We investigated the relationship between the intracranial pulse pressure (ICP/sub PP/) and the mean intracranial pressure (ICP/sub M/). In adult patients, several research groups have described a linear relationship b...
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We investigated the relationship between the intracranial pulse pressure (ICP/sub PP/) and the mean intracranial pressure (ICP/sub M/). In adult patients, several research groups have described a linear relationship between ICP/sub PP/ and ICP/sub M/ within the range of cerebral autoregulation. Current monitoring and therapy are mainly based on the mean ICP/sub M/, since it is believed that the ICP/sub M/ contains most of the information provided by the other pulse morphology metrics. In this paper we attempt to answer whether there is further information within the ICP morphology not explained by ICP/sub M/ that might be of prognostic significance. We screened ICP records of 42 patients admitted to the Pediatric Intensive Care Unit at Doernbecher Children's Hospital for segments in which the ICP/sub M/ varied at least 5 mmHg during a 1-hour period. We found 54 segments in 9 different pediatric TBI patients (ages 0.2-17.8 years, mean=9.9 years). ICP/sub PP/ and ICP/sub M/ were calculated for each pulse using an automatic pressure detection algorithm. The coefficient of linear correlation r was > 0.70 in 43/54 segments (p < 0.001), which indicates that there exists a linear relationship between ICP/sub PP/ and ICP/sub M/. However, we found r > 0.90 only in 16/54 segments (p=NS) . This result and visual inspection of ICP/sub PP/ vs. ICP/sub M/ density plots suggest that ICP pulse pressure is not fully explained by the ICP M.
The Level 1 Muon Trigger subsystem for BTeV will be implemented using the same architectural building blocks as the BTeV Level 1 Pixel Trigger: pipelined field programmable gate arrays feeding a farm of dedicated proc...
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The Level 1 Muon Trigger subsystem for BTeV will be implemented using the same architectural building blocks as the BTeV Level 1 Pixel Trigger: pipelined field programmable gate arrays feeding a farm of dedicated processing elements. The muon trigger algorithm identifies candidate tracks, and is sensitive to the muon charge (sign);candidate dimuon events are identified by complementary charge track-pairs. To insure that the trigger is operating effectively, the trigger development team is actively collaborating in an independent multi-university research program for reliable, self-aware, fault adaptive behavior in real-time embedded systems (RTES). Key elements of the architecture, algorithm, performance, and engineered reliability are presented.
Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems ...
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Aboard current ships, such as the DDG 51, engineering control and damage control activities are manpower intensive. It is anticipated that, for future combatants, the workload demand arising from operation of systems under conditions of normal steaming and during casualty response will need to be markedly reduced via automated monitoring, autonomous control, and other technology initiatives. Current DDG 51 class ships can be considered as a manpower baseline and under Condition III typical engineering control involves seven to eight watchstanders at manned stations in the Central Control Station, the engine rooms and other machinery spaces. In contrast to this manning level, initiatives such as DD 21 and the integrated engineering plant (IEP) envision a partnership between the operator and the automation system, with more and more of the operator's functions being shifted to the automation system as manning levels decrease. This paper describes some human systems integration studies of workload demand reduction and, consequently, manning reduction that can be achieved due to application of several advanced technology concepts. Advanced system concept studies in relation to workload demand are described and reviewed including. Piecemeal applications of diverse automation and remote control technology concepts to selected high driver tasks in current DDG 51 activities. Development of the reduced ship's crew by virtual presence system that will provide automated monitoring and display to operators of machinery health, compartment conditions, and personnel health. The IEP envisions the machinery control system as a provider of resources that are used by various consumers around the ship. Resource needs and consumer priorities are at all times dependent upon the ship's current mission and the availability of equipment pawnbrokers.
We present a robust and non-invasive optical method to accurately measure the oxygen saturation of hemoglobin in breast lesions, introducing the concept that the optimal wavelength pair is dependent on the lesion oxyg...
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The University of Notre Dame has developed a new first year engineeringprogram, and central to that program is a two-course sequence entitled "Introduction to engineering Systems." These courses use a seque...
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The University of Notre Dame has developed a new first year engineeringprogram, and central to that program is a two-course sequence entitled "Introduction to engineering Systems." These courses use a sequence of team-based, multidisciplinary projects to introduce students to the engineering profession and to assist them in developing fundamental problem-solving skills common to all engineering disciplines. This paper describes how these new courses were developed and outlines the learning objectives for the courses. It includes details on the implementation of the courses and the four projects that are central to these two courses. The paper details the ongoing assessment activities and the progress toward achieving the various desired outcomes set-forth for the courses.
Near-Infrared Spectroscopy (NIRS) is an effective technique for monitoring cerebral hemodynamics and oxygenation. We report a study of the cerebral hemoglobin concentration changes during electro- convulsive therapy (...
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In this paper we present a new, adaptive spatial-derivative circuit for CMOS image sensors. The circuit removes its offset as a natural part of its operation using a combination of electron tunneling and hot-electron ...
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In this paper we present a new, adaptive spatial-derivative circuit for CMOS image sensors. The circuit removes its offset as a natural part of its operation using a combination of electron tunneling and hot-electron injection to add or remove charge on a floating-gate of an auto-zeroing amplifier. We designed, fabricated and successfully tested a chip with the circuit. Test results show that the circuit reduces the offsets by more than an order of magnitude.
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