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Frequency-Specific Effects of Noninvasive Median Nerve Stimulation on Gastric Slow Wave Activity in Humans

Neuromodulation 2025年第5期28卷 775-786页

作者： Hendry, Elliot Thomas Balfe, Joseph Gonzales Du, Peng Cakmak, Yusuf Ozgur Cakmak Lab Department of Anatomy University of Otago Dunedin New Zealand Auckland Bioengineering Institute University of Auckland Auckland New Zealand Center for Bioengineering—Point-of-Care Technologies University of Otago Dunedin New Zealand Medtech Core New Zealand—Interventional Technologies Theme Auckland New Zealand Centre for Health Systems and Technology University of Otago Dunedin New Zealand

Objectives: The present study explored the effects of different frequencies of noninvasive median nerve stimulation (nMNS) on two autonomic responses: gastric slow waves under water-loading condition and heart rate variability (HRV). To the best of our knowledge, this is the first study to document the effects of different frequencies of nMNS on gastric slow waves (GSW) in humans under 5-minute water-loading condition. Materials and Methods: Twenty healthy adult participants were fitted with a noninvasive body-surface gastric mapping, electrocardiogram (ECG), and a transcutaneous electrical nerve stimulation device and administered with four different nMNS frequencies (placebo-0 Hz, 40 Hz, 120 Hz, and 200 Hz) on four separate counterbalanced days. After the baseline and stimulation periods, a 5-minute water-load test was applied, and a post–water-load period also is recorded for ECG and GSW activity. Time-domain HRV parameters are analyzed with repeated-measures one-way analysis of variance (ANOVA) and a post hoc Tukey multiple comparison test. Parameters that failed normality tests underwent a Freidman test with a post hoc Dunn multiple comparison test. GSW data are analyzed with repeated-measures mixed-effects ANOVA. Results: In empty stomach (baseline vs stimulation), only the 40-Hz frequency statistically significantly (p = 0.0129) increased GSW amplitude in comparison with its own baseline. In full (distended) stomach, 40-Hz and 200-Hz stimulations showed a statistically significant difference (post hoc multiple comparison adjusted, p = 0.0016 and p = 0.0183, respectively) in the Gastric Rhythm Index in comparison with the change obtained by placebo stimulation (baseline vs poststimulation periods);120-Hz nMNS showed a statistically significant difference (p = 0.0300) in the stress index in comparison with the decrease observed in the placebo group. However, 120-Hz nMNS did not induce a statistically significant change in gastric electrical activity compared to

关键词： Electrogastrogram gastric motility heart rate variability median nerve stimulation noninvasive neuromodulation

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Interaction pathways of implant metal localized corrosion and macrophage inflammatory reactions

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Bioactive Materials 2024年第1期31卷 355-367页

作者： Meng Li Jing Wu Wenbo Geng Pengfei Gao Yulu Yang Xuan Li Kun Xu Qiang Liao Kaiyong Cai Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing400044PR China Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing UniversityMinistry of EducationSchool of Energy and Power EngineeringChongqing400044PR China

Macrophages play a central role in immunological responses to metallic species associated with the localized corrosion of metallic implants,and mediating in peri-implant ***,the pathways of localized corrosion-macrophage interactions were systematically investigated on 316L stainless steel(SS)implant *** monitoring under macrophage-mediated inflammatory conditions showed a decreased pitting corrosion resistance of 316L SSs in the presence of RAW264.7 cells as the cells would disrupt biomolecule adsorbed layer on the metal *** pitting potentials were furtherly decreased when the RAW264.7 cells were induced to the M1 pro-inflammatory phenotype by the addition of lipopolysaccharide(LPS),and pitting corrosion preferentially initiated at the peripheries of *** overproduction of aggressive ROS under inflammatory conditions would accelerate the localized corrosion of 316L SS around *** pitting corrosion condition,the viability and pro-inflammatory polarization of RAW264.7 cells were region-dependent,lower viability and more remarkable morphology transformation of macrophages in the pitting corrosion region than the pitting-free *** pitting corrosion of 316L SS induced high expression of CD86,TNF-α,IL-6 and high level of intracellular ROS in *** release of metallic species(Fe^(2+),Cr^(3+),Ni^(2+),etc)and uneven distribution of surface overpotential stimulated macrophage inflammatory responses near the corrosion pits.A synergetic effect of localized corrosion and macrophages was revealed,which could furtherly promote localized corrosion of 316L SS and macrophage inflammatory *** results provided direct evidence of corrosion-macrophage interaction in metallic implants and disclosed the pathways of this mutual stimulation effect.

关键词： Metallic implant Macrophage Localized corrosion Inflammatory reaction Material-cell interaction

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Data Preprocessing Influence on the Medical Images Segmentation Quality

Data Preprocessing Influence on the Medical Images Segmentat...

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2023 Seminar on Information Computing and Processing, ICP 2023

作者： Valenkova, Daria Lyanova, Asya I. Tarapata, Svetlana Sinitca, Aleksandr St. Petersburg Electrotechnical University 'LETI' The Department of Bioengineering Systems St. Petersburg Russia St. Petersburg Electrotechnical University 'LETI' Centre for Digital Telecommunication Technologies St. Petersburg Russia

ISBN: (纸本)9798350369830

The paper is related to automating computer-tomography image processing. The main task of which is the segmentation of abdominal organs. A typical segmentation pipeline includes the following three stages: image preprocessing, segmentation, and mask post-processing. This article is devoted to the first stage, namely, medical image preprocessing. Generally, research related to medical image segmentation has not paid enough attention to data preprocessing research;usually researchers use conventional preprocessing such as normalization without a deep understanding of the effect on quality. The research is based on the state-of-the-art UNERT neural network and a widely used data set MICCAI 2015 with 30 abdominal clinical CT scans. They consist of 13 labeled abdominal organs in Nifty data format. Different methods of image normalization and preprocessing were investigated from the physical meaning of the Hounsfield scale and from the final quality point of view. © 2023 IEEE.

关键词： Computerized tomography

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Digital Twin-Enabled Service Optimization Sequence of Actions for Power Equalization

Digital Twin-Enabled Service Optimization Sequence of Action...

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2023 Asia Communications and Photonics Conference/2023 International Photonics and Optoelectronics Meetings, ACP/POEM 2023

作者： Sun, Chenyu Yang, Xin Charlet, Gabriel Stavrou, Photios A. Pointurier, Yvan Paris Research Center Optical Communication Technolog Lab Huawei Technologies France Boulogne-Billancourt France Information and Bioengineering Politecnico di Milano Department of Electronics Milan Italy Eurecom Communication Systems Department Sophia Antipolis France

We experimentally demonstrate that service SNR can be degraded by several dB if links are not equalized in the correct sequence;this is prevented with our digital twin-enabled heuristic to optimize the sequence for eq... 详细信息

ISBN: (纸本)9798350312614

关键词： digital twin optical network optimization

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Exploring Children’s Strategies in Response to Robot’s Advice During a Group Task with iCub and Nao 16th

Exploring Children’s Strategies in Response to Robot’s A...

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16th International Conference on Social Robotics, ICSR + AI 2024

作者： Pusceddu, Giulia Sangineto, Mariapia Cocchella, Francesca Bogliolo, Michela Belgiovine, Giulia Lastrico, Linda Casadio, Maura Rea, Francesco Gena, Cristina Sciutti, Alessandra Robotics Brain and Cognitive Science Department Italian Institute of Technology Genoa Italy Department of Informatics Bioengineering Robotics and Systems Engineering University of Genoa Genoa Italy Department of Computer Science University of Turin Turin Italy Cognitive Architecture for Collaborative Technologies Unit Italian Institute of Technology Genoa Italy Scuola di Robotica Genoa Italy

ISBN: (纸本)9789819635184

This study investigates children’s trust in two humanoid robots, Nao and iCub, through a cooperative game designed to elicit spontaneous behaviors and group dynamics. We investigate whether participants change their choices after hearing advice from a robot, considering rounds where the advice is correct or incorrect, with the robot apologizing for its mistakes. Results reveal that, in most cases, participants prefer not to change their moves after the robot’s advice. Additionally, after the robots made mistakes, participants are less likely to actively follow their advice and more likely to reject it. No significant differences in strategies among the iCub and Nao samples are evidenced. Furthermore, we examine the influence of group dynamics, identifying "Proactive Players" who consistently initiated moves. A significant association between the strategies of this player and their teammates is found, suggesting potential influence. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2025.

关键词： Adversarial machine learning

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Carbene chemistry for unnatural biosynthesis

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Science China(Life Sciences) 2024年第1期67卷 204-207页

作者： Jing Huang Jay D.Keasling Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeley 94720USA Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryville 94608USA Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeley 94720USA Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKongens Lyngby 2800Denmark Department of Bioengineering University of CaliforniaBerkeley 94720USA Synthetic Biochemistry Center Institute for Synthetic BiologyShenzhen Institutes for Advanced TechnologiesShenzhen 518055China

Previously,chemists working in synthesis were jealous of biologists since the enzymes found in nature usually exhibited great catalytic properties(e.g.,high catalytic efficiency,excellent selectivity such as substrate selectivity,regioselectivity and stereoselectivity).However,biological systems lack many counterparts of reactions widely used in chemical synthesis.

关键词： synthesis selectivity catalytic

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Working Memory-Based Architecture for Human-Aware Navigation in Industrial Settings

Working Memory-Based Architecture for Human-Aware Navigation...

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IEEE International Workshop on Robot and Human Communication (ROMAN)

作者： Lorenzo Landolfi Dario Pasquali Alice Nardelli Jasmin Bernotat Francesco Rea COgNiTive Architectures for Collaborative Technologies (CONTACT) Unit Italian Institute of Technology Genoa Italy Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS) University of Genoa Genoa Italy

To enable a smooth co-existence between robots and human workers in an industrial setting, we implemented two robot working memory configurations onto a mobile manipulator RB-KAIROS+ robot (Robotnik): A GRU-based one and a bioinspired alternative called WorkMATe which enabled the robot to adapt its navigation strategy depending on the presence of human workers. To evaluate the two working memory configurations against a non adaptive behavior, we tested a possible co-working scenario between two ostensible workers and the RB- KAIROS+ robot navigating in two mocked industrial set-ups. The application of behavioral adaptation through a working memory component was highly beneficial as it led to reduced energy consumption and, more importantly, to fewer acceleration anomalies in robot navigation than the non adaptive one. This suggests that a robot’s adaptive navigation through working memory can increase workers’ safety and improve the efficiency of the human-robot system as a whole in industrial applications.

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A 3D NONWOVEN ENZYMATIC ELECTROCHEMICAL BIOSENSOR 25

A 3D NONWOVEN ENZYMATIC ELECTROCHEMICAL BIOSENSOR

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25th International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Perrault, Natalie Mailley, Pascal Revol-Cavalier, Frédéric Perwuelz, Anne Vroman, Philippe Univ. Grenoble Alpes CEA LETI Technologies for Healthcare and Biology Division Microfluidic Systems and Bioengineering Lab ENSAIT Roubaix France GEMTEX Laboratory ENSAIT Roubaix France

ISBN: (纸本)9781733419031

This work presents a novel nonwoven-based enzymatic electrochemical biosensor and it's fabrication method. This method offers an easy and cost effective process inspired by industrial existing technologies, and therefore, offers perspectives for scale-up production of 3D porous biosensors. Moreover, with the integration of different types of fibers these offer a perspective for a modular biosensor as more and/or different types of fibers can be integrated in the process offering other properties such as compression or resilience for, for example, a direct pumping within a microfluidic device. The first engineered biosensors were based on carbon fibers mixed with one or two types of polyester terephthalate (PET) fibers. They showed high conductivity, good electrochemical reactivity and enlarged electroactive surface. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized systems for Chemistry and Life Sciences. All rights reserved.

关键词： Carbon fibers

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Like Robots, Like Humans: Pupil Dilation During Collaborative Object Manipulation

Like Robots, Like Humans: Pupil Dilation During Collaborativ...

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International Conference on Advanced Robotics (ICAR)

作者： Linda Lastrico Nuno Ferreira Duarte Alessandro Carfí Francesco Rea Fulvio Mastrogiovanni José Santos-Victor Alessandra Sciutti Cognitive Architecture for Collaborative Technologies Unit (CONTACT) Italian Institute of Technology Genoa Italy Institute for Systems and Robotics (ISR) Instituto Superior Técnico Universidade de Lisboa Lisbon Portugal Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS)

It is well known that pupil dilation reflects an increase in cognitive load during tasks that demand mental effort. Inspired by this, we questioned whether the same effect occurs during social interactions, particularly in joint object manipulation tasks that require attention and coordination for successful completion. In the first scenario, we measure pupil dilation during human-human interactive actions (handover), either as the object giver or receiver, against an individual action (pick-and-place). In the second scenario, pupillometry is associated with human-to-robot handovers. We present the two publicly available datasets collected in these contexts. Our results show a strong link between pupil dilation and collaborative actions, with both humans and robots. Indeed, an increment in pupil size corresponds to the object handover, which presents the added complexity of mutual coordination. Conversely, individual actions do not elicit the same physiological response at the level of the pupil. In both scenarios, we used objects with different physical properties, cups with varying water levels, but this factor influenced pupil dilation (and presumably, the mental workload) only during the interaction with the robot. With this study, we explore pupillometry as a physiological metric to evaluate cognitive load for collaborative object manipulation during human-human or human-robot collaborations.

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HIGHLY AUTOMATED ON CHIP MAGNETIC BEAD-BASED IMMUNOASSAYS FOR THE IDENTIFICATION AND QUANTIFICATION OF CARBAPENAMASE-PRODUCING ENTEROBACTERIACEAE 25

HIGHLY AUTOMATED ON CHIP MAGNETIC BEAD-BASED IMMUNOASSAYS FO...

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25th International Conference on Miniaturized systems for Chemistry and Life Sciences, MicroTAS 2021

作者： Lucas, Anne-Carey Rousseau, Fanny Cubizolles, Myriam Alessio, Manuel Boizot, François Boutal, Hervé Navarro, Fabrice Simon, Stéphanie Fouillet, Yves Parent, Charlotte Perez-Toralla, Karla Univ. Grenoble Alpes CEA LETI Technologies for Healthcare and Biology Division Microfluidic Systems and Bioengineering Lab Grenoble38000 France SPI Gif-sur-Yvette91191 France

ISBN: (纸本)9781733419031

In this paper, we present an Enzyme-Linked ImmunoSorbent Assays (ELISA) for detection of antibiotic resistance in bacteria integrated into a microfluidic format. The designed chip allows the automated manipulation of magnetic beads coated with specific monoclonal antibodies. This chip uses pneumatically actuated collapsible chambers, which allow a complete filling and draining of volumes using a dedicated instrument. This highly automated chip also integrates calibration curves, to achieve a complete quantitative ELISA assay. © 2021 MicroTAS 2021 - 25th International Conference on Miniaturized systems for Chemistry and Life Sciences. All rights reserved.

关键词： Microfluidics

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