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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: Biomedical Optics

作者： Gao, Gan Wang, Fiona Brenes, David Song, Andrew H. Chow, Sarah S.L. Mahmood, Faisal Liu, Jonathan T.C. Department of Mechanical Engineering University of Washington SeattleWA98195 United States Department of Computer Science University of Washington SeattleWA98195 United States Department of Pathology Brigham and Women's Hospital Harvard Medical School BostonMA02115 United States Department of Pathology Massachusetts General Hospital Harvard Medical School BostonMA02114 United States Cancer Program Broad Institute of Harvard and MIT CambridgeMA02142 United States Data Science Program Dana-Farber Cancer Institute BostonMA02215 United States Department of Bioengineering University of Washington SeattleWA98195 United States Department of Laboratory Medicine & Pathology University of Washington School of Medicine SeattleWA98195 United States

3D pathology can potentially improve disease detection, but the datasets are too large to review. We're developing a deep-learning-based triage method to identify the highest-risk 2D sections within 3D pathology d... 详细信息

关键词： Adversarial machine learning

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Phytotherapeutic efficacy of Mitragyna parvifolia for acute dermatolymphangioadenitis (ADLA)

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Journal of Parasitic Diseases 2025年 1-20页

作者： Jebaseelan, Jefrillah Venkatesan, Ashwathdaman Ambalam Manivannan R, Kalpana Kumar, Vinay Sugumar, Vimal Abdul Majeed, S. Mithra, S. Sahul Hameed, A.S. Jamespandi, Annaraj Natesan, Sankar Balakrishnan, Anand Setty Department of Genetic Engineering School of Biotechnology Madurai Kamaraj University Madurai India Department of Bioengineering Saveetha School of Engineering Institute of Biotechnology Saveetha Institute of Medical and Technical Sciences Tamil Nadu Thandalam Chennai 602 105 India Biomaterials and Tissue Engineering (BITE) Laboratory Department of Community Medicine Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Chennai India Molecular and Nanobiotechnology Laboratory (MNBL) Department of Biochemistry Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS) Tamil Nadu Thandalam Chennai 602105 India Aquatic Animal Health Laboratory PG and Research Department of Zoology C Abdul Hakeem College Tamil Nadu Melvisharam 632509 India Department of Material Science School of Chemistry Madurai Kamaraj University Madurai India Department of Epidemiology and Public Health Central University of Tamilnadu Thiruvarur India

This study extensively evaluated the therapeutic potential of Mitragyna parvifolia in treating filariasis-induced secondary lymphedema, with a specific focus on validating its efficacy as a dermal application for acute dermatolymphangioadenitis (ADLA). The research investigated the effects of M. parvifolia leaf extract, green-synthesized silver nanoparticles (Mp-AgNPs), and the primary alkaloid Mitraphylline through various assays. Silver nanoparticles were successfully synthesized from M. parvifolia leaves, confirmed by observable color changes and UV–Vis spectroscopy, highlighting their potential as enhanced wound dressing components. FTIR analysis revealed the presence of functional groups indicative of biochemical activities in Mp-AgNPs, while DLS and SEM studies elucidated their size and morphology characteristics, essential for understanding their application in therapeutic settings. Biocompatibility assessments demonstrated that all tested samples exhibited minimal hemolytic activity, supporting their suitability for further studies. Antioxidant assays showed significant radical scavenging activity in M. parvifolia extracts and Mp-AgNPs, surpassing that of Mitraphylline and demonstrating potential therapeutic benefits. The M. parvifolia leaf extract and its silver nanoparticles exhibited effective macrofilaricidal activity, with the nanoparticles showing enhanced inhibition at higher concentrations. Cytotoxicity evaluations on a Tilapia gill (TG) cell line revealed dose-dependent effects, suggesting Mp-AgNPs and the leaf extract's higher toxicity thresholds compared to purified Mitraphylline. Furthermore, wound healing assays indicated comparable efficacy among M. parvifolia derivatives in promoting wound closure, emphasizing their potential in managing lymphedema-related infections. Overall, this comprehensive evaluation underscores the therapeutic promise of M. parvifolia and its derivatives, particularly Mp-AgNPs, as effective topical treatments for second

关键词： ADLA Macrofilaricidal Mitragyna parvifolia Silver nanoparticles Tilapia gill cell line

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Isoxazoline: A Privileged Scaffold for Agrochemical Discovery

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Journal of agricultural and food chemistry 2025年第23期73卷 2025 Jun 3页

作者： Li Xiong Rui Zhang Kai-Long Zhang Baohui Qi Department of Bioengineering Zhuhai Campus of Zunyi Medical University Zhuhai 519041 Guangdong Province China. Hubei Key Laboratory of Low Dimensional Optoelectronic Material and Devices Hubei University of Arts and Science 296 Longzhong Road Xiangyang 441053 Hubei P. R. China. School of Chemical Engineering and Food Science Hubei University of Arts and Science 296 Longzhong Road Xiangyang 441053 Hubei P. R. China.

Isoxazolines are an important class of nitrogen- and oxygen-containing heterocycles that belong to the azole family. Recently, it has gained great attention in the field of agrochemical development. However, systematic reviews on the advancements of isoxazolines containing bioactive molecules are relatively lacking. To provide insight into advancements in discovering isoxazoline-containing molecules with agrochemical activities, we systematically reviewed and summarized bioactive isoxazoline compounds based on their structural diversity and active characteristics. The brief structure-activity relationship and mechanism of action of isoxazoline-containing compounds are also discussed. This article is meant to enable researchers in the discovery of novel agrochemicals to quickly understand and provide new ideas for developing novel agrochemicals with novel structures, potent activity, and new mechanism of action.

关键词： Isoxazoline Mechanistic studies Pesticidal activity Structure−activity relationship (SAR)

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Micro-vial Synthesis,Structure,Magnetic Properties and Hirshfeld Surface Analysis of a Penta-nuclear Fe(Ⅲ) Cluster

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Chinese Journal of Structural Chemistry 2020年第1期39卷 118-125,4页

作者： WANG Ji-Ming DENG Qian-Jun ZHANG Shu-Hua College of Chemistry and Bioengineering(Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials) Guilin University of TechnologyGuilin 541004China School of Material Science and Energy Engineering Foshan UniversityFoshan 528000China

A new penta-nuclear Fe^Ⅲ cluster,[HN(C2H5)3]·[Fe5(timb)4(ATZ)4(μ3-O)2]·(H2O)5(1),(H2timb is 4-bromo-2-[(1H-tetrazol-5-ylimino)-methyl]-phenol;HATZ is 5-amino-1,2,3,4-tetrazole),was synthesized through micro-vial synthesis methods,which was characterized by elemental analysis,FT-IR spectra,X-ray single-crystal diffraction,thermogravimetric *** single crystal belongs to the tetragonal system,space group √42d with a=0.19735(1),b=0.19735(1),c=0.26118(2)nm,Mr=1904.04,V=10.1724(10)nm^3,Z=4,Dc=1.118 g/cm^3,F(000)=3356,μ=2.314 mm^–1,R=0.0500 and wR=*** magnetic properties and Hirshfeld surface analysis of 1 were investigated and discussed in detail.

关键词： penta-nuclear Fe(Ⅲ)cluster micro-vial reaction Hirshfeld surface analysis magnetic properties

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Tunable Multimodal Guided Surface Lattice Resonances in Index-Discontinuous Environments

arXiv

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arXiv 2024年

作者： Huang, Suichu Yao, Kan Huang, Wentao Zhao, Xuezheng Zheng, Yuebing Pan, Yunlu Key Laboratory of Micro-Systems and Micro-Structures Manufacturing Ministry of Education School of Mechatronics Engineering Harbin Institute of Technology Harbin150001 China Walker Department of Mechanical Engineering Material Science and Engineering Program Texas Materials Institute The University of Texas at Austin AustinTX78712 United States

Surface lattice resonances (SLRs) in metasurfaces are promising in applications of sub-wavelength devices, owning properties such as high quality (high-Q) factors, large local field enhancement and extensive long-range interaction. The tunable peak position and multimodal resonances of SLRs further enhance their appeal for flexible and multi-wavelength light-matter interactions. Despite these advantages, the realization of tunable multimodal SLRs often requires reconfiguring the lattices, leading to limited tunability. Furthermore, current high-Q SLR implementations necessitate a homogeneous dielectric environment, restricting potential applications such as biosensors that are typically operated in an aqueous or air cladding on a substrate. Here we present guided-SLRs (gSLRs), which are easily accessible in index-discontinuous environments while retaining the multimodal property and straightforward tunability of mode number, resonance wavelengths and mode coupling strengths. The gSLRs are achieved by coupling the scattered light from metasurface units into a slab waveguide, creating a light propagating channel in the lattice plane within an index-asymmetric environment. Tailoring the radiation pattern of individual units with guided transverse electric (TE) and transverse magnetic (TM) modes, multimodal resonances in both orthogonal and parallel coupling directions are accomplished. The mode number and resonance wavelengths can be easily controlled by adjusting the waveguide configuration, while the mode coupling strength is tuned by the vertical position of lattices in the slab. Further shift of the multimodal gSLRs from visible to near-infrared is achieved by introducing a gold backplane. The easy-to-access, flexibly tunable and multimodal gSLRs in inhomogeneous media offer a promising solution to advancing the realization of ultrathin and ultracompact nano-optical and optoelectronic devices. Copyright © 2024, The Authors. All rights reserved.

关键词： Waveguides

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Development of biofertilizers for sustainable agriculture over four decades(1980-2022)

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Geography and Sustainability 2024年第1期5卷 19-28页

作者： Guangxu Zhao Xiaoling Zhu Gang Zheng Guangfan Meng Ziliang Dong Ju Hye Baek Che Ok Jeon Yanlai Yao Yuan Hu Xuan Jie Zhang Baolei Jia Xianghu Laboratory Hangzhou 311231China School of Bioengineering State Key Laboratory of Biobased Material and Green PapermakingQilu University of Technology(Shandong Academy of Sciences)Jinan 250000China Shandong Academy of Agricultural Sciences Jinan 250000China Taiji Group Chongqing 400000China Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Institute of Environment ResourceSoil and FertilizersZhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory of Elemento-Organic Chemistry Department of Chemical BiologyNational Pesticide Engineering Research Center(Tianjin)Nankai UniversityTianjin 300071China

The application of biofertilizers is becoming an inevitable trend to substitute chemical fertilizers for sustainable *** better understand the development of biofertilizers from 1980 to 2022,we used bibliometric mining to analyze 12,880 journal articles related to *** network cooccurrence analysis suggested that the biofertilizers research can be separated into three *** first stage(1980-2005)focused on nitrogen *** second stage(2006-2015)concentrated on the mechanisms for increasing plant *** third stage(2016-2022)was the application of biofertilizers to improve the soil *** keyword analysis revealed the mechanisms of biofertilizers to improve plant-growth:biofertilizers can impact the nutritional status of plants,regulate plant hormones,and improve soil environments and the *** bacteria use as biofertilizers,included Pseudomonas,Azospirillum,and Bacillus,were also identified through bibliometric *** findings provide critical discernment to aid further study of biofertilizers for sustainable agriculture.

关键词： Biofertilizer Plant-growth-promoting bacteria Plant-growth promoting rhizobacteria Bibliometric Research hotspots

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Corrosion resistance of Mg alloy with high Zn concentration including impurity Cu

Corrosion resistance of Mg alloy with high Zn concentration ...

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International Conference on Processing and Manufacturing of Advanced materials Processing, Fabrication, Properties, Applications, THERMEC 2021

作者： Ikoma, Masato Morishige, Taiki Kikuchi, Tetsuo Yoshida, Ryuichi Takenaka, Toshihide Graduate School of Science and Engineering Kansai University Suita564-8680 Japan Faculty of Chemistry Material and Bioengineering Kansai University Suita564-8680 Japan CHUO-KOSAN. LTD Tokyo103-0022 Japan

ISBN: (纸本)9783035736304

Mg alloys are very attractive materials for transportation industry due to their toughness and lightness. Recycling Mg alloys is desired for energy saving that otherwise would be required to produce its primary metal. However, secondary produced Mg tends to contain a few impurity elements that deteriorate its corrosion resistance. For example, contamination of Mg alloy by Cu induces second phase of Mg2Cu and it works as strong cathode, resulting in the corrosion rate rapidly increasing. It was previously reported that the corrosion resistance of Mg with impurity Cu was remarkably improved by addition of alloying element Zn. Addition of Zn into Mg formed MgZn2 phase and incorporated Cu into MgZn2 phase instead of Mg2Cu formation. In this way, since Zn serves to improve the corrosion resistance of Mg, Mg alloy with high Zn concentration may form a lot of MgZn2 and may have better corrosion resistance even with high Cu concentration. In this work, the corrosion behavior of Mg-6mass%-1mass%Al (ZA61) with different Cu content up to 1mass% was investigated. As a result, ZA61-1.0Cu had much lower corrosion rate compared to Mg-0.2%Cu and the corrosion rate was almost the same as that of pure Mg. © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Corrosion resistance

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Segmented readout for Cherenkov time-of-flight positron emission tomography detectors based on bismuth germanate

arXiv

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arXiv 2024年

作者： Yi, Minseok Lee, Daehee Gola, Alberto Merzi, Stefano Penna, Michele Lee, Jae Sung Cherry, Simon R. Kwon, Sun Il Department of Biomedical Engineering University of California Davis United States Interdisciplinary Program in Bioengineering College of Engineering Seoul National Graduate School Korea Republic of Integrated Major in Innovative Medical Science Seoul National Graduate School Korea Republic of Fondazione Bruno Kessler Italy Brightonix Imaging Inc. Korea Republic of

Positron emission tomography (PET) is the most sensitive biomedical imaging modality for noninvasively detecting and visualizing positron-emitting radiopharmaceuticals within a subject. In PET, measuring the time-of-flight (TOF) information for each pair of 511-keV annihilation photons improves effective sensitivity but requires high timing resolution. Hybrid materials that emit both scintillation and Cherenkov photons, such as bismuth germanate (BGO), recently offer the potential for more precise timing information from Cherenkov photons while maintaining adequate energy resolution from scintillation photons. However, a significant challenge in using such hybrid materials for TOF PET applications lies in the event-dependent timing spread caused by the mixed detection of Cherenkov and scintillation photons due to relatively lower production of Cherenkov photons. This study introduces an innovative approach by segmenting silicon photomultiplier (SiPM) pixels coupled to a single crystal, rather than using traditional SiPMs that are as large as or larger than the crystals they read. We demonstrated that multiple time stamps and photon counts obtained from the segmented SiPM can classify events by providing temporal photon density, effectively addressing this challenge. The approach and findings would lead to new opportunities in applications that require precise timing and photon counting, spanning the fields of medical imaging, high-energy physics, and optical physics. © 2024, CC BY.

关键词： Photons

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Statistical Analysis of Car Data Using Analysis of Covariance (ANCOVA) 1

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3rd International Conference on Mathematics and its Applications in science and engineering, ICMASE 2022

作者： Syam, Thaer Syam, Mahmoud M. Khan, Adnan Syam, Mahmoud I. Syam, Muhammad I. Department of Mechanical Engineering Texas A&M University College StationTX3123 TAMU United States School for Engineering of Matter Arizona State University Transport & Energy TempeAZ85287-6106 United States Department of Material Science and Engineering Texas A&M University College StationTX3003 TAMU United States Department of Mathematics Foundation Program Qatar University P.O. 2713 Doha Qatar Department of Mathematical Sciences College of Science UAE University Al-Ain Al Ain United Arab Emirates

ISBN: (数字)9783031217005

ISBN: (纸本)9783031216992

engineering statistics involves data concerning manufacturing processes such as: component dimensions, tolerances, type of material, and fabrication process control. In this work, some statistical analysis was done on a car data which was collected in 1983. This data set contains a sample of 66 cars from three different countries producers (USA, Japan, and Europe) in terms of their price and 13 different features. The objective was to determine how these quantitative variables affect the car price using the Analysis of Covariance (ANCOVA). Some analysis was done to find the best Multiple Linear Regression (MLR) model that identifies the most significant factors that influence the car price. The addition of removal of new factors was based on trial and error and based on the value of the linear correlation with the car price (Pearson coefficient of correlation r). 9 out of 13 factors were chosen based on MLR and the model selection/reduction analysis. The conclusion from ANCOVA analysis found that the European cars are the most expensive cars when compared to USA and Japan. Japan cars are the second expensive and USA cars are the cheapest. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Linear regression

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Correction: materials laboratories of the future for alloys, amorphous, and composite materials (MRS Bulletin, (2025), 50, 2, (190-207), 10.1557/s43577-024-00846-y)

引用

MRS Bulletin 2025年 1-2页

作者： Banerjee, Sarbajit Meng, Y. Shirley Minor, Andrew M. Zhang, Minghao Zaluzec, Nestor J. Chan, Maria K.Y. Seidler, Gerald McComb, David W. Agar, Joshua Mukherjee, Partha P. Melot, Brent Chapman, Karena Guiton, Beth S. Klie, Robert F. McCue, Ian D. Voyles, Paul M. Robertson, Ian Li, Ling Chi, Miaofang Destino, Joel F. Devaraj, Arun Marquis, Emmanuelle A. Segre, Carlo U. Liu, Huinan H. Yang, Judith C. Momeni, Kasra Misra, Amit Abdolrahim, Niaz Medvedeva, Julia E. Cai, Wenjun Sehirlioglu, Alp Dizbay-Onat, Melike Mehta, Apurva Graham-Brady, Lori Maruyama, Benji Rajan, Krishna Warner, Jamie H. Taheri, Mitra L. Kalinin, Sergei V. Reeja-Jayan, B. Schwarz, Udo D. Simon, Sindee L. Brown, Craig M. Department of Chemistry and Department of Materials Science & Engineering Texas A & M University College Station United States Pritzker School of Molecular Engineering The University of Chicago Chicago United States Department of Materials Science & Engineering University of California Berkeley Berkeley United States National Center for Electron Microscopy Molecular Foundry Lawrence Berkeley National Laboratory Berkeley United States Center for Nanoscale Materials Argonne National Laboratory Lemont United States Department of Physics University of Washington Seattle United States Department of Materials Science & Engineering The Ohio State University Columbus United States Department of Mechanical Engineering and Mechanics Drexel University Philadelphia United States School of Mechanical Engineering Purdue University West Lafayette United States Department of Chemistry University of Southern California Los Angeles United States Department of Chemistry Stony Brook University The State University of New York Stony Brook United States Department of Chemistry University of Kentucky Lexington United States Department of Physics University of Illinois at Chicago Chicago United States Department of Materials Science & Engineering Northwestern University Evanston Bangladesh Department of Materials Science & Engineering University of Wisconsin–Madison Madison United States Department of Materials Science and Engineering University of Pennsylvania Philadelphia United States Department of Mechanical Engineering and Materials Science Duke University Durham United States Department of Chemistry Creighton University Omaha United States Physical and Computational Sciences Directorate Pacific Northwest National Laboratory Richland United States Department of Materials Science & Engineering University of Michigan–Ann Arbor Ann Arbor United States Department of Physics Illinois Institute of Technology Chicago United States Department of Bioengineering and the Mater

This article was updated to correct Minghao Zhang’s affiliation from "Pritzker school of Molecular engineering, The University of Chicago, Chicago, USA" to "Pritzker school of Molecular engineering, The University of Chicago, Chicago, USA;Argonne National Laboratory, Lemont, USA." Argonne National Laboratory was left off the original publication. © The Author(s) 2025.

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