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5th International Seminar on Sciences, ISS 2018

作者： Taufikurahman, T. Istiqomah, I.N. Bioengineering Study Programme School of Life Sciences and Technology Institut Teknologi Bandung Bandung Indonesia

Microalgae have been used in a process of pollutants removal from wastewater, a process known as phycoremediation. In this study we used Chlorella vulgaris to remediate anaerobically digested dairy manure wastewater (ADDMW) which contained a high concentration of nitrogen and phosphor. The light intensity of 50, 100 μmol/m2s and sunlight were applied to the microalgal culture. Percentage of reduction in ammonium and orthophosphate content in the media were measured. Protein content in microalgal biomass was measured using hot-TCA method. At the light intensity of 100 μmol/m2s, microalgal productivity in biomass reached its high level i.e. 0.149 ± 0.03 gL-1d-1 with its protein content 10.74 ± 0.63%. However, the highest specific growth rate (0.343 ± 0.034 d-1) with the shortest doubling time (2.028 ± 0,141 d) were reached under sunlight conditions. The reduction rate of ammonium and orthophosphate content in the medium were 36-48 mgL-1h-1 and 5-6.62 mgL-1h-1 respectively in a culture which was inoculated with C. vulgaris. C. vulgaris can be used as phycoremediator for ammonium and orthophosphate, and ADDMW medium can supply C. vulgaris with appropriate nutrients. Moreover, light intensities of 50 and 100 μmol/m2s can be used in the indoor culture of microalgae. © Published under licence by IOP Publishing Ltd.

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Phycoremediation of anaerobic digested dairy manure wastewater using Chlorella vulgaris

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IOP Conference Series: Earth and Environmental Science 2019年第1期299卷

作者： T Taufikurahman I N Istiqomah Bioengineering Study Programme School of Life Sciences and Technology Institut Teknologi Bandung Bandung Indonesia

Microalgae have been used in a process of pollutants removal from wastewater, a process known as phycoremediation. In this study we used Chlorella vulgaris to remediate anaerobically digested dairy manure wastewater (ADDMW) which contained a high concentration of nitrogen and phosphor. The light intensity of 50, 100 μmol/m2s and sunlight were applied to the microalgal culture. Percentage of reduction in ammonium and orthophosphate content in the media were measured. Protein content in microalgal biomass was measured using hot-TCA method. At the light intensity of 100 μmol/m2s, microalgal productivity in biomass reached its high level i.e. 0.149 ± 0.03 gL−1d−1 with its protein content 10.74 ± 0.63%. However, the highest specific growth rate (0.343 ± 0.034 d−1) with the shortest doubling time (2.028 ± 0,141 d) were reached under sunlight conditions. The reduction rate of ammonium and orthophosphate content in the medium were 36-48 mgL−1h−1 and 5-6.62 mgL−1h−1 respectively in a culture which was inoculated with C. vulgaris. C. vulgaris can be used as phycoremediator for ammonium and orthophosphate, and ADDMW medium can supply C. vulgaris with appropriate nutrients. Moreover, light intensities of 50 and 100 μmol/m2s can be used in the indoor culture of microalgae.

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The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis

LANCET REGIONAL HEALTH-AMERICAS

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LANCET REGIONAL HEALTH-AMERICAS 2023年 25卷 100561-100561页

作者： Aguilar, Gisela Robles Swetschinski, Lucien R. Weaver, Nicole Davis Ikuta, Kevin S. Mestrovic, Tomislav Gray, Authia P. Chung, Erin Wool, Eve E. Han, Chieh Hayoon, Anna Gershberg Araki, Daniel T. Abdollahi, Ashkan Abu-Zaid, Ahmed Adnan, Mohammad Agarwal, Ramesh Dehkordi, Javad Aminian Aravkin, Aleksandr Y. Areda, Demelash Azzam, Ahmed Y. Berezin, Eitan N. Bhagavathula, Akshaya Srikanth Bhutta, Zulfiqar A. Bhuyan, Soumitra S. Browne, Annie J. Castaneda-Orjuela, Carlos A. Chandrasekar, Eeshwar K. Ching, Patrick R. Dai, Xiao-chen Darmstadt, Gary L. De la Hoz, Fernando Pio Diao, Nancy Diaz, Daniel dos Santos, Wendel Mombaque Eyre, David Garcia, Coralith Haines-Woodhouse, Georgina Hassen, Mohammed Bheser Henry, Nathaniel J. Hopkins, Susan Hossain, Md Mahbub Iregbu, Kenneth Chukwuemeka Iwu, Chidozie C. D. Jacobs, Jan Adriaan Janko, Mark M. Jones, Ronald Karaye, Ibraheem M. Khalil, Ibrahim A. Khan, Imteyaz A. Khan, Taimoor Khubchandani, Jagdish Khusuwan, Suwimon Kisa, Adnan Koyaweda, Giscard Wilfried Krapp, Fiorella Kumaran, Emmanuelle A. P. Kyu, Hmwe Hmwe Lim, Stephen S. Liu, Xuefeng Luby, Stephen Maharaj, Sandeep B. Maronga, Christopher Martorell, Miquel May, Jurgen McManigal, Barney Mokdad, Ali H. Moore, Catrin E. Mostafavi, Ebrahim Murillo-Zamora, Efren Mussi-Pinhata, Marisa Marcia Nanavati, Ruchi Nassereldine, Hasan Natto, Zuhair S. Qamar, Farah Naz Nunez-Samudio, Virginia Ochoa, Theresa J. Ojo-Akosile, Tolulope R. Olagunju, Andrew T. Olivas-Martinez, Antonio Ortiz-Brizuela, Edgar Ounchanum, Pradthana Paredes, Jose L. Patthipati, Venkata Suresh Pawar, Shrikant Pereira, Marcos Pollard, Andrew Ponce-De-Leon, Alfredo Prates, Elton Junio Sady Qattea, Ibrahim Reyes, Luis Felipe Roilides, Emmanuel Rosenthal, Victor Daniel Rudd, Kristina E. Sangchan, Weerawut Seekaew, Samroeng Seylani, Allen Shababi, Niloufar Sham, Sunder Sifuentes-Osornio, Jose Singh, Harpreet Stergachis, Andy Tasak, Nidanuch Tat, Nathan Y. Thaiprakong, Areerat Valdez, Pascual R. Yada, Dereje Y. Yunusa, Ismaeel Zastrozhin, Mikhail Sergeevich Hay, Simon I Univ Oxford Nuffield Dept Med Oxford England Univ Oxford Big Data Inst Oxford England Univ Oxford Dept Pediat Oxford England Univ Oxford Oxford Ctr Global Hlth Res Oxford England Univ Oxford Ctr Trop Med & Global Hlth Oxford England Univ Washington Inst Hlth Metr & Evaluat Seattle WA USA Univ Washington Seattle Childrens Hosp Dept Pediat Seattle WA USA Univ Washington Dept Appl Math Seattle WA USA Univ Washington Dept Hlth Metr Sci Sch Med Seattle WA USA Univ Washington Dept Global Hlth Seattle WA USA Univ Washington Dept Biostat Seattle WA USA Univ Washington Dept Pharm Seattle WA USA Vet Affairs Greater Los Angeles Div Infect Dis Los Angeles LA USA Univ North Univ Ctr Varazdin Varazhdin Croatia Univ Texas Hlth Sci Ctr Houston TX USA Johns Hopkins Univ Div Cardiol Dept Surg Baltimore MD USA Shiraz Univ Med Sci Sch Med Shiraz Iran Alfaisal Univ Dept Surg Riyadh Saudi Arabia Univ Tennessee Coll Grad Hlth Sci Memphis TN USA Indiana Univ Hlth Ball Mem Hosp Dept Neonatol Muncie IN USA All India Inst Med Sci Div Neonatol New Delhi India Univ Calif Berkeley Appl Sci & Technol Dept Berkeley CA USA Tarbiat Modares Univ Dept Chem Engn Biotechnol Grp Tehran Iran Univ Ottawa Coll Art & Sci Surprise AZ USA Arizona State Univ Coll Liberal Arts & Sci Tempe AZ USA Nested Knowledge Inc Dept Neurovasc Res St Paul MN USA October 6 Univ Fac Med 6th Of October City Egypt Univ Sao Paulo Dept Pediat Sao Paulo Brazil Santa Casa Sao Paulo Univ Hosp Dept Pediat Sao Paulo Brazil Univ Arkansas Dept Hlth Human Performance & Recreat Fayetteville AR USA Univ Toronto Ctr Global Child Hlth Toronto ON Canada Aga Khan Univ Ctr Excellence Women & Child Hlth Karachi Pakistan Rutgers State Univ Edward J Bloustein Sch Planning & Publ Policy New Brunswick NJ USA Rutgers State Univ Dept Pediat New Brunswick NJ USA Natl Inst Hlth Colombian Natl Hlth Observ Bogota Colombia Univ Nacl Colombia Dept Publ Hlth Bogota Colombia Univ Rochester Dept

Background Antimicrobial resistance (AMR) is an urgent global health challenge and a critical threat to modern health care. Quantifying its burden in the WHO Region of the Americas has been elusive-despite the region's long history of resistance surveillance. This study provides comprehensive estimates of AMR burden in the Americas to assess this growing health *** Weestimated deaths and disability-adjusted life-years (DALYs) attributable to and associated with AMR for 23 bacterial pathogens and 88 pathogen-drug combinations for countries in the WHO Region of the Americas in 2019. We obtained data from mortality registries, surveillance systems, hospital systems, systematic literature reviews, and other sources, and applied predictive statistical modelling to produce estimates of AMR burden for all countries in the Americas. Five broad components were the backbone of our approach: the number of deaths where infection had a role, the proportion of infectious deaths attributable to a given infectious syndrome, the proportion of infectious syndrome deaths attributable to a given pathogen, the percentage of pathogens resistant to an antibiotic class, and the excess risk of mortality (or duration of an infection) associated with this resistance. We then used these components to estimate the disease burden by applying two counterfactual scenarios: deaths attributable to AMR (compared to an alternative scenario where resistant infections are replaced with susceptible ones), and deaths associated with AMR (compared to an alternative scenario where resistant infections would not occur at all). We generated 95% uncertainty intervals (UIs) for final estimates as the 25th and 975th ordered values across 1000 posterior draws, and models were cross-validated for out-of-sample predictive validity. Findings We estimated 569,000 deaths (95% UI 406,000-771,000) associated with bacterial AMR and 141,000 deaths (99,900-196,000) attributable to bacterial AMR among the 35 coun

关键词： Antimicrobial resistance AMR Bacteria Disease burden Mortality Americas

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LifeTime and improving European healthcare through cell-based interceptive medicine (vol 587, pg 377, 2020)

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NATURE 2021年第7852期592卷 E8-E8页

作者： Rajewsky, Nikolaus Almouzni, Genevieve Gorski, Stanislaw A. Aerts, Stein Amit, Ido Bertero, Michela G. Bock, Christoph Bredenoord, Annelien L. Cavalli, Giacomo Chiocca, Susanna Clevers, Hans De Strooper, Bart Eggert, Angelika Ellenberg, Jan Fernandez, Xose M. Figlerowicz, Marek Gasser, Susan M. Hubner, Norbert Kjems, Jorgen Knoblich, Jurgen A. Krabbe, Grietje Lichter, Peter Linnarsson, Sten Marine, Jean-Christophe Marioni, John C. Marti-Renom, Marc A. Netea, Mihai G. Nickel, Dorthe Nollmann, Marcelo Novak, Halina R. Parkinson, Helen Piccolo, Stefano Pinheiro, Ines Pombo, Ana Popp, Christian Reik, Wolf Roman-Roman, Sergio Rosenstiel, Philip Schultze, Joachim L. Stegle, Oliver Tanay, Amos Testa, Giuseppe Thanos, Dimitris Theis, Fabian J. Torres-Padilla, Maria-Elena Valencia, Alfonso Vallot, Celine van Oudenaarden, Alexander Vidal, Marie Voet, Thierry Berlin Institute for Medical Systems Biology Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany Charité-Universitätsmedizin Berlin Germany Berlin Institute of Health (BIH) Berlin Germany German Center for Cardiovascular Research (DZHK) Partner Site Berlin Berlin Germany Institute for Biology Humboldt University of Berlin Berlin Germany Cardiovascular and Metabolic Sciences Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin Germany Department of Pediatric Oncology/Hematology Charité-Universitätsmedizin Berlin Berlin Germany Institut Curie CNRS PSL Research University Sorbonne Université Nuclear Dynamics Unit Equipe Labellisée Ligue contre le cancer Paris France VIB Center for Brain and Disease Research Leuven Belgium Department of Human Genetics KU Leuven Leuven Belgium Department of Neurosciences KU Leuven Leuven Belgium UK Dementia Research Institute at UCL University College London London UK Wellcome Sanger Institute Wellcome Genome Campus Cambridge UK Department of Immunology Weizmann Institute of Science Rehovot Israel Centre for Genomic Regulation (CRG) Barcelona Institute of Science and Technology Barcelona Spain CNAG-CRG Centre for Genomic Regulation Barcelona Institute of Science and Technology Barcelona Spain Universitat Pompeu Fabra Barcelona Spain ICREA Barcelona Spain CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria Department of Laboratory Medicine Medical University of Vienna Vienna Austria Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases Vienna Austria Department of Medical Humanities Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands Institute of Human Genetics UMR 9002 CNRS and University of Montpellier Montpellier France Department of Experimental Oncology IEO European Institute of Oncology IRCCS Milan Italy Department of Oncology and Hemato

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Shared heritability and functional enrichment across six solid cancers

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NATURE COMMUNICATIONS 2019年第1期10卷 431页

作者： Jiang, Xia Finucane, Hilary K. Schumacher, Fredrick R. Schmit, Stephanie L. Tyrer, Jonathan P. Han, Younghun Michailidou, Kyriaki Lesseur, Corina Kuchenbaecker, Karoline B. Dennis, Joe Conti, David V. Casey, Graham Gaudet, Mia M. Huyghe, Jeroen R. Albanes, Demetrius Aldrich, Melinda C. Andrew, Angeline S. Andrulis, Irene L. Anton-Culver, Hoda Antoniou, Antonis C. Antonenkova, Natalia N. Arnold, Susanne M. Aronson, Kristan J. Arun, Banu K. Bandera, Elisa V. Barkardottir, Rosa B. Barnes, Daniel R. Batra, Jyotsna Beckmann, Matthias W. Benitez, Javier Benlloch, Sara Berchuck, Andrew Berndt, Sonja I. Bickeboeller, Heike Bien, Stephanie A. Blomqvist, Carl Boccia, Stefania Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brenton, James D. Brook, Mark N. Brunet, Joan Brunnstrom, Hans Buchanan, Daniel D. Burwinkel, Barbara Butzow, Ralf Cadoni, Gabriella Caldes, Trinidad Caligo, Maria A. Campbell, Ian Campbell, Peter T. Cancel-Tassin, Geraldine Cannon-Albright, Lisa Campa, Daniele Caporaso, Neil Carvalho, Andre L. Chan, Andrew T. Chang-Claude, Jenny Chanock, Stephen J. Chen, Chu Christiani, David C. Claes, Kathleen B. M. Claessens, Frank Clements, Judith Collee, J. Margriet Correa, Marcia Cruz Couch, Fergus J. Cox, Angela Cunningham, Julie M. Cybulski, Cezary Czene, Kamila Daly, Mary B. defazio, Anna Devilee, Peter Diez, Orland Gago-Dominguez, Manuela Donovan, Jenny L. Doerk, Thilo Duell, Eric J. Dunning, Alison M. Dwek, Miriam Eccles, Diana M. Edlund, Christopher K. Edwards, Digna R. Velez Ellberg, Carolina Evans, D. Gareth Fasching, Peter A. Ferris, Robert L. Liloglou, Triantafillos Figueiredo, Jane C. Fletcher, Olivia Fortner, Renee T. Fostira, Florentia Franceschi, Silvia Friedman, Eitan Gallinger, Steven J. Ganz, Patricia A. Garber, Judy Garcia-Saenz, Jose A. Gayther, Simon A. Giles, Graham G. Godwin, Andrew K. Goldberg, Mark S. Goldgar, David E. Goode, Ellen L. Goodman, Marc T. Goodman, Gary Grankvist, Kjell Greene, Mark H. Gronberg, Henrik Gronwald, Jacek Guenel, Pascal Hakan Harvard TH Chan Sch Publ Hlth Program Genet Epidemiol & Stat Genet 677 Huntington Ave Boston MA 02115 USA Karolinska Inst Inst Environm Med Unit Cardiovasc Epidemiol Nobels Vagen 13 S-17177 Stockholm Sweden Harvard TH Chan Sch Publ Hlth Dept Epidemiol 677 Huntington Ave Boston MA 02115 USA Broad Inst MIT & Harvard Program Med & Populat Genet 75 Ames St Cambridge MA 02142 USA Case Western Reserve Univ Dept Populat & Quantitat Hlth Sci 10900 Eucid Ave Cleveland OH 44106 USA Univ Hosp Seidman Canc Ctr Cleveland OH 44106 USA H Lee Moffitt Canc Ctr & Res Inst Dept Canc Epidemiol 12902 Magnolia Dr MRC CANCONT Tampa FL 33612 USA H Lee Moffitt Canc Ctr & Res Inst Dept Gastrointestinal Oncol 12902 Magnolia Dr MRC CANCONT Tampa FL 33612 USA Univ Cambridge Dept Oncol Ctr Canc Genet Epidemiol 2 Worts Causeway Cambridge CB1 8RN England Geisel Sch Med Dartmouth Dept Biomed Data Sci 1 Med Ctr Dr Dartmouth NS Lebanon Univ Cambridge Dept Publ Hlth & Primary Care Ctr Canc Genet Epidemiol 2 Worts Causeway Cambridge CB1 8RN England Cyprus Inst Neurol & Genet Dept Elect Microscopy Mol Pathol CY-1683 Nicosia Cyprus Int Agcy Res Canc Genet Epidemiol Grp 150 Cours Albert Thomas F-69008 Lyon France Int Agcy Res Canc Sect Genet 150 Cours Albert Thomas F-69008 Lyon France UCL Div Psychiat Maple House149 Tottenham Court Rd London W1T 7NF England UCL UCL Genet Inst Gower St London WC1E 6BT England Univ Southern Calif Keck Sch Med Dept Prevent Med Norris Comprehens Canc Ctr Los Angeles CA 48109 USA Univ Virginia Publ Hlth Sci POB 800717 Charlottesville VI 80071 USA Univ Virginia Ctr Publ Hlth Genom POB 800717 Charlottesville VI 80071 USA Amer Canc Soc Epidemiol Res Program 250 Williams St NW Atlanta GA 30303 USA Fred Hutchinson Canc Res Ctr Div Publ Hlth Sci 1100 Fairview Ave N Seattle WA 98109 USA NCI Div Canc Epidemiol & Genet 9609 Med Ctr Dr Rockville MD 20850 USA Vanderbilt Univ Div Epidemiol Dept Thorac Surg Med Ctr 609 Oxford House Nashville

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

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Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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Nature communications 2019年第1期10卷 4386页

作者： Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Ch Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. xiajiang@hsph.harvard.edu. Unit of Cardiovascular Epidemiology Institute of Environmental Medicine Karolinska Institutet Nobels vagen 13 17177 Stockholm Sweden. xiajiang@hsph.harvard.edu. Department of Epidemiology Harvard T.H. Chan School of Public Health 677 Huntington Ave Boston MA 02115 USA. Program in Medical and Population Genetics Broad Institute of MIT and Harvard 75 Ames St Cambridge MA 02142 USA. Department of Population and Quantitative Health Sciences Case Western Reserve University 10900 Eucid Avenue Cleveland OH 44106 USA. Seidman Cancer Center University Hospitals Cleveland OH 44106 USA. Department of Cancer Epidemiology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute 12902 Magnolia Dr. MRC-CANCONT Tampa FL 33612 USA. Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Biomedical Data Science The Geisel School of Medicine at Dartmouth 1 Medical Center Drive Lebanon NH 03756 USA. Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care University of Cambridge 2 Worts' Causeway Cambridge CB1 8RN UK. Department of Electron Microscopy/Molecular Pathology The Cyprus Institute of Neurology and Genetics 1683 Nicosia Cyprus. Genetic Epidemiology Group International Agency for Research on Cancer 150 Cours Albert Thomas 69008 Lyon France. Section of Genetics International Agency for Research on Cancer 150 cours Albert Thomas 69008 Lyon France. Division of Psychiatry University College London Maple House 149 Tottenham Court Road London W1T 7NF UK. UCL Genetics Institute University College London Gower Street London WC1E 6BT UK.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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