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Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

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Nature communications 2018年第1期9卷 3472页

作者： David Z Pan Kristina M Garske Marcus Alvarez Yash V Bhagat James Boocock Elina Nikkola Zong Miao Chelsea K Raulerson Rita M Cantor Mete Civelek Craig A Glastonbury Kerrin S Small Michael Boehnke Aldons J Lusis Janet S Sinsheimer Karen L Mohlke Markku Laakso Päivi Pajukanta Arthur Ko Department of Human Genetics David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA. Bioinformatics Interdepartmental Program UCLA Los Angeles CA 90095 USA. Department of Genetics University of North Carolina Chapel Hill NC 27599 USA. Department of Biomedical Engineering University of Virginia Charlottesville VA 22904 USA. Big Data Institute University of Oxford Oxford OX3 7LF UK. Department of Twin Research and Genetic Epidemiology King's College London UK. Department of Biostatistics University of Michigan Ann Arbor MI 48109 USA. Department of Biomathematics David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA. Institute of Clinical Medicine Internal Medicine University of Eastern Finland and Kuopio University Hospital Kuopio FI-70210 Finland. Molecular Biology Institute at UCLA Los Angeles CA 90095 USA. Department of Human Genetics David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA. a5ko@ucla.edu. Molecular Biology Institute at UCLA Los Angeles CA 90095 USA. a5ko@ucla.edu.

In the original version of this Article, Supplementary Table 10 contained incorrect primer sequences for the mobility shift assay for SNP rs4776984. These errors have now been fixed and the corrected version of the Su...

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PATH-04. OPTIMIZING CELL-FREE DNA ASSAYS FOR LOW INPUT LIQUID BIOPSY SAMPLES FROM PEDIATRIC BRAIN TUMOR PATIENTS

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Neuro-Oncology 2024年第SUPPLEMENT_4期26卷 0–0页

作者： Tom T Fischer Kendra K Maaß Pitithat Puranachot Markus Mieskolainen Martin Sill Agnes M E Finster Paulina S Schad Fabian Rosing Tatjana Wedig Nathalie Schwarz Florian Iser Jochen Meyer Felix Sahm Benedikt Brors Hannu Haapasalo Stefan M Pfister Joonas Haapasalo Kristian W Pajtler Kristiina Nordfors Hopp Children’s Cancer Center (KiTZ) and Division of Pediatric Neurooncology National Center for Tumor Diseases (NCT) German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Pediatric Oncology Hematology Immunology and Pulmonology Heidelberg University Hospital Heidelberg Germany Princess Srisavangavadhana College of Medicine Chulabhorn Royal Academy Bangkok Thailand Unit of Neurosurgery Tampere University Hospital Tampere Finland Department of Pathology Tampere University Hospital Tampere Finland Clinic for Children and Adolescent Medicine Karlsruhe Hospital Karlsruhe Germany Clinical Cooperation Unit Neurooncology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Neurology and Neurooncology Program National Center for Tumor Diseases (NCT) Heidelberg University Hospital Heidelberg Germany Clinical Cooperation Unit Neuropathology German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Department of Neuropathology Heidelberg University Hospital Heidelberg Germany Division of Applied Bioinformatics National Center for Tumor Diseases (NCT) German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany Medical Faculty Heidelberg and Faculty of Biosciences Heidelberg University Heidelberg Germany Tampere Center for Child Health Research TU and Department of Pediatric Hematology and Oncology Tampere University Hospital Tampere Finland

BACKGROUND Genetic and epigenetic profiling have transformed biological understanding, diagnostics, and therapeutic approaches for pediatric central nervous system (CNS) tumors. Obtaining tumor tissue may be associated with neurosurgical risk, may not be feasible in some cases, and is not routinely performed during follow-up or at relapse. Liquid biopsies (LBs) have emerged as a minimally invasive, serially collectable source of tumor-derived DNA. Here, we collected cerebrospinal fluid (CSF) and serum LBs from a large, unselected, cross-entity pediatric CNS tumor cohort ( n=55 patients) for method optimization.

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Author Correction: Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer

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NPJ breast cancer 2023年第1期9卷 11页

作者： Shivangi Yadav Ranya Virk Carolina H Chung Mariana Bustamante Eduardo David VanDerway Duojiao Chen Kirsten Burdett Hongyu Gao Zexian Zeng Manish Ranjan Gannon Cottone Xiaoling Xuei Sriram Chandrasekaran Vadim Backman Robert Chatterton Seema Ahsan Khan Susan E Clare Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. Department of Biomedical Engineering Northwestern University Evanston IL 60208-2850 USA. Department of Biomedical Engineering University of Michigan Ann Arbor MI 48109 USA. Center of for Medical Genomics Indiana University School of Medicine Indianapolis IN 46202 USA. Department of Preventive Medicine Northwestern University Chicago IL 60611 USA. Department of Data Sciences Dana Farber Cancer Institute Harvard T.H. Chan School of Public Health Boston MA 02215 USA. Program in Chemical Biology University of Michigan Ann Arbor MI 48109 USA. Rogel Cancer Center University of Michigan Medical School Ann Arbor MI 48109 USA. Center for Computational Medicine and Bioinformatics University of Michigan Ann Arbor MI 48109 USA. Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago IL 60611 USA. Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. s-khan2@northwestern.edu. Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. susan.clare@northwestern.edu.

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Author Correction: Genome-Guided Phylo-Transcriptomic Methods and the Nuclear Phylogenetic Tree of the Paniceae Grasses

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Scientific reports 2018年第1期8卷 7120页

作者： Jacob D Washburn James C Schnable Gavin C Conant Thomas P Brutnell Ying Shao Yang Zhang Martha Ludwig Gerrit Davidse J Chris Pires Division of Biological Sciences 311 Bond Life Sciences Center University of Missouri Columbia MO 65211 USA. jdwr47@mail.missouri.edu. Department of Agronomy & Horticulture Beadle Center E207 University of Nebraska-Lincoln Lincoln NE 68588 USA. Donald Danforth Plant Sciences Center 975N Warson Rd. St. Louis MO 63132 USA. Division of Animal Sciences 920 East Campus Drive University of Missouri Columbia 65211 MO USA. Program in Genetics Bioinformatics Research Center Department of Biological Sciences 356 Ricks Hall North Carolina State University Raleigh NC 27695 USA. St. Jude Children´s Research Hospital MS 342 Room D-4047E 262 Danny Thomas Place Memphis TN 38105 USA. School of Molecular Sciences The University of Western Australia (M310) 35 Stirling Highway Crawley WA 6009 Australia. Missouri Botanical Garden P.O. Box 299 St. Louis Missouri 63166-0299 USA. Division of Biological Sciences 311 Bond Life Sciences Center University of Missouri Columbia MO 65211 USA.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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The genome-wide association study of serum IgE levels demonstrated a shared genetic background in allergic diseases

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Clinical immunology (Orlando, Fla.) 2024年 260卷 109897页

作者： Hsing-Fang Lu Chen-Hsing Chou Ying-Ju Lin Shunsuke Uchiyama Chikashi Terao Yu-Wen Wang Jai-Sing Yang Ting-Yuan Liu Henry Sung-Ching Wong Sean Chun-Chang Chen Fuu-Jen Tsai Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan. PhD Program for Health Science and Industry College of Health Care China Medical University Taichung Taiwan Department of Health Services Administration China Medical University Taichung Taiwan. Genetic Center Department of Medical Research China Medical University Hospital Taichung Taiwan School of Chinese Medicine China Medical University Taichung Taiwan. Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan Clinical Research Center Shizuoka General Hospital Shizuoka Japan The Department of Applied Genetics The School of Pharmaceutical Sciences University of Shizuoka Shizuoka Japan. Department of Medical Research China Medical University Hospital Taichung 404327 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404327 Taiwan. Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan. School of Chinese Medicine China Medical University Taichung Taiwan Department of Biotechnology and Bioinformatics Asia University Taichung Taiwan. Electronic address: d0704@mail.cmuh.org.tw.

Immunoglobulin E (IgE) synthessis is highly related to a variety of atopic diseases, and several genome-wide association studies (GWASs) have demonstrated the association between genes and IgE level. In this study, we conducted the largest genome-wide association study of IgE involving a Taiwanese Han population. Eight independent variants exhibited genome-wide significance. Among them, an intronic SNP of CD28, rs1181388, and an intergenic SNP, rs1002957030, on 11q23.2 were identified as novel signals for IgE. Seven of the loci were replicated successfully in a meta-analysis using data on Japanese population. Among all the human leukocyte antigen (HLA) regions, HLA-DQA1*03:02 - HLA-DQB1*03:03 was the most significant haplotype (OR = 1.25, SE = 0.02, FDR = 1.6 × 10), corresponding to HLA-DQA1 Asp160 and HLA-DQB1 Leu87 amino acid residues. The genetic correlation showed significance between IgE and allergic diseases including asthma, atopic dermatitis, and pollinosis. IgE PRS was significantly correlated with total IgE levels. Furthermore, the top decile IgE polygenic risk score (PRS) group had the highest risk of asthma for the Taiwan Biobank and Biobank Japan cohorts. IgE PRS may be used to aid in predicting the occurrence of allergic reactions before symptoms occur and biomarkers are detectable. Our study provided a more comprehensive understanding of the impact of genomic variants, including complex HLA alleles, on serum IgE levels.

关键词： Allergy genome-wide association study human leukocyte antigen immunoglobulin E

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Author Correction: Generation of accurate, expandable phylogenomic trees with uDance

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Nature biotechnology 2024年第5期42卷 814页

作者： Metin Balaban Yueyu Jiang Qiyun Zhu Daniel McDonald Rob Knight Siavash Mirarab Bioinformatics and Systems Biology Graduate Program University of California San Diego La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. Biodesign Center for Fundamental and Applied Microbiomics Arizona State University Tempe AZ USA. School of Life Sciences Arizona State University Tempe AZ USA. Department of Pediatrics University of California San Diego La Jolla CA USA. Department of Computer Science and Engineering Jacobs School of Engineering University of California San Diego La Jolla CA USA. Department of Bioengineering University of California San Diego La Jolla CA USA. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. Department of Electrical and Computer Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu. Department of Computer Science and Engineering Jacobs School of Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu. Center for Microbiome Innovation Jacobs School of Engineering University of California San Diego La Jolla CA USA. smirarab@ucsd.edu.

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Author Correction: Structural basis for delta cell paracrine regulation in pancreatic islets

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Nature communications 2019年第1期10卷 4218页

作者： Rafael Arrojo E Drigo Stefan Jacob Concha F García-Prieto Xiaofeng Zheng Masahiro Fukuda Hoa Tran Thi Nhu Olga Stelmashenko Flavia Letícia Martins Peçanha Rayner Rodriguez-Diaz Eric Bushong Thomas Deerinck Sebastien Phan Yusuf Ali Ingo Leibiger Minni Chua Thomas Boudier Sang-Ho Song Martin Graf George J Augustine Mark H Ellisman Per-Olof Berggren Lee Kong Chian School of Medicine Nanyang Technological University Singapore 636921 Singapore. Salk Institute for Biological Studies Molecular and Cell Biology Laboratory San Diego 92037 USA. Karolinska Intitutet The Rolf Luft Research Center for Diabetes and Endocrinology Stockholm 171 77 Sweden. Molecular Neurophysiology Laboratory Signature Program in Neuroscience and Behavioral Disorders Duke-NUS Medical School Singapore 169857 Singapore. Bioinformatics Institute (ASTAR) and Image and Pervasive Access Lab (IPAL) Singapore 138632 Singapore. Sorbonne University UPMC University Paris 75005 France. Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro 21941-901 Brazil. Miller School of Medicine University of Miami Miami 33136 USA. National Center for Microscopy and Imaging Research (NCMIR) University of California San Diego San Diego 92093 USA. Lee Kong Chian School of Medicine Nanyang Technological University Singapore 636921 Singapore. per-olof.berggren@ki.se. Karolinska Intitutet The Rolf Luft Research Center for Diabetes and Endocrinology Stockholm 171 77 Sweden. per-olof.berggren@ki.se. Miller School of Medicine University of Miami Miami 33136 USA. per-olof.berggren@ki.se.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Proceedings of the 15th Annual UT-KBRIN bioinformatics Summit 2016 : Cadiz, KY, USA. 8-10 April 2016

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BMC bioinformatics 2016年第SUPPL 10期17卷 297页

作者： Eric C. Rouchka Julia H. Chariker Benjamin J. Harrison Juw Won Park Xueyuan Cao Stanley Pounds Susana Raimondi James Downing Raul Ribeiro Jeffery Rubnitz Jatinder Lamba Bernie J. Daigle Deborah Burgess Stephanie Gehrlich John C. Carmen Nicholas Johnson Chandrakanth Emani Kalpani De Silva Michael P. Heaton Theodore S. Kalbfleisch Teeradache Viangteeravat Rahul Mudunuri Oluwaseun Ajayi Fatih Şen Eunice Y. Huang Mohammad Mohebbi Luaire Florian Douglas J. Jackson John F. Naber AKM Sabbir Sally R. Ellingson Yuping Lu Charles A Phillips Michael A. Langston Rahul K. Sevakula Raghuveer Thirukovalluru Nishchal K. Verma Yan Cui Mohammed Sayed Jing Wang Qi Liu Yu Shyr Xiaofei Zhang Naresh Prodduturi Gavin R. Oliver Diane Grill Jie Na Jeanette Eckel-Passow Eric W. Klee Michael M. Goodin Mark Farman Harrison Inocencio Chanyong Jang Jerzy W. Jaromczyk Neil Moore Kelly Sovacool Leon Dent Mike Izban Sammed Mandape Shruti Sakhare Siddharth Pratap Dana Marshall M Scotty DePriest James N. MacLeod Hanady Adam Ethan Blandford Joel Campbell Joshua Castlen Brittany Dixon Ginger Gilbert Aaron Hall Philip Kreisle Jessica Lasher Bethany Oakes Allison Speer Maximilian Valentine Naga Satya V. Rao Nagisetty Rony Jose Robert Rooney David Hains Department of Computer Engineering and Computer Science University of Louisville Duthie Center for Engineering Louisville USA Kentucky Biomedical Research Infrastructure (KBRIN) Bioinformatics Core Louisville USA Department of Psychological and Brain Sciences University of Louisville Louisville USA Department of Anatomical Sciences and Neurobiology University of Louisville Louisville USA Department of Biostatistics St. Jude Children’s Research Hospital Memphis USA Department of Pathology St. Jude Children’s Research Hospital Memphis USA Department of Oncology St. Jude Children’s Research Hospital Memphis USA Department of Pharmacotherapy and Translational Research College of Pharmacy University of Florida Gainesville USA Department of Biological Sciences University of Memphis Memphis USA Department of Computer Science University of Memphis Memphis USA Department of Computer Science Northern Kentucky University Highland Heights USA Department of Biological Sciences Northern Kentucky University Highland Heights USA Department of Biology Western Kentucky University Bowling Green USA Interdisciplinary Studies Program: Specialization in Bioinformatics University of Louisville Louisville USA United States Department of Agriculture Agricultural Research Service United States Meat Animal Research Center Clay Center USA Department of Biochemistry and Molecular Genetics School of Medicine University of Louisville Louisville USA Biomedical Informatics Core Children’s Foundation Research Institute Memphis USA Department of Pediatrics University of Tennessee Health Science Center Memphis USA Department of Electrical and Computer Engineering University of Louisville Louisville USA Department of Computer Science University of Kentucky Lexington USA Division of Biomedical Informatics College of Medicine University of Kentucky Lexington USA Department of Electrical Engineering and Computer Science University of Tennessee Knoxville USA Department of Electrical E

I1 Proceedings of the Fifteenth Annual UT- KBRIN bioinformatics Summit 2016 Eric C. Rouchka, Julia H. Chariker, Benjamin J. Harrison, Juw Won Park P1 CC-PROMISE: Projection onto the Most Interesting Statistical Evidence (PROMISE) with Canonical Correlation to integrate gene expression and methylation data with multiple pharmacologic and clinical endpoints Xueyuan Cao, Stanley Pounds, Susana Raimondi, James Downing, Raul Ribeiro, Jeffery Rubnitz, Jatinder Lamba P2 Integration of microRNA-mRNA interaction networks with gene expression data to increase experimental power Bernie J Daigle, Jr. P3 Designing and writing software for in silico subtractive hybridization of large eukaryotic genomes Deborah Burgess, Stephanie Gehrlich, John C Carmen P4 Tracking the molecular evolution of Pax gene Nicholas Johnson; Chandrakanth Emani P5 Identifying genetic differences in thermally dimorphic and state specific fungi using in silico genomic comparison Stephanie Gehrlich, Deborah Burgess, John C Carmen P6 Identification of conserved genomic regions and variation therein amongst Cetartiodactyla species using next generation sequencing Kalpani De Silva, Michael P Heaton, Theodore S Kalbfleisch P7 Mining physiological data to identify patients with similar medical events and phenotypes Teeradache Viangteeravat, Rahul Mudunuri, Oluwaseun Ajayi, Fatih Şen, Eunice Y Huang P8 Smart brief for home health monitoring Mohammad Mohebbi, Luaire Florian, Douglas J Jackson, John F Naber P9 Side-effect term matching for computational adverse drug reaction predictions AKM Sabbir, Sally R Ellingson P10 Enrichment vs robustness: A comparison of transcriptomic data clustering metrics Yuping Lu, Charles A Phillips, Michael A Langston P11 Deep neural networks for transcriptome-based cancer classification Rahul K Sevakula, Raghuveer Thirukovalluru, Nishchal K. Verma, Yan Cui P12 Motif discovery using K-means clustering Mohammed Sayed, Juw Won Park P13 Large scale discovery of active enhancers from nasce

关键词： True Negative Differential Expression UCSC Genome Browser Laboratory Information Management System Biomedical Informatics

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Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

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Nature medicine 2018年第9期24卷 1481页

作者： Neibla Priego Lucía Zhu Cátia Monteiro Manon Mulders David Wasilewski Wendy Bindeman Laura Doglio Liliana Martínez Elena Martínez-Saez Santiago Ramón Y Cajal Diego Megías Elena Hernández-Encinas Carmen Blanco-Aparicio Lola Martínez Eduardo Zarzuela Javier Muñoz Coral Fustero-Torre Elena Piñeiro-Yáñez Aurelio Hernández-Laín Luca Bertero Valeria Poli Melchor Sanchez-Martinez Javier A Menendez Riccardo Soffietti Joaquim Bosch-Barrera Manuel Valiente Brain Metastasis Group Spanish National Cancer Research Centre (CNIO) Madrid Spain. Institute of Neuropathology University Medical Center Hamburg-Eppendorf Hamburg Germany. Centre for Developmental Neurobiology King's College London London UK. Pathology Department Vall d'Hebron Hospital Barcelona Spain. Spanish Biomedical Research Network Centre in Oncology (CIBERONC) Barcelona Spain. Confocal Microscopy Unit Spanish National Cancer Research Centre (CNIO) Madrid Spain. Experimental Therapeutics Program Spanish National Cancer Centre (CNIO) Madrid Spain. Flow Cytometry Unit Spanish National Cancer Research Centre (CNIO) Madrid Spain. ProteoRed-ISCIII. Proteomics Unit Spanish National Cancer Research Centre (CNIO) Madrid Spain. Bioinformatics Unit Spanish National Cancer Research Centre (CNIO) Madrid Spain. Neuropathology Unit Hospital Universitario 12 de Octubre Research Institute Madrid Spain. Medical Sciences Department Division of Pathology University and City of Health and Science University Hospital of Turin Turin Italy. Molecular Biotechnology Centre University of Turin Turin Italy. Mind the Byte Barcelona Spain. Program Against Cancer Therapeutic Resistance (ProCURE) Metabolism and Cancer Group Catalan Institute of Oncology Girona Spain. Molecular Oncology Group Girona Biomedical Research Institute (IDIBGI) Girona Spain. Neuro-Oncology Department University and City of Health and Science University Hospital of Turin Turin Italy. Department of Medical Sciences Medical School University of Girona Girona Spain. Catalan Institute of Oncology (ICO) Dr. Josep Trueta University Hospital Girona Spain. Brain Metastasis Group Spanish National Cancer Research Centre (CNIO) Madrid Spain. mvaliente@cnio.es.

In the version of this article originally published, the names of three authors were incorrect. The authors were listed as "Coral Fustero-Torres", "Elena Pineiro" and "Melchor Sánchez-Mar...

In the version of this article originally published, the names of three authors were incorrect. The authors were listed as "Coral Fustero-Torres", "Elena Pineiro" and "Melchor Sánchez-Martínez". Their respective names are "Coral Fustero-Torre", "Elena Piñeiro-Yáñez" and "Melchor Sanchez-Martinez". The errors have been corrected in the print, HTML and PDF versions of this article.

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Author Correction: Antibodies from dengue patients with prior exposure to Japanese encephalitis virus are broadly neutralizing against Zika virus

Communications biology

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Communications biology 2024年第1期7卷 252页

作者： Gielenny M Salem Jedhan Ucat Galula Shang-Rung Wu Jyung-Hurng Liu Yen-Hsu Chen Wen-Hung Wang Sheng-Fan Wang Cheng-Sheng Song Fan-Chi Chen Adrian B Abarientos Guan-Wen Chen Cheng-I Wang Day-Yu Chao Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung City 402 Taiwan. Institute of Oral Medicine School of Dentistry College of Medicine National Cheng Kung University Tainan City 701 Taiwan. Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan City 701 Taiwan. Graduate Institute of Genomics and Bioinformatics College of Life Sciences National Chung Hsing University Taichung City 40227 Taiwan. School of Medicine College of Medicine National Sun Yat-Sen University Kaohsiung City 80424 Taiwan. Center for Tropical Medicine and Infectious Disease Research Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Division of Infectious Diseases Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical University Kaohsiung City 80708 Taiwan. Doctoral Program in Microbial Genomics National Chung Hsing University and Academia Sinica Taichung City 402 Taiwan. Singapore Immunology Network Agency for Science Technology and Research (A*STAR) 8A Biomedical Grove Immunos Singapore 138648 Singapore. Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung City 402 Taiwan. dychao@nchu.edu.tw. Doctoral Program in Microbial Genomics National Chung Hsing University and Academia Sinica Taichung City 402 Taiwan. dychao@nchu.edu.tw. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung City 402 Taiwan. dychao@nchu.edu.tw.

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