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arXiv 2024年

作者： Park, Hyeryun Kwak, Jeongwon Jang, Dongsuk Park, Sumin Choi, Jinwook Interdisciplinary Program for Bioengineering Graduate School Seoul National University Korea Republic of Integrated Major in Innovative Medical Science Graduate School Seoul National University Korea Republic of Department of Biomedical Engineering College of Medicine Seoul National University Korea Republic of Medical Research Center Institute of Medical and Biological Engineering Seoul National University Korea Republic of

Fact-checking techniques can mitigate hallucinations in Large Language Models (LLMs), a prominent issue in specialized domains. As parameter-efficient techniques such as Low-Rank Adaptation (LoRA) can overcome substantial computational overhead, some studies have explored the integration of multiple LoRAs. While previous studies focus on parallel integration, this paper investigates methods to establish connections among multiple LoRAs. We create three reasoning datasets tailored to fact-checking and fine-tune individual LoRAs, allowing them to view and reason from diverse perspectives. Then, we explore strategies for allocating these reasoning LoRAs and introduce LoraMap, an approach to map connections between them. The results of the fact-checking task demonstrate that the performance of LoraMap is superior to LoraHub, an existing method for integrating LoRAs. LoraMap also outperforms with significantly fewer trainable parameters than LoraConcat, which concatenates LoRAs and further fine-tunes them. Copyright © 2024, The Authors. All rights reserved.

关键词： Problem oriented languages

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Reduction of Reflected Light on Fluorescence Emission for Indocyanine Green

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Journal of engineering and Science in Medical Diagnostics and Therapy 2022年第1期5卷 011004页

作者： Kwon, So Yoon Yoon, Ki-Cheol Kim, Kwang Gi Interdisciplinary Program in Bioengineering Seoul National University Seoul08826 Korea Republic of Medical Devices R&D Center Gachon University Gil Medical Center 774 beon-gil Namdong-daero Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Medicine Gachon University 38-13 Dokjom-ro 3 Namdong-gu Incheon21565 Korea Republic of Department of Biomedical Engineering College of Health Science Gachon University 191 Hambakmoero Yeonsu-gu Incheon21936 Korea Republic of Gachon University 38-13 3 Dokjom-ro Namdong-gu Incheon21565 Korea Republic of

Inside the brain tumor, the blood vessels are intricately composed, and the tumors and blood vessels are similar in color. Therefore, when observing tumors and blood vessels with the naked eye or a surgical microscope, it is difficult to distinguish between tumors and blood vessels. Fluorescence staining with indocyanine green (ICG) is performed to distinguish between brain tumors and blood vessels using a surgical microscope. However, when observing the blood circulation state of a tumor or blood vessel through a surgical microscope, light reflection occurs from the camera. In the process of observing the state of the blood vessel, due to the occurrence of light reflection, an obstruction phenomenon in which the observation field is blocked by the blood vessel of the object to be observed occurs. Therefore, it is difficult to diagnose the vascular condition. In this experiment, the 780 nm light-emitting diode (LED) was irradiated to the ICG phantom, and then, when the fluorescence expression image was observed, the polarizing filter such as circular polarized light (CPL) filter and linear polarized light (LPL) filter was inserted into the camera, and the reflected light was reduced. Therefore, it is possible to reduce the reflected light from the fluorescence expression image by using a polarizing filter, and it is expected to be applicable to surgery and diagnostic fields of cancer such as surgery. Copyright © 2022 by ASME.

关键词： Microscopes

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Development of 3D-printing composite inks based on photoreactive cartilage extracellular matrix and gelatin nanoparticles

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Bioprinting 2023年 36卷

作者： Hogan, Katie J. Perez, Marissa R. Öztatlı, Hayriye Si, Sophia Wang, Ziwen Jiang, Emily Y. Diba, Mani Garipcan, Bora Mikos, Antonios G. Department of Bioengineering Rice University Houston 77030 TX United States Baylor College of Medicine Medical Scientist Training Program Houston 77030 TX United States Institute of Biomedical Engineering Boğaziçi University İstanbul Turkey

Decellularized extracellular matrix (dECM)-based materials possess innate biochemical cues to drive cell recruitment and differentiation and are of interest for cartilage tissue engineering. While 3D-printing (3DP) provides a means for achieving the precise architecture needed for cartilage tissue engineering, dECM hydrogels have proven difficult to translate to 3DP due to low viscosity and weak mechanical properties. In this study, a cartilage dECM (cdECM, 3 w/v%) was combined with varied amounts of gelatin nanoparticles (GNPs;10, 12.5, 15 w/v%) to form novel hydrogel-colloidal composite materials for 3DP. The addition of GNPs increased the viscosity and rheological properties of the cdECM hydrogel in a dose-dependent manner, directly improving the printability of cdECM 3DP inks. Additionally, functionalization of both materials yielded a UV-crosslinkable material for post-printing crosslinking, and increased GNP content increased post-UV storage moduli with 15 w/v% GNPs yielding a storage modulus 26x greater than that of cdECM alone. 3DP construct swelling and degradation were decreased as a function of increased UV-crosslinking dosage (0, 1.5, and 3 J/cm²). After 14 d of swelling in PBS, construct non-porous area was increased by ∼40 % and pore area was increased by ∼30 % for uncrosslinked (0 J/cm²) constructs versus highly crosslinked (3 J/cm²) constructs. Roughly 40 % higher mass retention was observed across GNP content groups for 3 J/cm² versus 0 J/cm² UV exposure after 14 d of enzymatic degradation, showing the potential for tuning physicochemical properties via UV exposure. Likewise, the retention of key biochemical components of cdECM over the course of degradation was evaluated. Sulfated glycosaminoglycans, a key reservoir for tissue-specific growth factors, were found to be retained within scaffolds over 14 d of degradation and to be released relative to construct degradation and UV-crosslinking. The

关键词： 3D-printing Cartilage tissue engineering Colloidal gel Decellularized extracellular matrix

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Implantable Biosensor for Continuous Serotonin Detection in Freely Moving Crayfish

Implantable Biosensor for Continuous Serotonin Detection in ...

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International Conference on Solid State Sensors and Actuators (TRANSDUCERS)

作者： Jinjing Han Tawen Ho Justin M. Stine Michael A. Straker Jens Herberholz Reza Ghodssi Department of Electrical and Computer Engineering University of Maryland College Park MD USA Institute for System Research University of Maryland College Park MD USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD USA Department of Psychology University of Maryland College Park MD USA Program in Neuroscience and Cognitive Science University of Maryland College Park MD USA Fischell Department of Bioengineering University of Maryland College Park MD USA

This work presents, for the first time, an implantable biosensor for continuous in vivo serotonin (5-HT) monitoring in freely moving crayfish. 5-HT is an important neurotransmitter that regulates animal behaviors. Conventional methods for detecting 5-HT do not provide real-time information. Our approach facilitates continuous electrochemical monitoring of 5-HT levels without impeding animal natural behavior. The sensing system shows a linear range of 0.4 - 1.2 μΜ with a sensitivity of 0.07 μΑ/μΜ for 5-HT detection. With a 3D-printed package, the sensor can be easily attached to crayfish dorsal carapace allowing electrodes implantation into crayfish heart to monitor neurohormonal dynamics of 5-HT. The implantable biosensor system displayed a significant increase in oxidation currents after 5-HT injections. The device successfully demonstrates the application for in vivo detection of 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater.

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A DISEASE-SPECIFIC FOUNDATION MODEL USING OVER 100K FUNDUS IMAGES: RELEASE AND VALIDATION FOR ABNORMALITY AND MULTI-DISEASE CLASSIFICATION ON DOWNSTREAM TASKS

arXiv

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arXiv 2024年

作者： Jang, Boa Ahn, Youngbin Choe, Eun Kyung Yoon, Chang Ki Choi, Hyuk Jin Kim, Young-Gon Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Korea Republic of Department of Transdisciplinary Medicine Seoul National University Hospital Korea Republic of Interdisciplinary Program of Medical Informatics Seoul National University College of Medicine Korea Republic of Department of Surgery Seoul National University Hospital Healthcare System Gangnam Center Korea Republic of Department of Ophthalmology Seoul National University College of Medicine Korea Republic of Department of Ophthalmology Seoul National University Hospital Healthcare System Gangnam Center Korea Republic of Department of Medicine Seoul National University College of Medicine Korea Republic of

Artificial intelligence applied to retinal images offers significant potential for recognizing signs and symptoms of retinal conditions and expediting the diagnosis of eye diseases and systemic disorders. However, developing generalized artificial intelligence models for medical data often requires a large number of labeled images representing various disease signs, and most models are typically task-specific, focusing on major retinal diseases. In this study, we developed a Fundus-Specific Pretrained Model (Image+Fundus), a supervised artificial intelligence model trained to detect abnormalities in fundus images. A total of 57,803 images were used to develop this pretrained model, which achieved superior performance across various downstream tasks, indicating that our proposed model outperforms other general methods. Our Image+Fundus model offers a generalized approach to improve model performance while reducing the number of labeled datasets required. Additionally, it provides more disease-specific insights into fundus images, with visualizations generated by our model. These disease-specific foundation models are invaluable in enhancing the performance and efficiency of deep learning models in the field of fundus imaging. Copyright © 2024, The Authors. All rights reserved.

关键词： Ophthalmology

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Santa Fe Oxa: Self-Assembled Oxaliplatin Nanomicelle for Enhanced Cascade Cancer Chemotherapy Via Self-Sensitized Ferroptosis

SSRN

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SSRN 2024年

作者： Shi, Jianbin Ma, Wenjing Zheng, Shunzhe Xia, Fengli Liu, Xinying Kikkawa, Ayumi Tanaka, Kaho Kamei, Ken-Ichiro Tian, Chutong Department of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University Shenyang110016 China Kyoto University Kyoto606-8501 Japan Program of Biology Division of Science New York University Abu Dhabi Abu Dhabi United Arab Emirates Program of Bioengineering Division of Engineering New York University Abu Dhabi Abu Dhabi United Arab Emirates Department of Biomedical Engineering Tandon School of Engineering New York University MetroTech BrooklynNY11201 United States Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province Hangzhou310058 China

The clinical utility of chemotherapy is often compromised by its limited efficacy and significant side effects. Addressing these concerns, we develop a self-assembled nanomicelle, namely SANTA FE OXA, which is composed of hyaluronic acid (HA) conjugated with ferrocene methanol (FC-OH), oxaliplatin prodrug (OXA(Ⅳ)) and glycol-coupled linoleic acid (EG-LA). Targeted delivery is achieved as HA binds to the CD44 receptors that are overexpressed on tumor cells, facilitating drug uptake. Once internalized, hyaluronidase (HAase) catalyzes the digestions of the SANTA FE OXA, releasing FC and reducing OXA(Ⅳ) into an active form. Active OXA induces DNA damage, while simultaneously promoting intracellular hydrogen peroxide levels via cascade reactions. In parallel, FC disrupts the redox balance within tumor cells, inducing ferroptosis. The synergistic combination of cascade chemotherapy and self-sensitized ferroptosis therapy has demonstrated remarkable anti-cancer efficacy in both in vitro and in vivo models. Moreover, this SANTA FE OXA significantly mitigates the systemic toxicity commonly associated with platinum-based chemotherapeutics. Our findings suggest a compelling advancement in nanomedicine for enhanced cascade cancer therapy. © 2024, The Authors. All rights reserved.

关键词： Chemotherapy

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Reinforcement learning for efficient and robust multi-setpoint and multi-trajectory tracking in bioprocesses

arXiv

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arXiv 2025年

作者： Espinel-Ríos, Sebastián Avalos, José L. Chanona, Ehecatl Antonio del Rio Zhang, Dongda Biomedical Manufacturing Program Commonwealth Scientific and Industrial Research Organisation Clayton Australia Department of Chemical and Biological Engineering Princeton University Princeton United States Omenn-Darling Bioengineering Institute Princeton University Princeton United States The Andlinger Center for Energy and the Environment Princeton University Princeton United States High Meadows Environmental Institute Princeton University Princeton United States Department of Chemical Engineering Imperial College London London United Kingdom Department of Chemical Engineering University of Manchester Manchester United Kingdom

Efficient and robust bioprocess control is essential for maximizing performance and adaptability in advanced biotechnological systems. In this work, we present a reinforcement-learning framework for multi-setpoint and multi-trajectory tracking. Tracking multiple setpoints and time-varying trajectories in reinforcement learning is challenging due to the complexity of balancing multiple objectives, a difficulty further exacerbated by system uncertainties such as uncertain initial conditions and stochastic dynamics. This challenge is relevant, e.g., in bioprocesses involving microbial consortia, where precise control over population compositions is required. We introduce a novel return function based on multiplicative reciprocal saturation functions, which explicitly couples reward gains to the simultaneous satisfaction of multiple references. Through a case study involving light-mediated cybergenetic growth control in microbial consortia, we demonstrate via computational experiments that our approach achieves faster convergence, improved stability, and superior control compliance compared to conventional quadratic-cost-based return functions. Moreover, our method enables tuning of the saturation function’s parameters, shaping the learning process and policy updates. By incorporating system uncertainties, our framework also demonstrates robustness, a key requirement in industrial bioprocessing. Overall, this work advances reinforcement-learning-based control strategies in bioprocess engineering, with implications in the broader field of process and systems engineering. © 2025, CC BY.

关键词： Trajectories

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In Silico Assessment of Arrhythmic Risk in Infarcted Ventricles Engrafted with Engineered Heart Tissues

In Silico Assessment of Arrhythmic Risk in Infarcted Ventric...

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Computers in Cardiology (CinC)

作者： Ricardo M Rosales Konstantinos A Mountris Manuel Doblare Manuel M Mazo Esther Pueyo Aragon Institute of Engineering Research University of Zaragoza IIS Aragon Zaragoza Spain CIBER in Bioengineering Biomaterials & Nanomedicine (CIBER-BBN) Spain Department of Mechanical Engineering University College London London United Kingdom Regenerative Medicine Program CIMA Universidad de Navarra Pamplona Spain Hematology and Cell Therapy Clinica Universidad de Navarra Pamplona Spain

Engineered heart tissues (EHTs) from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent novel alternatives to repair damaged cardiac tissue after myocardial infarction (MI). However, their associated slow conduction and prolonged action potential duration (APD) can favor proarrhythmicity. We coupled biventricular (BiV) and EHT in silico elec-trophysiological models. The BiV model, defined from magnetic resonance imaging, included an MI region. The EHT model was deformed to follow the epicardial surface. Different values of EHT electrical conductivity (EHTc) and degree of myocardial attachment (EHTa) were tested. Results showed that even a minimum degree of EHTa inhibited EHT automaticity. Activation time and APD were driven by myocardial tissue when engrafted. Importantly, higher EHTc and EHTa led to lower repolarization gradients (RTGs), considered as a surrogate of arrhythmic risk. Maximum RTG decreased by 52.3 ms/mm when EHTa var-iedfrom 25 % to 100 % under low EHTc and decreased by 98.8 ms/mm when EHTc raised to 90 % of the myocardium conductivity under low EHTa. Proarrhythmicity in cardiac tissue engineering highly depends on EHT conductivity and degree of engraftment on the myocardium.

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Biophysics of amplitude-modulated giga-hertz electromagnetic waves stimulation

Biophysics of amplitude-modulated giga-hertz electromagnetic...

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Asilomar Conference on Signals, Systems & Computers

作者： Fatima Ahsan Aravind C. Govindaraju Robert M. Raphael Taiyun Chi Sameer A. Sheth Wayne Goodman Behnaam Aazhang Department of Electrical and Computer Engineering Rice University Houston TX USA Applied Physics Graduate Program Smalley-Curly Institute Rice University Houston TX Department of Bioengineering Rice University Houston TX USA Department of Neurosurgery Baylor College of Medicine Houston TX USA Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine Houston TX USA

This paper presents the biophysical modeling for neuronal stimulation caused by amplitude-modulated giga-hertz (GHz) electromagnetic (EM) waves. We model a 1D cable equation for electrical signal propagation in a vestibular ganglion neuronal fiber and use Hodgkin-Huxley formalism to model voltage-dependent channel conductances. We find out that for a given stimulation signal strength, the GHz waveform amplitude-modulated at a low frequency of Δf causes neuronal firing with the frequency of Δf whereas the continuous wave GHz did not elicit any neuronal firing. Moreover, the voltage-dependent channel gating dynamics of the Δf amplitude-modulated GHz stimulation matches that of a simple low frequency stimulation at Δf. Additionally, we find that the modulation depth controls the firing rate of the neurons. The significance of this property is that the amplitude modulation caused by the interference of two similar high frequency signals could be leveraged to focally excite neurons at depth without stimulating overlying cortical regions. These theoretical predictions based on the Hodgkin-Huxley model can later be tested experimentally.

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Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microcatheter for Transarterial Chemoembolization of Liver Cancer

Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microca...

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IEEE International Conference on Soft Robotics (RoboSoft)

作者： Bailey M. Felix Jordi T. Andreou Sarah McHugh Jack E. McCann Olivia M. Young Molly A. Carton Dheeraj Gandhi Miroslaw Janowski Mark Fuge Axel Kreiger Clifford R. Weiss Christopher R. Bailey Ryan D. Sochol Fischell Department of Bioengineering University of Maryland College Park MD USA Department of Mechanical Engineering University of Maryland College Park MD USA Department of Diagnostic Radiology and Nuclear Medicine Program in Image Guided Neurointerventions University of Maryland School of Medicine Baltimore MD USA Department of Mechanical Engineering ETH Zurich Zurich Switzerland Department of Mechanical Engineering Johns Hopkins University Baltimore MD USA The Russell H. Morgan Department of Radiology and Radiological Science Division of Vascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore MD USA Maryland Robotics Center University of Maryland College Park MD USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD USA

ISBN: (数字)9798331520205

ISBN: (纸本)9798331520212

Transarterial chemoembolization (TACE)—i.e., the delivery of chemotherapeutics directly into the vasculature of liver tumors—necessitates the use of guidewire-microcatheter systems to navigate tortuous vascular networks. These guide-wires and microcatheters typically lack effective steering controls, making successful navigation through geometrically complex anatomy challenging. Recent advancements in the area of soft microrobotics could offer a pathway to remotely steerable microcatheters at size scales relevant to TACE procedures; however, the difficulties associated with fabricating such systems have represented a critical hurdle. To overcome this barrier, here we present a multimaterial additive nanomanufacturing— or "three-dimensional (3D) nanoprinting"—strategy to achieve steerable soft robotic microcatheters that not only facilitate on-demand regulation of catheter tip deflection, but also comprise 2 French (Fr) outer dimensions (i.e., ⌀ = 666 μm) that are suitable for clinical chemoembolization of liver cancers. Specifically, we use "Two-Photon Direct Laser Writing (DLW)" to 3D nanoprint 1.5 mm-tall microcatheters capable of unidirectional tip bending of approximately 140° as well as mediating delivery of a fluidic payload. Experimental results for navigating the soft robotic microcatheter through a vascular phantom to deliver fluid payloads to target sites suggest the presented strategy holds promise for TACE as well as additional endovascular interventions and minimally invasive surgeries.

关键词： Liver cancer Actuators Navigation Deformation Phantoms Liver Soft robotics Bending Three-dimensional printing Payloads

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