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Review of designing an information processing ware for a Diabetic Chip

Journal of Diabetes science and Technology 2008年第5期2卷 873-881页

作者： Al-Sheikh, Youssef T. Andrade, Joseph D. Millington, Jared Wong, Anthony Department of Biomedical Informatics School of Medicine University of Utah Salt Lake City UT 84112 26 South 2000 East United States Department of Bioengineering School of Engineering University of Utah Salt Lake City UT United States Department of Physics School of Science University of Utah Salt Lake City UT United States Intermountain Healthcare Salt Lake City UT United States Department of Ophthalmology and Visual Science School of Medicine University of Utah Salt Lake City UT United States Program in Human Molecular Biology and Genetics Eccles Institute of Human Genetics University of Utah Salt Lake City UT United States Utah Science Center at The Leonardo Salt Lake City Main Library Salt Lake City UT United States

Miniaturization of clinical chemistry analyzers can empower research conducted to better understand, diagnose, manage, and cure diseases such as diabetes. For the last decade, we have been working on the design and development of miniaturized clinical chemistry devices, including a Diabetic Chip (diabetiChip). These devices measure a small array of analytes, are small, portable, fast, easy-to-operate, and inexpensive. The chosen analytical method for the diabetiChip uses bioluminescence, which is highly sensitive and specific, and is based on photon counting and specific enzymatic reactions. Bioluminescent reactions were intentionally chosen for analyzing metabolic reactions because they use some of the central nodes of metabolism, such as adenosine triphosphate. Operations of the diabetiChip's information processing ware are the focus of this paper;we show the feasibility of using a set of kinase-containing enzymatic reactions of a firefly bioluminescencecoupled glucose assay in designing the diabetiChip. We have developed and tested the feasibility of the glucose assay;the assay's analytical detection limits (before sample dilution) were 5-185 μM. Uncertainty associated with reporting a 100 μM concentration was about ± 5 μM. The results show that an FFL bioluminescentcoupled glucose assay is promising in terms of reducing sample volume and cost. The concept of GlucoFaces^™ in visualizing measurements of the diabetiChip is also discussed. © Diabetes Technology Society.

关键词： Assay calibration Bioluminescence Diabetic Chip Information ware Lab-on-a-chip Simulation Visual display

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Drop-on-demand printing of cells and materials for designer tissue constructs

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materials science and engineering C 2007年第3期27卷 372-376页

作者： Boland, Thomas Tao, Xu Damon, Brook J. Manley, Brian Kesari, Priya Jalota, Sahil Bhaduri, Sarit Department of Bioengineering Clemson University Clemson SC 29634 United States Department of Physics and Astronomy University of Missouri Columbia MO 65211 United States School of Material Science and Engineering Clemson University Clemson SC 29634 United States

Adapting bottom-up approaches to tissue engineering is a real challenge. Since the first application of fused deposition modeling for tissue engineering scaffolds, considerable effort has been focused on printing synthetic biodegradable scaffolds. Concurrently a variety of rapid prototyping techniques have been developed to define macroscopically the shapes of deposited biomaterials, including photolithography, syringe-based gel deposition, and solid freeform fabrication. These designed scaffolds have shown promise in regenerating tissues at least equivalent to other scaffolding methods. An exciting advance in scaffold aided tissue regeneration is presented here, that of cell and organ printing, which allows direct printing of cells and proteins within 3D hydrogel structures. Cell printing opens the possibility to programmed deposition of scaffold structure and cell type, thus controlling the type of tissue that can be regenerated within the scaffold. Several examples of printed tissues will be presented including contractile cardiac hybrids. The hybrid materials have properties that can be tailored in 3D to achieve desired porosities, mechanical and chemical properties. The materials include alginate hydrogels with controlled microshell structures that can be built by spraying cross-linkers onto ungelled alginic acid. Endothelial cells were seen to attach to the inside of these microshells. The cells remained viable in constructs as thick as 1 cm due to the programmed porosity. Finite element modeling was used to predict the mechanical properties and to generate CAD models with properties matching cardiac tissue. These results suggest that the printing method could be used for hierarchical design of functional cardiac patches, balanced with porosity for mass transport and structural support. © 2006 Elsevier B.V. All rights reserved.

关键词： Genetic engineering

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Comparison of Water-soluble CdSe Quantum Dots Made from Hydrothermal and Traditional Routes

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Journal of Wuhan University of Technology(materials science) 2007年第B12期22卷 834-836页

作者：王德平 Institute of BioEngineering and Information Technology Materials School of Material Science and EngineeringTongji University

The comparison of traditional route to the simple synthesis of CdSe semiconductor nanocrystals, with the hydrothermal route, where the reaction temperature can be reached at 220℃, was presented in this paper. The optical properties of the water-soluble CdSe quantum dots from the hydrothermal and traditional were characterized by UV-vis absorption spectra, photoluminescence （PL） spectra and HRTEM techniques. The HRTEM results show that with the increase of the reaction temperature, the naocrystal defects decreased. The UV-vis absorption peak moved to long wave-length with the increase of reaction temperature. The photoluminescence （PL） spectra show that the wavelength of the bright point, the PL quantum yield （QY） increased when the nanocrystal defects decreased. The optical property data confirm that hydrothermal router is a preferable method to traditional route for preparing water-soluble CdSe quantum dots.

关键词： semiconductor nanocrystals CdSe photoluminescence hydrothermal process

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Abstracts for the 6th Congress of Asian Sleep Research Society

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Sleep and Biological Rhythms 2009年第4期7卷 A1-A49页

作者： Seog Ju Kim In Kyoon Lyoo Yu-Jin Lee Do-Un Jeong Hirohiko Kanai Masanori Ookubo Atsushi Yoshimura Masako Okawa Noto Yamada Takeshi Munezawa Yoshitaka Kaneita Yoneatsu Osaki Hideyuki Kanda Tadahiro Ohtsu Masumi Minowa Kenji Suzuki Susumu Hijuchi Hiroyuki Suzuki Takashi Ohida Takashi Abe Yoko Komada Shoichi Asaoka Yuichi Inoue Jin-Seong Lee Sang-Yong Cho Deependra Kumar Hruda N. Mallick Velayudhan M. Kumar Mahesh K. Kaushik Akihiro Karashima Noiihiro Katayama Mitsuyuki Nakao Ravindra P. Nagendra Sathiamma Sulekha Sathyaprabha T. Narasappa Pradhan Nityanadan Bindu M. Kutty M. Nirmala P. N. Ravindra Basavaraj Ramappa Tubaki T. N. Sathyaprabha D. Sudhakar G. S. Lavekar C. R. Chandrashekar Kazuyoshi Kitaoka Mika Shimizu Sachiko Chikahisa Kazuo Yoshizaki Hiroyoshi Sei Jong-Won Kim Misa Takegami Shin Yamazaki Yasuaki Hayashino Rei Ono Koji Otani Miho Sekiguchi Shinichi Konno Shunichi Fukuhara Antonia J. Jakobson Paul Fitzgerald Russell Conduit Xin Shirley Li Siu Ping Joyce Lam Wai Man Mandy Yu Yun Kwok Wing Kazue Okamoto-Mizuno Koh Mizuno Mituaki Yamamoto Shuichiro Shirakawa Hirokazu Doi Mikako Kato Kazuyuki Shinohara Masako Tamaki Shiori Matsuda Katsuo Yamazaki Tadao Hori Keiko Ogawa Kazumi Takahashi Kunio Kitahama Katuo Yamazaki Yoshimasa Koyama Kohei Shioda Yugo Ueda Yukiko Nakamura Clara Inoue Kazushige Goto Sunao Uchida Yuko Morita Yoshiko Honda Tohru Kodama Mari Hagihara Toru Nakajima Masato Saito Yoshihiko Koga Shinichiro Tanaka Hiroshi Yamadera Madoka Takahara Sachiko Suwa Minoru Onozuka Sadao Sato Fumiharu Togo Taiki Komatsu Takeshi Mitani Jongbae Choi Bin Zhang Taeko Sasai Hiromi Mitsubayashi Mitsuhiro Ohtsu Isao Hasegawa Tatsuya Ishii Akira Komori Asami Suzuki Yue Nakahara Mitsuyasu Hiroki Mariko Nakauma Nobuo Someya Tomomasa Ochiai Shouhei Komori Rayleigh Ping-Ying Chiang Zai-Ting Yeh Seong T. Kim Seung H. Yoon Jeong S. Kwon Jong H. Choi Hyung J. Ahn Youngsoo Kim Bolortuya Yunren Lichao Chen Radhika Basheer Robert W. Mccarley Robert E. Strecker Makoto Honda Tetsuaki Arai Miyuki Fukazawa Yutaka Honda Kuniaki T Department of Psychiatry Gachon University of Medicine and Science Incheon Republic of Korea Department of Psychiatry Seoul National University Seoul Republic of Korea Department of Neuropsychiatry and Center for Sleep and Chronobiology Seoul National University Hospital Seoul Republic of Korea Department of Neuropsychiatry Seoul National University Hospital Seoul Republic of Korea Seoul National University Hospital Seoul Republic of Korea Department of Psychiatry Shiga University of Medical Science Otsu Japan Division of Public Health Department of Social Medicine Nihon University School of Medicine Tokyo Japan Department of Public Health Nihon University School of Medicine Tokyo Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan Department of Hygiene and Preventive Medicine Fukushima Medical University Fukushima Japan Department of Public Health Showa University School of Medicine Tokyo Japan Faculty of Humanities Seitoku University Matsudo Japan Section on Behavioral Science Division of Clinical Research National Hospital Organization Kurihama Alcoholism Center Yokosuka Japan Department of Otolaryngology Second Hospital Fujita Health University Nagoya Japan National Hospital Organization Kurihama Alcoholism Center Kanagawa Japan Metropolitan Police Department Criminal Investigation Laboratory Tokyo Japan Japan Somnology Center Neuropsychiatrie Research Institute Tokyo Japan Department of Somnology Tokyo Medical University Tokyo Japan Japan Somnology Center Neuropsychiatric Research Institute Tokyo Japan Department of Somnology Tokyo Medical and Dental University Tokyo Japan Center for Sleep and Chronobiology Department of Psychiatry and Behavioral Science Seoul National University College of Medicine Seoul Republic of Korea Department of Psychiatry and Behavioral Science Center for Sleep and Chronobiology Seoul Republic of Korea Department of Physiology Al

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Perfusion culture improves the maintenance of cultured liver tissue slices

Perfusion culture improves the maintenance of cultured liver...

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作者： Schumacher, Karl Khong, Yuet-Mei Chang, Shi Ni, Jun Sun, Wanxin Yu, Hanry Institute of Bioengineering and Nanotechnology A STAR Singapore Singapore Graduate Program in Bioengineering NUS Graduate School of Integrative Science and Engineering National University of Singapore Singapore Singapore Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR The Nanos 31 Biopolis Way Singapore 138669 Singapore

Cultured precision-cut liver tissue slices are useful for studying the metabolism and toxicity of xenobiotics in liver. They may also be used to investigate the behavior of and interaction between different cell types in an intact histo-architectere. Because cultured liver tissues undergo a loss of function and morphology because of their separation from the blood supply, we investigated changes in key protein marker expressions in parenchymal and non-parenchymal cells, as well as in the extracellular matrix (ECM) at different time points. We also compared conventional culture methods such as static and dynamic cultures with perfusion culture, which allows a continuous exchange of the culture medium. In conventional culture methods, the expression of vimentin and collagen type IV decreased after 5 h in the non-parenchymal cells and the ECM, respectively, whereas the hepatocyte nuclear factor 4 alpha (HNF4α) staining in the hepatocytes remained constant. In perfusion culture, on the other hand, vimentin, collagen type IV, and HNF4α staining were clearly detectable after 5 h. The histo-architecture obtained from perfusion culture was also more compact than those obtained from conventional culture methods. After 24 h, only the perfusion cultured sample retained protein marker expression in all components of the liver tissue. Our results suggest that, to develop improved culture techniques for liver slices, changes at the early time-points should be taken into consideration. Our results also show that culture techniques that enable a continuous exchange of the culture medium seem to be superior to static or dynamic cultures in terms of maintaining the protein expression and the histo-architecture. © Mary Ann Liebert, Inc.

关键词： Cell culture

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The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell

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Journal of Inclusion Phenomena and Macrocyclic Chemistry 2007年第3-4期58卷 205-219页

作者： Nagasaki, Takeshi Shinkai, Seiji Department of Applied Chemistry and Bioengineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku. Osaka 558-8585 Japan SORST Program Japan Science and Technology Corporation Kawaguchi. Saitama 332-0012 Japan Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan Center for Future Chemistry Kyushu University Fukuoka 819-0395 Japan

Since the first generation of molecular machines including photoresponsive crown ethers and its analogues was reported by Shinkai et al., a huge number of molecular machines exhibiting dynamic chemical and physical functions have been designed and developed. On the other hand, non-viral vectors are desired to possess conflicting properties to associate with DNA until reaching the nucleus as their final destination and dissociate from DNA there. In other words, non-viral vectors should work as a sort of molecular machinery. To overcome this dilemma, recently, much attention is focused on the development of the intelligent vectors, also called as "stimuli responsive vectors' working as molecular machines. In this review, stimulus responsive gene delivery systems in which some structural factors and/or physiological properties are regulated in response to extracellular signals such as redox, pH, ultrasound, light, temperature, etc. are introduced as a new generation of non-viral vectors. These extracellular signals such as ultrasound, light, and temperature can be potent stimuli capable of site-, timing-, and duration-specific gene expression. © Springer science+Business Media B.V. 2007.

关键词： Ultrasonics

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Contributors to the Lab on a Chip cell and tissue engineering in microsystems special issue

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Lab on a Chip 2007年第6期7卷 667-671页

作者： Bhatia, Sangeeta N. Chen, Christoper Bashir, Rashid Beebe, David J. Desai, Tejal Gottwald, Eric Khademhosseini, Ali Langer, Robert S. Piel, Matthieu Takayama, Shuichi Thorsen, Todd Tien, Joe Voldman, Joel Vunjak-Novakovic, Gordana Wu, Mingming Yu, Hanry Massachusetts Institute of Technology Harvard-MIT Division of Health Sciences and Technology Department of Electrical Engineering and Computer Science United States Laboratory for Multiscale Regenerative Technologies United States Department of Innovation University of Pennsylvania Department of Bioengineering United States Cell Biology and Physiology Program Cell Growth and Cancer Program Tissue Microfabrication Laboratory Department of Electrical and Computer Engineering and Biomedical Engineering Purdue University United States Department of Electronics University of Glasgow United Kingdom Department of Physiology and Bioengineering University of California San Francisco CA United States California Institute for Quantitative Biomedical Research UCSF/UC Berkeley Graduate Group in Bioengineering United States Laboratory of Therapeutic Micro and Nanotechnology Institute for Biological Interfaces Germany 3D-Cell Culture Techniques Group Institute for Biological Interfaces Germany Department of Medicine and Health Sciences and Technology Massachusetts Institute of Technology (MIT) United States Institut Curie UMR 144 IC/CNRS France Biomedical Engineering Department University of Michigan United States Department of Biomedical Engineering Macromolecular Science and Engineering Program United States Sibley School of Mechanical and Aerospace Engineering School of Chemical and Molecular Engineering Cornell University United States National University of Singapore Singapore Institute of Bioengineering and Nanotechnology A STAR Singapore

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Molecular dynamic simulation of heat pulse propagation in multiwall carbon nanotubes

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Physical Review B 2007年第15期76卷 155424-155424页

作者： Taejin Kim Mohamed A. Osman Cecilia D. Richards David F. Bahr Robert F. Richard Material Science Program Washington State University Pullman Washington 99164-4620 USA Department of Physics Washington State University Pullman Washington 99164-2814 USA School of Electrical Engineering and Computer Science Washington State University Pullman Washington 99164-2752 USA School of Mechanical and Materials Engineering Washington State University Pullman Washington 99164-2920 USA

The propagation of heat pulses in zigzag and armchair double wall nanotubes (DWNTs) has been investigated using molecular dynamics simulations. It is found that the leading heat wave packets in zigzag (9,0)∕(18,0) and armchair (5,5)∕(10,10) DWNTs move with the speed of longitudinal acoustic (LA) phonon modes. The intensities of the leading heat wave packets in outer and inner shells in DWNTs were found to be five to seven times larger than that of the corresponding single wall nanotubes (SWNTs). The heat energy carried by the leading heat wave packets in zigzag DWNT was about four and five times more than those in armchair DWNT shells. Within the leading LA wave packet, the strain in the inner shell of the DWNTs is stronger than the strain in the outer shell and considerably larger than strain in the corresponding SWNTs. The regions with the largest strain coincide with the regions of high kinetic temperatures within the LA mode wave packets. The higher energy of the LA mode waves in DWNT shells compared to SWNT is attributed to the presence of higher strain fields in DWNTs compared to individual SWNTs. The higher strain in the inner shell of DWNT compared to the outer shell accounts for the three to five times higher kinetic energy of leading wave packets in inner shells compared to those in outer shells. The induced strain fields in zigzag DWNT are distributed over a wider region compared to armchair DWNT, and the strains in inner and outer shells of zigzag DWNT are out phase by 180°.

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engineering education and the global economy: The search for policy

Engineering education and the global economy: The search for...

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113th Annual ASEE Conference and Exposition, 2006

作者： Devon, Richard Kisenwether, Elizabeth Schuhmann, Richard Pangborn, Robert Barron, Kim Pennsylvania State University United States Department of Engineering Design Engineering Design Program School for Engineering Design Technology United States Engineering Entrepreneurship Program Engineering Leadership Program United States Department of Civil and Environmental Engineering Undergraduate Studies and International Programs College of Engineering Department of Material Science Industrial Engineering at Penn State United States

engineering education in the United States is confronted with some new realities, both real and perceived. engineering is increasingly a globally distributed, cooperative activity and the US outsourcing of research, design, manufacturing, and construction overseas is growing. Further, the production of engineers in the United States is falling to around 5-6% of the global supply with clear signs that engineering education is available at lower costs, often far lower, in other countries. Many have viewed this globalization as a competitive situation for engineering education in the United States that we are losing. We will present the view that in terms of the quality of engineering education (which engineering educators can influence) as opposed to the global economy (about which we can do little), engineering education is still very strong in the US and likely to remain that way. However, we will present some recommendations based on our professional responsibilities in running programs in entrepreneurship, leadership, and design. In particular, we will review survey data collected from Penn State engineering graduates over the last decade which helps define new paths for integrating entrepreneurship, leadership and design into the engineering curriculum. We believe that there are some very real ways in which engineering education can, and should be, responding to the new requirements for success in professional engineering careers that derive from national needs as well as from the globalization of engineering. © American Society for engineering Education, 2006.

关键词： engineering education

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Preparation of hydrogen bonding polymer structures using ultra high pressure technology as drug carrier

Preparation of hydrogen bonding polymer structures using ult...

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2006 AIChE Annual Meeting

作者： Miura, Yoshiyuki Kimura, Tsuyoshi Nam, Kwangwoo Mutsuo, Shingo Yoshizawa, Hidekazu Fujisato, Toshiya Kishida, Akio Institute of Biomaterials and Bioengineering Tokyo Medical and Dental University Tokyo Japan Department of Material and Energy Science Gradual School of Environmental Science Okayama University Okayama Japan Department of Regeneration Medicine and Tissue Engineering National Cardiovascular Center Research Institute Osaka Japan

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ISBN: (纸本)081691012X

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