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arXiv 2024年

作者： Ozturk, Caglar Pak, Daniel H. Rosalia, Luca Goswami, Debkalpa Robakowski, Mary E. McKay, Raymond Nguyen, Christopher T. Duncan, James S. Roche, Ellen T. Institute for Medical Engineering and Science Massachusetts Institute of Technology CambridgeMA United States Bioengineering Science Research Group School of Engineering University of Southampton Southampton United Kingdom Department of Biomedical Engineering Yale University New HavenCT United States Health Sciences and Technology Program Harvard–Massachusetts Institute of Technology CambridgeMA United States Cardiovascular Innovation Research Center Heart Vascular & Thoracic Institute Cleveland Clinic ClevelandOH United States Department of Cardiovascular Medicine Heart Vascular & Thoracic Institute Cleveland Clinic ClevelandOH United States Department of Chemical and Biomedical Engineering Cleveland State University ClevelandOH United States Interventional Cardiology Hartford Hospital HartfordCT United States Department of Mechanical Engineering Massachusetts Institute of Technology CambridgeMA United States

Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However, their use is currently limited by complex workflows necessitating lengthy expert-driven manual operations. Here, we propose an AI-powered computational framework for accelerated and democratized patient-specific modeling of AS hemodynamics from computed tomography. First, we demonstrate that our automated meshing algorithms can generate task-ready geometries for both computational and benchtop simulations with higher accuracy and 100 times faster than existing approaches. Then, we show that our approach can be integrated with fluid-structure interaction and soft robotics models to accurately recapitulate a broad spectrum of clinical hemodynamic measurements of diverse AS patients. The efficiency and reliability of these algorithms make them an ideal complementary tool for personalized high-fidelity modeling of AS biomechanics, hemodynamics, and treatment planning. Copyright © 2024, The Authors. All rights reserved.

关键词： Computational fluid dynamics

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Multimodal Spatial Attention Network for Automatic Head and Neck Tumor Segmentation in FDG-PET and CT Images 1

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2nd 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2021, held in conjunction with 24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021

作者： Cho, Minjeong Choi, Yujin Hwang, Donghwi Yie, Si Young Kim, Hanvit Lee, Jae Sung School of Electrical and Electronics Engineering Chung-Ang University Seoul06974 Korea Republic of Department of Biomedical Engineering Kyunghee University College of Electronics and Information 1732 Deogyeong-daero Giheung-gu Gyeonggi-do Yongin-si Korea Republic of Department of Nuclear Medicine Seoul National University College of Medicine Seoul03080 Korea Republic of Department of Biomedical Sciences Seoul National University College of Medicine Seoul03080 Korea Republic of Interdisciplinary Program in Bioengineering Seoul National University Graduate School Seoul Korea Republic of Integrated Major in Innovative Medical Science Seoul National University Graduate School Seoul Korea Republic of Ulsan Korea Republic of Artificial Intelligence Institute Seoul National University Seoul08826 Korea Republic of Brightonix Imaging Inc. Seoul04782 Korea Republic of

ISBN: (数字)9783030982539

ISBN: (纸本)9783030982522

Quantitative positron emission tomography/computed tomography (PET/CT), owing to the functional metabolic information and anatomical information of the human body that it presents, is useful to achieve accurate tumor delineation. However, manual annotation of a Volume Of Interest (VOI) is a labor-intensive and time-consuming task. In this study, we automatically segmented the Head and Neck (H&N) primary tumor in combined PET/CT images. Herein, we propose a convolutional neural network named Multimodal Spatial Attention Network (MSA-Net), supplemented with a Spatial Attention Module (SAM), which uses a PET image as an input. We evaluated this model on the MICCAI 2021 HEad and neCK TumOR (HECKTOR) segmentation challenge dataset. Our method delivered a competitive cross-validation efficiency, with Dice Similarity Coefficient (DSC) 0.757, precision 0.788, and recall 0.785. When we tested out method on test dataset, we achieved an average DSC and Hausdorff Distance at 95% (HD95) of 0.766 and 3.155 respectively. Our team name is ‘Heck_Uihak’. © 2022, Springer Nature Switzerland AG.

关键词： Tumors

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A Volatile Organic Compound Free Unibody Triboelectric Nanogenerator and its Application as a Smart Green Track

SSRN

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SSRN 2022年

作者： Wu, Wenjie Wen, Shipeng Wei, Yi Ruan, Lu Li, Fanzhu Cao, Xia Wang, Zhong Lin Zhang, Liqun Center of Advanced Elastomer Materials State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing100029 China Engineering Research Center of Ministry of Education on Energy and Resource Saved Elastomers Beijing University of Chemical Technology Beijing100029 China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing100140 China Research Center for Bioengineering and Sensing Technology Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological engineering Beijing Municipal Key Laboratory of New Energy Materials and Technologies University of Science and Technology Beijing Beijing100083 China School of Material Science and Engineering Georgia Institute of Technology AtlantaGA30332-0245 United States

Exercise not only builds up one’s health but also reduces the risk of developing diseases including type 2 diabetes, cancer, and cardiovascular diseases. Being one of the most classic and popular sports, track and field will does harm to one’s knees if not enough buffering is provided by the track. In a world that is urgently calling for environmental protection while steadily embracing the internet of things, environment-friendliness and smartness should also be taken into consideration when designing an optimized track. Hitherto most of the tracks are made of in-situ casted polyurethane (PU) and prefabricated ethylene propylene diene monomer (EPDM), which leads to emission of volatile organic compounds (VOCs) including polycyclic aromatic, hydrocarbons (PAHs), phthalates etc. In the meantime, intelligentization is seldom taken in consideration when designing and fabricating a track. Herein, we introduce an unibody silicone rubber-based track featured by adequate buffering providing, environment-friendliness, energy harvesting and sensing with an expected service life longer than 50 years. We also established a finite element model of the track to assess its deformation and energy dissipation capabilities. This track can work as a triboelectric nanogenerator (TENG) whose current density is 703 nC/cm 2, serving as both an electric generator and a gait sensor. It will give guidance to development of unibody TENG and open a new avenue for the next generation of self-powered smart track. © 2022, The Authors. All rights reserved.

关键词： Volatile organic compounds

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Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microcatheter for Transarterial Chemoembolization of Liver Cancer

Multimaterial 3D Nanoprinting of a 2 Fr Soft Robotic Microca...

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IEEE International Conference on Soft Robotics (RoboSoft)

作者： Bailey M. Felix Jordi T. Andreou Sarah McHugh Jack E. McCann Olivia M. Young Molly A. Carton Dheeraj Gandhi Miroslaw Janowski Mark Fuge Axel Kreiger Clifford R. Weiss Christopher R. Bailey Ryan D. Sochol Fischell Department of Bioengineering University of Maryland College Park MD USA Department of Mechanical Engineering University of Maryland College Park MD USA Department of Diagnostic Radiology and Nuclear Medicine Program in Image Guided Neurointerventions University of Maryland School of Medicine Baltimore MD USA Department of Mechanical Engineering ETH Zurich Zurich Switzerland Department of Mechanical Engineering Johns Hopkins University Baltimore MD USA The Russell H. Morgan Department of Radiology and Radiological Science Division of Vascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore MD USA Maryland Robotics Center University of Maryland College Park MD USA Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD USA

ISBN: (数字)9798331520205

ISBN: (纸本)9798331520212

Transarterial chemoembolization (TACE)—i.e., the delivery of chemotherapeutics directly into the vasculature of liver tumors—necessitates the use of guidewire-microcatheter systems to navigate tortuous vascular networks. These guide-wires and microcatheters typically lack effective steering controls, making successful navigation through geometrically complex anatomy challenging. Recent advancements in the area of soft microrobotics could offer a pathway to remotely steerable microcatheters at size scales relevant to TACE procedures; however, the difficulties associated with fabricating such systems have represented a critical hurdle. To overcome this barrier, here we present a multimaterial additive nanomanufacturing— or "three-dimensional (3D) nanoprinting"—strategy to achieve steerable soft robotic microcatheters that not only facilitate on-demand regulation of catheter tip deflection, but also comprise 2 French (Fr) outer dimensions (i.e., ⌀ = 666 μm) that are suitable for clinical chemoembolization of liver cancers. Specifically, we use "Two-Photon Direct Laser Writing (DLW)" to 3D nanoprint 1.5 mm-tall microcatheters capable of unidirectional tip bending of approximately 140° as well as mediating delivery of a fluidic payload. Experimental results for navigating the soft robotic microcatheter through a vascular phantom to deliver fluid payloads to target sites suggest the presented strategy holds promise for TACE as well as additional endovascular interventions and minimally invasive surgeries.

关键词： Liver cancer Actuators Navigation Deformation Phantoms Liver Soft robotics Bending Three-dimensional printing Payloads

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Effect of Surface Activation on the Corrosion Resistance of a MAO/Ni-P Composite Coating on LZ91 Magnesium Alloy

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Journal of the Taiwan Institute of Chemical Engineers 2023年第1期147卷

作者： Chen, Chi-An Lee, Jeou-Long Jian, Shun-Yi Lee, Chia-Yu Ger, Ming-Der Combination Medical Device Technology Division Medical Devices R&D Service Department Metal Industries Research & Development Centre Kaohsiung802 Taiwan Department of Chemical and Materials Engineering Lung Hwa University of Science and Technology Taoyuan330 Taiwan Department of Material Engineering Ming Chi University of Technology New Taipei City Taiwan Center for Plasma and Thin Film Technologies Ming Chi University of Technology New Taipei Taiwan Graduate School of Defense Science Chung Cheng Institute of Technology National Defense University Taoyuan Taiwan Department of Chemical & Materials Engineering Chung Cheng Institute of Technology National Defense University Taoyuan Taiwan System Engineering and Technology Program National Chiao Tung University Hsin-Chu Taiwan

Background: LZ91 Magnesium alloy with a dual-phase structure has improved mechanical properties and a low density of about 1.48 g/cm3 but their limited resistance to corrosion limits their application. Therefore, it is a great challenge to increase the stability of LZ91 alloys under corrosive factors and environments. Methods: This study uses micro-arc oxidation (MAO) and an electroless nickel-phosphorus (Ni-P) plated composite film to increase the corrosion resistance of LZ91 magnesium alloy. Before electroless Ni-P plating, the MAO layers are activated by palladium catalysts at different pH values to produce composite coatings. SEM, EDS and Image J are used to determine the surface properties and elemental composition of the samples. The corrosion resistance is measured using a potentiodynamic polarization test and electrochemical impedance spectroscopy (EIS) in 3.5 wt.% NaCl solution. Findings: The results show that the MAO coating is activated by an acid catalyst and the surface is obviously corroded. The electroless Ni-P plating grows into the MAO coating and the substrate corrodes. Therefore, corrosive medium (chloride ion) easily enter to the substrate and pitting corrosion occurred. On the contrary, activation by a neutral catalyst (pH=7) maintains the original structure of the MAO coating and provides a good bonding interface for the Ni-P coating. Form the potentiodynamic analysis can be finds that the corrosion potential for the neutral catalyst treated sample is -0.35V and the corrosion current density value is 1.77×10−6 A/cm2, so the corrosion characteristic become better than the acid catalyst treated samples. In terms of the long-term resistance after 48 h, EIS analysis shows that the resistance value remains at about 7.6×104 Ω•cm2. A composite coating that is compact and with excellent resistance to corrosion resistance is produced, which provides better protection for LZ91 magnesium alloys. © 2023 Taiwan Institute of Chemical Engineers

关键词： Corrosion resistance

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CuO NWs boosted triboelectric microfluidic nanosensor functionalized by collagen-protein interactions for real-time platelet count monitoring

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Chemical engineering Journal 2024年 490卷

作者： Lin, Jia-Cheng Kaswan, Kuldeep Chatterjee, Subhodeep Wu, Yu-Wen Kumar Sharma, Manish Ranjan, Ashok Roy Barman, Snigdha Lin, Yu-Zih Burnouf, Thierry Boireau, Wilfrid Lu, Ming-Yen Tu, Yong-Kwang Su, I-Chang Wu, Ping-Hsiu Lin, Zong-Hong Fan, Yu-Jui School of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Taipei Neuroscience Institute Taipei Medical University Taipei11031 Taiwan Department of Biomedical Engineering National Taiwan University Taipei11031 Taiwan International Intercollegiate PhD Program National Tsing Hua University Hsinchu30013 Taiwan Department of Power Mechanical Engineering National Tsing Hua University Hsinchu30013 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering Taipei Medical University Taipei11031 Taiwan Department of Material Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International PhD Program in Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Université de Franche-Comté CNRS Institut FEMTO-ST BesançonF-25030 France Department of Neurosurgery Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan Department of Surgery School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Radiology School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Radiation Oncology Taipei Medical University Hospital Taipei11031 Taiwan Center for Precision Health and Quantitative Sciences Taipei Medical University Hospital Taipei 11031 Taiwan

Blood platelet count significantly affects the development of severe conditions like myocardial infarction, peripheral arterial ischemia, respiratory compromise, stroke, diabetes, coronavirus disease 2019 (COVID-19), along with chemotherapy patients and those suffering cardiovascular diseases (CVDs). These conditions necessitate frequent monitoring of platelet counts to guide diagnostic and therapeutic decisions. However, existing techniques are relatively time-consuming, lack of accuracy and require precise operation. The emergence of these severe diseases underscored the need to develop advanced platelet count-monitoring techniques which are rapid, highly precise, and conveniently portable for point-of-care applications. In this study, we emphasized the development of a triboelectric microfluidic nanosensor (TMNS) for platelet quantification through the assessment of flow resistance. The functionality of TMNS device is based on immobilization of platelets on a collagen layer coated inside a microfluidic channel. The triboelectric voltage output is measured as a detection signal of the flow resistance and is enhanced by incorporating high surface area copper oxide nanowires (CuO NWs) on the interior of copper tubes. These copper tubes serve as terminal electrodes and for flow guiding. The flow resistance of plasma solutions is elevated when the platelet concentration increases due to heightened adherence of platelets onto the collagen layer. Variations in flow resistance induce alterations in contact electrification, causing changes in output voltage at load terminals. Fine-tuning of the TMNS device was achieved by optimizing the channel width and length, flowing liquid viscosity, and voltage measurement technique. Platelet quantification sensing data were acquired through the combination of platelet-rich plasma (PRP) and platelet-poor plasma (PPP) solutions. The described device exhibits promising capabilities for platelet-count monitoring in whole-blood samples c

关键词： Copper oxides

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Identification of a Reactive Ferrous Hydroxide in the Core-Shell Structure of Nano-Zero-Valent Iron by Mössbauer and X-Ray Photoelectron Spectroscopies

SSRN

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SSRN 2022年

作者： Ruby, Christian Abdelmoula, M. Mallet, M. Ghanbaja, Jaafar Coustel, R. Scudiero, Louis Wang, Wei-Jyun Université de Lorraine CNRS LCPME NancyF-54000 France Université de Lorraine CNRS IJL NancyF-54000 France Chemistry Department and Materials Science and Engineering Program Washington State University PullmanWA99164 United States The Gene and Linda Voiland School of Chemical Engineering and Bioengineering Washington State University PullmanWA99164 United States

Synthesized Fe@FeOx nanoparticles (NPs) were fully characterized by spectroscopic techniques and (scanning-)transmission electron microscopy to resolve the presence of iron hydroxide (Fe(OH)2). The different phases detected in the core-shell nanostructure of those nanoparticles were corroborated by Mössbauer and X-rays photoelectron spectroscopies. Metallic Fe0, Fe(OH)2, magnetite (FeIII2FeIIO4) and a top layer of ferric oxide were identified. Interestingly, Fe(OH)2 reacted with Pd2+aq upon coating of the supporting core-shell material with palladium to produce Fe@FeOx/Pd NPs. © 2022, The Authors. All rights reserved.

关键词： Shells (structures)

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Radiation tolerance study of scintillation properties with 6 MeV electron beam on inorganic scintillators

Radiation tolerance study of scintillation properties with 6...

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IEEE Symposium on Nuclear science (NSS/MIC)

作者： C. Park S. Kim J. Seo M. Alima H. Kim H. Park K. Lee S. Cho J.-Y. Yeom Global Health Technology Research Center Korea University Seongbuk-Gu Republic of Korea Interdisciplinary Program in Precision Public Health Korea University Seongbuk-Gu Republic of Korea Department of Health and Safety Convergence Science Korea University Seongbuk-Gu Republic of Korea Department of Bioengineering Korea University Seongbuk-Gu Republic of Korea Department of Radiation Oncology Chonnam National University Medical School Dong-Gu Republic of Korea School of Biomedical Engineering Korea University Seongbuk-Gu Republic of Korea

The radiation tolerance of several inorganic scintillators was investigated to ensure their reproducibility in electron beam exposure. LuAG:Pr, GPS:Ce, LYSO:Ce, GAGG:Ce single, and GAGG:Ce ceramic scintillators were prepared with all faces polished mechanically and thermally annealed. Electron beam exposures at 50, 100, 500, 1000, and 3000 Gy were conducted using a 6 MeV clinical electron beam from a Varian Novalis Tx linear accelerator with a 270-degree bending magnet. Energy spectra were acquired by exciting a 137 Cs source coupled to a photomultiplier tube (PMT) kept in the dark box with a biased high voltage of -900 V. The relative light output of GPS:Ce and LuAG:Pr compared to the baseline decreased steadily after electron beam exposure, recording 66.2% and 56.9%, respectively, at a dose of 3 kGy. The transmittance and photoluminescence of these scintillators also deteriorated with increasing crystallographic defects. In contrast, LYSO:Ce and GAGG:Ce scintillators demonstrated high tolerance to electron beams. Thermal annealing was shown to restore the scintillation properties of the degraded scintillators. These findings provide valuable insights into the radiation tolerance of inorganic scintillators and have implications for the design of radiation detectors for various applications, including radiation therapy and aerospace. Using inorganic scintillators in radiation therapy is particularly critical for estimating radiation exposure. The potential of these scintillators in aerospace applications will also be explored based on the promising results of this study.

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Data gap/outlier correction and treatment

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AIP Conference Proceedings 2024年第1期3034卷

作者： Juan Zuluaga Michael Castillo Divya Syal Andres Calle Navid Shaghaghi Ethical Pragmatic and Intelligent Computing (EPIC) Research Laboratory and the Healthcare Innovation and Design (HID) Program Departments of Computer Science and Engineering (CSEN) and Bioengineering (BIOE) of the School of Engineering (SoE) at Santa Clara University (SCU) in Santa Clara California USA

The prevalence of gaps and outliers within datasets presents substantial challenges, particularly in the realm of time series fore-casting and various other predictive machine learning (ML) tasks. This paper, introduces an effective technique for correcting gaps and outliers in data and validates the approach by applying it to datasets with outlier zones drawn from three diverse contexts. This innovative technique holds promising potential to enhance the performance of machine learning models by treating the data to alleviate the complications posed by these issues and in doing so contributes a valuable tool to the data science toolbox.

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Synergistic Effect of Fe Nanoparticles Supported on Nanoporous Carbon for Catalyzing Hydrogen Storage Properties of Mg(Bh4)2

SSRN

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SSRN 2023年

作者： Wahab, Md. Abdul Karim, Mohammad Rezaul Al-Mubaddel, Fahad S. Sindan, A. Will, Geoffrey Abdala, Ahmed Nanomaterials Centre Australian Institute for Bioengineering and Nanotechnology The University of Queensland St Lucia BrisbaneQLD4072 Australia Energy and Process Engineering Division School of Mechanical Medical and Process Engineering Science and Engineering Faculty Queensland University of Technology 2 George Street QLD4001 Australia Chemical Engineering Program Texas A and M University Education City Doha Qatar King Saud University Riyadh11421 Saudi Arabia K.A. CARE Energy Research and Innovation Center King Saud University Riyadh11451 Saudi Arabia Chemical Engineering Department King Saud University PO Box 800 Riyadh11421 Saudi Arabia

This study investigates synergistic effects of Fe nanoparticles (FeNPs) supported on mesoporous carbon (MC) for catalyzing hydrogen storage properties of Mg(BH4)2 (MBH). The study compares two methods for dispersing Fe NPs in MC: (i) ultrasonication nanoconfinement (un) and (ii) postnanoconfinement (pn) via stirring. Based on the results, it is found that the ultrasonication nanoconfinement method can effectively disperse the FeNPs with 5 nm in MC support (FeNP-unMC), later which can efficiently confine MBH (FeNP-un-MC@MBH system). The hydrogen (H2) desorption properties of the FeNP-un-MC@MBH system were found to be better than that of postconfinement-mediated FeNP-pn-MC@MBH system. For instance, H2 started to desorb from the FeNP-un-MC@MBH system at only 66°C (Tonset) and reached its peak at ~153°C, compared to 270°C (Tonset) and its peak ~350°C for pure MBH, respectively. The ultrasonication-mediated nanoconfined FeNP-un-MC@MBH system released a total of 7.01 wt% H2 within 90 minutes at 350°C. The study shows that the activation energy (Ea) of FeNP-un-MC@MBH is 19.57 kJ/mol, achieved due to the improved dehydrogenation kinetics of MBH. These improvements are due to the synergistic effects of nano-compartmentalization and highly dispersed Fe NP catalyst sites in the MC support. The research emphasizes the promising application of ultrasonication-mediated nanoconfined Fe NPs in mesoporous carbon which can be used as an effective catalyst for enhancing the hydrogen storage properties of metal-based hydrides (MBH). © 2023, The Authors. All rights reserved.

关键词： Hydrogen storage

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