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WE-173. Combining excitability and connectivity measures from interictal invasive-EEG estimates the epileptogenic zone, even in the absence of frank epileptiform activity

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Clinical Neurophysiology 2022年 141卷 S81-S82页

作者： Billardello, Roberto Ntolkeras, Georgios Pesce, Matthew Harmon, Joseph Hadjinicolaou, Aristides Madsen, Joseph Taffoni, Fabrizio Pearl, Phillip Papadelis, Christos Grant, Ellen Tamilia, Eleonora Fetal-Neonatal Neuroimaging and Developmental Science Center Boston Children’s Hospital Harvard Medical School Boston USA Research Unit of Advanced Robotics and Human-Centred Technologies Department of Engineering University Bio-Medico Campus of Rome Rome Italy Baystate Children's Hospital Springfield USA Division of Epilepsy and Clinical Neurophysiology Department of Neurology Boston Children’s Hospital Harvard Medical School Boston USA Epilepsy Surgery Program Department of Neurosurgery Boston Children’s Hospital Harvard Medical School Boston USA Jane and John Justin Neurosciences Center Cook Children’s Health Care System Fort Worth USA Department of Bioengineering University of Texas at Arlington Arlington USA

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Influence of immobilization on phenanthrene degradation by Bacillus sp. P1 in the presence of Cd(II)

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The science of the total environment 2019年 655卷 1279-1287页

作者： Shao-Heng Liu Zhuo-Tong Zeng Qiu-Ya Niu Rong Xiao Guang-Ming Zeng Yang Liu Min Cheng Kai Hu Lu-Huang Jiang Xiao-Fei Tan Jian-Jun Tao College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education Changsha 410082 PR China College of Chemistry and Material Engineering Hunan University of Arts and Science Changde 415000 Hunan PR China. Department of Dermatology Second Xiangya Hospital Central South University Changsha 410011 Hunan PR China. College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education Changsha 410082 PR China. College of Environmental Science and Engineering Hunan University and Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education Changsha 410082 PR China. Electronic address: zgming@***. School of Minerals Processing and Bioengineering and Key Laboratory of Biometallurgy of Ministry of Education Central South University Changsha 410083 PR China. College of Chemistry and Material Engineering Hunan University of Arts and Science Changde 415000 Hunan PR China.

Suspended microbes gradually lost advantages in practical applications of PAHs and heavy metals bioremediation. Therefore this study investigated the effect of immobilization on phenanthrene degradation by Bacillus sp. P1 in the presence of different Cd(II) concentrations. Condensed Bacillus sp. P1 was immobilized with polyvinyl alcohol and sodium alginate and PVA-SA-cell cryogel beads were prepared. The results indicated that the use of gel beads increased the number of adsorption sites thus accelerating phenanthrene degradation. In addition, changes in detoxification indices, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH), were determined to elucidate the immobilization mechanisms related to cells protection from Cd(II) when degrading phenanthrene. By protecting the gel membrane, oxidative damage was minimized, while SOD activity increased from 55.72 to 81.33 U/mgprot as Cd(II) increased from 0 to 200 mg/L but later dropped to 44.29 U/mgprot as Cd(II) increased to 300 mg/L for the non-immobilized system. On the other hand, the SOD activity kept increasing from 52.23 to 473.35 U/mgprot for the immobilized system exposed to Cd(II) concentration between 0 and 300 mg/L. For CAT and GSH, immobilization only slowed down the depletion process without any change on the variation trends. The changes in surface properties and physiological responses of microbes caused the differences of immobilization effect on phenanthrene biodegradation in the presence of Cd(II), which is a novel finding.

关键词： Bacillus sp. Cd(II) Detoxification Immobilization Phenanthrene

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Mechanical Properties of Coconut Shell Reinforced Unsaturated Polyester Composites with the Presence of Titanium Dioxide as Additional Filler

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IOP Conference Series: materials science and engineering 2020年第1期743卷

作者： Nurzarihah Shahidan Mohamad Bashree Abu Bakar Mazlan Mohamed Azwan Mat Lazim Ayub Ahmed Janvekar Advances Material Research Cluster Faculty of Bioengineering and Technology Universiti Malaysia Kelantan Jeli Campus 17600 Jeli Kelantan Malaysia School of Chemical Sciences and Food Technology Faculty of Science and Technology University Kebangsaan Malaysia 43600 Bangi Selangor Malaysia School of Mechanical Engineering Universiti Sains Malaysia Engineering Campus 14300 Nibong Tebal Penang Malaysia

Unsaturated polyester (UPE) composites filled with coconut shell (CS) powder was prepared by compression molding technique. To improve the mechanical and physical properties of CS-UPE composites, titanium dioxide (TiO2) filler was added. CS also undergo two types of chemical treatment which were alkaline (NaOH) and silane treatment. Fourier transform infrared (FTIR) was used to investigate the changes of fibers chemical constituents after the two chemical treatments have been done. CS-TiO2-UPE composites was characterized with physical testing (density, water absorption and thickness swelling), mechanical properties (tensile and flexural test) and scanning electron microscopy (SEM). Overall, the result shows that, the presence of CS and TiO2 filler in UPE composites demonstrated the highest density. For water absorption and thickness swelling study, it was observed that the treated CS-UPE composites showed lower water absorption properties in comparison to those of untreated CS-UPE composites. The presence of TiO2 filler showed an increased in those water absorption properties but still low compared to CS filled UPE. Both chemical treatment of CS caused a significant increase in the tensile and flexural properties. The presence of TiO2 filler demonstrated a significant improvement in modulus properties but at the expense of strength properties. SEM investigation has shown that the surface modification of CS has better fiber-matrix interaction. Thus, chemical treatments on the CS improve fiber/matrix adhesion of UPE composites.

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Towards chirality control of graphene nanoribbons embedded in hexagonal boron nitride

arXiv

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arXiv 2020年

作者： Wang, Hui Shan Chen, Lingxiu Elibol, Kenan He, Li Wang, Haomin Chen, Chen Jiang, Chengxin Li, Chen Wu, Tianru Cong, Chun Xiao Pennycook, Timothy J. Argentero, Giacomo Zhang, Daoli Watanabe, Kenji Taniguchi, Takashi Wei, Wenya Yuan, Qinghong Meyer, Jannik C. Xie, Xiaoming State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences 865 Changning Road Shanghai200050 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing100049 China Faculty of Physics University of Vienna Boltzmanngasse 5 Vienna1090 Austria School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan430074 China School of Physical Science and Technology ShanghaiTech University Shanghai201210 China Shanghai200050 China Department of Lithospheric Research University of Vienna Althanstrasse 14 Vienna1090 Austria State Key Laboratory of ASIC & System School of Information Science and Technology Fudan University Shanghai200433 China National Institute for Materials Science 1-1 Namiki Tsukuba305-0044 Japan State Key Laboratory of Precision Spectroscopy School of Physics and Material Science East China Normal University Shanghai200062 China Centre for Theoretical and Computational Molecular Science Australian Institute for Bioengineering and Nanotechnology University of Queensland BrisbaneQLD4072 Australia School of Chemistry Trinity College Dublin CRANN - Advanced Microscopy Laboratory Unit 27/29 Trinity Enterprise CentrePearse St Dublin 2 Ireland University Antwerpen Groenenborgerlaan 171 Antwerpen2020 Belgium Institute for Applied Physics and Natural and Medical Sciences Institute University of Tübingen Tübingen Germany

The integrated in-plane growth of two dimensional materials (e.g. graphene and hexagonal boron nitride (h-BN)) with similar lattices, but distinct electrical properties, could provide a promising route to achieve integrated circuitry of atomic thickness. However, fabrication of edge-specific graphene nanoribbons (GNR) in the lattice of h-BN still remains an enormous challenge for present approaches. Here we developed a two-step growth method and successfully achieved sub-5 nm-wide zigzag and armchair GNRs embedded in h-BN, respectively. Further transport measurements reveal that the sub-7 nm-wide zigzag GNRs exhibit openings of the band gap inversely proportional to their width, while narrow armchair GNRs exhibit some fluctuation in the bandgap-width relationship. Transistors made of these GNRs with large bandgaps (>0.4 eV) exhibit excellent electronic performance even at room temperature (e.g. conductance on-off ratio more than 105 and carrier mobility more than 1,500 cm2 V−1 s−1). An obvious conductance peak is observed in the transfer curves of 8-10 nm-wide zigzag GNRs while it is absent in most of armchair GNRs of similar width. Magneto-transport experiments show that zigzag GNRs exhibit relatively small magneto-conductance (MC) while armchair GNRs have much higher MC than zigzag GNRs. This integrated lateral growth of edge-specific GNRs in h-BN brings semiconducting building blocks to atomically thin layer, and will provide a promising route to achieve intricate nanoscale electrical circuits on high-quality insulating h-BN substrates. Copyright © 2020, The Authors. All rights reserved.

关键词： Boron nitride

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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers

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Nature communications 2025年第1期16卷 5009页

作者： Brandon M Lehrich Evan R Delgado Tyler M Yasaka Silvia Liu Catherine Cao Yuqing Liu Mohammad N Taheri Xiangnan Guan Hartmut Koeppen Sucha Singh Vik Meadows Jia-Jun Liu Anya Singh-Varma Yekaterina Krutsenko Minakshi Poddar T Kevin Hitchens Lesley M Foley Binyong Liang Alex Rialdi Ravi P Rai Panari Patel Madeline Riley Aaron Bell Reben Raeman Tulin Dadali Jason J Luke Ernesto Guccione Mo R Ebrahimkhani Amaia Lujambio Xin Chen Martin Maier Yulei Wang Wendy Broom Junyan Tao Satdarshan P Monga Organ Pathobiology and Therapeutics Institute University of Pittsburgh School of Medicine Pittsburgh PA USA. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh PA USA. Pittsburgh Liver Research Center University of Pittsburgh and University of Pittsburgh Medical Center Pittsburgh PA USA. Medical Scientist Training Program University of Pittsburgh Pittsburgh PA USA. Department of Pathology Division of Experimental Pathology University of Pittsburgh School of Medicine Pittsburgh PA USA. Department of Bioengineering Swanson School of Engineering University of Pittsburgh Pittsburgh PA USA. Translational Medicine Genentech Inc. San Francisco CA USA. University of Pittsburgh School of Medicine Pittsburgh PA USA. Hepatic Surgery Center Department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China. Department of Oncological Sciences Icahn School of Medicine at Mount Sinai New York NY USA. Alnylam Pharmaceuticals Boston MA USA. UPMC Hillman Cancer Center and University of Pittsburgh Pittsburgh PA USA. Cancer Biology Program University of Hawaii Cancer Center Honolulu HI USA. Organ Pathobiology and Therapeutics Institute University of Pittsburgh School of Medicine Pittsburgh PA USA. junyantao2010@***. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh PA USA. junyantao2010@***. Pittsburgh Liver Research Center University of Pittsburgh and University of Pittsburgh Medical Center Pittsburgh PA USA. junyantao2010@***. Organ Pathobiology and Therapeutics Institute University of Pittsburgh School of Medicine Pittsburgh PA USA. smonga@pitt.edu. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Pittsburgh PA USA. smonga@pitt.edu. Pittsburgh Liver Research Center University of Pittsburgh and University of Pittsburgh Medical Center Pittsburgh PA USA. smonga

First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in CTNNB1 (encoding for β-catenin), AXIN1/2, or APC, and demonstrate heterogeneous and limited benefit to ICI due to an immune excluded tumor microenvironment. We show significant tumor responses in multiple β-catenin-mutated immunocompetent HCC models to a novel siRNA encapsulated in lipid nanoparticle targeting CTNNB1 (LNP-CTNNB1). Both single-cell and spatial transcriptomics reveal cellular and zonal reprogramming, along with activation of immune regulatory transcription factors IRF2 and POU2F1, re-engaged type I/II interferon signaling, and alterations in both innate and adaptive immunity upon β-catenin suppression with LNP-CTNNB1 at early- and advanced-stage disease. Moreover, ICI enhances response to LNP-CTNNB1 in advanced-stage disease by preventing T cell exhaustion and through formation of lymphoid aggregates (LA). In fact, expression of an LA-like gene signature prognosticates survival for patients receiving atezolizumab plus bevacizumab in the IMbrave150 phase III trial and inversely correlates with CTNNB1-mutatational status in this patient cohort. In conclusion, LNP-CTNNB1 is efficacious as monotherapy and in combination with ICI in CTNNB1-mutated HCCs through impacting tumor cell-intrinsic signaling and remodeling global immune surveillance, providing rationale for clinical investigations.

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Amorphous silicon carbide probe mechanics for insertion in the cerebral cortex of rats, pigs, and macaques

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Journal of neural engineering 2025年第3期22卷 2025 May 21页

作者： Mahasty Khajehzadeh Negar Geramifard Justin Abbott Yupeng Wu Shreya Tirumala Kumara Teresa Thai Ana G Hernandez-Reynoso Alexandra Joshi-Imre Kyle P Blum Lee E Miller Juan M Pascual Joseph J Pancrazio Stuart Cogan Department of Bioengineering The University of Texas at Dallas 800 W Campbell rd Richardson Texas 75080-3021 UNITED STATES. Department of Material Science Engineering The University of Texas at Dallas 800 W Campbell rd Richardson Texas 75080-3021 UNITED STATES. Department of Biomedical Engineering Case Western Reserve University 10300 Euclid Ave Cleveland Ohio 44106-7078 UNITED STATES. Office of Research and Innovation The University of Texas at Dallas 800 W Campbell rd Richardson Texas 75080-3021 UNITED STATES. Neuroscience Northwestern University - Chicago Campus 303 E Chicago Ave Chicago Illinois 60611-3071 UNITED STATES. Physiology Northwestern University Feinberg School of Medicine 303 East Chicago Ave Chicago Illinois 60611-3008 UNITED STATES. Department of Pediatrics Cornell University Weill Cornell Medicine 525 East 68th Street New York New York 10065 UNITED STATES. Department of Bioengineerging The University of Texas at Dallas 800 W Campbell rd Richardson Texas 75080-3021 UNITED STATES.

OBJECTIVE: Intracortical microelectrode arrays (MEAs) are implantable devices used for neural recording and stimulation. However, their long-term performance is often compromised due, at least in part, to glial scar formation, initiated by microglial migration and astrocyte activation following implantation. To address this issue, ultra-thin microelectrode arrays (UMEAs) have been proposed as an alternative due to their reduced cross-sectional area and enhanced flexibility that minimizes the mechanical mismatch between brain tissue and the electrode. These properties are expected to mitigate the persistent foreign-body response associated with micromotion. However, unaided implantation of UMEAs can be challenging, as their high flexibility may increase the likelihood of buckling and curtail the precise penetration into the brain. APPROACH:We investigated flexible amorphous silicon carbide (a-SiC) probe designs with varying cross-sectional areas and lengths to identify geometries that enable unsupported implantation into the cerebral cortices of rat, pig, and macaques. The critical buckling force of the a-SiC probes was experimentally determined as a function of geometry and formally described via finite element modeling (FEM), which predicted buckling behavior. Additionally, the penetration behavior of a-SiC probes was evaluated by measuring force-displacement responses during insertion into cortical tissues across species. Main results: Our findings demonstrated that the penetration force and cortical dimpling depth were not significantly influenced by the range of probe geometries tested. However, we observed that penetration force and dimpling depth were significantly lower in rat cortices than in larger species. Importantly, probe geometries with a higher ratio (≥2) of critical buckling force to penetration force exhibited a 100% success rate for unaided insertion. SIGNIFICANCE:This study provides a framework for designing and evaluating UMEA geometr

关键词： Amorphous silicon carbide cortical dimpling intracortical insertion macaque microelectrode array pial penetration pig

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Comparative cellular analysis of motor cortex in human, marmoset and mouse (vol 598, pg 111, 2021)

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NATURE 2022年第7904期604卷 E8-E8页

作者： Bakken, Trygve E. Jorstad, Nikolas L. Hu, Qiwen Lake, Blue B. Tian, Wei Kalmbach, Brian E. Crow, Megan Hodge, Rebecca D. Krienen, Fenna M. Sorensen, Staci A. Eggermont, Jeroen Yao, Zizhen Aevermann, Brian D. Aldridge, Andrew I. Bartlett, Anna Bertagnolli, Darren Casper, Tamara Castanon, Rosa G. Crichton, Kirsten Daigle, Tanya L. Dalley, Rachel Dee, Nick Dembrow, Nikolai Diep, Dinh Ding, Song-Lin Dong, Weixiu Fang, Rongxin Fischer, Stephan Goldman, Melissa Goldy, Jeff Graybuck, Lucas T. Herb, Brian R. Hou, Xiaomeng Kancherla, Jayaram Kroll, Matthew Lathia, Kanan van Lew, Baldur Li, Yang Eric Liu, Christine S. Liu, Hanqing Lucero, Jacinta D. Mahurkar, Anup McMillen, Delissa Miller, Jeremy A. Moussa, Marmar Nery, Joseph R. Nicovich, Philip R. Niu, Sheng-Yong Orvis, Joshua Osteen, Julia K. Owen, Scott Palmer, Carter R. Pham, Thanh Plongthongkum, Nongluk Poirion, Olivier Reed, Nora M. Rimorin, Christine Rivkin, Angeline Romanow, William J. Sedeno-Cortes, Adriana E. Siletti, Kimberly Somasundaram, Saroja Sulc, Josef Tieu, Michael Torkelson, Amy Tung, Herman Wang, Xinxin Xie, Fangming Yanny, Anna Marie Zhang, Renee Ament, Seth A. Behrens, M. Margarita Bravo, Hector Corrada Chun, Jerold Dobin, Alexander Gillis, Jesse Hertzano, Ronna Hof, Patrick R. Hollt, Thomas Horwitz, Gregory D. Keene, C. Dirk Kharchenko, Peter V. Ko, Andrew L. Lelieveldt, Boudewijn P. Luo, Chongyuan Mukamel, Eran A. Pinto-Duarte, Antonio Preiss, Sebastian Regev, Aviv Ren, Bing Scheuermann, Richard H. Smith, Kimberly Spain, William J. White, Owen R. Koch, Christof Hawrylycz, Michael Tasic, Bosiljka Macosko, Evan Z. McCarroll, Steven A. Ting, Jonathan T. Zeng, Hongkui Zhang, Kun Feng, Guoping Ecker, Joseph R. Linnarsson, Sten Lein, Ed S. Allen Institute for Brain Science Seattle WA USA Department of Physiology and Biophysics University of Washington Seattle WA USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Bioengineering University of California San Diego La Jolla CA USA The Salk Institute for Biological Studies La Jolla CA USA Epilepsy Center of Excellence Department of Veterans Affairs Medical Center Seattle WA USA Stanley Institute for Cognitive Genomics Cold Spring Harbor Laboratory Cold Spring Harbor NY USA Department of Genetics Harvard Medical School Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA LKEB Department of Radiology Leiden University Medical Center Leiden The Netherlands Pattern Recognition and Bioinformatics group Delft University of Technology Delft The Netherlands J. Craig Venter Institute La Jolla CA USA Department of Pathology University of California San Diego CA USA Division of Vaccine Discovery La Jolla Institute for Immunology La Jolla CA USA Genomic Analysis Laboratory The Salk Institute for Biological Studies La Jolla CA USA Computer Science and Engineering Program University of California San Diego La Jolla CA USA Howard Hughes Medical Institute The Salk Institute for Biological Studies La Jolla CA USA Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA Institute for Genomes Sciences University of Maryland School of Medicine Baltimore MD USA Center for Epigenomics Department of Cellular and Molecular Medicine University of California San Diego La Jolla CA USA Ludwig Institute for Cancer Research La Jolla CA USA Department of Computer Science University of Maryland College Park College Park MD USA Sanford Burnham Prebys Medical Discovery Institute La Jolla CA USA Biomedical Sciences Program School of Medicine University of California San Diego La Jolla CA USA University of Connecticut Storrs CT USA Department

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Characterization of Hydroxyapatite Coated Mg for Biomedical Applications

Characterization of Hydroxyapatite Coated Mg for Biomedical ...

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MRS Advances

作者： Lin, Jiajia Tian, Qiaomu Aslani, Arash Liu, Huinan Materials Science and Engineering Program University of California RiversideCA92521 United States Department of Bioengineering University of California RiversideCA92521 United States Biomedical Sciences Program School of Medicine University of California RiversideCA92521 United States N2 Biomedical LLC One Patriots Park BedfordMA01730 United States

Magnesium (Mg) and its alloys have showed a promising potential for medical implant applications due to their attractive biocompatibility and mechanical strength. Despite these promising properties, the critical challenge with Mg-based implants is rapid degradation in physiological environment that results in early loss of mechanical strength and hydrogen gas accumulation at the local site. Hydroxyapatite (HA) coatings provide a sound solution for controlling Mg degradation at the bone interface. In this paper, HA coatings with different particle sizes, namely, microHA (mHA) and nanoHA (nHA), were deposited on Mg plates and rods with two different pressures using N2 Biomedical's proprietary deposition process called IonTiteTM. Surface characterization of the deposited layers showed mHA coated Mg prepared at high pressure had more homogeneous HA particles distribution with less defects. Copyright © materials Research Society 2018.

关键词： Coatings

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A LRET Nanoplatform Consisting of Lanthanide and Amorphous Manganese Oxide for NIR-II Luminescence Lifetime Imaging of Tumor Redox Status

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Angewandte Chemie 2022年第47期134卷

作者： Dr. Mengyao Zhao Dr. Hongjun Zhuang Dr. Hongxin Zhang Dr. Benhao Li Jiang Ming Prof. Xiaoyuan Chen Prof. Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Macau 999078 China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Contribution: Conceptualization (lead) Investigation (lead) Writing - original draft (lead) Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China Contribution: Investigation (supporting) Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore 138673 Singapore Contribution: Funding acquisition (lead) Supervision (lead)

Designing luminescence lifetime sensors in the second near-infrared (NIR-II) window is a great challenge due to the difficult structural construction. Here, we report a tumor redox responsive and easily synthesized material, amorphous manganese oxide (MnO x ) with indirect band gap of 1.02 eV, as an energy acceptor to build a luminescence resonance energy transfer (LRET) toolbox for universally regulating NIR-I to NIR-II luminescence lifetimes of lanthanide nanoparticles, in which energy transfer is based on matched energy gap instead of conventional overlapped spectra. We further utilize ytterbium (Yb 3+ )-doped YbNP@MnO x as an NIR-II luminescence lifetime sensor to realize in vitro quantitative redox visualization with relative errors under 5 % in samples covered with mouse skin. Furthermore, HepG2 cells and tumors with high redox state have been accurately distinguished by NIR-II luminescence lifetime imaging. The quantified intracellular and intratumor glutathione (GSH) levels are highly consistent with the commercial kit results, illustrating the reliable redox visualization ability in biological tissue.

关键词： Amorphous Manganese Oxide Lanthanide Luminescence Lifetime Imaging NIR-II LRET Quantitative Redox Visualization

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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (vol 603, pg 131, 2022)

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NATURE 2024年第8020期631卷 E7-E7页

作者： Brown, Anna-Leigh Wilkins, Oscar G. Keuss, Matthew J. Hill, Sarah E. Zanovello, Matteo Lee, Weaverly Colleen Bampton, Alexander Lee, Flora C. Y. Masino, Laura Qi, Yue A. Bryce-Smith, Sam Gatt, Ariana Hallegger, Martina Fagegaltier, Delphine Phatnani, Hemali Phatnani, Hemali Newcombe, Jia Gustavsson, Emil K. Seddighi, Sahba Reyes, Joel F. Coon, Steven L. Ramos, Daniel Schiavo, Giampietro Fisher, Elizabeth M. C. Raj, Towfique Secrier, Maria Lashley, Tammaryn Ule, Jernej Buratti, Emanuele Humphrey, Jack Ward, Michael E. Fratta, Pietro UCL Queen Square Motor Neuron Disease Centre Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology UCL London UK The Francis Crick Institute London UK UK Dementia Research Institute University College London London UK Department of Molecular Biology and Nanobiotechnology National Institute of Chemistry Ljubljana Slovenia National Institute of Neurological Disorders and Stroke NIH Bethesda MD USA Medical Scientist Training Program Johns Hopkins University School of Medicine Baltimore MD USA Center for Alzheimer’s and Related Dementias National Institutes of Health Bethesda MD USA Queen Square Brain Bank UCL Queen Square Institute of Neurology University College London London UK Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology University College London London UK Great Ormond Street Institute of Child Health Genetics and Genomic Medicine University College London London UK Center for Genomics of Neurodegenerative Disease New York Genome Center (NYGC) New York NY USA NeuroResource Department of Neuroinflammation UCL Queen Square Institute of Neurology London UK Molecular Genomics Core Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH Bethesda MD USA Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA Ronald M. Loeb Center for Alzheimer’s Disease Icahn School of Medicine at Mount Sinai New York NY USA Department of Pathology Fishberg Department of Neuroscience Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA Estelle and Daniel Maggin Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA Department of Genetics Evolution and Environment UCL Genetics Institute University College London London UK Mole

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