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International Journal of Particle Therapy 2024年 12卷

作者： Chao Wang Bowen Lin Yuting Lin Suzanne M. Shontz Weizhang Huang Ronald Chen Hao Gao Department Of Radiation Oncology University of Kansas Medical Center Kansas City United States of America Department Of Intervention Medicine The Second Hospital of Shandong University Jinan China Department Of Electrical Engineering And Computer Science Institute For Information Sciences Bioengineering Program University of Kansas Lawrence United States of America Department Of Mathematics University of Kansas Lawrence United States of America

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Dynamic optical contrast imaging for real-time delineation of tumor resection margins using head and neck cancer as a model

arXiv

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arXiv 2022年

作者： Hu, Yong Huang, Shan Han, Albert Y. Moon, Seong Krane, Jeffrey F. Stafsudd, Oscar Grundfest, Warren St. John, Maie A. Los AngelesCA United States Department of Bioengineering UCLA Los AngelesCA United States Department of Materials Science and Engineering UCLA Los AngelesCA United States UCLA Head and Neck Cancer Program UCLA Medical Center Los AngelesCA United States Jonsson Comprehensive Cancer Center UCLA Medical Center Los AngelesCA United States Department of Pathology & Laboratory Medicine UCLA Medical Center Los AngelesCA United States Department of Electrical and Computer Engineering UCLA Los AngelesCA United States

Complete surgical resection of the tumor for Head and neck squamous cell carcinoma (HNSCC) remains challenging, given the devastating side effects of aggressive surgery and the anatomic proximity to vital structures. To address the clinical challenges, we introduce a widefield, label-free imaging tool that can assist surgeons delineate tumor margins real-time. We assume that autofluorescence lifetime is a natural indicator of the health level of tissues, and ratio-metric measurement of the emission-decay state to the emission-peak state of excited fluorophores will enable rapid lifetime mapping of tissues. Here, we describe the principle, instrumentation, characterization of the imager and the intraoperative imaging of resected tissues from 13 patients undergoing head and neck cancer resection. 20 x 20 mm2 imaging takes 2 second/frame with a working distance of 50 mm, and characterization shows that the spatial resolution reached 70 μm and the least distinguishable fluorescence lifetime difference is 0.14 ns. Tissue imaging and Hematoxylin-Eosin stain slides comparison reveals its capability of delineating cancerous boundaries with submillimeter accuracy and a sensitivity of 91.86% and specificity of 84.38%. Copyright © 2022, The Authors. All rights reserved.

关键词： Tumors

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Spinal functional Magnetic Resonance Imaging (fMRI) on Human Studies: A Literature Review

Spinal functional Magnetic Resonance Imaging (fMRI) on Human...

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2019 Advances in science and Engineering Technology International Conferences, ASET 2019

作者： Al-Momani, Sajedah Dhou, Salam Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Computer Science and Engineering Biomedical Engineering Graduate Program Biosciences and Bioengineering Research Institute American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781538682715

Spinal functional Magnetic Resonance Imaging (fMRI) is a newly emerging non-invasive imaging technique that has been introduced to study the Blood Oxygenation Level Dependent (BOLD) changes in the spinal cord associated with a certain activity or even at rest. Spinal fMRI is also used to assess the treatment of many dysfunctions affect the spinal cord such as spinal cord injury (SCI) and Multiple sclerosis (MS). The purpose of this paper is to propose a literature review of spinal fMRI studies performed on healthy human volunteers. The studies reviewed are divided based on the paradigm being performed during image acquisition into (1) studies under activities and stimulus which are further classified according to the type of the stimuli, and (2) studies at resting state. Moreover, the limitations of spinal fMRI and how to tackle them are discussed. © 2019 IEEE.

关键词： Magnetic resonance imaging

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Review of Image-Guided Percutaneous Coronary Interventions

Review of Image-Guided Percutaneous Coronary Interventions

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2019 Advances in science and Engineering Technology International Conferences, ASET 2019

作者： Alatoom, Aseel Farhat, Jumana Dhou, Salam Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Computer Science and Engineering Biomedical Engineering Graduate Program Biosciences and Bioengineering Research Institute American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781538682715

Image-guided surgery (IGS) involves using surgical instruments tracking system to guide the surgeon during invasive surgical procedures. The use of preoperative or intraoperative images is very essential in providing navigation for different medical applications. In this paper, a literature review of different imaging modalities that aid in the diagnosis and treatment of coronary artery disease (CAD) is proposed. The imaging modalities discussed include x-ray fluoroscopy, coronary computed tomography angiography (CCTA), fractional flow reserve (FFR), cardiac single-photon emission computed tomography (SPECT), cardiovascular magnetic resonance imaging (CMRI) and ultrasound. Additionally, pseudoaneurysms, which can result from percutaneous coronary interventions (PCI) procedure, are reviewed as well as the treatment procedure. Finally, a comparison between the different imaging modalities is carried out, based on the number of papers that have been published, in addition to the sensitivity and specificity for each modality according to PubMed and Web of science databases. © 2019 IEEE.

关键词： Ultrasonics

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Author Correction: Dynamical flexible inference of nonlinear latent factors and structures in neural population activity

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Nature biomedical engineering 2025年第2期9卷 283页

作者： Hamidreza Abbaspourazad Eray Erturk Bijan Pesaran Maryam M Shanechi Ming Hsieh Department of Electrical and Computer Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. Departments of Neurosurgery Neuroscience and Bioengineering University of Pennsylvania Philadelphia PA USA. Ming Hsieh Department of Electrical and Computer Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. shanechi@usc.edu. Thomas Lord Department of Computer Science Alfred E. Mann Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los Angeles CA USA. shanechi@usc.edu.

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Direct stimulation of somatosensory cortex results in slower reaction times compared to peripheral touch in humans (vol 9, 3292, 2019)

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SCIENTIFIC REPORTS 2019年第1期9卷 1-11页

作者： Caldwell, David J. Cronin, Jeneva A. Wu, Jing Weaver, Kurt E. Ko, Andrew L. Rao, Rajesh P. N. Ojemann, Jeffrey G. Department of Bioengineering University of Washington Seattle USA. djcald@uw.edu. Medical Scientist Training Program University of Washington Seattle USA. djcald@uw.edu. National Science Foundation Center for Neurotechnology Seattle USA. djcald@uw.edu. Department of Bioengineering University of Washington Seattle USA. jcronin@uw.edu. National Science Foundation Center for Neurotechnology Seattle USA. jcronin@uw.edu. Department of Bioengineering University of Washington Seattle USA. National Science Foundation Center for Neurotechnology Seattle USA. Department of Radiology University of Washington Seattle USA. Department of Neurological Surgery University of Washington Seattle USA. Department of Computer Science and Engineering University of Washington Seattle USA.

Direct cortical stimulation (DCS) of primary somatosensory cortex (S1) could help restore sensation and provide task-relevant feedback in a neuroprosthesis. However, the psychophysics of S1 DCS is poorly studied, including any comparison to cutaneous haptic stimulation. We compare the response times to DCS of human hand somatosensory cortex through electrocorticographic grids with response times to haptic stimuli delivered to the hand in four subjects. We found that subjects respond significantly slower to S1 DCS than to natural, haptic stimuli for a range of DCS train durations. Median response times for haptic stimulation varied from 198 ms to 313 ms, while median responses to reliably perceived DCS ranged from 254 ms for one subject, all the way to 528 ms for another. We discern no significant impact of learning or habituation through the analysis of blocked trials, and find no significant impact of cortical stimulation train duration on response times. Our results provide a realistic set of expectations for latencies with somatosensory DCS feedback for future neuroprosthetic applications and motivate the study of neural mechanisms underlying human perception of somatosensation via DCS.

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In vivo imaging with a flat, lensless microscope

Research Square

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Research Square 2021年

作者： Adams, Jesse K. Yan, Dong Wu, Jimin Boominathan, Vivek Gao, Sibo Rodriguez, Alex V. Carns, Jennifer Richards-Kortum, Rebecca Kemere, Caleb Veeraraghavan, Ashok Robinson, Jacob T. Applied Physics Program Rice University 6100 Main Street HoustonTX77005 United States Department of Electrical and Computer Engineering Rice University 6100 Main Street HoustonTX77005 United States Department of Neuroscience Baylor College of Medicine One Baylor Plaza HoustonTX77030 United States Department of Bioengineering Rice University 6100 Main Street HoustonTX77005 United States Department of Computer Science Rice University 6100 Main Street HoustonTX77005 United States

Lenless microscopes that form images using simple, compact optics, along with associated computational algorithms provide several advantages: small, inexpensive form factors, large fields of view (FOV), and the ability to refocus an image after capture. To date, however, lensless microscopy has yet to be demonstrated for in vivo biological imaging. The primary challenge with in vivo bio-imaging is these dense, low-contrast scenes cannot be accurately reconstructed with existing lensless techniques. To overcome this challenge, we designed an optical phase mask that creates a point-spread function consisting of high-contrast contours with a broad spatial frequency spectrum. Here we show that this "contour" phase mask enables in vivo imaging where previous lensless imaging technologies have failed. As a proof of concept, we demonstrate 3D imaging of a behaving invertebrate, functional calcium imaging in mouse cortex, and in vivo imaging of microvasculature in the human oral mucosa. Together these results demonstrate the ability of lensless imaging to operate in realistic biological imaging applications ranging from pre-clinical animal models to clinical biomedical imaging. Overall, this "Bio-FlatScope" is a clinically relevant imaging technique with advantages of 3D computational refocusing in a low-cost, small form factor that is useful for low-resource settings and difficult-to-reach areas of the body. © 2021, CC BY.

关键词： Microscopes

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Learn How to Design High-Quality Qualitative Educational Research! – A Workshop for Disciplinary STEM Faculty by Disciplinary STEM Faculty

Learn How to Design High-Quality Qualitative Educational Res...

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Frontiers in Education (FIE) Conference

作者： John R. Morelock Michelle Jarvie-Eggart Heather Chenette Sara Hooshangi Betsy Chestnutt Sarah Wilson Azadeh Bolhari Kirsten Dodson Iglika Pavlova Rebecca Reck Engineering Education Transformations Institute University of Georgia Athens GA USA Engineering Fundamentals Michigan Technological University Houghton MI USA Chemical Engineering Rose-Hulman Institute of Technology Terre Haute IN USA Computer Science - Northern Virginia Center Virginia Tech Washington D.C. USA Engineering Fundamentals University of Tennessee Knoxville Knoxville TN USA Chemical Engineering University of Kentucky Lexington KY USA Environmental Engineering Program University of Colorado Boulder Boulder CO USA Mechanical Engineering Lipscomb University Nashville TN USA Department of Biology University of North Carolina Greensboro Greensboro NC USA Bioengineering University of Illinois Urbana-Champaign Champaign IL USA

The purpose of this workshop-designed for instructional and disciplinary STEM faculty interested in learning about qualitative research-is to (1) introduce participants to high-quality qualitative research design and (2) practice this design process alongside disciplinary STEM faculty to expand their STEM education research abilities and network. We will do so using the ProQual approach, a methodologically unencumbered and widely accessible way of thinking about qualitative research design that was deployed and refined over the last three years as part of the NSF-funded ProQual Institute for Research Methods [1]. This workshop will be conducted by ProQual Institute alumni, who are culturally sensitive to the challenges faced by disciplinary STEM faculty. Leveraging a propagation model of effecting academic change [2], the workshop leaders will serve as a community of practice to help participants move their educational research ideas forward during and after the workshop. In doing so, we strive to further FIE's mission to create a collaborative, supportive, and inclusive community of educational researchers.

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A PARALLEL VARIATIONAL MESH QUALITY IMPROVEMENT METHOD FOR TETRAHEDRAL MESHES 28

A PARALLEL VARIATIONAL MESH QUALITY IMPROVEMENT METHOD FOR T...

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28th International Meshing Roundtable, IMR 2019

作者： Shontz, Suzanne M. Varilla, M.A.L. Huang, Weizhang Department of Electrical Engineering and Computer Science Bioengineering Program Information and Telecommunication Technology Center University of Kansas LawrenceKS United States Husky Injection Molding Systems Ltd. Luxembourg Luxembourg Department of Mathematics University of Kansas LawrenceKS United States

ISBN: (纸本)9781733489003

There are numerous large-scale applications requiring mesh adaptivity, e.g., computational uid dynamics and weather prediction. Parallel processing is needed for simulations involving large-scale adaptive meshes. In this paper, we propose a parallel variational mesh quality improvement algorithm for use with distributed memory machines. Our method parallelizes the serial variational mesh quality improvement method by Huang and Kamenski. Their approach is based on the use of the Moving Mesh PDE method to adapt the mesh based on the minimization of an energy functional for mesh equidistribution and alignment. This leads to a system of ordinary differential equations (ODEs) to be solved which determine where to move the interior mesh nodes. An efficient solution is obtained by solving the ODEs on subregions of the mesh with overlapped communication and computation. Strong and weak scaling experiments on up to 128 cores for meshes with up to 160M elements demonstrate excellent results. © 2019 Proceedings of the 28th International Meshing Roundtable, IMR 2019. All rights reserved.

关键词： Ordinary differential equations

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Deep learning-based super-resolution and image transformation into structured illumination microscopy

Deep learning-based super-resolution and image transformatio...

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Microscopy Histopathology and Analytics, Microscopy 2020

作者： Wang, Hongda Rivenson, Yair Jin, Yiyin Wei, Zhensong Gao, Ronald Günaydin, Harun Bentolila, Laurent A. Kural, Comert Ozcan, Aydogan Electrical and Computer Engineering Department University of California Los AngelesCA90095 United States Bioengineering Department University of California Los AngelesCA90095 United States California NanoSystems Institute University of California Los AngelesCA90095 United States Computer Science Department University of California Los AngelesCA90095 United States Department of Chemistry and Biochemistry University of California Los AngelesCA90095 United States Department of Physics Ohio State University ColumbusOH43210 United States Biophysics Graduate Program Ohio State University ColumbusOH43210 United States Department of Surgery David Geffen School of Medicine University of California Los AngelesCA90095 United States

We demonstrate single-image super-resolution in fluorescence microscopy using a trained neural-network, matching the resolution of structured illumination microscopy (SIM). This performance is achieved without any par... 详细信息

ISBN: (纸本)9781943580743

关键词： Fluorescence microscopy

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