Shape had been intuitively recognized to play a dominant role in determining the global motion patterns of bio-molecular assemblies. However, it is not clear exactly how shape determines the motion patterns. What abou...
详细信息
The concept of smart building includes the optimization of energy usage in a building. One of the possible solutions for this is to adaptively adjust appliances utilization according to activity level in the building....
The concept of smart building includes the optimization of energy usage in a building. One of the possible solutions for this is to adaptively adjust appliances utilization according to activity level in the building. Thus, an intelligent activity estimation system needs to be developed. However, massive annotated dataset is necessary to train the system. Therefore, we propose a system that enables rapid data annotation to collect the massive dataset. With the proposed system, an image can be annotated within 4.8 seconds in average.
Machine learning plays an important and growing role in molecular simulation. The newest version of the OpenMM molecular dynamics toolkit introduces new features to support the use of machine learning potentials. Arbi...
详细信息
Machine learning is a modern approach to problem-solving and task automation. In particular, machine learning is concerned with the development and applications of algorithms that can recognize patterns in data and us...
详细信息
Ecology is a branch of biology that studies the interaction and relationship between organisms and their environment. Abundance, distribution of organisms and patterns of biodiversity are great interests for many ecol...
详细信息
Systems biology involves the integration of multiple data types (across different data sources) to offer a more complete picture of the biological system being studied. While many existing biological databases are imp...
详细信息
ISBN:
(纸本)9781728118680
Systems biology involves the integration of multiple data types (across different data sources) to offer a more complete picture of the biological system being studied. While many existing biological databases are implemented using the traditional SQL (Structured Query Language) database technology, NoSQL database technologies have been explored as a more relationship-based, flexible and scalable method of data integration. In this paper, we describe how to use the Neo4J graph database to integrate a variety of types of data sets in the context of systems vaccinology. Specifically, we have converted into a common graph model diverse types of vaccine response measurement data from the NIH/NIAID ImmPort data repository, pathway data from Reactome, influenza virus strains from WHO, and taxonomic data from NCBI Taxon. While Neo4J provides a graph-based query language (Cypher) for data retrieval, we develop a web-based dashboard for users to easily browse and visualize data without the need to learn Cypher. In addition, we have prototyped a natural language query interface for users to interact with our system. In conclusion, we demonstrate the feasibility of using a graph-based database for storing and querying immunological data with complex biological relationships. Querying a graph database through such relationships has the potential to reveal novel relationships among heterogeneous biological data.
暂无评论