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第十八届全国波谱学学术年会

作者： Kian-Kai Cheng Baek-Seok Lee Takeshi Masuda Takuro Ito Kazutaka Ikeda Akiyoshi Hirayama Lingli Deng Jiyang Dong Kazuyuki Shimizu Tomoyoshi Soga Masaru Tomita Bernhard O.Palsson Martin Robert Institute for Advanced Biosciences Keio UniversityTsuruokaYamagata 997-0017Japan Systems Biology Program Graduate School of Media and GovernanceKeio UniversityKanagawa 252-8520Japan Institute of Bioproduct Development & Department of Bioprocess Engineering Universiti Teknologi Malaysia81310 JohorMalaysia PRESTO Japan Science and Technology AgencyKawaguchiSaitama 332-0012Japan Department of Electronic Science Xiamen University Kyushu Institute of Technology IizukaFukuoka820-8502Japan Department of Bioengineering University of CaliforniaSan DiegoLa JollaCA 92093-0412USA

自2006年开始,基因组的重新测序有效地鉴定了细菌适于新环境时所引起的基因突变[1]。然而,相关的促生长机制还没有得到很好的诠释。本文联合利用代谢组学、蛋白质组学和脂类组学的方法对适于甘油的进化菌株中的glpK和rpoC两个基因突变[2... 详细信息

自2006年开始,基因组的重新测序有效地鉴定了细菌适于新环境时所引起的基因突变[1]。然而,相关的促生长机制还没有得到很好的诠释。本文联合利用代谢组学、蛋白质组学和脂类组学的方法对适于甘油的进化菌株中的glpK和rpoC两个基因突变[2,3]的促生长机制进行深入研究,结果表明:进化大肠杆菌细胞株是通过两种不同的代谢方式来实现在甘油培基内更快的增长。首先,rpoC基因27bp的缺失提高了

关键词：基因突变大肠杆菌细胞大肠杆菌

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Chapter green nanotechnology: Development of nanomaterials for environmental and energy applications

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ACS Symposium Series 2013年 1124卷 201-229页

作者： Han, Changseok Andersen, Joel Pillai, Suresh C. Fagan, Rachel Falaras, Polycarpos Byrne, J. Anthony Dunlop, Patrick S.M. Choi, Hyeok Jiang, Wenjun O'Shea, Kevin Dionysiou, Dionysios D. Environmental Engineering and Science Program University of Cincinnati Cincinnati OH 45221-0012 United States FOCAS Institute Dublin Institute of Technology Kevin St. Dublin 8 Ireland Division of Physical Chemistry Institute of Advanced Materials Physicochemical Processes Nanotechnology and Microsystems National Center for Scientific Research Demokritos 15310 Aghia Parakevi Attikis Athens Greece Nanotechnology and Integrated BioEngineering Centre School of Engineering University of Ulster Northern-Ireland BT37 0QB United Kingdom Department of Civil Engineering University of Texas at Arlington Arlington TX 76019-0308 United States Department of Chemistry and Biochemistry Florida International University University Park Miami FL 33199 United States Nireas-International Water Research Centre University of Cyprus 20537 Nicosia Cyprus

ISBN: (纸本)9780841227842

This book chapter discusses the syntheses of various nanomaterials, for green nanotechnology applications in detail. Special attention is given to the development of emerging areas, such as environmental as well as energy materials. Various approaches for preparing nanostructured photocatalysts, such as titanium dioxide, zinc oxide, iron oxide, and metal sulfides, different conventional methods and novel methods, including sol-gel methods, hydrothermal methods, microwave-assisted methods and sonochemical methods are introduced. The use of nanomaterials as photocatalysts, supporting materials for solar cells, and disinfectants is reported for environmental remediation and energy applications. Advanced applications of nanomaterials for water detoxification, air purification, and the inactivation of pathogenic microorganisms in water as well as dye-sensitized solar cells is also discussed. The enhancement of selectivity of photocatalysis, especially TiO2 systems, for the destruction of target contaminants in water is comprehensively presented. Finally, the role of reactive oxygen species (ROS), such as hydroxyl radical (•OH), superoxide anion radical (O2•-), singlet oxygen (1O2) and hydrogen peroxide (H2O2), in semiconductor photocatalysis is introduced and various experimental techniques to detect ROS are also discussed. © 2013 American Chemical Society.

关键词： Nanostructured materials

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Metabolomics and network biology for sensitive monitoring of how growth environment changes affect the physiology of industrial-scale perfusion cultures

Metabolomics and network biology for sensitive monitoring of...

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12th IFAC Symposium on Computer Applications in Biotechnology, CAB 2013

作者： Vernardis, S.I. Goudar, C.T. Klapa, M.I. Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering Foundation for Research and Technology-Hellas Patras GR-265 04 Greece Cell Culture Development Global Biological Development Bayer HealthCare 800 Dwight Way Berkeley CA 94710 United States Interdepartmental Graduate Program in Informatics in Life Sciences Medical School University of Patras Greece Cell Science and Technology AMGEN Inc. Thousand Oaks CA 91320 United States Depts. of Chemical and Biomolecular Eng. and Bioengineering University of Maryland College Park MD 20742 United States

ISBN: (纸本)9783902823588

Metabolomic analysis can indeed enhance the prime variable dataset for the monitoring of perfusion cultures by providing a higher resolution view of the metabolic state. Metabolic profiles can capture physiological state shifts over the course of the perfusion cultures and indicate a metabolic "signature" of the phase transitions, which is not observable from prime variable data. Notably, metabolomics provides orthogonal (to prime variables) evidence that all cultures follow this same metabolic state shift with cell age, independently of bioreactor scale. Additionally, this analysis can increase the information content of process development experiments by helping better understand the impact of changes in bioreactor operating conditions on cell physiology. In this context, metabolic profiling could be integrated into the monitoring of cell physiology in perfusion cultures. © IFAC.

关键词： Bioreactors

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Inside Cover: Out-of-Cell Oxygen Diffusivity Evaluation in Lithium–Air Batteries (ChemElectroChem 12/2014)

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ChemElectroChem 2014年第12期1卷 2032-2032页

作者： Prof. Weidong He Xiaoning Wang Luhan Ye Yu Pan Yuanqiang Song Aifang Liu Wei Wang Hongping Zhang Hongxue Qi Ming Zhou Zhiguo Wang Kelvin H. L. Zhang James H. Dickerson School of Energy Science and Engineering University of Electronic Science and Technology (UESTC) Chengdu Sichuan 611731 (P. R. China) Interdisciplinary Program in Materials Science Vanderbilt University Nashville Tennessee 37234-0106 (USA) Vanderbilt Institute of Nanoscale Science and Engineering Vanderbilt University Nashville Tennessee 37234-0106 (USA) Shenzhen Key Laboratory for Advanced Materials Department Material Science and Engineering Shenzhen Graduate School Harbin Institute of Technology University Town Shenzhen 518055 (P. R. China) School of Materials Science and Engineering Southwest University of Science and Technology Mianyang Sichuan 621010 (P. R. China) Department of Chemistry The University of Hong Kong Pokfulam Road (Hong Kong) Department of Applied Physics University of Electronic Science and Technology of China Chengdu 610054 (P. R China) Department of Chemistry Chemistry Research Laboratory University of Oxford Mansfield Road Oxford OX1 3TA (UK) Department of Physics Brown University Providence RI 02912 (USA)

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Microchannels: In Situ Realization of Asymmetric Ratchet Structures within Microchannels by Directionally Guided Light Transmission and Their Directional Flow Behavior (Adv. Mater. 17/2014)

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Advanced materials 2014年第17期26卷

作者： Won‐Gyu Bae Sang Moon Kim Se‐Jin Choi Sang Geun Oh Hyunsik Yoon Kookheon Char Kahp Y. Suh School of Mechanical & Aerospace Engineering Seoul National University Seoul 151‐742 Republic of Korea Interdisciplinary Program of Bioengineering Seoul National University Seoul 151‐742 Republic of Korea MCNet Co. Ltd. Room 307‐1 Building 103 SK Ventium Dangjeong‐dong Gunpo‐si Gyeonggi‐do 435‐833 Korea Department of Chemical & Biomolecular Engineering Seoul National University of Science & Technology Seoul 139‐743 Republic of Korea The National Initiative Creative Research Center for Intelligent Hybrids & the World Class University Program for Chemical Convergence for Energy & Environment School of Chemical & Biological Engineering Seoul National University Seoul 151‐744 Republic of Korea

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Poster abstracts

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Sleep and Biological Rhythms 2016年第1期5卷 A1-A189页

作者： J. Ferrie M. Shipley F. Cappuccio E. Brunner M. Miller M. Kumari M. Marmot A. Coenen J. L. Castillo F. Araya G. Bustamante L. Montecino C. Torres S. Oporto J. Gronli E. Fiske R. Murison B. Bjorvatn E. Sorensen R. Ursin C. M. Portas S. Rajaraman A. Gribok N. Wesensten T. Balkin J. Reifman N. Dursunoglu S. Ozkurt S. Baser O. Delen S. Sarikaya P. Sadler P. Mitchell D. Françon M. Decobert B. Herve A. Richard G. Griebel P. Avenet B. Scatton G. L. Fur D. Eckert A. Jordan A. Wellman S. Smith A. Malhotra D. White D. Bruck I. Thomas A. Kritikos W. Oertel K. Stiasny-Kolster D. Garcia-Borreguero W. Poewe B. Hoegl R. Kohnen E. Schollmayer J. Keffel C. Trenkwalder A. Valle S. Roizenblatt F. Fregni P. Boggio S. Tufik K. Ward L. Robertson L. Palmer P. Eastwood D. Hillman J. Lee S. Mukherjee V. de Padova G. Barbato G. Ficca I. Zilli P. Salzarulo M. Veldi T. Hion V. Vasar M. Kull L. Nowak J. Davis Y. Latzer O. Tzischinsky S. Crowley M. Carskadon M. Anca-Herschkovitsch D. Frey J. Ortega C. Wiseman C. Farley K. Wright A. Campbell A. Neill K. Spiegel R. Leproult E. Tasali N. Scherberg E. van Cauter A. T. Noradina N. A. Karim I. Norlinah A. A. Raymond R. Sahathevan B. Hamidon E. Werth R. Poryazova R. Khatami C. Bassetti R. G. Beran L. Ainley G. Holand J. Duncan H. Kinney B. Davis B. Hood S. Frey C. Schmidt M. Hofstetter P. Peigneux C. Cajochen W.-P. Hu J.-D. Li C. Zhang L. Boehmer J. Siegel Q.-Y. Zhou Y. Sagawa H. Kondo T. Takemura H. Kanayama Y. Kaneko M. Sato T. Kanbayashi Y. Hishikawa T. Shimizu A. Viola L. James L. Schlangen D.-J. Dijk R. Andretic Y.-C. Kim K.-A. Han F. Jones R. Greenspan L. Sanford L. Yang X. Tang K. Dieter E. Uta H. Sven M. Richard N. Oyane S. Pallesen F. Holsten Y. Inoue M. Fujita N. Emura K. Kuroda N. Uchimura A. Johnston J. Astbury G. Kennedy K. Hoedlmoser M. Schabus T. Pecherstorfer S. Moser G. Gruber P. Anderer W. Klimesch N. Naidoo M. Ferber A. Pack D. Neu O. Mairesse G. Hoffmann A. Dris L. Lambrecht P. Linkowski P. Verbanck O. Le Bon N. Matsuura M. Yamao N. Adachi R. Aritomi Y. Komada H. Tanaka S. Shirak University College London London UK University College London London USA Warwick Medical School London UK Warwick Medical School Coventry USA Radboud University Nijmegen Nijmegen Netherlands Department of Neurology University of Chile Santiago Chile Neurology Service Hospital del Salvador Santiago Chile Family Health Center Juan Pablo II Santiago Chile Department of Biomedicine Section on Physiology Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care Univeristy of Bergen Bergen Norway Department of Public Health and Primary Health Care University of Bergen Bergen Norway Norwegian Competence Center for Sleep Disorders Haukeland University Hospital Bergen Norway Department of Child and Adolescent Psychiatry Haukeland University Hospital Univeristy of Bergen Bergen Norway Department of Biomedicine University of Bergen Bergen Norway US Army Medical Research and Materiel Command Fort Detrick Frederick USA Walter Reed Army Institute of Research Silver Spring USA Department of Behavioral Biology Walter Reed Army Institute of Research Silver Spring USA Faculty Department of Pulmonology Pamukkale University Medical Denizli Turkey University of Ballarat Ballarat Australia Sanofi-Aventis Recherche et Developpement Paris France Brigham and Women’s Hospital Harvard Medical School Boston USA The University of Queensland Adelaide Australia School of Psychology University of Queensland Brisbane Australia The University of Queensland Brisbane Australia Victoria University Melbourne Australia Department of Psychology Victoria University Melbourne Australia School of Psychology Victoria University Melbourne Australia Philips-Universität Marburg Germany Philips-Universitaet-Marburg Marburg Germany Instituto de Investigaciones del Sueno Madrid Spain Universitätsklinik für Neurologie Innsbruck Austria Universitaetsklinik fuer Neurologie Innsbruck Austria IMEREM GmbH Nuernberg Germany Schwarz Pharma AG Monheim Germany

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ESICM LIVES 2016: part two

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Intensive Care Medicine Experimental 2016年第1期4卷 205-404页

作者： S. Sivakumar F. S. Taccone K. A. Desai C. Lazaridis M. Skarzynski M. Sekhon W. Henderson D. Griesdale L. Chapple A. Deane L. Williams R. Strickland K. Lange D. Heyland M. Chapman M. J. Rowland P. Garry J. Westbrook R. Corkill C. A. Antoniades K. T. Pattinson G. Fatania A. J. Strong R. B. Myers C. M. Jermaine C. S. Robertson C. G. Rusin J. Hofmeijer L. Sondag M. C. Tjepkema-Cloostermans A. Beishuizen F. H. Bosch M. J. A. M. van Putten L. Carteron C. Patet D. Solari M. Oddo M. A. Ali C. Dias R. Almeida A. Vaz-Ferreira J. Silva E. Monteiro A. Cerejo A. P. Rocha A. A. Elsayed A. M. Abougabal B. N. Beshey K. M. Alzahaby S. Pozzebon A. Blandino Ortiz S. Cristallini O. Lheureux A. Brasseur J. L. Vincent J. Creteur M. Hravnak K. Yousef Y. Chang E. Crago R. M. Friedlander S. A. Abdelmonem S. A. Tahon T. A. Helmy H. S. Meligy F. Puig I. Dunn-Siegrist J. Pugin S. Gupta D. Govil S. Srinivasan S. J. Patel J. K. N A. Gupta D. S. Tomar M. Shafi R. Harne D. P. Arora N. Talwar S. Mazumdar E. E. Papakrivou D. Makris E. Manoulakas B. Tsolaki B. Karadodas E. Zakynthinos I. Palacios Garcia A. Diaz Martin V. Sanchez Encinares M. Pachón Ibañez J. Garnacho Montero G. Labrador T. Cebrero Cangueiro V. Poulose J. Koh J. W. Kam H. Yeter A. Kara O. Aktepe A. Topeli I. Tsolakoglou G. Intas P. Stergiannis A. A. Kolaros E. Chalari E. Athanasiadou A. Martika G. Fildisis V. Faivre C. Mengelle B. Favier D. Payen A. Poppe M. S. Winkler E. Mudersbach J. Schreiber M. L. Wruck E. Schwedhelm S. Kluge C. Zöllner T. Tavladaki A. M. Spanaki H. Dimitriou E. Kondili C. Choulaki E. Meleti D. Kafetzopoulos D. Georgopoulos G. Briassoulis A. García-de la Torre M. V. de la Torre-Prados T. Tsvetanova-Spasova P. Nuevo-Ortega C. Rueda-Molina A. Fernández-Porcel E. Camara-Sola L. Salido-Díaz A. García-Alcántara D. E. Meleti B. Suberviola J. Riera L. Rellan M. Sanchez J. C. Robles E. Lopez R. Vicente E. Miñambres M. Santibañez M. Le Guen J. Moore N. Mason M. Windpassinger O. Plattner E. Mascha D. I. Sessler Outcomes Research U. Melia J. Fontanet J. P. van den Berg M. Baylor College of Medicine Neurology/Neurocritical Care Houston USA Erasmus Hospital Intensive Care Medicine Brussels Belgium Centre Hospitalier Régional Orléans Réaimation Médicale Orléans France University of British Columbia Vancouver Canada University of Adelaide Discipline of Acute Care Medicine Adelaide Australia Royal Adelaide Hospital Intensive Care Adelaide Australia Griffith University Menzies Health Institute of Queensland Gold Coast Australia University of Adelaide Discipline of Medicine Adelaide Australia Kingston General Hospital Clinical Evaluation Research Unit Kingston Canada University of Oxford Nuffield Department of Clinical Neurosciences Oxford UK Oxford University Hospitals NHS Foundation Trust Neurosciences Intensive Care Unit Oxford UK King’s College Hospital Department of Neurosurgery London UK King’ College London Institute of Psychiatry Psychology and Neuroscience Department of Clinical Neuroscience London UK Rice University Computer Science Houston USA Baylor College of Medicine Neurosurgery Houston USA Baylor College of Medicine Pediatric Cardiology Houston USA University of Twente Clinical Neurophysiology Enschede Netherlands Rijnstate Hospital Neurology Arnhem Netherlands Medical Spectrum Twente Clinical Neurophysiology Enschede Netherlands Medical Spectrum Twente Intensive Care Enschede Netherlands Rijnstate Hospital Intensive Care Arnhem Netherlands CHUV Department of Intensive Care Medicine Neuroscience Critical Care Research Group Lausanne Switzerland Aga Khan University Hospital Anaesthesiology Karachi Pakistan Centro Hospitalar São João Intensive Care Porto Portugal Faculty of Medicine University of Porto Medicine Porto Portugal Faculdade de Ciências Universidade do Porto Departamento de Matemática Porto Portugal Centro de Matemática Universidade do Porto Porto Portugal The Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine Zaragoza Spain Centro Hospitalar

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Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins

Distinct mechanisms of FAK mechanoactivation by different ex...

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第五届中美生物医学工程暨海内外生物力学学术研讨会

作者： Jihye Seong Arash Tajik Jie Sun Jun-Lin Guan Martin J.Humphries Susan E.Craig Asha Shekaran Andres J.Garcia Ning Wang Yingxiao Wang Neuroscience Program University of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Mechanical Science and Engineering University of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Bioengineering & Beckman Institute for Advanced Science and Technology University of IllinoisUrbana-ChampaignUrbanaIL61801USA Division of Molecular Medicine and Genetics Departments of Internal Medicine and Cell & Developmental BiologyUniversity of Michigan Medical SchoolAnn ArborMI48109USA Wellcome Trust Centre for Cell-Matrix Research Faculty of Life SciencesUniversity of ManchesterManchesterUK Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGA30332USA Department of Biomedical Engineering School of Life Science and TechnologyHuazhong University of Science and Technology Department of Integrative and Molecular Physiology Center for Biophysics and Computational BiologyInstitute for Genomic BiologyUniversity of IllinoisUrbana-ChampaignUrbanaIL61801USA Department of Bioengineering University of CaliforniaSan DiegoCA92093USA

Introduction Cells can sense and respond to the mechanical microenvironment by converting forces into biochemical signals inside the cells,*** adhesions are the major sites of interaction between a cell and its extracellular matrix(ECM) microenvironment, thus outside mechanical signals can be sensed at focal adhesions through transmembrane receptor *** particular,it has been shown that matrix elasticity can control the cell fate

关键词： FAK Distinct mechanisms of FAK mechanoactivation by different extracellular matrix proteins ECM

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Metabolomics and Network Biology for sensitive monitoring of how growth environment changes affect the physiology of industrial-scale perfusion cultures

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IFAC Proceedings Volumes 2013年第31期46卷 227-232页

作者： S.I. Vernardis C.T. Goudar M.I. Klapa Metabolic Engineering and Systems Biology Laboratory Institute of Chemical Engineering Foundation for Research and Technology-Hellas Patras GR- 265 04 Greece Cell Culture Development Global Biological Development Bayer HealthCare 800 Dwight Way Berkeley CA 94710 Interdepartmental Graduate Program in “Informatics in Life Sciences” Medical School University of Patras Greece & Current Address: Cell Science and Technology AMGEN Inc. Thousand Oaks CA 91320 USA Secondary Affiliation: Depts of Chemical & Biomolecular Eng and Bioengineering University of Maryland College Park MD 20742 USA

Metabolomic analysis can indeed enhance the prime variable dataset for the monitoring of perfusion cultures by providing a higher resolution view of the metabolic state. Metabolic profiles can capture physiological state shifts over the course of the perfusion cultures and indicate a metabolic “signature” of the phase transitions, which is not observable from prime variable data. Notably, metabolomics provides orthogonal (to prime variables) evidence that all cultures follow this same metabolic state shift with cell age, independently of bioreactor scale. Additionally, this analysis can increase the information content of process development experiments by helping better understand the impact of changes in bioreactor operating conditions on cell physiology. In this context, metabolic profiling could be integrated into the monitoring of cell physiology in perfusion cultures.

关键词： industrial cell culture engineering GC-MS metabolomics perfusion cultures multivariate statistical analysis metabolic network reconstruction growth environmental variations

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Encoding of liquid capped microcapsule and heterogeneous assembly for multiplexed assay

Encoding of liquid capped microcapsule and heterogeneous ass...

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16th International Conference on Miniaturized Systems for Chemistry and Life sciences, MicroTAS 2012

作者： Song, Younghoon Kwon, Taehong Lee, Daewon Kim, Junhoi Oh, Dongyoon Park, Taejoon Kwon, Sunghoon School of Electrical Engineering and Computer Science Seoul Naional University Korea Republic of Inter-University Semiconductor Research Center Korea Republic of Interdisciplinary Program for Bioengineering Korea Republic of

ISBN: (纸本)9780979806452

In this paper, we have demonstrated a technology for encoding of liquid capped microcapsule and dispensing thousands of heterogeneous encoded liquid drops into microwell array with only a single pipetting step, which would normally requires thousands of individual pipetting. With our technology, we can take advantages of both high coding capacity and liquid-liquid reaction, which is impossible in conventional droplet and bead-based assay platforms.

关键词： Liquids

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