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Optical coherence tomography of breast cancer: Feasibility for surgical guidance

Optical coherence tomography of breast cancer: Feasibility f...

引用

Biomedical Topical Meeting, BIOMED 2004

作者： Bredfeldt, Jeremy S. Luo, Wei Marks, Daniel L. Singletary, Keith W. Wisseman, Charles L. Johnson, Patricia A. Boppart, Stephen A. Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign United States Department of Food Science and Human Nutrition Functional Foods for Health Program University of Illinois at Urbana-Champaign United States Surgical Pathology and Oncology Carle Foundation Hospital UrbanaIL United States Department of Electrical and Computer Engineering Beckman Institute for Advanced Science and Technology Bioengineering Program College of Medicine University of Illinois at Urbana-Champaign 405 N. Mathews Avenue UrbanaIL61801 United States

We present the use of OCT for breast cancer imaging. In situ rat mammary and excised human breast tumors were imaged. The feasibility of OCT for applications in surgical oncology of the breast is discussed. © 200... 详细信息

ISBN: (纸本)1557527695

关键词： Optical tomography

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Multiresolution image registration based on kullback-leibler distance

引用

7th International Conference on Medical Imaging and computer Assisted Intervention, MICCAI 2004

作者： Gan, Rui Wu, Jue Chung, Albert C.S. Yu, Simon C.H. Wells, William M. Department of Computer Science Hong Kong University of Science and Technology Hong Kong Bioengineering Program School of Engineering Hong Kong University of Science and Technology Hong Kong Dept of Diagnostic Radiology and Organ Imaging Prince of Wales Hospital Hong Kong Brigham and Women’s Hospital Harvard Medical School BostonMA United States MIT CSAI Laboratory CambridgeMA United States

ISBN: (纸本)3540229760

This paper extends our prior work on multi-modal image registration based on the a priori knowledge of the joint intensity distribution that we expect to obtain, and Kullback-Leibler distance. This expected joint distribution can be estimated from pre-aligned training images. Experimental results show that, as compared with the Mutual Information and Approximate Maximum Likelihood based registration methods, the new method has longer capture range at different image resolutions, which can lead to a more robust image registration method. Moreover, with a simple interpolation algorithm based on non-grid point random sampling, the proposed method can avoid interpolation artifacts at the low resolution registration. Finally, it is experimentally demonstrated that our method is applicable to a variety of imaging modalities. © Springer-Verlag Berlin Heidelberg 2004.

关键词： Image resolution

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Multi-modality three-dimensional optical imaging of engineered tissues

Multi-modality three-dimensional optical imaging of engineer...

引用

Biomedical Topical Meeting, BIOMED 2004

作者： Tan, Wei Fahrner, Lester J. Sendemir-Urkmez, Aylin Jamison, Russell D. Leckband, Deborah E. Boppart, Stephen A. Beckman Institute for Advanced Science and Technology University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Materials Science and Engineering University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Chemical Engineering University of Illinois at Champaign-Urbana UrbanaIL61801 United States Department of Electrical and Computer Engineering Bioengineering Program Beckman Institute for Advanced Science and Technology College of Medicine University of Illinois at Urbana-Champaign 405 North Mathews Avenue UrbanaIL61801 United States

Optical coherence tomography (OCT), confocal, and multiphoton microscopy are used to nondestructively monitor in situ cell distribution and cell-matrix interaction in 3-D engineered tissues composed of chitosan scaffo... 详细信息

ISBN: (纸本)1557527695

关键词： Tissue

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Multiresolution image registration based on Kullback-Leibler distance

Multiresolution image registration based on Kullback-Leibler...

引用

Medical Image Computing and computer-Assisted Intervention, MICCAI 2004 - 7th International Conference, Proceedings

作者： Gan, Rui Wu, Jue Chung, Albert C.S. Yu, Simon C.H. Wells III, William M. Department of Computer Science Hong Kong University of Science and Technology Hong Kong Hong Kong Bioengineering Program School of Engineering Hong Kong University of Science and Technology Hong Kong Hong Kong Dept. of Diagnostic Radiology and Organ Imaging Prince of Wales Hospital Hong Kong Hong Kong Brigham and Women's Hospital Harvard Medical School Boston MA United States MIT CSAI Laboratory Cambridge MA United States

关键词： Medical imaging

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Use of molecular beacons to study mixing and hybridization in microfluidic devices

Use of molecular beacons to study mixing and hybridization i...

引用

International Conference on Microtechnologies in Medicine and Biology

作者： Chuanwu Xi M. Balberg J. Selby S. Boppart L. Raskin Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign Urbana-Champaign IL USA Department of Electrical and Computer Engineering Bioengineering Program Beckman Institute for Advanced Science and Technology University of Illinois Urbana-Champaign Urbana-Champaign IL USA

We present the use of molecular beacons as sensitive indicators in microfluidic bioMEM devices. A method has been developed to study mixing and hybridization of molecular beacons to target nucleic acids in real time in a microfluidic channel. This method allows quantification of DNA and RNA molecules in solution, i.e., without the prerequisite of an immobilization step necessary in most other hybridization formats. The detection limit for DNA was determined to be in the order of femtomoles. Our results suggest the feasibility of using molecular beacon hybridization in microfluidic devices for the detection of pathogenic bacteria in environmental and medical fluids.

关键词： Microfluidics DNA RNA Microorganisms Kinetic theory Probes Sequences Ultrafast optics Fabrication USA Councils

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Body surface Laplacian mapping from potential recordings in man

Body surface Laplacian mapping from potential recordings in ...

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Southern Biomedical Engineering Conference

作者： N. Mehdi X. Yu D. Wu N. Jojic B. Baker P. Gosavi A. Seyd S. Bodak K. Umetani B. He Bioengineering Program University of Illinois Chicago USA Department of Electrical Engineering and Computer Science University of Illinois Chicago USA

Body surface Laplacian maps were studied from a set of unipolar potential data in healthy human subjects. The present results indicate that body surface Laplacian maps can be obtained with high reproducibility in the human subjects studied, and can reveal detailed information regarding the underlying ventricular conduction process.

关键词： Laplace equations Helium Humans Electrodes Electrocardiography Bioelectric phenomena Biomedical engineering Electric potential Board of Directors Reproducibility of results

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Development of a X-window based bioelectric mapping software system

Development of a X-window based bioelectric mapping software...

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Southern Biomedical Engineering Conference

作者： X. Yu D. Wu B. He Department of Electrical Engineering and Computer Science University of Illinois Chicago USA Bioengineering Program University of Illinois Chicago USA

The authors have developed a multi-purpose X-window based mapping software system. This software system can be used to analyze and display body surface maps of the Laplacian electrocardiogram, potential electrocardiog... 详细信息

关键词： Bioelectric phenomena Software systems Laplace equations Electric potential Humans Electrocardiography Helium Data analysis Heart Signal processing

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Combined diagonal/Fourier preconditioning methods for image reconstruction in emission tomography

Combined diagonal/Fourier preconditioning methods for image ...

引用

IEEE International Conference on Image Processing

作者： S.D. Booth J.A. Fessler Bioengineering Program and Department of Electrical Engineering and Computer Science University of Michigan MI USA

Iterative methods for tomographic image reconstruction often converge slowly. Preconditioning methods can often accelerate gradient-based iterations. Previous preconditioning methods for PET reconstruction have used either diagonal or Fourier-based preconditioners. Fourier-based preconditioners are well suited to problems with near-circulant Hessian matrices. However, due to the nonuniform Poisson noise variance in PET, the circulant approximation to the Hessian is suboptimal. This paper shows that a particular combined diagonal/Fourier preconditioner yields a more accurate approximation to the Hessian and gives significantly faster convergence rates than does either preconditioner used alone.

关键词： Image reconstruction Tomography Character generation Symmetric matrices Equations Iterative methods Minimization methods Covariance matrix Spatial resolution Yield estimation

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A complex arithmetic digital signal processor using CORDIC rotators

A complex arithmetic digital signal processor using CORDIC r...

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International Conference on Acoustics, Speech, and Signal Processing (ICASSP)

作者： S. Freeman M. O'Donnell Electrical Engineering and Computer Science Department and Bioengineering Program University of Michigan Ann Arbor MI USA

A versatile signal processor has been designed that can perform multiple rotations, multiplications and additions within one clock cycle. The computational elements of this processor include four pipelined CORDIC rotators, two pipelined fast multipliers and two adders. A combination of register files, SRAM, and ROM provides on chip storage for coefficients, running sums and programs. The chip architecture and its applicability to complex valued signal processing tasks are discussed.

关键词： Digital arithmetic Digital signal processors Signal processing Process design Signal design Clocks Adders Registers Random access memory Read only memory

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Ultrasound phased arrays for noninvasive myocardial ablation: initial studies

Ultrasound phased arrays for noninvasive myocardial ablation...

引用

IEEE Symposium (IUS) Ultrasonics

作者： J.-U. Kluiwstra Y. Zhang P. VanBaren S.A. Strickberg E.S. Ebbini C.A. Cain Electrical Engineering and Computer Science Department And Bioengineering Program University of Michigan Ann Arbor MI USA

Catheter based ablation of cardiac tissue has been shown to provide an immediate and long lasting cure for cardiac arrhythmia. However, the procedure does not always allow placing the catheter in close proximity to the pathological tissues requiring ablation. Use of non-invasive focused ultrasound ablation in the moving heart is an attractive potential alternative to catheter based ablative therapy. In this paper, initial studies have been performed to explore the feasibility of using ultrasound phased array technology for this application. A 3-D treatment planning software package was developed to study the available acoustic windows allowing ultrasound to be focused on the myocardium. Numerical simulation studies of the feasibility of precise beam forming by propagating ultrasound around the ribs shows that the beam, even though formed by an irregularly shaped subset of phased array elements not blocked by ribs and air, was very sharply focused at the target. Using invasive phase aberration correction algorithms developed in the authors' lab, experiments with pork and human rib phantoms confirm the ability to precisely form beams with phased array through the available noncontiguous windows.

关键词： Phased arrays Ultrasonic imaging Myocardium Catheters Acoustic beams Ribs Cardiac tissue Pathology Heart Medical treatment

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