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22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

作者： Han, Jinjing Ho, Tawen Stine, Justin M. Straker, Michael A. Herberholz, Jens Ghodssi, Reza University Of Maryland Department Of Electrical And Computer Engineering College ParkMD United States University Of Maryland Institute For System Research College ParkMD United States University Of Maryland Robert E. Fischell Institute For Biomedical Devices College ParkMD United States University Of Maryland Department Of Psychology College ParkMD United States University Of Maryland Program In Neuroscience And Cognitive Science College ParkMD United States University Of Maryland Fischell Department Of Bioengineering College ParkMD United States

ISBN: (纸本)9784886864352

This work presents, for the first time, an implantable biosensor for continuous in vivo serotonin (5-HT) monitoring in freely moving crayfish. 5-HT is an important neurotransmitter that regulates animal behaviors. Conventional methods for detecting 5-HT do not provide real-time information. Our approach facilitates continuous electrochemical monitoring of 5-HT levels without impeding animal natural behavior. The sensing system shows a linear range of 0.4 - 1.2 μΜ with a sensitivity of 0.07 μA/μΜ for 5-HT detection. With a 3D-printed package, the sensor can be easily attached to crayfish dorsal carapace allowing electrodes implantation into crayfish heart to monitor neurohormonal dynamics of 5-HT. The implantable biosensor system displayed a significant increase in oxidation currents after 5-HT injections. The device successfully demonstrates the application for in vivo detection of 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater. © 2023 IEEJ.

关键词： Biosensing Electrochemical Device Electrochemistry Implantable Electrode In Vivo Sensing

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CELL-E 2: translating proteins to pictures and back with a bidirectional text-to-image transformer 23

CELL-E 2: translating proteins to pictures and back with a b...

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Proceedings of the 37th International Conference on Neural Information Processing Systems

作者： Emaad Khwaja Yun S. Songt Aaron Agarunov Bo Huang UC Berkeley - UCSF Joint Bioengineering Graduate Program and Computer Science Division UC Berkeley CA Department of Statistics UC Berkeley CA and Computer Science Division UC Berkeley CA Department of Pathology Memorial Sloan Kettering Cancer Center Department of Pharmaceutical Chemistry UCSF San Francisco CA and Department of Biochemistry and Biophysics UCSF San Francisco CA and Chan Zuckerberg Biohub - San Francisco San Francisco CA

We present CELL-E 2, a novel bidirectional transformer that can generate images depicting protein subcellular localization from the amino acid sequences (and vice versa). Protein localization is a challenging problem that requires integrating sequence and image information, which most existing methods ignore. CELL-E 2 extends the work of CELL-E, not only capturing the spatial complexity of protein localization and produce probability estimates of localization atop a nucleus image, but also being able to generate sequences from images, enabling de novo protein design. We train and finetune CELL-E 2 on two large-scale datasets of human proteins. We also demonstrate how to use CELL-E 2 to create hundreds of novel nuclear localization signals (NLS). Results and interactive demos are featured at https://***/CELL-E_2/.

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Sample Preconcentration Through Airjet-Induced Liquid Phase Enrichment

SSRN

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SSRN 2023年

作者： Wang, Edward Laurent, Louise C. Hall, Drew A. Lo, Yu-Hwa Department of Aerospace and Mechanical Engineering Materials Science and Engineering Program University of California La Jolla San DiegoCA United States Sanford Consortium of Regenerative Medicine United States Department of Electrical and Computer Engineering University of California La Jolla San DiegoCA United States Department of Bioengineering

Sample preparation is essential for nucleic acid assays, affecting their sensitivity and reliability. However, this process often results in a significant loss or dilution of the analyte, which becomes a bottleneck that limits downstream assay performance, particularly for assays that accept a limited input sample volume. To overcome this challenge, we present an evaporative-based sample enrichment method that uses an airjet to concentrate analytes within a small, defined volume by reversing the coffee-ring effect. A small, concentrated sample can then be collected for analysis to increase the initial sample load. The effectiveness of the reported airjet enrichment was quantified using qPCR of λ-DNA, HeLa-S3 RNA, and heat-inactivated SARS-CoV-2 samples. Comparisons between airjet enrichment and conventional evaporative concentration methods demonstrated significant advantages of airjet enrichment, including the ability to concentrate a high percentage of analyte within a 1 µL volume. The enrichment method was then integrated and adapted for various fluid volumes commonly found in nucleic acid sample preparation procedures. Here, airjet enrichment reduced the overall [[EQUATION]] by an average of 9.27 cycles for each analyte, resulting in a 600-fold enrichment from the initial concentration. In addition, to perform selective enrichment and prevent salt-based interference in downstream analysis, PEG was added to reduce the co-enrichment of salt. These studies show how airjet enrichment technology can be easily integrated into existing laboratory protocols with minimal modification and significantly improve the performance of nucleic acid amplification assays. © 2023, The Authors. All rights reserved.

关键词： Biomolecules

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Optimizing Marker Design to Improve Precision of Optical Camera-Based Rigid-Body Motion Tracking and Correction in Medical Imaging

Optimizing Marker Design to Improve Precision of Optical Cam...

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2021 IEEE Nuclear science Symposium and Medical Imaging Conference, NSS/MIC 2021

作者： Fisher, Jonathan Kim, Chris C. Groll, Andrew Levin, Craig S. Stanford University Department of Electrical Engineering CA United States Stanford University Department of Computer Science CA United States Stanford University Department of Radiology Molecular Imaging Program CA United States Bioengineering at Stanford University Department of Radiology and by Courtesy Physics Electrical Engineering CA United States

ISBN: (纸本)9781665421133

In this work we evaluated the performance of a camera-based rigid body motion correction solution using a 2D checkerboard marker and a 3D encoded marker. The context of the results presented is in PET/MR imaging, but in principle this motion compensation method could be used in any type of medical imaging modality. A high precision, computer-controlled motion stage with four degrees of freedom was used to control the marker positions and orientations (a.k.a. 'poses'). Still images of the markers taken in different poses mimicking a patient moving her/his head from side to side, were used to assess performance of this method. Comparing the known stage motion to the estimated motion, our results indicate that the 2D marker achieves better angular accuracy while the 3D marker's translational (linear) accuracy is superior. For all axes, the angular error was less than 0.96, 0.35 [deg], and the translational error was less than 2.24, 4.76 [mm] for the 3D and 2D markers, respectively. © 2021 IEEE.

关键词： Medical imaging

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eVision: Forecasting the spread of Tuberculosis in India with Deep Learning

eVision: Forecasting the spread of Tuberculosis in India wit...

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International Conference on Computational science and Computational Intelligence (CSCI)

作者： Juan Zuluaga Michael Castillo Divya Syal Andres Calle Navid Shaghaghi Department of Bioengineering (BIOE) Computer Science & Engineering (CSEN) Ethical Pragmatic & Intelligent Computing (EPIC) Laboratory in collaboration with the Healthcare Innovation & Design (HID) Program Information Systems & Analytics (ISA) and Mathematics & Computer Science (MCS) Santa Clara University Santa Clara California USA

Humanity has battled tuberculosis for all of recorded history. Some studies estimate that Mycobacterium tuberculosis may have been around as long as 3 million years but it was only in 1834 when Johann Schonlein officially presented the characteristics of it. Even though the TB epidemic has touched all corners of the world, Africa and Asia are the regions that currently suffer the worst consequences. The purpose of this study is to construct a model within the eVision forecasting environment, capable of forecasting the trend of Tuberculosis cases in India, as India is the country that accounts for the largest percentage of TB cases and deaths worldwide. And being able to make predictions for India may also lead to successful results for other regions in Asia and Africa. In order to do so, this study presents different test cases that show the effectiveness of the model, varying the number of steps for each one of the data sets created. It's important to note, that these data sets are combinations of data gathered from the states with the most TB cases in India in the last years, as well as the total data for India, and supplemental data from Google Trends, as a way to facilitate the machine learning model. Even though the final results were respectable compared to past research done on India and other countries, the model nevertheless has a limitation on the number of weeks ahead which the predictions are still considered to be good; with 7 weeks being the optimal result.

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Guiding Brain-to-Vocalization Decoder Design Using Structured Generalization Error 46

Guiding Brain-to-Vocalization Decoder Design Using Structure...

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46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024

作者： Huang, Jingya Tostado-Marcos, Pablo Narasimha, Sowmya Manojna Patel, Aashish N. Arneodo, Ezequiel. M. Gentner, Timothy Q. Mishne, Gal Gilja, Vikash University of California San Diego Department of Electrical and Computer Engineering La Jolla CA92092 United States University of California San Diego Department of Bioengineering La Jolla CA92092 United States University of California San Diego Institute for Neural Computation La Jolla CA92092 United States University of California San Diego Neuroscience Graduate Program La Jolla CA92092 United States University of California San Diego Department of Physics La Jolla CA92092 United States University of California San Diego Department of Psychology La Jolla CA92092 United States University of California San Diego Halicioǧlu Data Science Institute La Jolla CA92092 United States

ISBN: (纸本)9798350371499

State-of-the-art intracortical neuroprostheses currently enable communication at 60+ words per minute for anarthric individuals by training on over 10K sentences to account for phoneme variability in different word contexts. There is limited understanding about whether this performance can be maintained in decoding naturalistic speech with 40K+ word vocabularies across elicited, spontaneous, and conversational speech contexts. We introduce a vocal-unit-level generalization test to explicitly evaluate neural decoder performance with an expanded and more diverse behavioral repertoire. Tested on neural decoders modeling zebra finch vocalization, an analog to human vocal production, we compare three decoders with different input types: spike trains, neural factors, and firing rates. The factors and rates are latent neural features inferred using trained Latent Factor Analysis via Dynamical Systems (LFADS) models that capture the population neural dynamics during vocal production. While the conventional random holdout generalization error measure is similar for all three decoders, factor- and rate-based decoders outperform spike-based decoders when testing vocal-unit-holdout generalization error. These results suggest the later models better adapt to flexible vocalization inference when trained with partial observation of data variation, motivating further exploration of decoders incorporating latent neural and vocalization dynamics. © 2024 IEEE.

关键词： Errors

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Correction: Materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

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MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker School of Molecular Engineering, The University of Chicago, Chicago, USA" to "Pritzker School of Molecular Engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

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Guiding Brain-to-Vocalization Decoder Design Using Structured Generalization Error

Guiding Brain-to-Vocalization Decoder Design Using Structure...

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Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

作者： Jingya Huang Pablo Tostado-Marcos Sowmya Manojna Narasimha Aashish N. Patel Ezequiel. M. Arneodo Timothy Q. Gentner Gal Mishne Vikash Gilja Department of Electrical and Computer Engineering University of California San Diego CA Department of Bioengineering University of California San Diego CA Institute for Neural Computation University of California San Diego CA Neuroscience Graduate Program University of California San Diego CA Department of Physics University of California San Diego CA Department of Psychology University of California San Diego CA Halıcıoğlu Data Science Institute University of California San Diego CA

ISBN: (数字)9798350371499

ISBN: (纸本)9798350371505

关键词： Training Adaptation models Vocabulary Firing Measurement uncertainty Neuroprostheses Production Decoding Engineering in medicine and biology Testing

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Technology Roadmap for Flexible Sensors

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ACS NANO 2023年第6期17卷 5211-5295页

作者： Luo, Yifei Abidian, Mohammad Reza Ahn, Jong-Hyun Akinwande, Deji Andrews, Anne M. Antonietti, Markus Bao, Zhenan Berggren, Magnus Berkey, Christopher A. Bettinger, Christopher John Chen, Jun Chen, Peng Cheng, Wenlong Cheng, Xu Choi, Seon-Jin Chortos, Alex Dagdeviren, Canan Dauskardt, Reinhold H. Di, Chong-an Dickey, Michael D. Duan, Xiangfeng Facchetti, Antonio Fan, Zhiyong Fang, Yin Feng, Jianyou Feng, Xue Gao, Huajian Gao, Wei Gong, Xiwen Guo, Chuan Fei Guo, Xiaojun Hartel, Martin C. He, Zihan Ho, John S. Hu, Youfan Huang, Qiyao Huang, Yu Huo, Fengwei Hussain, Muhammad M. Javey, Ali Jeong, Unyong Jiang, Chen Jiang, Xingyu Kang, Jiheong Karnaushenko, Daniil Khademhosseini, Ali Kim, Dae-Hyeong Kim, Il-Doo Kireev, Dmitry Kong, Lingxuan Lee, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Li, Fengyu Li, Jinxing Liang, Cuiyuan Lim, Chwee Teck Lin, Yuanjing Lipomi, Darren J. Liu, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Loh, Xian Jun Lu, Nanshu Lv, Zhisheng Magdassi, Shlomo Malliaras, George G. Matsuhisa, Naoji Nathan, Arokia Niu, Simiao Pan, Jieming Pang, Changhyun Pei, Qibing Peng, Huisheng Qi, Dianpeng Ren, Huaying Rogers, John A. Rowe, Aaron Schmidt, Oliver G. Sekitani, Tsuyoshi Seo, Dae-Gyo Shen, Guozhen Sheng, Xing Shi, Qiongfeng Someya, Takao Song, Yanlin Stavrinidou, Eleni Su, Meng Sun, Xuemei Takei, Kuniharu Tao, Xiao-Ming Tee, Benjamin C. K. Thean, Aaron Voon-Yew Trung, Tran Quang Wan, Changjin Wang, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Weiss, Paul S. Wen, Hanqi Xu, Sheng Xu, Tailin Yan, Hongping Yan, Xuzhou Yang, Hui Yang, Le Yang, Shuaijian Yin, Lan Yu, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Zamburg, Evgeny Zhang, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhao, Siyuan Zhao, Xuanhe Zheng, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zhou, Tao Zhu, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zou, Guijin Chen, Xiaodong 08-03 Innovis Singapore 138634 Republic of Singapore Innovative Centre for Flexible Devices (iFLEX) School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Biomedical Engineering University of Houston Houston Texas 77024 United States School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea Department of Electrical and Computer Engineering The University of Texas at Austin Austin Texas 78712 United States Microelectronics Research Center The University of Texas at Austin Austin Texas 78758 United States Department of Chemistry and Biochemistry California NanoSystems Institute and Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior and Hatos Center for Neuropharmacology University of California Los Angeles Los Angeles California 90095 United States Colloid Chemistry Department Max Planck Institute of Colloids and Interfaces 14476 Potsdam Germany Department of Chemical Engineering Stanford University Stanford California 94305 United States Laboratory of Organic Electronics Department of Science and Technology Campus Norrköping Linköping University 83 Linköping Sweden Wallenberg Initiative Materials Science for Sustainability (WISE) and Wallenberg Wood Science Center (WWSC) SE-100 44 Stockholm Sweden Department of Materials Science and Engineering Stanford University Stanford California 94301 United States Department of Biomedical Engineering and Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Department of Bioengineering University of California Los Angeles Los Angeles California 90095 United States School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University Singapore 637457 Singapore Nanobionics Group Department of Chemical and Biological Engineering Monash University Clayton Australia 3800 Monash

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional rigid counterparts. Despite rapid advancement in bench-side research over the last decade, the market adoption of flexible sensors remains limited. To ease and to expedite their deployment, here, we identify bottlenecks hindering the maturation of flexible sensors and propose promising solutions. We first analyze continued...challenges in achieving satisfactory sensing performance for real-world applications and then summarize issues in compatible sensor-biology interfaces, followed by brief discussions on powering and connecting sensor networks. Issues en route to commercialization and for sustainable growth of the sector are also analyzed, highlighting environmental concerns and emphasizing nontechnical issues such as business, regulatory, and ethical considerations. Additionally, we look at future intelligent flexible sensors. In proposing a comprehensive roadmap, we hope to steer research efforts towards common goals and to guide coordinated development strategies from disparate communities. Through such collaborative

关键词： soft materials mechanics engineering flexible electronics conformable sensors bioelectronics human-machine interfaces body area sensor networks technology translation sustainable electronics

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High-order mesh generation based on optimal affine combinations of nodal positions 12th

High-order mesh generation based on optimal affine combinati...

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12th International Conference on Spectral and High-Order Methods, ICOSAHOM 2018

作者： Stees, Mike Shontz, Suzanne M. Department of Electrical Engineering and Computer Science Information and Telecommunication Technology Center University of Kansas LawrenceKS United States Department of Electrical Engineering and Computer Science Bioengineering Program Information and Telecommunication Technology Center University of Kansas LawrenceKS United States

ISBN: (纸本)9783030396466

In this paper, we propose a new optimization-based method for high-order mesh generation. Our proposed method is based on affine combinations of nodal positions. For each interior node in the high-order straight-sided mesh, a set of weights that relates the node to its neighbors is calculated. After the high-order boundary nodes are curved to conform with the true boundary, the interior nodes are moved based on the generated weights and the new boundary positions. We present results from applying our method to several aerospace engineering geometries in 2D and 3D which demonstrate the capabilities of our method. © 2020, The Author(s).

关键词： Mesh generation

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