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Author Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

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Nature genetics 2018年第12期50卷 1754页

作者： Huipeng Li Elise T Courtois Debarka Sengupta Yuliana Tan Kok Hao Chen Jolene Jie Lin Goh Say Li Kong Clarinda Chua Lim Kiat Hon Wah Siew Tan Mark Wong Igor Cima Min-Han Tan Lawrence J K Wee Axel M Hillmer Iain Beehuat Tan Paul Robson Shyam Prabhakar Computational and Systems Biology Genome Institute of Singapore Singapore Singapore. Developmental Cellomics Laboratory Genome Institute of Singapore Singapore Singapore. Department of Computer Science and Engineering and Center for Computational Biology Indraprastha Institute of Information Technology Delhi India. Synthetic Biology Genome Institute of Singapore Singapore Singapore. Cancer Therapeutics and Stratified Oncology Genome Institute of Singapore Singapore Singapore. Department of Medical Oncology National Cancer Centre Singapore Singapore Singapore. Department of Pathology Singapore General Hospital Singapore Singapore. Department of Colorectal Surgery Singapore General Hospital Singapore Singapore. Institute of Bioengineering and Nanotechnology Singapore Singapore. Data Analytics Department Institute for Infocomm Research Singapore Singapore. Cancer Therapeutics and Stratified Oncology Genome Institute of Singapore Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Department of Medical Oncology National Cancer Centre Singapore Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Program in Cancer and Stem Cell Biology Duke-NUS Medical School Singapore Singapore. iain.tan.b.h@singhealth.com.sg. Developmental Cellomics Laboratory Genome Institute of Singapore Singapore Singapore. paul.robson@***. The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA. paul.robson@***. Department of Genetics and Genome Sciences Institute for Systems Genomics University of Connecticut Farmington Connecticut USA. paul.robson@***. Department of Biological Sciences National University of Singapore Singapore Singapore. paul.robson@***. Computational and Systems Biology Genome Institute of Singapore Singapore Singapore. prabhakars@gis.a-star.edu.sg.

In the version of the article published, the author list is not accurate. Igor Cima and Min-Han Tan should have been authors, appearing after Mark Wong in the author list, while Paul Jongjoon Choi should not have been listed as an author. Igor Cima and Min-Han Tan both have the affiliation Institute of bioengineering and Nanotechnology, Singapore, Singapore, and their contributions should have been noted in the Author Contributions section as "I.C. preprocessed Primary Cell Atlas data with inputs from M.-H.T." The following description of the contribution of Paul Jongjoon Choi should not have appeared: "P.J.C. supported the smFISH experiments." In the 'RCA: global panel' section of the Online Methods, the following sentence should have appeared as the second sentence, "An expression atlas of human primary cells (the Primary Cell Atlas) was preprocessed similarly to in ref. 55," with new reference 55 (Cima, I. et al. Tumor-derived circulating endothelial cell clusters in colorectal cancer. science Transl. Med. 8, 345ra89, 2016).

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Optogenetic brain interfaces

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IEEE Reviews in Biomedical engineering 2014年 7卷 3-30页

作者： Pashaie, Ramin Anikeeva, Polina Lee, Jin Hyung Prakash, Rohit Yizhar, Ofer Prigge, Matthias Chander, Divya Richner, Thomas J. Williams, Justin Electrical Engineering Department University OfWisconsin Milwaukee WI 53211 United States Material Sciences and Engineering Department Massachusetts Institute of Technology Cambridge MA 02139 United States Bioengineering Neurology and Neurological Sciences and Neurosurgery Departments Stanford University Stanford CA 94305 United States Bioengineering Department Medical School Stanford University Stanford CA 94305 United States Department OfNeurobiology Weizmann Institute of Science Rehovot 76100 Israel Medical School Stanford University Stanford CA 94305 United States Biomedical Engineering Department University of Wisconsin Madison WI 53706 United States

The brain is a large network of interconnected neurons where each cell functions as a nonlinear processing element. Unraveling the mysteries of information processing in the complex networks of the brain requires versatile neurostimulation and imaging techniques. Optogenetics is a new stimulation method which allows the activity of neurons to be modulated by light. For this purpose, the cell-types of interest are genetically targeted to produce light-sensitive proteins. Once these proteins are expressed, neural activity can be controlled by exposing the cells to light of appropriate wavelengths. Optogenetics provides a unique combination of features, including multimodal control over neural function and genetic targeting of specific cell-types. Together, these versatile features combine to a powerful experimental approach, suitable for the study of the circuitry of psychiatric and neurological disorders. The advent of optogenetics was followed by extensive research aimed to produce new lines of light-sensitive proteins and to develop new technologies: for example, to control the distribution of light inside the brain tissue or to combine optogenetics with other modalities including electrophysiology, electrocorticography, nonlinear microscopy, and functional magnetic resonance imaging. In this paper, the authors review some of the recent advances in the field of optogenetics and related technologies and provide their vision for the future of the field. © 2014 IEEE.

关键词： Proteins

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FANTOM5 CAGE profiles of human and mouse samples

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Scientific Data 2017年第1期4卷 1-10页

作者： Noguchi, Shuhei Arakawa, Takahiro Fukuda, Shiro Furuno, Masaaki Hasegawa, Akira Hori, Fumi Ishikawa-Kato, Sachi Kaida, Kaoru Kaiho, Ai Kanamori-Katayama, Mutsumi Kawashima, Tsugumi Kojima, Miki Kubosaki, Atsutaka Manabe, Ri-Ichiroh Murata, Mitsuyoshi Nagao-Sato, Sayaka Nakazato, Kenichi Ninomiya, Noriko Nishiyori-Sueki, Hiromi Noma, Shohei Saijyo, Eri Saka, Akiko Sakai, Mizuho Simon, Christophe Suzuki, Naoko Tagami, Michihira Watanabe, Shoko Yoshida, Shigehiro Arner, Peter Axton, Richard A. Babina, Magda Kenneth Baillie, J. Barnett, Timothy C. Beckhouse, Anthony G. Blumenthal, Antje Bodega, Beatrice Bonetti, Alessandro Briggs, James Brombacher, Frank Carlisle, Ailsa J. Clevers, Hans C. Davis, Carrie A. Detmar, Michael Dohi, Taeko Edge, B. Albert S. Edinger, Matthias Ehrlund, Anna Ekwall, Karl Endoh, Mitsuhiro Enomoto, Hideki Eslami, Afsaneh Fagiolini, Michela Fairbairn, Lynsey Farach-Carson, Mary C. Faulkner, Geoffrey J. Ferrai, Carmelo Fisher, Malcolm E. Forrester, Lesley M. Fujita, Rie Furusawa, Jun-Ichi Geijtenbeek, Teunis B. Gingeras, Thomas Goldowitz, Daniel Guhl, Sven Guler, Reto Gustincich, Stefano Ha, Thomas J. Hamaguchi, Masahide Hara, Mitsuko Hasegawa, Yuki Herlyn, Meenhard Heutink, Peter Hitchens, Kelly J. Hume, David A. Ikawa, Tomokatsu Ishizu, Yuri Kai, Chieko Kawamoto, Hiroshi Kawamura, Yuki I. Kempfle, Judith S. Kenna, Tony J. Kere, Juha Khachigian, Levon M. Kitamura, Toshio Klein, Sarah Peter Klinken, S. Knox, Alan J. Kojima, Soichi Koseki, Haruhiko Koyasu, Shigeo Lee, Weonju Lennartsson, Andreas MacKay-Sim, Alan Mejhert, Niklas Mizuno, Yosuke Morikawa, Hiromasa Morimoto, Mitsuru Moro, Kazuyo Morris, Kelly J. Motohashi, Hozumi Mummery, Christine L. Nakachi, Yutaka Nakahara, Fumio Nakamura, Toshiyuki Nakamura, Yukio Nozaki, Tadasuke Ogishima, Soichi Ohkura, Naganari Ohno, Hiroshi Ohshima, Mitsuhiro Okada-Hatakeyama, Mariko Okazaki, Yasushi Orlando, Valerio Ovchinnikov, Dmitry A. Passier, Robert Patrikakis, Margaret Pombo, Ana Pradhan-Bhatt, Swati Qin, Xian-Yang Rehli, Michael Rizzu, Patrizia Roy, S Division of Genomic Technologies RIKEN Center for Life Science Technologies Yokohama Kanagawa 230-0045 Japan RIKEN Omics Science Center Yokohama Kanagawa 230-0045 Japan Department of Medicine Karolinska Institutet Stockholm 14186 Sweden Karolinska University Hospital Center for Metabolism and Endocrinology Stockholm 14186 Sweden Scottish Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive Edinburgh EH164UU United Kingdom Department of Dermatology and Allergy Charite University Medicine Berlin Charitéplatz 1 Berlin 10117 Germany Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh EH259RG United Kingdom Australian Infectious Diseases Research Centre University of Queensland St Lucia 4072 QLD Australia School of Chemistry and Molecular Biosciences University of Queensland St Lucia 4072 QLD Australia Bio-Rad Laboratories Pty Ltd Hercules 94547 CA United States University of Queensland Diamantina Institute University of Queensland Woolloongabba 4102 QLD Australia IRCCS Fondazione Santa Lucia Via del Fosso di Fiorano 64 Rome 00143 Italy Australian Institute for Bioengineering and Nanotechnology University of Queensland Brisbane St Lucia 4072 QLD Australia Division of Immunology Institute of Infectious Diseases and Molecular Medicine University of Cape Town Anzio Road Observatory 7925 South Africa Immunology of Infectious Diseases Faculty of Health Sciences South African Medical Research Council University of Cape Town Anzio Road 7925 South Africa International Centre for Genetic Engineering and Biotechnology Cape Town Component Anzio Road 7925 South Africa Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Uppsalalaan 8 3584 Netherlands University Medical Centre Utrecht Postbus 85500 Utrecht 3508 Netherlands Genomics Cold Spring Harbor Laboratory Cold Spring Harbor New York 11797 NY United States Institute of Pharmaceutical Sciences ETH Zurich Vladi

In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of Gene Expression) coupled with single-molecule sequencing. Approximately three thousands of samples, consisting of a variety of primary cells, tissues, cell lines, and time series samples during cell activation and development, were subjected to a uniform pipeline of CAGE data production. The analysis pipeline started by measuring RNA extracts to assess their quality, and continued to CAGE library production by using a robotic or a manual workflow, single molecule sequencing, and computational processing to generate frequencies of transcription initiation. Resulting data represents the consequence of transcriptional regulation in each analyzed state of mammalian cells. Non-overlapping peaks over the CAGE profiles, approximately 200,000 and 150,000 peaks for the human and mouse genomes, were identified and annotated to provide precise location of known promoters as well as novel ones, and to quantify their activities.

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3D Printing: Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems (Adv. Mater. Technol. 1/2016)

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Advanced materials Technologies 2016年第1期1卷

作者： Hiroki Ota Sam Emaminejad Yuji Gao Allan Zhao Eric Wu Samyuktha Challa Kevin Chen Hossain M. Fahad Amit K. Jha Daisuke Kiriya Wei Gao Hiroshi Shiraki Kazuhito Morioka Adam R. Ferguson Kevin E. Healy Ronald W. Davis Ali Javey Electrical Engineering and Computer Sciences University of California Berkeley CA 94720 USA Berkeley Sensor and Actuator Center University of California Berkeley CA 94720 USA Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Stanford Genome Technology Center Stanford School of Medicine 3165 Porter Drive Palo Alto CA 94304 USA Mechanical Engineering Tianjin University 92 Weijin Road Nankai Tianjin 300072 P.R. China Bioengineering University of California Berkeley CA 94720 USA Material Science and Engineering University of California Berkeley CA 94720 USA Neurological Surgery University of California San Francisco 1001 Potrero Avenue CA 94110 USA

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Bone Remodeling: Theranostic Bioabsorbable Bone Fixation Plate with Drug‐Layered Double Hydroxide Nanohybrids (Adv. Healthcare Mater. 21/2016)

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Advanced Healthcare materials 2016年第21期5卷

作者： Myung Hun Kim Woojune Hur Goeun Choi Hye Sook Min Tae Hyun Choi Young Bin Choy Jin‐Ho Choy Center for Intelligent Nano‐Bio Materials (CINBM) Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 Republic of Korea Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea Biomedical Research Institute Seoul National University Hospital Seoul 03080 Republic of Korea Department of Plastic and Reconstructive Surgery Institute of Human‐Environment Interface Biology College of Medicine Seoul National University Seoul 03080 Republic of Korea Department of Preventive Medicine Graduate School of Public Health Seoul National University Seoul 08826 Korea Institute of Medical and Biological Engineering Medical Research Center and Department of Biomedical Engineering College of Medicine Seoul National University Seoul 03080 Republic of Korea

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An enzymatic biosensor based on three-dimensional ZnO nanotetrapods spatial net modified AlGaAs/GaAs high electron mobility transistors

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Applied Physics Letters 2014年第21期105卷 213703-213703页

作者： Song, Yu Zhang, Xiaohui Yan, Xiaoqin Liao, Qingliang Wang, Zengze Zhang, Yue State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing100083 China Bioengineering Program Lehigh University BethlehemPA18015 United States

We designed and constructed three dimensional (3D) zinc oxide Nanotetrapods (T-ZnOs) modified AlGaAs/GaAs high electron mobility transistors (HEMTs) for enzymatic uric acid (UA) detection. The chemical vapor deposition synthesized T-ZnOs was distributed on the gate areas of HEMTs in order to immobilize uricase and improve the sensitivity of the HEMTs. Combining with the high efficiency of enzyme immobilization by T-ZnOs and high sensitivity from HEMT, the as-constructed uricase/T-ZnOs/HEMTs biosensor showed fast response towards UA at ∼1 s, wide linear range from 0.2 nM to 0.2 mM and the low detect limit at 0.2 nM. The results point out an avenue to design electronic device as miniaturized lab-on-chip device for high sensitive and specific in biomedical and clinical diagnosis applications. © 2014 AIP Publishing LLC.

关键词： Zinc oxide

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Corrigendum to "Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity", [Exp. Neurol. 273 (2015), 151-160]

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Experimental neurology 2016年 280卷 121页

作者： Erez Eitan Emmette R Hutchison Nigel H Greig David Tweedie Hasan Celik Soumita Ghosh Kenneth W Fishbein Richard G Spencer Carl Y Sasaki Paritosh Ghosh Soumen Das Susheela Chigurapati James Raymick Sumit Sarkar Srinivasulu Chigurupati Sudipta Seal Mark P Mattson Laboratory of Neurosciences National Institute on Aging Intramural Research Program Baltimore MD 21224 USA. Translational Gerontology Branch National Institute on Aging Intramural Research Program Baltimore MD 21224 USA. Laboratory of Clinical Investigation National Institute on Aging Intramural Research Program Baltimore MD 21224 USA. Laboratory of Immunology National Institute on Aging Intramural Research Program Baltimore MD 21224 USA. Material Science and Engineering College of Medicine University of Central Florida Orlando FL 32816 USA. Arkansas Regional Laboratory Office of Regulatory Affairs U.S. Food and Drug Administration 3900 NCTR Road Building 26 Jefferson AR 72079 USA. Division of Neurotoxicology National Center for Toxicological Research/FDA Jefferson AR 72079 USA. Advanced Materials Processing and Analysis Centre Nanoscience Technology Center Mechanical Materials Aerospace Engineering University of Central Florida Orlando FL 32816 USA. Laboratory of Neurosciences National Institute on Aging Intramural Research Program Baltimore MD 21224 USA Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Electronic address: mark.mattson@nih.gov.

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Correction: Ni–Cu alloy nanoparticles loaded on various metal oxides acting as efficient catalysts for photocatalytic H2 evolution

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RSC Advances 2015年第59期5卷 47997-47997页

作者： Yusuke Yamada Shinya Shikano Shunichi Fukuzumi Department of Material and Life Science Graduate School of Engineering Osaka University ALCA and SENTAN Japan Science and Technology Agency (JST) Suita Osaka 565-0871 Japan Department of Applied Chemistry & Bioengineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku Osaka 558-8585 Japan Faculty of Science and Engineering Meijo University ALCA and SENTAN Japan Science and Technology Agency (JST) Nagoya Aichi 468-0073 Japan Department of Bioinspired Science Ewha Womans University Seoul 120-750 Korea

Correction for ‘Ni–Cu alloy nanoparticles loaded on various metal oxides acting as efficient catalysts for photocatalytic H2 evolution’ by Yusuke Yamada et al., RSC Adv., 2015, 5, 44912–44919.

Correction for ‘Ni–Cu alloy nanoparticles loaded on various metal oxides acting as efficient catalysts for photocatalytic H₂ evolution’ by Yusuke Yamada et al., RSC Adv., 2015, 5, 44912–44919.

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Temperature-dependent time-resolved photoluminescence study of monocrystalline CdTe/MgCdTe double heterostructures with low defect density

Temperature-dependent time-resolved photoluminescence study ...

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2014 IEEE 40th Photovoltaic Specialist Conference (PVSC)

作者： Xin-Hao Zhao Michael J. DiNezza Shi Liu Pathiraja A. R. D. Jayathilaka Odille C. Noriega Thomas H. Myers Yong-Hang Zhang School for Engineering of Matter Transport and Energy Arizona State University Tempe Arizona School of Electrical Computer and Energy Engineering Arizona State University Tempe Arizona Material Science Engineering & Commercialization Program Texas State University San Marcos TX

Confocal photoluminescence scans of monocrystalline CdTe/MgCdTe double heterostructures epitaxially grown on lattice-matched InSb substrates reveal very low twin defect density, below 1 × 10 5 cm -2 . Room-temperature Shockley-Read-Hall (SRH) lifetimes of these samples are determined in the range of 35 ns to 86 ns using time-resolved photoluminescence (TRPL) measurements. Temperature-dependent TRPL measurements show that the carrier lifetime reaches a peak of 910 ns at 200 K. Excitation-dependent PL measurements reveal the radiative recombination coefficient of CdTe to be 4.3 × 10 -9 cm 3 ·s -1 .

关键词： Temperature measurement Thickness measurement Nuclear measurements Abstracts Indexes Molecular beam epitaxial growth

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Toward the Multi-scale Simulation for a Human Body Using the Next-generation Supercomputer

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Procedia IUTAM 2014年 10卷 193-200页

作者： Yoichiro Matsumoto Satoshi Ii Seiji Shiozaki Kazuyasu Sugiyama Shu Takagi School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Department of Mechanical Science and Bioengineering Osaka University 1-1 Machikaneyama Toyonaka Osaka 560-0043 Japan Computational Science Research Program RIKEN 2-1 Hirosawa Wako Saitama 351-0198 Japan

We have developed novel numerical methods for fluid-structure and fluid-membrane interaction problems. The basic equation set is formulated in a full Eulerian framework. The method is based on the finite difference volume-of-fluid scheme with fractional step algorithm. It is validated through a numerical solution to a deformable vesicle problem, and applied to blood flows including red blood cells (RBCs) and platelets. Further, to gain insight into the mechanism of thrombus formation, a stochastic Monte Carlo model to describe the platelet-vessel wall interaction is incorporated into the Eulerian method. The effect of the RBCs on the platelet motion is discussed.

关键词： Eulerian method fluid-structure interaction blood flow stochastic Monte Carlo method

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