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Cover Feature: Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3-b]pyridine Derivatives with Anticancer Activity (ChemMedChem 3/2025)

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ChemMedChem 2025年第3期20卷

作者： Reymark Ereje Jantana Yahuafai Theeranuch Jaroenchuensiri Patcharaporn Supakijjanusorn Sukanya Unson Borwornlak Toopradab Thanyada Rungrotmongkol Somsak Pianwanit Chanat Aonbangkhen Tanatorn Khotavivattana Center of Excellence in Natural Products Department of Chemistry Faculty of Science Chulalongkorn University Pathumwan Bangkok 10330 Thailand Department of Physical Sciences College of Science University of the Philippines Baguio Baguio City 2600 Philippines Clinical Research Section Division of Research and Academic Support National Cancer Institute Bangkok 10400 Thailand Program in Bioinformatics and Computational Biology Graduate School Chulalongkorn University Pathumwan Bangkok 10330 Thailand Center of Excellence in Computational Chemistry Department of Chemistry Faculty of Science Chulalongkorn University Pathumwan Bangkok 10330 Thailand

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Peer Teaching as bioinformatics Training Strategy: Incentives, Challenges, and Benefits

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Medical Reference Services Quarterly 2022年第1期41卷 13-25页

作者： Rahman, Nur-Taz Meyer, Caitlin Thakral, Durga Cai, Wesley L. Chen, Ann T. Obaid, Razib Garcia-Milian, Rolando Bioinformatics Support Program Research and Education Services Harvey Cushing/John Hay Whitney Medical Library Yale University New Haven CT United States Department of Dermatology Yale School of Medicine New Haven CT United States Department of Pathology Yale School of Medicine New Haven CT United States Department of Biomedical Engineering Yale University New Haven CT United States RARAF Radiological Research Accelerator Facility Nevis Laboratory Columbia University Irvington NY United States

bioinformatics is essential for basic and clinical research. Peer-to-peer (P2P) teaching was used to respond to the bioinformatics training needs at a research-intensive institution. In addition to the data collected from the workshops, personal experiences of the teachers were used to understand incentives, challenges, and benefits of P2P teaching. Developing communication skills such as confidence in teaching, explaining complex concepts, and better understanding of topics benefited P2P teachers. Lack of time and classroom management were identified as major challenges. Hence, P2P teaching can be beneficial not only for bioinformatics trainees but also as a professional development opportunity for peer teachers. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

关键词： bioinformatics computational biology data education peer teaching training

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Mobile App-Based Mindfulness Intervention for Addressing Psychological Distress Among Survivors of Hospitalization for COVID-19 Infection

CHEST Critical Care

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CHEST Critical Care 2024年第2期2卷 100063-100063页

作者： Cox, Christopher E. Gallis, John A. Olsen, Maren K. Porter, Laura S. Gremore, Tina M. Iwashyna, Theodore J. Caldwell, Ellen S. Greeson, Jeffrey M. Moss, Marc Hough, Catherine L. Division of Pulmonary and Critical Care Medicine Durham NC Program to Support People and Enhance Recovery (ProSPER) Durham NC Department of Biostatistics and Bioinformatics Duke University Durham NC Center of Innovation Durham Veterans Affairs Medical Center Veterans Administration Durham NC Department of Psychology Duke University Durham NC Department of Medicine Johns Hopkins University Baltimore MD Department of Medicine Oregon Health & Science University Portland OR Department of Psychology Rowan University Glassboro NJ United States Department of Medicine University of Colorado Denver CO

Background: Psychological distress symptoms are present and persistent among many patients who survive a critical illness like COVID-19. Research Question: Could a self-directed mobile app-delivered mindfulness intervention be feasibly and rapidly implemented within a clinical trials network to reduce distress symptoms? Study Design and Methods: A randomized clinical trial was conducted between January 2021 and May 2022 at 29 US sites and included survivors of hospitalization due to COVID-19-related illness with elevated symptoms of depression at discharge. Participants were randomized to intervention or usual care control. The intervention consisted of four themed weeks of daily audio, video, and text content. All study procedures were virtual. The primary outcome was depression symptoms assessed with the Patient Health Questionnaire 9 at 3 months. Secondary outcomes included anxiety (Generalized Anxiety Disorder 7-item scale), quality of life (EQ-5D), and adherence. We used general linear models to estimate treatment arm differences in outcomes over time. Results: Among 56 randomized participants (mean age ± SD, 51.0 ± 13.2 years;38 female [67.9%];14 Black participants [25%]), 45 (intervention: n = 23 [79%];control: n = 22 [81%]) were retained at 6 months. There was no difference in mean improvement between intervention and control participants at 3 months in Patient Health Questionnaire 9 (−0.5 vs 0.1), Generalized Anxiety Disorder 7-item scale (−0.3 vs 0.1), or EQ-5D (−0.03 vs 0.02) scores, respectively;6-month results were similar. Only 15 participants (51.7%) initiated the intervention, whereas the mean number ± SD of the 56 prescribed intervention activities completed was 12.0 ± 15.2. Regulatory approvals delayed trial initiation by nearly a year. Interpretation: Among survivors of COVID-19 hospitalization with elevated psychological distress symptoms, a self-directed mobile app-based mindfulness intervention had poor adherence. Future psychological distress

关键词： COVID-19 critical illness mobile app post-intensive care unit syndrome psychological distress

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Information visualization services in a library? A public health case study

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Bulletin of the Association for Information Science and Technology 2009年第5期35卷

作者： Barrie Hayes Hong Yi Andrés Villaveces Bioinformatics librarian and Collaboration Center manager in the Biomedical Informatics Research Support and Training Program of the Health Sciences Library at the University of North Carolina at Chapel Hill Sernior research software developer Renaissance Computing Institute University of North Carolina at Chapel Hill Research assistant professor Department of Epidemiology and the Injury Prevention Research Center at the University of North Carolina at Chapel Hill

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Climate-influenced vector-borne diseases in Africa:a call to empower the next generation of African researchers for sustainable solutions

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Infectious Diseases of Poverty 2024年第2期13卷 83-92页

作者： Judicaël Obame-Nkoghe Adjoavi Esse Agossou Gerald Mboowa Basile Kamgang Cyril Caminade Dawn C.Duke Andrew Karanja Githeko Obed M.Ogega Nestor Engone Elloué Fatou Bintou Sarr DieudonnéNkoghe Pierre Kengne Nicaise T.Ndam Christophe Paupy Moses Bockarie Patricks Voua Otomo Molecular and Cellular Biology Laboratory(LabMC) Biology DepartmentUniversity of Science and Technology of MasukuBP 901FrancevilleGabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of FrancevilleBP 769FrancevilleGabon Department of Zoology and Entomology Faculty of Natural and Agricultural SciencesUniversity of the Free StatePrivate Bag x13Phuthaditjhaba 9866Republic of South Africa Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal PhysiologyFaculty of Science and TechnologyUniversity of Abomey-CalaviBP 526CotonouBenin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases InstituteCollege of Health SciencesMakerere UniversityP.O Box 22418KampalaUganda Africa Centers for Disease Control and Prevention African Union CommissionRoosevelt StreetP.O.Box 3243W21 K19 Addis AbabaEthiopia Centre for Research in Infectious Diseases P.O.Box 13591YaoundéCameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical PhysicsTriesteItaly Africa Research Excellence Fund 99 Charterhouse StreetLondon EC1M 6HRUK Community Health Support Program P.O.Box 872Kisumu 40100Kenya The African Academy of Sciences NairobiKenya Center for Phylosophical Studies and Research(CERP) Omar Bongo University(UOB)BP 13131LibrevilleGabon UMRED Health Training and Research UnitUniversity of Iba Der Thiam of ThièsBP 967ThièsSenegal National Parasitic Diseases Control Program Ministry of HealthLibrevilleGabon MIVEGEC Univ.MontpellierCNRSIRDMontpellierFrance MERIT IRDParis CitéUniversity75006 ParisFrance Department of Parasitology Noguchi Memorial Institute for Medical ResearchUniversity of GhanaLG 54AccraGhana School of Community Health Sciences Njala UniversityBoSierra Leone

We look at the link between climate change and vector-borne diseases in low-and middle-income countries in *** large endemicity and escalating threat of diseases such as malaria and arboviral diseases,intensified by climate change,disproportionately affects vulnerable communities *** highlight the urgency of prioritizing research and development,advocating for robust scientific inquiry to promote adaptation strategies,and the vital role that the next generation of African research leaders will play in addressing these *** significant challenges such as funding shortages within countries,various pan-African-oriented funding bodies such as the African Academy of Sciences,the Africa Research Excellence Fund,the Wellcome Trust,the *** Institutes of Health,and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association,have empowered(or are empowering)these researchers by supporting capacity building activities,including continental and global networking,skill development,mentoring,and African-led *** article underscores the urgency of increased national investment in research,proposing the establishment of research government agencies to drive evidence-based *** between governments and scientific communities,sustained by pan-African funding bodies,is *** these efforts,African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively,fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

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Proteomics Standards Initiative's ProForma 2.0: Unifying the Encoding of Proteoforms and Peptidoforms

arXiv

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arXiv 2021年

作者： LeDuc, Richard D. Deutsch, Eric W. Binz, Pierre-Alain Fellers, Ryan T. Cesnik, Anthony J. Klein, Joshua A. Van Den Bossche, Tim Gabriels, Ralf Yalavarthi, Arshika Perez-Riverol, Yasset Carver, Jeremy Bittremieux, Wout Kawano, Shin Pullman, Benjamin Bandeira, Nuno Kelleher, Neil L. Thomas, Paul M. Vizcaíno, Juan Antonio National Resource for Translational and Developmental Proteomics Northwestern University EvanstonIL60611 United States Institute for Systems Biology SeattleWA98109 United States Clinical Chemistry Service Lausanne University Hospital Lausanne1011 Switzerland Department of Genetics Stanford University StanfordCA94305 United States Chan Zuckerberg Biohub 499 Illinois St San FranciscoCA94158 United States SciLifeLab School of Engineering Sciences in Chemistry Biotechnology and Health KTH-Royal Institute of Technology Stockholm 113 51 SolnaSE-171 21 Sweden Program for Bioinformatics Boston University BostonMA02215 United States VIB-UGent Center for Medical Biotechnology VIB Technologiepark 75-FSVM II Ghent9052 Belgium Department of Biomolecular Medicine Faculty of Medicine and Health Sciences Ghent University Ghent9000 Belgium Cambridge HinxtonCB10 1SD United Kingdom La Jolla CA92093 United States La Jolla CA92093 United States La Jolla CA92093 United States Toyama University of International Studies Toyama Higashikuromaki 6 5-1 Toyama930-1292 Japan Database Center for Life Science Joint Support-Center for Data Science Research Research Organization of Information and Systems Chiba Kashiwa277-0871 Japan

It is important for the proteomics community to have a standardized manner to represent all possible variations of a protein or peptide primary sequence, including natural, chemicallyinduced and artifactualmodifications. The Human Proteome Organization (HUPO) Proteomics Standards Initiative (PSI) in collaboration with several members of the Consortium for Top-Down Proteomics (CTDP) has developed a standard notation called ProForma 2.0, which is a substantial extension of the original ProForma notation developed by the CTDP. ProForma 2.0 aims to unify the representation of proteoforms and peptidoforms. ProForma 2.0 supports use cases needed for bottom-up and middle-/top-down proteomics approaches and allows the encoding of highly modified proteins and peptides using a humanand machine-readable string. ProForma 2.0 can be used to represent protein modifications in a specified or ambiguous location, designated by mass shifts, chemical formulas, or controlled vocabulary terms, including cross-links (natural and chemical), and atomic isotopes. Notational conventions are based on public controlled vocabularies and ontologies. The most up-to-date full specification document and information about software implementations are available at http://***/proforma. © 2021, CC0.

关键词： Mass spectrometry

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11th German Conference on Chemoinformatics (GCC 2015) Abstracts

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JOURNAL OF CHEMINFORMATICS 2016年第SUPPL 1期8卷 1-27页

作者： [Anonymous] GDCh-CIC Division Associated Board Member Beilstein-Institut zur Förderung der Chemischen Wissenschaften Trakehner Str. 7-9 60487 Frankfurt Germany. ufechner@beilstein-institut.de. Division Medicinal Chemistry Amsterdam Institute for Molecules Medicines and Systems (AIMMS) VU University Amsterdam The Netherlands. Centre for Bioinformatics Uni Hamburg Bundesstr. 43 20146 Hamburg Germany. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. stefan.guessregen@***. Sanofi-Aventis Deutschland GmbH 65926 Frankfurt am Main Germany. GlaxoSmithKline Stevenage SG1 2NY UK. nicola.j.richmond@***. Discngine Paris 75011 France. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. marwin.segler@wwu.de. Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Germany. Bundeskriminalamt Wiesbaden Central Analytics II 65173 Wiesbaden Germany. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. shea@chem.ucsb.edu. Department of Chemistry and Biochemistry University of California Santa Barbara CA 93111 USA. Chemistry Department Ludwig-Maximilians-Universität München Butenandtstr. 7 81377 Munich Germany. Inorganic Chemistry and Center for Nanointegration University of Duisburg-Essen Essen Germany. CAM-D Technologies Essen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. Institute for Bioinformatics and Chemoinformatics Westphalian University of Applied Sciences Recklinghausen Germany. achim.zielesny@w-hs.de. Leiden University Leiden Netherlands. j.fraaije@chem.leidenuniv.nl. Culgi BV Berlin Germany. Physikalische Chemie III TU Dortmund 44227 Dortmund Germany. stefan.kast@tu-dortmund.de. Centre for Molecular Informatics Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW United Kingdom. kcb27@cam.ac.uk. Centre for Molecular Informatics Department of Chemistry

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Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Dec, 10.1038/s41467-019-13824-9, 2022)

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NATURE COMMUNICATIONS 2022年第1期13卷 1-1页

作者： Sieverling, Lina Hong, Chen Koser, Sandra D. Ginsbach, Philip Kleinheinz, Kortine Hutter, Barbara Braun, Delia M. Cortes-Ciriano, Isidro Xi, Ruibin Kabbe, Rolf Park, Peter J. Eils, Roland Schlesner, Matthias Brors, Benedikt Rippe, Karsten Jones, David T. W. Feuerbach, Lars Division of Applied Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Faculty of Biosciences Heidelberg University 69120 Heidelberg Germany Division of Applied Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Faculty of Biosciences Heidelberg University Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) 69120 Heidelberg Germany Department for Bioinformatics and Functional Genomics Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant 69120 Heidelberg Germany Division of Theoretical Bioinformatics German Cancer Research Center (DKFZ) Heidelberg Germany Institute of Pharmacy and Molecular Biotechnology and BioQuant Heidelberg University Heidelberg Germany German Cancer Consortium (DKTK) Heidelberg Germany National Center for Tumor Diseases (NCT) Heidelberg Heidelberg Germany Heidelberg Center for Personalized Oncology (DKFZ-HIPO) German Cancer Research Center (DKFZ) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany Division of Chromatin Networks German Cancer Research Center (DKFZ) and BioQuant 69120 Heidelberg Germany Department of Biomedical Informatics Harvard Medical School Boston Massachusetts 02115 USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge CB2 1EW UK Ludwig Center at Harvard Medical School Boston Massachusetts 02115 USA Department of Biomedical Informatics Harvard Medical School Boston MA USA Department of Chemistry Centre for Molecular Science Informatics University of Cambridge Cambridge UK Ludwig Center at Harvard Medical School Boston MA USA School of Mathematical Sciences and Center for Statistical Science Peking University Beijing 100871 China Heidelberg University Heidelberg Germany New BIH Digital Health Center Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin Berlin Germany Bioi

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Patterns of somatic structural variation in human cancer genomes (vol 578, pg 112, 2020)

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NATURE 2023年第7948期614卷 E38-E38页

作者： Li, Yilong Roberts, Nicola D. Wala, Jeremiah A. Shapira, Ofer Schumacher, Steven E. Kumar, Kiran Khurana, Ekta Waszak, Sebastian Korbel, Jan O. Haber, James E. Imielinski, Marcin Weischenfeldt, Joachim Beroukhim, Rameen Campbell, Peter J. Cancer Genome Project Wellcome Trust Sanger Institute Hinxton UK Totient Inc Cambridge MA USA Wellcome Sanger Institute Wellcome Genome Campus Hinxton UK Department of Haematology University of Cambridge Cambridge UK Cambridge University Hospitals NHS Foundation Trust Cambridge UK Korea Advanced Institute of Science and Technology Daejeon South Korea Department of Zoology Genetics and Physical Anthropology University of Santiago de Compostela Santiago de Compostela Spain Centre for Research in Molecular Medicine and Chronic Diseases (CIMUS) University of Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) University of Vigo Vigo Spain Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain Department of Zoology Genetics and Physical Anthropology (CiMUS) Universidade de Santiago de Compostela Santiago de Compostela Spain The Biomedical Research Centre (CINBIO) Universidade de Vigo Vigo Spain The Broad Institute of Harvard and MIT Cambridge MA USA Bioinformatics and Integrative Genomics Harvard University Cambridge MA USA Department of Cancer Biology Dana-Farber Cancer Institute Boston MA USA Broad Institute of MIT and Harvard Cambridge MA USA Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA Harvard Medical School Boston MA USA Massachusetts General Hospital Center for Cancer Research Charlestown MA USA Dana-Farber Cancer Institute Boston MA USA Department of Biostatistics and Computational Biology Dana-Farber Cancer Institute and Harvard Medical School Boston MA USA Weill Cornell Medical College New York NY USA Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA Controlled Department and Institution New York NY USA Englander Institute for Precision Medicine Weill Cornell Medicine Ne

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The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

NPJ Biodiversity

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NPJ Biodiversity 2024年第1期3卷 28页

作者： Mc Cartney, Ann M. Formenti, Giulio Mouton, Alice De Panis, Diego Marins, Luísa S. Leitão, Henrique G. Diedericks, Genevieve Kirangwa, Joseph Morselli, Marco Salces-Ortiz, Judit Escudero, Nuria Iannucci, Alessio Natali, Chiara Svardal, Hannes Fernández, Rosa De Pooter, Tim Joris, Geert Strazisar, Mojca Wood, Jonathan M. D. Herron, Katie E. Seehausen, Ole Watts, Phillip C. Shaw, Felix Davey, Robert P. Minotto, Alice Fernández, José M. Böhne, Astrid Alegria, Carla Alioto, Tyler Alves, Paulo C. Amorim, Isabel R. Aury, Jean-Marc Backstrom, Niclas Baldrian, Petr Baltrunaite, Laima Barta, Endre Bedhom, Bertrand Belser, Caroline Bergsten, Johannes Bertrand, Laurie Bilandija, Helena Binzer-Panchal, Mahesh Bista, Iliana Blaxter, Mark Borges, Paulo A. V. Dias, Guilherme Borges Bosse, Mirte Brown, Tom Bruggmann, Rémy Buena-Atienza, Elena Burgin, Josephine Buzan, Elena Cariani, Alessia Casadei, Nicolas Chiara, Matteo Chozas, Sergio Jr, Fedor Čiampor Crottini, Angelica Cruaud, Corinne Cruz, Fernando Dalen, Love Biase, Alessiode Delcampo, Javier Delic, Teo Dennis, Aliceb. Derks, Martijn F. L. Diroma, Maria Angela Djan, Mihajla Duprat, Simone Eleftheriadi, Klara Feulner, Philine G. D. Flot, Jean-François Forni, Giobbe Fosso, Bruno Fournier, Pascal Fournier-Chambrillon, Christine Gabaldon, Toni Garg, Shilpa Gissi, Carmela Giupponi, Luca Gomez-Garrido, Jessica González, Josefa Grilo, Miguel L. Grüning, Björn Guerin, Thomas Guiglielmoni, Nadege Gut, Marta Haesler, Marcel P. Hahn, Christoph Halpern, Balint Harrison, Peter W. Heintz, Julia Hindrikson, Maris Höglund, Jacob Howe, Kerstin Hughes, Graham M. Istace, Benjamin Cock, Mark J. Janžekovič, Franc Jonsson, Zophonias O. Joye-Dind, Sagane Koskimäki, Janne J. Krystufek, Boris Kubacka, Justyna Kuhl, Heiner Kusza, Szilvia Labadie, Karine Lähteenaro, Meri Lantz, Henrik Lavrinienko, Anton Leclère, Lucas Lopes, Ricardo Jorge Madsen, Ole Magdelenat, Ghislaine Magoga, Giulia Manousaki, Tereza Mappes, Tapio Marques, Joao Pedro Redondo, Gemma I. Martinez Maumus, Florian McCarthy, Shane A. M Genomics Institute University of California SantaCruz CA United States TheVertebrate Genome Laboratory The Rockefeller University NewYork NY United States Department of Biology University of Florence Sesto Fiorentino Italy InBios-Conservation Genetics Laboratory University of Liege Liege Belgium Leibniz Institut für Zoo und Wildtierforschung Berlin Germany Berlin Center for Genomics in Biodiversity Research Berlin Germany Department of Biology University of Antwerp Antwerp Belgium Institute of Zoology University of Cologne Cologne Germany Department of Chemistry Life Sciences and Environmental Sustainability University of Parma Parma Italy Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra Barcelona Spain Naturalis Biodiversity Center Leiden Netherlands Neuromics Support Facility VIB Center for Molecular Neurology VIB Antwerp Belgium Neuromics Support Facility Department of Biomedical SciencesUniversity ofAntwerp Antwerp Belgium Tree of Life WellcomeSanger Institute Cambridge Hinxton United Kingdom School of Biology and Environmental Science University College Dublin Belfield Ireland Aquatic Ecology & Evolution Institute of Ecology & Evolution University of Bern Bern Switzerland Department of Fish Ecology & Evolution Eawag Kastanienbaum Switzerland Department of Biological and Environmental Science University of Jyvaskyla Jyvaskyla Finland The EarlhamInstitute NorwichResearchPark Norwich United Kingdom Digital Science London United Kingdom Barcelona Supercomputing Center Spanish National Bioinformatics Institute ELIXIR Spain Getafe Spain Leibniz Institute for the Analysis of Biodiversity Change Museum Koenig Bonn Bonn Germany CE3C—Centre for Ecology Evolution and Environmental Changes & CHANGE—Global Change and Sustainability Institute Faculdade de Ciências Universidade de Lisboa Campo Grande Lisboa Portugal Centro Nacional de Análisis Genómico (CNAG) Barcelona Spain Universitat de Barcelona (UB) Barcelona Spain CIBIO Cen

A genomic database of all Earth’s eukaryotic species could contribute to many scientific discoveries;however, only a tiny fraction of species have genomic information available. In 2018, scientists across the world united under the Earth BioGenome Project (EBP), aiming to produce a database of highquality reference genomes containing all ~1.5 million recognized eukaryotic species. As the European node of the EBP, the European Reference Genome Atlas (ERGA) sought to implement a new decentralised, equitable and inclusive model for producing reference genomes. For this, ERGA launched a Pilot Project establishing the first distributed reference genome production infrastructure and testing it on 98 eukaryotic species from 33 European countries. Here we outline the infrastructure and explore its effectiveness for scaling high-quality reference genome production, whilst considering equity and inclusion. The outcomes and lessons learned provide a solid foundation for ERGA while offering key learnings to other transnational, national genomic resource projects and the EBP. © The Author(s) 2024, corrected publication 2024.

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