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Phase-change metal ink with pH-controlled chemical sintering for versatile and scalable fabrication of variable stiffness electronics

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science advances 2025年第22期11卷 eadv4921页

作者： Simok Lee Gun-Hee Lee Inho Kang Woojin Jeon Semin Kim Yejin Ahn Choong Yeon Kim Do A Kwon Michael D Dickey Steve Park Seongjun Park Jae-Woong Jeong School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. Medical Research Center Seoul National University Seoul 03080 Republic of Korea. Departments of Cogno-Mechatronics Engineering and Optics and Mechatronics Engineering Pusan National University Busan 46241 Republic of Korea. Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Information and Electronics Research Institute Daejeon 34141 Republic of Korea. Research Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Chemical and Biomolecular Engineering North Carolina State University (NCSU) Raleigh NC 27606 USA. Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Institute for NanoCentury Daejeon 34141 Republic of Korea. Department of Biomedical Sciences College of Medicine Seoul National University Seoul 03080 Republic of Korea. School of Transdisciplinary Innovations Seoul National University Seoul 03080 Republic of Korea. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea. Department of Transdisciplinary Medicine Seoul National University Hospital Seoul 03080 Republic of Korea. KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea.

Variable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft electronics in a single system through dynamic mechanical modulation. While gallium's high modulus tuning ratio and rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, high surface tension, and unintended phase transitions during processing pose substantial challenges. Here, we introduce STiffness-Adjustable temperature-Responsive ink (STAR ink), a chemically sinterable gallium composite electronic ink designed to overcome these obstacles. STAR ink enables high-resolution (~50 micrometers) circuit patterning, large-scale batch fabrication, and three-dimensional structure coating at room temperature. Through pH-controlled chemical sintering, STAR ink-based TES exhibits exceptional mechanical tunability (tuning ratio: 1465) and electrical conductivity (2.27 × 10 siemens per meter). Demonstrated applications-from multilayered variable stiffness printed circuit boards (PCBs) matching standard PCBs' complexity to body-temperature responsive neural probe-underscore STAR ink's potential for reconfigurable electronics across consumer electronics and biomedical devices.

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Activatable NIR-II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery

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Angewandte Chemie 2023年第25期135卷

作者： Dr. Benhao Li Dr. Mengyao Zhao Weiping Lai Dr. Xuanbo Zhang Bowei Yang Prof. Xiaoyuan Chen Prof. Qianqian Ni Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Centre for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Contribution: Investigation (lead) Writing - original draft (lead) Contribution: Investigation (supporting) Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore 138673 Singapore Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (equal)

Endosomal escape remains a central issue limiting the high protein expression of mRNA therapeutics. Here, we present second near-infrared (NIR-II) lipid nanoparticles (LNPs) containing pH activatable NIR-II dye conjugated lipid (Cy-lipid) for potentiating mRNA delivery efficiency via a s timulus-responsive p hotothermal-promoted e ndosomal e scape d elivery (SPEED) strategy. In acidic endosomal microenvironment, Cy-lipid is protonated and turns on NIR-II absorption for light-to-heat transduction mediated by 1064 nm laser irradiation. Then, the heat-promoted LNPs morphology change triggers rapid escape of NIR-II LNPs from the endosome, allowing about 3-fold enhancement of enhanced green fluorescent protein (eGFP) encoding mRNA translation capacity compared to the NIR-II light free group. In addition, the bioluminescence intensity induced by delivered luciferase encoding mRNA in the mouse liver region shows positive correlation with incremental radiation dose, indicating the validity of the SPEED strategy.

关键词： Endosomal Escape Lipid Nanoparticle Photothermal Effect Second Near-Infrared Window

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Historical growth of concept networks in Wikipedia

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Collective Intelligence 2022年第2期1卷 26339137221109839页

作者： Harang Ju Dale Zhou Ann S Blevins David M Lydon-Staley Judith Kaplan Julio R Tuma Dani S Bassett Neuroscience Graduate Group University of Pennsylvania Philadelphia PA USA Department of Bioengineering School of Engineering & Applied Science University of Pennsylvania Philadelphia PA USA Annenberg School for Communication University of Pennsylvania Philadelphia PA USA Department of History and Sociology of Science College of Arts and Sciences University of Pennsylvania Philadelphia PA USA Integrated Studies Program College of Arts and Sciences University of Pennsylvania Philadelphia PA USA Integrated Studies Program College of Arts and Sciences University of Pennsylvania Philadelphia PA USA Department of Philosophy College of Arts and Sciences University of Pennsylvania Philadelphia PA USA Department of Electrical & Systems Engineering School of Engineering & Applied Science University of Pennsylvania Philadelphia PA USA Department of Physics & Astronomy College of Arts & Sciences University of Pennsylvania Philadelphia PA USA Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Psychiatry Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Santa Fe Institute Santa Fe NM USA

Philosophers of science have long questioned how collective scientific knowledge grows. Although disparate answers have been posited, empirical validation has been challenging due to limitations in collecting and systematizing large historical records. Here, we introduce new methods to analyze scientific knowledge formulated as a growing network of articles on Wikipedia and their hyperlinks. We demonstrate that in Wikipedia, concept networks in subdisciplines of science do not grow by expanding from their central core to reach an ancillary periphery. Instead, science concept networks in Wikipedia grow by creating and filling knowledge gaps. Notably, the process of gap formation and closure may be valued by the scientific community, as evidenced by the fact that it produces discoveries that are more frequently awarded Nobel prizes than other processes. To determine whether and how the gap process is interrupted by paradigm shifts, we operationalize a paradigm as a particular subdivision of scientific concepts into network modules. Hence, paradigm shifts are reconfigurations of those modules. The approach allows us to identify a temporal signature in structural stability across scientific subjects in Wikipedia. In a network formulation of scientific discovery, our findings suggest that data-driven conditions underlying scientific breakthroughs depend as much on exploring uncharted gaps as on exploiting existing disciplines and support policies that encourage new interdisciplinary research.

关键词： science of science networks philosophy of science Wikipedia cavity

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Modification of activated carbon with cationic surfactant for heavy metals removal

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AIP Conference Proceedings 2022年第1期2454卷

作者： Norhafieza Mohd Azmi Mazlan Mohamed Azwan Mat Lazim Mohamad Bashree Abu Bakar Sharizal Ahmad Sobri Mohamad Najmi Masri Ayub Ahmed Janvekar Hasnah Zakaria 1Advanced Material Research Cluster Faculty of Bioengineering and Technology Jeli Campus Universiti Malaysia Kelantan Jeli 17600 Malaysia 2School of Chemical Sciences and Food Technology Faculty of Science and Technology University Kebangsaan Malaysia 43600 Bangi Selangor Malaysia 3School of Mechanical Engineering VIT-Chennai Campus Chennai TN 600127 India 4I Medikel Pharmaceutical Sdn. Bhd Lot 153 Bangunan PKINK Cabang 3 Pengkalan Chepa 16100 Kota Bharu Kelantan Malaysia

Heavy metal presence in wastewater in particular fine particles poses a potential risk to the health of humans. The purpose of this experiment was to improve the adsorption method by modified activated carbon with cationic surfactant (CTAB) for the removal of different heavy metals such as zinc, copper, and chromium. CTAB provided more actives site in AC to increase the adsorption. Due to its highly effective ability to absorb, activated carbon used as an adsorbent to eliminate heavy metal and also an easy to handle and low-cost method. Modified activated carbon was mixed with a metal solution within different contact times. Then, the mixture was filtered to analyze the solution after adsorption. The samples were characterized by UV-Vis, SEM, XRD, FTIR, and BET to know the efficiency of modified activated carbon absorbed heavy metals. The characterization showed the formation of porosity in SEM analysis and the reduced surface area and pore volume in BET analysis. The adsorption test also indicated the improvement in the percentage of removal of heavy metal for modification of activated carbon and the removal of heavy metals have tendency in selective chromium as it has negative charges that react with positive charges of CTAB surfactant. The percentage of removal chromium increased from 57.15 % to 85.72%.

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Modification of activated carbon with anionic surfactant for dye removal

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AIP Conference Proceedings 2022年第1期2454卷

作者： Siti Fazniyati Fauzi Mazlan Mohamed Azwan Mat Lazim Mohamad Najmi Masri Sharizal Ahmad Sobri Mohd Hazim Mohamad Amini Ayub Ahmed Janvekar Hasnah Zakaria 1Advanced Material Research Cluster Faculty of Bioengineering and Technology Jeli Campus Universiti Malaysia Kelantan Jeli 17600 Malaysia 2School of Chemical Sciences and Food Technology Faculty of Science and Technology University Kebangsaan Malaysia 43600 Bangi Selangor Malaysia 3School of Mechanical Engineering VIT-Chennai Campus Chennai TN 600127 India 4I Medikel Pharmaceutical Sdn. Bhd Lot 153 Bangunan PKINK Cabang 3 Pengkalan Chepa 16100 Kota Bharu Kelantan Malaysia

This study aims to enhance the effect of activated carbon modified anionic surfactant due to the lack of functional group in order to extract specific pollutant. The characteristic of the adsorbent, activated carbon and modified activated carbon was analysed. The adsorbents were used for the removal of methylene blue, cationic dye from aqueous solution. For characterisation of the activated carbon and SLS-AC, Fourier transforms infrared (FTIR), Scanning Electron Microscope (SEM), X-ray diffractometer (XRD), and Brunauer–Emmett–Teller (BET) were used. The effect of the parameters such as contact time and temperature for adsorption using activated carbon and SLS-AC were investigated to estimate the effect of adsorption performance. The surface area for the activated carbon was 572.537 mg2/g while for the SLS-AC was respectively reduced to 221.732 mg2/g. The addition of SLS surfactant has exhibited higher adsorption percentage of dye removal due to the presence of the functional group on the surface area activated carbon. Besides, the effect of contact time for SLS-AC can achieve maximum percentage 48.9% after 15 minutes contact time with initial dye 0.1 M concentration. Figure 5, 84.4% MB was removed at 50°C, which was higher than the activated carbon 81.1 % removal. According to the results, SLS-AC has shown the characteristic for applications in the removal of organic compounds in wastewater.

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Analysis of a reduced model of epithelialmesenchymal fate determination in cancer metastasis as a singularly-perturbed monotone system

arXiv

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arXiv 2019年

作者： Al-Radhawi, M. Ali Sontag, Eduardo D. Departments of Bioengineering and Electrical and Computer Engineering Northeastern University 360 Huntington Avenue BostonMA02115 United States Laboratory of Systems Pharmacology Program in Therapeutic Science Harvard Medical School BostonMA02115

Tumor metastasis is one of the main factors responsible for the high fatality rate of cancer. Metastasis can occur after malignant cells transition from the epithelial phenotype to the mesenchymal phenotype. This transformation allows cells to migrate via the circulatory system and subsequently settle in distant organs after undergoing the reverse transition. The core gene regulatory network controlling these transitions consists of a system made up of coupled SNAIL/miRNA-34 and ZEB1/miRNA-200 subsystems. In this work, we formulate a mathematical model and analyze its long-term behavior. We start by developing a detailed reaction network with 24 state variables. Assuming fast promoter and mRNA kinetics, we then show how to reduce our model to a monotone four-dimensional system. For the reduced system, monotone dynamical systems theory can be used to prove generic convergence to the set of equilibria for all bounded trajectories. The theory does not apply to the full model, which is not monotone, but we briefly discuss results for singularly-perturbed monotone systems that provide a tool to extend convergence results from reduced to full systems, under appropriate time separation assumptions. Copyright © 2019, The Authors. All rights reserved.

关键词： Diseases

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Chiral Phonons with Giant Magnetic Moments in a Topological Crystalline Insulator

arXiv

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arXiv 2022年

作者： Hernandez, Felix G.G. Baydin, Andrey Chaudhary, Swati Tay, Fuyang Katayama, Ikufumi Takeda, Jun Nojiri, Hiroyuki Okazaki, Anderson K. Rappl, Paulo H.O. Abramof, Eduardo Rodriguez-Vega, Martin Fiete, Gregory A. Kono, Junichiro Instituto de Física Universidade de São Paulo SP São Paulo05508-090 Brazil Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics The University of Texas at Austin AustinTX78712 United States Department of Physics Northeastern University BostonMA02115 United States Department of Physics Massachusetts Institute of Technology CambridgeMA02139 United States Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics Graduate School of Engineering Science Yokohama National University Yokohama240-8501 Japan Institute for Materials Research Tohoku University Sendai980-8577 Japan Instituto Nacional de Pesquisas Espaciais SP São José dos Campos12201-970 Brazil Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Material Science and NanoEngineering Rice University HoustonTX77005 United States

We have studied the magnetic response of transverse optical phonons in Pb1−xSnxTe films. Polarization-dependent terahertz magnetospectroscopy measurements revealed Zeeman splittings and diamagnetic shifts, demonstrating that these phonon modes become chiral in magnetic fields. Films in the topological crystalline insulator phase (x > 0.32) exhibited magnetic moment values that are larger than those for topologically trivial films (x Copyright © 2022, The Authors. All rights reserved.

关键词： Phonons

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Some Remarks on Robust Gene Regulation in a Biomolecular Integral Controller

Some Remarks on Robust Gene Regulation in a Biomolecular Int...

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IEEE Annual Conference on Decision and Control

作者： Deepak K. Agrawal Ryan Marshall M. Ali Al-Radhawi Vincent Noireaux Eduardo D Sontag Department of Bioengineering and Department of Electrical and Computer Engineering Northeastern University Boston MA USA School of Physics and Astronomy University of Minnesota Minneapolis MN USA Laboratory of Systems Pharmacology Program in Therapeutic Science Harvard Medical School Boston MA USA

ISBN: (数字)9781728113982

ISBN: (纸本)9781728113999

Integral feedback can help achieve robust tracking independently of external disturbances. Motivated by this knowledge, biological engineers have proposed various designs of biomolecular integral feedback controllers to regulate biological processes. In this paper, we theoretically analyze the operation of a particular synthetic biomolecular integral controller, which we have recently proposed and implemented experimentally. Using a combination of methods, ranging from linearized analysis to sum-of-squares (SOS) Lyapunov functions, we demonstrate that, when the controller is operated in closed-loop, it is capable of providing integral corrections to the concentration of an output species in such a manner that the output tracks a reference signal linearly over a large dynamic range. We investigate the output dependency on the reaction parameters through sensitivity analysis, and quantify performance using control theory metrics to characterize response properties, thus providing clear selection guidelines for practical applications. We then demonstrate the stable operation of the closed-loop control system by constructing quartic Lyapunov functions using SOS optimization techniques, and establish global stability for a unique equilibrium. Our analysis suggests that by incorporating effective molecular sequestration, a biomolecular closed-loop integral controller that is capable of robustly regulating gene expression is feasible.

关键词： Steady-state Robustness Mathematical model Proteins Gene expression Kinetic theory Production

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Deep learning-based super-resolution and image transformation into structured illumination microscopy

Deep learning-based super-resolution and image transformatio...

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Microscopy Histopathology and Analytics, Microscopy 2020

作者： Wang, Hongda Rivenson, Yair Jin, Yiyin Wei, Zhensong Gao, Ronald Günaydin, Harun Bentolila, Laurent A. Kural, Comert Ozcan, Aydogan Electrical and Computer Engineering Department University of California Los AngelesCA90095 United States Bioengineering Department University of California Los AngelesCA90095 United States California NanoSystems Institute University of California Los AngelesCA90095 United States Computer Science Department University of California Los AngelesCA90095 United States Department of Chemistry and Biochemistry University of California Los AngelesCA90095 United States Department of Physics Ohio State University ColumbusOH43210 United States Biophysics Graduate Program Ohio State University ColumbusOH43210 United States Department of Surgery David Geffen School of Medicine University of California Los AngelesCA90095 United States

We demonstrate single-image super-resolution in fluorescence microscopy using a trained neural-network, matching the resolution of structured illumination microscopy (SIM). This performance is achieved without any par... 详细信息

ISBN: (纸本)9781943580743

关键词： Fluorescence microscopy

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Bee products in the fight against Helicobacter pylori and molecular interactions

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Microbial Pathogenesis 2025年 205卷 107707页

作者： El-Seedi, Hesham R. Refaey, Mohamed S. Abd El-Wahed, Aida A. Albadawy, Aida Karav, Sercan El-Seedi, Shaden H. Cheng, Guiguang Salem, Mohamed F. Liu, Lianliang Tang, Jie Abolibda, Tariq Z. Zou, Xiaobo Guo, Zhiming Khalifa, Shaden A.M. International Research Center for Food Nutrition and Safety Jiangsu University Zhenjiang 212013 China Department of Chemistry Faculty of Science Islamic University of Madinah Madinah 42351 Saudi Arabia Department of Pharmacognosy Faculty of Pharmacy University of Sadat City Sadat City 32897 Egypt Department of Pharmacognosy and Natural Products Faculty of Pharmacy Menoufia National University Km Cairo-Alexandria Agricultural Road Menoufia Egypt Department of Bee Research Plant Protection Research Institute Agricultural Research Centre Giza 12627 Egypt Translational Medicine Laboratory School of Pharmacy and Medical Sciences Faculty of Life Sciences University of Bradford Bradford BD7 1DP United Kingdom Department of Molecular Biology and Genetics Çanakkale Onsekiz Mart University Çanakkale 17000 Turkey Dietician Program Uppsala University Sweden Faculty of Food Science and Engineering Kunming University of Science and Technology Kunming 650500 China Department of Environmental Biotechnology Genetic Engineering and Biotechnology Research Institute GEBRI University of Sadat City Sadat City P.O. Box:79 Egypt School of Food and Pharmaceutical Sciences Ningbo University Zhejiang Ningbo China School of Food and Bioengineering Xihua University Si Chuan Province Chengdu China School of Food and Biological Engineering Jiangsu University Zhenjiang 212013 China Neurology and Psychiatry Department Capio Saint Göran's Hospital Sankt Göransplan 1 Stockholm 112 19 Sweden

Gastric or duodenal ulcers can lead to upper gastrointestinal (GI) bleeding. Infection with Helicobacter pylori (H. pylori) is one of the most common infections in the world and can cause both gastric ulcers and gastric cancer. The treatment aims to eradicate H. pylori and treatment with antibiotics has made it possible to cure gastric ulcers. The most common complication of untreated peptic ulcer disease is bleeding (hematemesis, melena, and anemia), while perforation occurs in a smaller proportion of patients. In some individuals, the infection causes mucosal changes with increasing age that lead to atrophy and intestinal metaplasia. It is believed that atrophy and especially intestinal metaplasia are a prerequisite for the most common form of gastric cancer, adenocarcinoma. There is presently a demand for an alternate treatment devoid of the current strategies drawbacks including recurrence, resistance and antibiotic abuse. The current workhighlights the possibility of bee product-based treatments for preventing and eliminating H. pylori infestation. Sci-finder, Google Scholar, PubMed, scienceDirect, Web of science, and Scopus were used for literature screening. Terms and keywords, i.e. “helicobacter pylori”, “epidemiology”, “chemotherapy”, “honey”, “propolis”, “bee venom”, “bioactive compounds”, and “mechanism of action” were used in the search. Bee products are important alternatives that have been utilized for treating many ailments due to their diverse biochemical and biological characteristics. Various mechanisms, such as direct antibacterial, antioxidant, anti-inflammatory, and wound healing capacities, are proposed to explain the potential effect of bee products against H. pylori. The bee product's metabolites have a role in the adherence of H. pylori to stomach epithelial cells. The disruption of bacterial cell membranes and the inhibition of virulence factors are the two mechanisms behind the bee product's promising therapeutic applications against H. py

关键词： Bee venom Bioactive compounds H. pylori Honey Mechanism Propolis

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