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检索条件"机构=Bioinformatics Program"
2061 条 记 录,以下是1861-1870 订阅
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DNA binding shapes upAssociated Content
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Nature 2009年 第7268期461卷 1225-1226页
作者: Tom Tullius Tom Tullius is in the Department of Chemistry and the Program in Bioinformatics Boston University Boston Massachusetts 02215 USA. tullius@bu.edu
来源: 评论
Rank-based clustering analysis for the time-microarray data
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Journal of bioinformatics and Computational Biology 2009年 第1期7卷 75-91页
作者: Yi, Sung-Gon Joo, Yoon-Jeong Park, Taesung Department of Statistics Seoul National University Seoul 151-742 San 56-1 Sillim-dong Gwanak-gu South Korea Program in Bioinformatics Seoul National University Seoul 151-742 San 56-1 Sillim-dong Gwanak-gu South Korea
Microarray technology allows the monitoring of expression levels for thousands of genes simultaneously. In time-course microarray experiments in which gene expression is monitored over time, we are interested in clust... 详细信息
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Inference of large-scale gene regulatory networks using regression-based network approach
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Journal of bioinformatics and Computational Biology 2009年 第4期7卷 717-735页
作者: Kim, Haseong Lee, Jae K. Park, Taesung Interdisciplinary Program in Bioinformatics Seoul National University Seoul San 56-1 Shilim-dong South Korea Division of Biostatistics and Epidemiology University of Virginia Charlottesville VA 22908 United States Department of Statistics Seoul National University Seoul San 56-1 Shilim-dong South Korea
The gene regulatory network modeling plays a key role in search for relationships among genes. Many modeling approaches have been introduced to find the causal relationship between genes using time series microarray d... 详细信息
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Redesign of high-affinity nonspecific nucleases with altered sequence preference
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Journal of the American Chemical Society 2009年 第47期131卷 17345-17353页
作者: Wang, Yi-Ting Wright, Jon D. Doudeva, Lyudmila G. Jhang, Hua-Ci Lim, Carmay Yuan, Hanna S. Institute of Molecular Biology Academia Sinica Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Institute of Chemical Biology and Molecular Biophysics Taiwan International Graduate Program Academia Sinica Taipei Taiwan Institute of Bioinformatics and Structural Biology Department of Chemistry National Tsing Hua University HsinChu Taiwan Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
It is of crucial importance to elucidate the underlying principles that govern the binding affinity and selectivity between proteins and DNA. Here we use the nuclease domain of Colicin E7 (nColE7) as a model system to... 详细信息
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Structural insights into TDP-43 in nucleic-acid binding and domain interactions
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Nucleic Acids Research 2009年 第6期37卷 1799-1808页
作者: Kuo, Pan-Hsien Doudeva, Lyudmila G. Wang, Yi-Ting Shen, Che-Kun James Yuan, Hanna S. Institute of Bioinformatics and Structural Biology National Tsing Hua University Taipei Taiwan Institute of Molecular Biology National Taiwan University Taipei Taiwan Taiwan International Graduate Program Chemical Biology and Molecular Biophysics National Taiwan University Taipei Taiwan Graduate Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degenera...
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A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data
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BMC proceedings 2009年 第7期3 Suppl 7卷 S91页
作者: David H Ballard Chatchawit Aporntewan Ji Young Lee Joon Sang Lee Zheyang Wu Hongyu Zhao Program in Computational Biology and Bioinformatics Yale University 300 George Street Suite 503 New Haven Connecticut 06511 USA. david.ballard@yale.edu.
The identification of several hundred genomic regions affecting disease risk has proven the ability of genome-wide association studies have proven their ability to identify genetic contributors to disease. Currently, ... 详细信息
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Purification and characterization of thermostable monomeric chloroplastic Cu/Zn superoxide dismutase from Chenopodium murale
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Physiology and Molecular Biology of Plants 2009年 第3期15卷 199-209页
作者: Sundaram, Sabarinath Khanna, Sunil Khanna-Chopra, Renu Water Technology Centre Indian Agricultural Research Institute New Delhi 110 012 India Department of Biotechnology and Bioinformatics NIIT Institute of Information Technology (TNI) New Delhi 110 019 NIIT House Balaji Estate Kalkaji India Plant Molecular Biology Program Horticultural Sciences Department University of Florida Gainesville FL 32611-0690 United States
Superoxide dismutase is the first line of defense against oxidative stress and thus helps in maintaining the cellular integrity. Chenopodium murale, a weed species adapted to widely varying climatic conditions faces e... 详细信息
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An approach to comparing tiling array and high throughput sequencing technologies for genomic transcript mapping
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BMC Research Notes 2009年 第1期2卷 1-7页
作者: Sasidharan, Rajkumar Agarwal, Ashish Rozowsky, Joel Gerstein, Mark Molecular Biophysics and Biochemistry Department Yale University New Haven CT 06520 United States Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 United States Department of Computer Science Yale University New Haven CT 06520 United States
Background. There are two main technologies for transcriptome profiling, namely, tiling microarrays and high-throughput sequencing. Recently there has been a tremendous amount of excitement about the latter because of... 详细信息
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Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis
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BMC proceedings 2009年 第7期3 Suppl 7卷 S25页
作者: Seoae Cho Haseong Kim Sohee Oh Kyunga Kim Taesung Park Interdisciplinary Program in Bioinformatics Seoul National University Kwan-ak St 599 Kwan-ak Gu Seoul South Korea 151-741 Republic of Korea. sacho71@snu.ac.kr.
The current trend in genome-wide association studies is to identify regions where the true disease-causing genes may lie by evaluating thousands of single-nucleotide polymorphisms (SNPs) across the whole genome. Howev... 详细信息
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Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium
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BMC proceedings 2009年 第7期3 Suppl 7卷 S34页
作者: Jungsun Park Junghyun Namkung Mina Jhun Taesung Park Interdisciplinary Program in Bioinformatics Seoul National University San56-l Shin Lim-Dong Kwan Ak-Ku Seoul 151-747 Republic of Korea. pj518@snu.ac.kr.
Recent genome-wide association studies on several complex diseases have focused on individual single-nucleotide polymorphism (SNP) analysis; however, not many studies have reported interactions among genes perhaps bec... 详细信息
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