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检索条件"机构=Bioinformatics Program"
2078 条 记 录,以下是1881-1890 订阅
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Redesign of high-affinity nonspecific nucleases with altered sequence preference
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Journal of the American Chemical Society 2009年 第47期131卷 17345-17353页
作者: Wang, Yi-Ting Wright, Jon D. Doudeva, Lyudmila G. Jhang, Hua-Ci Lim, Carmay Yuan, Hanna S. Institute of Molecular Biology Academia Sinica Taipei Taiwan Institute of Biomedical Sciences Academia Sinica Taipei Taiwan Institute of Chemical Biology and Molecular Biophysics Taiwan International Graduate Program Academia Sinica Taipei Taiwan Institute of Bioinformatics and Structural Biology Department of Chemistry National Tsing Hua University HsinChu Taiwan Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
It is of crucial importance to elucidate the underlying principles that govern the binding affinity and selectivity between proteins and DNA. Here we use the nuclease domain of Colicin E7 (nColE7) as a model system to... 详细信息
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Structural insights into TDP-43 in nucleic-acid binding and domain interactions
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Nucleic Acids Research 2009年 第6期37卷 1799-1808页
作者: Kuo, Pan-Hsien Doudeva, Lyudmila G. Wang, Yi-Ting Shen, Che-Kun James Yuan, Hanna S. Institute of Bioinformatics and Structural Biology National Tsing Hua University Taipei Taiwan Institute of Molecular Biology National Taiwan University Taipei Taiwan Taiwan International Graduate Program Chemical Biology and Molecular Biophysics National Taiwan University Taipei Taiwan Graduate Institute of Biochemistry and Molecular Biology National Taiwan University Taipei Taiwan
TDP-43 is a pathogenic protein: its normal function in binding to UG-rich RNA is related to cystic fibrosis, and inclusion of its C-terminal fragments in brain cells is directly linked to frontotemporal lobar degenera...
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A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data
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BMC proceedings 2009年 第7期3 Suppl 7卷 S91页
作者: David H Ballard Chatchawit Aporntewan Ji Young Lee Joon Sang Lee Zheyang Wu Hongyu Zhao Program in Computational Biology and Bioinformatics Yale University 300 George Street Suite 503 New Haven Connecticut 06511 USA. david.ballard@yale.edu.
The identification of several hundred genomic regions affecting disease risk has proven the ability of genome-wide association studies have proven their ability to identify genetic contributors to disease. Currently, ... 详细信息
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Purification and characterization of thermostable monomeric chloroplastic Cu/Zn superoxide dismutase from Chenopodium murale
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Physiology and Molecular Biology of Plants 2009年 第3期15卷 199-209页
作者: Sundaram, Sabarinath Khanna, Sunil Khanna-Chopra, Renu Water Technology Centre Indian Agricultural Research Institute New Delhi 110 012 India Department of Biotechnology and Bioinformatics NIIT Institute of Information Technology (TNI) New Delhi 110 019 NIIT House Balaji Estate Kalkaji India Plant Molecular Biology Program Horticultural Sciences Department University of Florida Gainesville FL 32611-0690 United States
Superoxide dismutase is the first line of defense against oxidative stress and thus helps in maintaining the cellular integrity. Chenopodium murale, a weed species adapted to widely varying climatic conditions faces e... 详细信息
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An approach to comparing tiling array and high throughput sequencing technologies for genomic transcript mapping
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BMC Research Notes 2009年 第1期2卷 1-7页
作者: Sasidharan, Rajkumar Agarwal, Ashish Rozowsky, Joel Gerstein, Mark Molecular Biophysics and Biochemistry Department Yale University New Haven CT 06520 United States Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 United States Interdepartmental Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 United States Department of Computer Science Yale University New Haven CT 06520 United States
Background. There are two main technologies for transcriptome profiling, namely, tiling microarrays and high-throughput sequencing. Recently there has been a tremendous amount of excitement about the latter because of... 详细信息
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Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis
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BMC proceedings 2009年 第7期3 Suppl 7卷 S25页
作者: Seoae Cho Haseong Kim Sohee Oh Kyunga Kim Taesung Park Interdisciplinary Program in Bioinformatics Seoul National University Kwan-ak St 599 Kwan-ak Gu Seoul South Korea 151-741 Republic of Korea. sacho71@snu.ac.kr.
The current trend in genome-wide association studies is to identify regions where the true disease-causing genes may lie by evaluating thousands of single-nucleotide polymorphisms (SNPs) across the whole genome. Howev... 详细信息
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Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium
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BMC proceedings 2009年 第7期3 Suppl 7卷 S34页
作者: Jungsun Park Junghyun Namkung Mina Jhun Taesung Park Interdisciplinary Program in Bioinformatics Seoul National University San56-l Shin Lim-Dong Kwan Ak-Ku Seoul 151-747 Republic of Korea. pj518@snu.ac.kr.
Recent genome-wide association studies on several complex diseases have focused on individual single-nucleotide polymorphism (SNP) analysis; however, not many studies have reported interactions among genes perhaps bec... 详细信息
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Development of a database and ontology for pathogenic pathways in periodontitis
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In Silico Biology 2009年 第4期9卷 233-243页
作者: Suzuki, Asami Takai-Igarashi, Takako Numabe, Yukihiro Tanaka, Hiroshi Department of General Dentistry The Nippon Dental University Hospital at Tokyo Tokyo Japan Biomedical Clinical Omics Educational Program Tokyo Medical and Dental University Tokyo Japan Department of Bioinformatics School of Biomedical Science Tokyo Medical and Dental University Bunkyo-Ku Tokyo 113-8510 1-5-45 Yushima Japan Department of Periodontology The Nippon Dental University School of Life Dentistry at Tokyo Tokyo Japan
It is getting familiar that pathway information greatly contributes to elucidate the molecular basis of human disease with large-scale biological data. We developed a pathway database for molecular pathology in period... 详细信息
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Francisella tularensis subsp. novicida isolated from a human in Arizona
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BMC Research Notes 2009年 第1期2卷 1-6页
作者: Birdsell, Dawn N Stewart, Tasha Vogler, Amy J Lawaczeck, Elisabeth Diggs, Alisa Sylvester, Tammy L Buchhagen, Jordan L Auerbach, Raymond K Keim, Paul Wagner, David M Center for Microbial Genetics and Genomics Northern Arizona University Flagstaff AZ 86011-4073 United States Maricopa County Department of Public Health Phoenix AZ 85012 United States Arizona Department of Health Services Phoenix AZ 85007 United States Translational Genomics Research Institute Phoenix AZ 85004 United States Program in Computational Biology and Bioinformatics Yale University New Haven CT 06520 United States
Background. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that diffe... 详细信息
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Multiple Routes to Characterize the Folding of a Small DNA Hairpin†
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Angewandte Chemie 2010年 第42期122卷
作者: Guillem Portella Modesto Orozco Joint IRB‐BSC Research Program in Computational Biology Institute for Research in Biomedicine (IRB) Josep Samitier 1‐5 Barcelona 08028 (Spain) Barcelona Supercomputing Centre (BSC) Jordi Girona 29 Barcelona 08034 (Spain) Departament de Bioquímica i Biología Molecular Facultat de Biología Universitat de Barcelona Avgda Diagonal 645 Barcelona 08028 (Spain) National Institute of Bioinformatics Parc Científic de Barcelona Josep Samitier 1–5 Barcelona 08028 (Spain)
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