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3rd International Congress of Biomedical engineering and bioengineering, CIIBBI 2024

作者： Baquero Silva, Laura Sofia Garzon Garzon, Maria Alejandra Vega-Medina, Lizeth Luengas, Carlos Paez Universidad El Bosque Faculty of Engineering Bioengineering Program Bogotá Colombia Universidad El Bosque Osiris and Bioaxis Bioengineering Program Bogotá Colombia Bogotá Colombia

ISBN: (纸本)9798331532352

Cataracts are a frequent cause of blindness in canines, and their timely diagnosis and treatment are crucial to preserve the animal's quality of life. Although surgery is the primary treatment, its success depends on the surgeon's skill;the extracapsular extraction technique, one of the most commonly used, presents intraoperative complications since cadaver training does not adequately replicate the ocular biomechanical properties. A simulator prototype has been developed for the training of this technique, which allows realistic practices and improves professional competence. The development involved the characterization of the eye and the surgical technique using a bibliographic and experimental review, as well as a biomechanical analysis of the eye considering the forces generated by the extraocular muscles and the force required for the initial incision in the sclera (2.36 N), which an electronic system will measure during the procedure. In the design stage, CAD tools, 3D printing, and casting techniques were used to obtain the parts that simulate the tissues, the mesocephalic head of the canine, and strain gauges were used to measure the force set using a Wheatstone bridge. A first evaluation showed improvements in terms of size and arrangement of the interchangeable parts. © 2024 IEEE.

关键词： Transplantation (surgical)

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Design and Development of a System to Wake Up People with Hearing Loss Based on Biodesign Methodology 3

Design and Development of a System to Wake Up People with He...

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3rd International Congress of Biomedical engineering and bioengineering, CIIBBI 2024

作者： Camacho-Nino, Natalia Charry-Retavizca, Martin F. Cordoba-Fernandez, Guillermo Rodriguez-Duenas, William R. Pontificia Universidad Javeriana Bioengineering Program Faculty of Engineering Bogota110231 Colombia

ISBN: (纸本)9798331532352

Hearing loss represents 20% of the world's population, while in Colombia this condition reaches the 1,2%. It is a condition in which activities of daily living, such as waking up in the morning, can become a challenge. Some technologies have been implemented but difficulties such as the adaptability of the equipment, comfort regarding device design and effectiveness of the technology to wake the user remain in its use. Part of the success in the use of these technologies lies in a good needs identification stage, as is recommended for the Biodesign framework, a methodology to design and build health technologies. This work presents the design and development of an alternative system for the comfortable awakening of people with hearing loss, using the Biodesign methodology. The system obtained includes a tabletop device and a wireless portable instrument, with visual and tactile stimulation respectively. Preliminary results obtained show that the system is viable, and responds to basic needs identified. © 2024 IEEE.

关键词： Audition

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Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient

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Microsystems & Nanoengineering 2023年第1期9卷 191-202页

作者： Kai Duan Mengyang Zhou Yong Wang Jose Oberholzer Joe F.Lo Department of Mechanical Engineering Bioengineering ProgramUniversity of Michigan at DearbornDearbornMI48128USA Department of Surgery/Transplant University of VirginiaCharlottesvilleVA22908USA

One distinct advantage of microfluidic-based cell assays is their scalability for multiple concentrations or *** scaling can be extremely powerful when combining multiple parameters and ***,in situ stimulation and detection eliminates variability between individual ***,conventional microfluidics must combat diffusion,which limits the spatial distance and time for molecules traveling through ***,we leveraged a multilayered microfluidic approach to integrate a novel oxygen gradient(0–20%)with an enhanced hydrogel sensor to study pancreatic beta *** enabled our microfluidics to achieve spatiotemporal detection that is difficult to achieve with traditional *** this device,we demonstrated the in situ detection of calcium,insulin,and ATP(adenosine triphosphate)in response to glucose and oxygen ***,insulin was quantified at levels as low as 25 pg/mL using our imaging ***,by analyzing the spatial detection data dynamically over time,we uncovered a new relationship between oxygen and beta cell *** observed an optimum oxygen level between 10 and 12%,which is neither hypoxic nor normoxic in the conventional cell culture *** results provide evidence to support the current islet oscillator *** future applications,this spatial microfluidic technique can be adapted for discrete protein detection in a robust platform to study numerous oxygen-dependent tissue dysfunctions.

关键词： hypoxic stimulation gradient

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Micro-electrode array (MEA) electrophysiological signal analysis by descriptive stochastic tests of the probability density structure

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Research on Biomedical engineering 2025年第2期41卷 1-13页

作者： Faria, Vinícius Naves Rezende Ramos, Marina Abadia Martinoia, Sérgio Destro-Filho, João-Batista Postgraduate Program in Electrical Engineering Universidade Federal de MG Uberlândia Brazil Postgraduate Program in Biomedical Sciences Universidade Federal de MG Uberlândia Brazil Division of Informatics Bioengineering Robotics and System Engineering Università Degli Studi Di Genova Genova Italy

Purpose: The primary objective of this study is to present, analyze, and quantitatively characterize the electrical signals obtained from neuronal cultures coupled to micro-electrode arrays (MEAs). Special attention is given to the temporal evolution of electrical activity across distinct geometric regions of the MEA devices. Methods: The proposed methodology involves signal acquisition, classical analysis based on spike and burst detection, and, critically, the characterization of the probability density structure of the signals. This is achieved through the quantification of Gaussianity—expressed as the percentage of segments non-Gaussian (PSNG)—and stationarity— expressed as the percentage of segments non-stationary (PSNE). Results: Initial analyses showed that first-order power spectral density quantifiers lacked the statistical robustness required to effectively describe the complex components of MEA signals. In contrast, PSNG and PSNE demonstrated strong potential in capturing the different stages of neuronal culture development. Cluster analysis further supported the discriminative capacity of these quantifiers. Conclusion: The phase corresponding to decreased neuronal activity and onset of cell death—a biologically critical stage—exhibited the strongest correlation among the studied variables. These results suggest a discernible biological organization and highlight the relevance of PSNG and PSNE as promising tools for assessing neuronal culture dynamics. © The Author(s), under exclusive licence to The Brazilian Society of Biomedical engineering 2025.

关键词： Cell death

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Phasor-FSTM:a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing

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Light(Science & Applications) 2025年第1期14卷 258-270页

作者： Luwei Wang Yue Chen Jiaqing Guo Xiaoyu Weng Wei Yan Jun Song Tong Ye Junle Qu Center for Biomedical Optics and Photonics&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen518060China The Photonics Center of Shenzhen University Shenzhen UniversityShenzhen518060China Department of Bioengineering CU-MUSC Bioengineering ProgramClemson UniversityCharlestonSouth Carolina29634USA

Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular *** methods have individually transformed cellular imaging by allowing detailed visualization of cellular and subcellular structures,as well as organelle ***,integrating multicolor and super-resolution microscopy into a single method remains challenging due to issues like spectral overlap,crosstalk,photobleaching,phototoxicity,and technical *** challenges arise from the conflicting requirements of using different fluorophores for multicolor labeling and fluorophores with specific properties for super-resolution *** propose a novel multicolor super-resolution imaging method called phasor-based fluorescence spatiotemporal modulation(Phasor-FSTM).This method uses time-resolved detection to acquire spatiotemporal data from encoded photons,employs phasor analysis to simultaneously separate multiple components,and applies fluorescence modulation to create super-resolution ***-FSTM enables the identification of multiple structural components with greater spatial accuracy on an enhanced laser scanning confocal microscope using a single-wavelength *** demonstrate the capabilities of Phasor-FSTM,we performed two-color to four-color super-resolution imaging at a resolution of~λ/5 and observed the interactions of organelles in live cells during continuous imaging for a duration of over 20 *** method stands out for its simplicity and adaptability,seamlessly fitting into existing laser scanning microscopes without requiring multiple laser lines for excitation,which also provides a new avenue for other super-resolution imaging technologies based on different principles to build multi-color imaging systems with the requirement of a lower budget.

关键词： resolution lifetime simplicity

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Recent advances on the systems metabolically engineered Pseudomonas species as versatile biosynthetic platforms for the production of polyhydroxyalkanoates

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Systems Microbiology and Biomanufacturing 2024年第2期4卷 473-499页

作者： Hye Min Song Seo Young Jo Haeyoung Lee Subeen Jeon Dohye Yun Chaerin Kim Jina Son Yu Jung Sohn Jong-Il Choi Si Jae Park Department of Chemical Engineering and Materials Science Graduate Program in System Health Science and EngineeringEwha Womans UniversitySeoul 03760Republic of Korea Department of Biotechnology and Bioengineering Chonnam National UniversityGwangju 61186Republic of Korea

Pseudomonas *** been considered one of the most promising microbial platform strains due to its versatile metabolism,enabling the valorization of waste materials into value-added chemical *** the native producer of polyhydroxyal-kanoates(PHAs),the biodegradable biopolyesters,it has been widely engineered by various metabolic engineering tools for the production of PHAs composed of short-chain-length and medium-chain-length monomers with adjustable composition from diverse carbon sources,ranging from pure sugars to crude oils and fatty *** review discusses the feasibility of Pseudomonas *** the industrial host strain and the recent advances regarding the systems metabolic engineering strategies for PHAs production in Pseudomonas sp.

关键词： Pseudomonas sp. Polyhydroxyalkanoates Systems metabolic engineering Synthetic biology Fermentation

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Single-photon emission from colloidal perovskite nanocrystals

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National Science Review 2025年第5期12卷 10-14页

作者： Qingsen Zeng Shinyoung Hwang Hyeree Kim Tae-Woo Lee Department of Materials Science and Engineering Seoul National University Research Institute of Advanced Materials Seoul National University Interdisciplinary Program in Bioengineering Seoul National University SN Display Co.Ltd Institute of Engineering Research Soft Foundry Research Institute of Advanced Materials Seoul National University

A single-photon source (SPS) is a device that emits individual photons sequentially. SPSs are fundamental to the progress of quantum information technologies, in which photons convey quantum information. Photons have properties such as polarization, and spatial and temporal modes, which can be used to encode quantum information.

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In vivo tumor ultrasound-switchable fluorescence imaging via intravenous injections of size-controlled thermosensitive nanoparticles

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Nano Research 2023年第1期16卷 1009-1020页

作者： Liqin Ren Yang Liu Tingfeng Yao Kytai TNguyen Baohong Yuan Ultrasound and Optical Imaging Laboratory Department of Bioengineeringthe University of Texas at ArlingtonArlingtonTX 76019USA Joint Biomedical Engineering Program the University of Texas at Arlington and the University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Bioengineering the University of Texas at ArlingtonArlingtonTX 76019USA

Near-infrared fluorescence imaging has emerged as a noninvasive,inexpensive,and ionizing-radiation-free monitoring tool for assessing tumor growth and treatment *** particular,ultrasound switchable fluorescence(USF)imaging has been explored with improved imaging sensitivity and spatial resolution in centimeter-deep *** study achieved the size control of polymer-based and indocyanine green(ICG)encapsulated USF contrast agents,capable of accumulating in the tumor after intravenous *** nanoprobes varied in size from 58 to 321 *** bioimaging profiles demonstrated that the proposed nanoparticles can efficiently eliminate the background light from normal tissue and show a tumor-specific fluorescence enhancement in the BxPC-3 tumor-bearing mice models possibly via the enhanced permeability and retention *** vivo tumor USF imaging further demonstrated that these nanoprobes can effectively be switched“ON”with enhanced fluorescence in response to a focused ultrasound stimulation in the tumor microenvironment,contributing to the high-resolution USF ***,our findings suggest that ICG-encapsulated nanoparticles are good candidates for USF imaging of tumors in live animals,indicating their great potential in optical tumor imaging in deep tissue.

关键词： in vivo tumor imaging deep tissue near-infrared(NIR)imaging high resolution ultrasound-switchable fluorescence imaging indocyanine green(ICG)

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

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Bioactive Materials 2024年第10期40卷 582-596页

作者： Wonmoon Song Young Hwan Choi Young Gi Moon Changyub Lee M.Nivedhitha Sundaram Nathaniel S.Hwang School of Chemical and Biological Engineering Institute for Chemical ProcessesSeoul National UniversitySeoul08826Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul08826Republic of Korea Bio-MAX/N-Bio Institute Institute of BioEngineeringSeoul National UniversitySeoul08826Republic of Korea Division of Pediatric Cardiac Surgery Department of SurgeryJohns Hopkins School of MedicineBaltimoreMDUSA Institute of Engineering Research Seoul National UniversitySeoul08826Republic of Korea

Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma,manifest in diverse types and locations. Although numerous wound dressings are available for various woundscenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse woundsituations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties andcapacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantagesin wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecularweighthyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging thatcould synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy inthree distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively,these findings underscore the potential of the sHA-CA patch as a promising candidate for the nextgenerationwound dressing.

关键词： Adhesive patch Anti-inflammation Sulfated hyaluronic acid Post-surgical adhesion Diabetic wound Hemostasis

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