This study aims to address the common issue of biased estimation errors in time series modeling by analyzing the error in locating ideal hyperparameters and defining appropriate validation methods. Specifically, it fo...
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Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness....
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The rapid advancement in biological data acquisition technologies has led to massive biological datasets, which requires the development and application of computational methods to analyze and interpret the informatio...
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ISBN:
(纸本)9781479984558
The rapid advancement in biological data acquisition technologies has led to massive biological datasets, which requires the development and application of computational methods to analyze and interpret the information. bioinformatics is the confluence of biology, computer science, and information technology. The bioinformaticsprograms are offered by more than 100 universities in the United States, and much more worldwide. Different degree (including BS, MS, and PhD), and certificate programs in bioinformatics have been performed. The current bioinformaticsprograms in the US have been studied, regarding their curriculum, program competencies, sizes of the faculty, and student enrollments. The job market is also explored for bioinformatics professional training and career planning. The bioinformatics skill requirements are analyzed. Systematical analysis is carried out by integrating the core competences and curriculum improvements in bioinformatics. The potential employers for bioinformatics professionals are analyzed according to the properties of the companies, such as the sizes, the focus areas, the locations, the skill requirements, and other information. The results provide guidance for bioinformatics curriculum development, such as the minimized courses to cover the basic required skill sets for a bioinformatics student to be a successful bioinformatician. In addition, the analytical results are applied to the redesign of the curriculum in our bioinformaticsprogram which offers MS, PhD, and PhD Minor. In summary, the systematic study of the existing bioinformaticsprograms in the US and the current market needs for professionals in bioinformatics provide great insight for education in bioinformatics. It helps the curriculum development and reexamination. It also provides the students with the required knowledge for their future career.
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to dat...
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High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
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