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Cover Feature: Effect of UV Light Exposure Duration on the Removal of Exfoliation Agent Residues in Two-Dimensional Perovskite Nanosheets: An AFM Study (ChemPlusChem 3/2025)

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ChemPlusChem 2025年第3期90卷

作者： Fatma Pinar Gordesli-Duatepe Begümnur Küçükcan Özge Sağlam Department of Genetics and Bioengineering Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey Bioengineering Graduate Program Graduate School Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey Department of Mechanical Engineering Izmir University of Economics Sakarya Cad. Izmir 35330 Turkey

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Physics-based learned design for Fourier DiffuserScope

Physics-based learned design for Fourier DiffuserScope

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Computational Optical Sensing and Imaging, COSI 2021 - Part of OSA Imaging and Applied Optics Congress 2021

作者： Markley, Eric Liu, Fanglin Linda Kellman, Michael Antipa, Nick Waller, Laura UCB/UCSF Joint Graduate Program in Bioengineering University of California Berkeley United States Department of Electrical Engineering and Computer Sciences University of California Berkeley United States Department of Pharmaceutical Chemistry University of California San Francisco United States Department of Electrical and Computer Engineering University of California San Diego United States

We couple a differentiable forward model of diffuser-based single-shot 3D microscopy (Fourier DiffuserScope) with an invertible and differentiable reconstruction algorithm to jointly optimize the imaging system and th... 详细信息

ISBN: (纸本)9781557528209

关键词： Imaging systems

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Engineering FRET biosensor for H3K9 acetylation imaging in single living cells

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Med-X 2024年第1期2卷 446-461页

作者： Shitian Li Chang Sun Reed E.S.Harrison Leonardo Cheng Li Gao Longwei Liu Yingxiao Wang Qin Peng Department of Bioengineering Institute of Engineering in MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Biological Sciences Graduate Program University of CaliforniaSan DiegoLa JollaCA 92093USA Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518132China Alfred E.Mann Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA School of Chemical Engineering and Technology North University of ChinaTaiyuanShanxi 030051China

Histone acetylation is an important epigenetic modification that governs gene expression,chromatin changes in stress response,and cell fate *** biosensors have been developed for various epigenetic events to enable spatiotemporal tracking of sub-cellular signaling *** reported histone H3 acetylation biosensor recognizing two acetyl residues lacked *** this study,using a single bromodomain of the BRD4,we have developed a genetically encoded H3K9ac *** systematically investigated different combinations of the BET family protein as binding domains and performed site-saturated mutagenesis to optimize the biosensor,achieving a dynamic FRET change up to 30%under TSA *** the application of the optimized H3K9ac biosensor,we revealed different basal active chromatin architectures in invasive tumor cells compared to benign tumor ***,we found that H3K9ac level increased dramatically when cancer cells passed through microchannels,which models the physical constraints and mechanical microenvironmental conditions that cancer cells encounter when passing through narrow spaces within the *** result highlights the chromatin plasticity in response to external mechanical *** summary,our H3K9ac biosensor provides a versatile tool for mechanistic investigation of cell fate transition in cancer and mechanotransduction.

关键词： FRET biosensor H3K9 acetylation Nuclear deformation Cancer cell migration

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Accuracy Enhancement of L-Band EPR Tooth Dosimetry by Implementing Multiple Harmonic Detection

SSRN

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SSRN 2024年

作者： Oh, Jeonghun Koo, Chang Uk Park, Jong In Choi, Kwon Lee, Junyoung Hirata, Hiroshi Ye, Sung-Joon Program in Biomedical Radiation Sciences Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Ionizing Radiation Metrology Group Korea Research Institute of Standards and Science Daejeon34113 Korea Republic of Research Institute for Convergence Science Seoul National University Seoul08826 Korea Republic of Division of Bioengineering and Bioinformatics Faculty of Information Science and Technology Hokkaido University Sapporo060–0814 Japan Department of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul08826 Korea Republic of Advanced Institute of Convergence Technology Seoul National University Suwon16629 Korea Republic of Biomedical Research Institute Seoul National University Hospital Seoul03080 Korea Republic of

In a large-scale radiation accident, the swift classification of individuals exposed to high levels of radiation is crucial to minimize casualties. In-vivo tooth dosimetry using L-band electron paramagnetic resonance (EPR) spectroscopy is a promising method for this purpose, as it can estimate individual exposure levels rapidly and non-invasively. However, the accuracy of dose estimation associated with this technique remains a great challenge. To enhance the accuracy, digital multiple harmonic detection (MHD) was incorporated into a home-built L-band EPR spectrometer. This approach enabled the utilization of information present in higher harmonics of EPR signals, which has been often discarded in traditional EPR spectroscopy. Acquired multiple harmonic spectra were reconstructed to the first derivative spectrum to merge information and mitigate the signal broadening. The modulation amplitude varied in a range of 0.3 to 0.7 mT to maximize the accuracy. In a 0.5-minute measurement at 0.6 mT, the standard error of inverse prediction (SEIP) was reduced to 0.57 Gy from 0.71 Gy. The statistical significancy of the enhancement was validated. In conclusion, the accuracy enhanced by this MHD can contribute to improving the efficiency of triage systems in the aftermath of a mass radiation accident. © 2024, The Authors. All rights reserved.

关键词： Paramagnetic resonance

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Microfluidic rheology to characterize viscoelastic properties of malignant and non-malignant epithelial cells 21

Microfluidic rheology to characterize viscoelastic propertie...

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21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

作者： Kim, Junghyun Sohn, Lydia L. Department of Mechanical Engineering University of California at Berkeley BerkeleyCA United States Graduate Program in Bioengineering University of California Berkeley University of California San Francisco BerkeleyCA United States

ISBN: (纸本)9780692941836

This study introduces a novel microfluidic rheology platform to quantify the viscoelastic properties of cells at the single-cell level. We measured both the storage (G') and loss (G") moduli of malignant and non-malignant epithelial cells, and simultaneously evaluate the frequency dependence of the moduli through a power-law structure damping model. With our unique platform's ability to screen large cellular populations, we have established a clear difference between the viscoelastic response of malignant and non-malignant cells. © 17CBMS-0001.

关键词： Cytology

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Compressed sensing 3D fluorescence microscopy using optimized phase mask

Compressed sensing 3D fluorescence microscopy using optimize...

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Computational Optical Sensing and Imaging, COSI 2020 - Part of Imaging and Applied Optics Congress 2020

作者： Yanny, Kyrollos Antipa, Nick Liberti, William Dehaeck, Sam Monakhova, Kristina Liu, Fanglin Linda Shen, Konlin Ng, Ren Waller, Laura UCB/UCSF Joint Graduate Program in Bioengineering University of California Berkeley United States Department of Electrical Engineering and Computer Sciences University of California Berkeley United States Brussels1050 Belgium

We demonstrate a single-shot miniature 3D computational microscope with an optimized phase encoder. Our method uses sparsity-based reconstruction to achieve a 2.76µm lateral and 15µm axial resolution across ... 详细信息

ISBN: (纸本)9781557528209

关键词： Fluorescence microscopy

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Effects of Polyvinyl Chloride and Low-Density Polyethylene Microplastics on Oxidative Stress and Mitochondria Function of Earthworm (Eisenia Foetida)

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SSRN 2024年

作者： Lee, Songhee Choi, Jisun Jho, Eun Hea Shin, Sooim Interdisciplinary Program of Bioenergy and Biomaterials Graduate School Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of Department of Biotechnology and Bioengineering Chonnam National University Gwangju61186 Korea Republic of Korea Water Resources Corporation Daejeon34045 Korea Republic of Department of Agricultural and Biological Chemistry Chonnam National University 77 Yongbong-ro Buk-gu Gwangju61186 Korea Republic of

Plastics are widely used worldwide due to their convenience. However, microplastics (MPs) accumulation poses a serious threat to ecosystem health. Therefore, understanding the effects of MPs on living organisms within their native ecosystem is crucial. Previous studies have primarily focused on the impacts of MPs in aquatic environments, whereas the effects of MPs on terrestrial ecosystems have remained largely understudied. Therefore, our study assessed the impacts of MPs on soil ecosystems by characterizing their toxic effects on earthworms (Eisenia foetida). Here, we exposed earthworms to two representative plastics within soil environments: polyvinyl chloride (PVC) and low-density polyethylene (LDPE). Given the known link between MPs and oxidative stress, we next quantified oxidative stress markers and mitochondrial function to assess the effects of MPs on the redox and energy metabolism of earthworms. Mitochondria are crucial metabolic organelles that generate reactive oxygen species via uncontrolled ATP production. Our findings demonstrated that MPs exert different effects depending on their type. Neither the PVC-exposed groups nor the LDPE-exposed groups exhibited changes in oxidative stress (ROS/RNS), as worked by the strong action of glutathione (GSH). While treatment of the two types of MP did not significantly affect the amount of ROS/RNS generated, PVC exhibited a more pronounced effect on antioxidant system compared to LDP. However, mitochondrial function was markedly decreased in the group exposed to high LDPE concentrations, suggesting that the examined LDPE concentrations were too low to activate compensatory mechanisms to protect energy production. Collectively, our findings demonstrated that exposure of MPs not only influences the antioxidant defense mechanisms of earthworms but also alters their mitochondrial function depending on their types. © 2024, The Authors. All rights reserved.

关键词： Microplastic

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Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition

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Biomedicine and Pharmacotherapy 2025年 188卷 118169-118169页

作者： Kim, Minji Lim, Dong Wook Kim, Min-Sun Nam, Heejin Shin, Sooim Lee, Changho Um, Min Young Food Functionality Research Division Korea Food Research Institute Wanju 55365 South Korea Department of Food Biotechnology University of Science & Technology Daejeon 34113 South Korea Interdisciplinary Program of Bioenergy and Biomaterials Graduate School College of Engineering Chonnam National University Gwangju 61186 South Korea Department of Biotechnology & Bioengineering College of Engineering Chonnam National University Gwangju 61186 South Korea

Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties;however, its role in reducing stress hormone-induced depression remains unclear. This study examined the antidepressant effects of Rosa multiflora fructus extract (RMFE) on corticosterone (CORT)-induced depressive-like behaviors in mice and explored the underlying molecular mechanisms. ICR mice were administered CORT (40 mg/kg/day, i.p.) for 8 weeks to induce depressive-like behaviors. They were then treated with RMFE (100 or 300 mg/kg/day, p.o.) or selegiline (10 mg/kg/day, p.o.) as a positive control. RMFE treatment significantly alleviated depressive-like behaviors, as evaluated by the tail suspension and forced swimming tests. Furthermore, RMFE reduced hippocampal astrocyte hypertrophy and lowered the protein and mRNA expression of monoamine oxidase A and B (MAOA and MAOB). Phytochemical analysis using UPLC-MS/MS identified five flavonoids in RMFE, including ellagic acid (EA), hyperoside, isoquercetin, quercetin, and quercetin-3-glucuronide. In silico molecular docking revealed that these phenolic compounds interact with MAOA and MAOB, with EA exhibiting the strongest binding affinity. Consistently, EA administration effectively alleviated depressive-like behaviors and increased monoamine neurotransmitter levels in CORT-treated mice. These results suggest that RMFE exerts antidepressant effects by inhibiting MAO, restoring monoamine levels, and modulating hippocampal astrocytic hypertrophy, with EA identified as the primary bioactive compound driving its efficacy. © 2025

关键词： Corticosterone Depression Ellagic acid Monoamine oxidase Rosa multiflora fructus

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Guiding Brain-to-Vocalization Decoder Design Using Structured Generalization Error 46

Guiding Brain-to-Vocalization Decoder Design Using Structure...

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46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Huang, Jingya Tostado-Marcos, Pablo Narasimha, Sowmya Manojna Patel, Aashish N. Arneodo, Ezequiel. M. Gentner, Timothy Q. Mishne, Gal Gilja, Vikash University of California San Diego Department of Electrical and Computer Engineering La Jolla CA92092 United States University of California San Diego Department of Bioengineering La Jolla CA92092 United States University of California San Diego Institute for Neural Computation La Jolla CA92092 United States University of California San Diego Neuroscience Graduate Program La Jolla CA92092 United States University of California San Diego Department of Physics La Jolla CA92092 United States University of California San Diego Department of Psychology La Jolla CA92092 United States University of California San Diego Halicioǧlu Data Science Institute La Jolla CA92092 United States

ISBN: (纸本)9798350371499

State-of-the-art intracortical neuroprostheses currently enable communication at 60+ words per minute for anarthric individuals by training on over 10K sentences to account for phoneme variability in different word contexts. There is limited understanding about whether this performance can be maintained in decoding naturalistic speech with 40K+ word vocabularies across elicited, spontaneous, and conversational speech contexts. We introduce a vocal-unit-level generalization test to explicitly evaluate neural decoder performance with an expanded and more diverse behavioral repertoire. Tested on neural decoders modeling zebra finch vocalization, an analog to human vocal production, we compare three decoders with different input types: spike trains, neural factors, and firing rates. The factors and rates are latent neural features inferred using trained Latent Factor Analysis via Dynamical Systems (LFADS) models that capture the population neural dynamics during vocal production. While the conventional random holdout generalization error measure is similar for all three decoders, factor- and rate-based decoders outperform spike-based decoders when testing vocal-unit-holdout generalization error. These results suggest the later models better adapt to flexible vocalization inference when trained with partial observation of data variation, motivating further exploration of decoders incorporating latent neural and vocalization dynamics. © 2024 IEEE.

关键词： Errors

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Biophysics of amplitude-modulated giga-hertz electromagnetic waves stimulation

Biophysics of amplitude-modulated giga-hertz electromagnetic...

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Asilomar Conference on Signals, Systems & Computers

作者： Fatima Ahsan Aravind C. Govindaraju Robert M. Raphael Taiyun Chi Sameer A. Sheth Wayne Goodman Behnaam Aazhang Department of Electrical and Computer Engineering Rice University Houston TX USA Applied Physics Graduate Program Smalley-Curly Institute Rice University Houston TX Department of Bioengineering Rice University Houston TX USA Department of Neurosurgery Baylor College of Medicine Houston TX USA Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA

This paper presents the biophysical modeling for neuronal stimulation caused by amplitude-modulated giga-hertz (GHz) electromagnetic (EM) waves. We model a 1D cable equation for electrical signal propagation in a vestibular ganglion neuronal fiber and use Hodgkin-Huxley formalism to model voltage-dependent channel conductances. We find out that for a given stimulation signal strength, the GHz waveform amplitude-modulated at a low frequency of Δf causes neuronal firing with the frequency of Δf whereas the continuous wave GHz did not elicit any neuronal firing. Moreover, the voltage-dependent channel gating dynamics of the Δf amplitude-modulated GHz stimulation matches that of a simple low frequency stimulation at Δf. Additionally, we find that the modulation depth controls the firing rate of the neurons. The significance of this property is that the amplitude modulation caused by the interference of two similar high frequency signals could be leveraged to focally excite neurons at depth without stimulating overlying cortical regions. These theoretical predictions based on the Hodgkin-Huxley model can later be tested experimentally.

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