEE.

关键词： Microsystems

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Integral videography autostereoscopic display using multiprojection

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Systems and Computers in Japan 2006年第5期37卷 34-45页

作者： Liao, Hongen Iwahara, Makoto Koike, Takefumi Momoi, Yasuyuki Hata, Nobuhiko Sakuma, Ichiro Dohi, Takeyoshi Graduate School of Engineering University of Tokyo Tokyo 113-8656 Japan Z-axis Ltd. Japan Hitachi Ltd. Tokyo 101-8010 Japan Graduate School of Frontier Sciences University of Tokyo Tokyo 113-8656 Japan Graduate School of Information Science and Technology University of Tokyo Tokyo 113-8656 Japan Nano Bioengineering Education Program Graduate School of Engineering University of Tokyo Z-axis Ltd. Systems Development Laboratory Hitachi Ltd. Graduate School of Information Science and Technology University of Tokyo Institute of Environmental Studies Graduate School of Frontier Sciences University of Tokyo

Various techniques of autostereoscopic three-dimensional (3D) display for displaying real 3D information have been investigated in recent years. We have performed research and application of integral videography (IV), which is an animated display technique based on the principle of integral photography (IP). Although IV and IP are ideal ways to display 3D images, their spatial viewing resolution and high-speed image rendering algorithm must be improved. The pixel pitch of the display and the lens pitch are the main factors affecting IV image quality. We improved the image quality by increasing the number and density of the pixels. Parallel image processing and displaying method were also developed for animated IV imaging. We have created a scalable high-resolution image using multiple projection and project it onto a small screen to achieve high-density pixels using long-focal-length projection optics. Furthermore, an image calibration method was developed for geometrical correction and color modulation to generate seamless IV images. We evaluated the developed device by displaying an X-ray computed tomography (CT) image. Measurement of the geometrical accuracy of the reproduced IV images demonstrated that the spatial resolution of the display system matched that by theoretical analysis. Experimental results showed that our technique is very effective in obtaining 3D animated images with practical spatial resolution. © 2006 Wiley Periodicals, Inc.

关键词： Display devices

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Utilization of the k‐space Computational Method to Design an Intracavitary Transrectal Ultrasound Phased Array Applicator for Hyperthermia Treatment of Prostate Cancer

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AIP Conference Proceedings 2006年第1期829卷 435-439页

作者： Osama M. Al‐Bataineh Christopher M. Collins Victor W. Sparrow Robert M. Keolian Nadine Barrie Smith *Department of Bioengineering The Pennsylvania State University University Park PA 16802 ¶Department of Radiology The Pennsylvania State University Hershey PA 17033 †Graduate Program in Acoustics The Pennsylvania State University University Park PA 16802 ‡Applied Research Laboratory The Pennsylvania State University University Park PA 16802

This research utilizes the k‐space computational method to design an intracavitary probe for hyperthermia treatment of prostate cancer. A three‐dimensional (3D) photographical prostate model, utilizing imaging data from the Visible Human Project®, was the basis for inhomogeneous acoustical model development. The acoustical model accounted for sound speed, density, and absorption variations. The k‐space computational method was used to simulate ultrasound wave propagation of the designed phased array through the acoustical model. To insure the uniformity and spread of the pressure in the length of the array, and the steering and focusing capability in the width of the array, the equal‐sized elements of the phased array were 1 × 14 mm. The anatomical measurements of the prostate were used to predict the final phased array specifications (4 × 20 planar array, 1.2 MHz, element size = 1 × 14 mm, array size = 56 × 20 mm). Good agreement between the exposimetry and the k‐space results was achieved. As an example, the −3 dB distances of the focal volume were differing by 9.1% in the propagation direction for k‐space prostate simulation and exposimetry results. Temperature simulations indicated that the rectal wall temperature was elevated less than 2°C during hyperthermia treatment. Steering and focusing ability of the designed probe, in both azimuth and propagation directions, were found to span the entire prostate volume with minimal grating lobes (−10 dB reduction from the main lobe) and least heat damage to the rectal wall. Evaluations of the probe included ex vivo and in vivo controlled experiments to deliver the required thermal dose to the targeted tissue. With a desired temperature plateau of 43.0°C, the MRI temperature results at the steady state were 42.9 ± 0.38°C and 43.1 ± 0.80°C for ex vivo and in vivo experiments, respectively. Unlike conventional computational methods, the k‐space method provides a powerful tool to predict pressure wavefield and temperature r

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Noninvasive Ultrasound Transdermal Insulin Delivery and Glucose Monitoring Using a Low‐Profile Cymbal Array

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AIP Conference Proceedings 2006年第1期829卷 553-557页

作者： E.‐J. Park J. Luis R. J. Meyer M. V. Pishko N. B. Smith *Department of Bioengineering The Pennsylvania State University University Park PA 16802 †Graduate Program in Acoustics The Pennsylvania State University University Park PA 16802 ‡Applied Research Laboratory The Pennsylvania State University University Park PA 16802 §Department of Chemical Engineering The Pennsylvania State University University Park PA 16802

Recent studies have shown that ultrasound mediated transdermal drug delivery offers promising results for noninvasive drug administration. The purpose of this study was to demonstrate ultrasonic transdermal insulin delivery and in vivo sensing glucose with a novel, low‐profile ultrasound array based on the cymbal transducer. As a practical device, the array composed of circular cymbal transducers was thin (< 7mm) and weighed less than 22g. Using this array on hyperglycemic rats, our previous experiments demonstrated that blood glucose would decrease by 296.7 mg/dL from 60 minutes of ultrasound exposure. With a similar intensity, our goal was to evaluate the feasibility of insulin delivery with large animals (rabbits and pigs) and noninvasively determine the glucose level of hyperglycemic rats with the array system. Ultrasound was exposed for 60 minutes at Isptp=100 mW/cm2. With the same procedure, a preliminary experiment of large animal was performed on a pig (12 kg) at Isptp=50 mW/cm2. For the control experiments in insulin delivery, the blood glucose level varied little from the initial baseline. However, for the ultrasound and insulin exposure experiment, the glucose level was found to decrease by 132.6 mg/dL in 60 minutes and continued to decrease by 208.1 mg/dL in 90 minutes. From the preliminary pig experiment, the blood glucose level decreased by 120 mg/dL in 90 minutes. To noninvasively determine the glucose level, ultrasound exposure experiments with an electrochemical glucose biosensor were performed on hyperglycemic rats. After 20 minutes ultrasound exposure, the biosensor was placed at the exposure area to determine the concentration of glucose diffused through the skin. The glucose level of rats determined by the biosensor was 408 mg/dL which was very similar to the results of conventional glucose meter reading 396.7 mg/dL. Recently, a rectangular cymbal transducer was developed to obtain a larger sonication area without an increase in array size. Prel

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Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

Capturing Cellular Communication with Guided Electrode Netwo...

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2006 8th International Conference on Solid-State and Integrated Circuit Technology

作者： Mansun Chan Chi-Kong Yeung Yijin Wang Jin He Sven Ingebrandt Andreas Offenhaeusser Dept.of Electronic and Computer Engineering Hong Kong University of Science & Technology Bioengineering Graduate Program Hong Kong University of Science & Technology Institute of Microelectronic Peking University Juelich Research Center Institute for Thin Films and Interfaces(ISG-2)Leo-Brandt Str.52425 JuelichGermany

ISBN: (纸本)1424401607

This paper describes the development of a Multi-Electrode Array(MEA)with Guided Network for Cell-to-Cell Communication Transduction using a standard integrated circuit(IC) fabrication *** conventional electronic system,bio-system requires a special handling environment that is uncommon in conventional IC *** work presented here demonstrated the interaction between electrically active cells such as neuron and cardiac cells and an IC based *** a carefully designed array,and ionic action of a cell, extracellular signals can be captured and imaged.

关键词： Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

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Preparation of zeolite microspheres and their application in biology

Preparation of zeolite microspheres and their application in...

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2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005

作者： Wong, L.W. Yeung, K.L. Bioengineering Graduate Program HKUST Kowloon Hong Kong Department of Chemical Engineering HKUST Kowloon Hong Kong

ISBN: (纸本)0976798514

Hollow zeolite microspheres were prepared by growing a thin zeolite membrane shell on seeded polystyrene beads. The removal of the organic growth directing agent and polystyrene bead was successfully performed without damaging the thin zeolite shell. The storage and delivery of sodium pervanadate, a potent tyrophosphatase inhibitor to MDCK cells was successfully carried out. Thus, demonstrating the potential use of these materials for biological studies of cell signaling.

关键词： Zeolites

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CMR 2005: 1.03: Analysis of hepatic uptake of anionic magnetic nanoparticles

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Contrast Media & Molecular Imaging 2006年第2期1卷

作者： E. Lee F. Gazeau O. Beuf J‐C. Bacri A. Briguet M. Janier C. Billotey Laboratoire de RMN CNRS UMR 5012 Université Claude Bernard Lyon 1—CPE Villeurbanne France Graduate Program in Bioengineering National University of Singapore Singapore LMDH Université Paris 6 Paris France Animage‐CREATIS UMR 5515 Université Claude Bernard Lyon 1 Villeurbanne France

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Financial market model based on self-organized percolation

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Chinese Science Bulletin 2005年第19期50卷 2140-2144页

作者： YANG Chunxia WANG Jie ZHOU Tao LIU Jun XU Min ZHOU Peiling WANG Binghong Department of Electronic Science and Technology University of Science and Technology of China Hefei 230026 China Department of Modem Physics University of Science and Technology of China Hefei 230026 China Graduate Program of Bioengineering National University of Singapore Singapore

Starting with the self-organized evolution of the trader group’s structure, a parsimonious percolation model for stock market is established, which can be considered as a kind of betterment of the Cont-Bouchaud model. The return distribution of the present model obeys Lévy form in the center and displays fat-tail property, in accord with the styl-ized facts observed in real-life financial time series. Fur-thermore, this model reveals the power-law relationship be-tween the peak value of the probability distribution and the time scales, in agreement with the empirical studies on the Hang Seng Index.

关键词：金融市场模型自组织过滤 Lévy分布行业组织概率分布

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A designed glycopeptide array for characterization of sugar-binding proteins toward a glycopeptide chip technology

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Nanobiotechnology 2005年第2期1卷 191-199页

作者： Usui, Kenji Ojima, Tetsunori Tomizaki, Kin-Ya Mihara, Hisakazu Department of Bioengineering and the COE21 Program Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology Midori-ku Yokohama 226-8501 Nagatsuta-cho 4259 B-40 Japan

For the realization of a practical high-throughput protein detection and analysis system, a novel peptide array has been constructed using a designed glycopeptide model library with an α-helical secondary structure. This study will contribute the increment of the diversity of such an array system and the application to focused proteomics and ligand screening by effective detection of sugar-binding proteins. Fluorescent glycopeptides with an α-helix, a β-strand, or a loop structure were designed initially to select a suitable scaffold for the detection of a model protein. After selection of the α-helical structure as the best scaffold, a small model library with various saccharides was constructed to have charge and hydrophobicity variations in the peptide sequences. When various sugar-binding proteins were added to the peptide library array, the fluorescent peptides showed different responses in fluorescence intensities depending on their sequences as well as saccharides. The patterns of these responses could be regarded as "protein fingerprints" (PFPs), which are able to establish the identities of the target proteins. The resulting PFPs reflected the recognition properties of the proteins. Furthermore, statistical data analysis from obtained PFPs was performed using a cluster analysis. The PFPs of sugar-binding proteins were clustered successfully depending on their families and binding properties. These studies demonstrate that arrays with glycopeptide libraries based on designed structures can be promising tools to detect and analyze the target proteins. Designed peptides with functional groups such as sugars will play roles as the capturing agents of high-throughput protein nano/micro arrays for focused proteomics and ligand screening studies. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.

关键词： α-helix Focused proteome Glycosidase Lectin Microarray Peptide Protein chip Sugar

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Chitosan for Biofunctionalization of Microsystems

Chitosan for Biofunctionalization of Microsystems

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IEEE/NLM Life Science Systems and Applications Workshop

作者： Stephan T. Koev Michael A. Powers Vlad Badilita Hyunmin Yi William E. Bentley Gregory F. Payne Gary W. Rubloff Reza Ghodssi Institute for Systems Research ISR University of Maryland College Park MD USA University System of Maryland Adelphi MD US Department of Materials Science and Engineering University of Maryland College Park MD USA Department of Chemical Engineering University of Maryland College Park MD 20742 University of Maryland Biotechnology Institute (UMBI) University of Maryland College Park MD 20742 Bioengineering Graduate Program University of Maryland College Park MD 20742 University of Maryland College Park MD USA University of Maryland Biotechnology Institute College Park MD USA Institute for Systems Research (ISR) University of Maryland College Park MD 20742 Department of Materials Science and Engineering University of Maryland College Park MD 20742 Department of Electrical and Computer Engineering University of Maryland College Park MD 20742 Institute for Systems Research (ISR) University of Maryland College Park MD 20742

ISBN: (纸本)1424402778

We present the use of the polysaccharide chitosan for immobilizing biomolecules on microfabricated device surfaces. The main advantages of chitosan are its abundance of primary amine groups and its ability to be electrodeposited. Biomolecules are easily attached to chitosan 's amines by standard glutaraldehyde chemistry. The electrodeposition of chitosan allows accurate spatial and temporal control of biomolecule placement. We have demonstrated this biofunctionalization method for two different bioMEMS devices: a biophotonic sensor and a micromechanical biosensor. We have successfully assembled probe DNA on each of them and detected hybridization with target DNA as a demonstration of sensor operation. Here, we briefly present the fabrication procedure and testing results for both of these bioMEMS sensing devices

关键词： DNA Biosensors Molecular biophysics Probes Micromechanical devices Optical sensors Optical surface waves Optical interferometry Assembly Biomedical optical imaging

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