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2010 International Symposium on Evolving Intelligent Systems, EIS'10, Organised in the 2010 Annual Convention of the Society for Study of Artificial Intelligence and Simulation of Behaviour, AISB'10

作者： Tschumitschew, Katharina Klawonn, Frank Department of Computer Science Ostfalia University of Applied Sciences Salzdahlumer Str. 45/48 D-38302 Wolfenbuettel Germany Department of Bioinformatics and Statistics Helmholtz Centre for Infection Research Inhoffenstrasse 7 D-38124 Braunschweig Germany

ISBN: (纸本)190295694X

The problem with real data is often that noise and forms of randomness are involved. This causes a specific problem for evolving systems. They must be able to distinguish between changes according to noise and changes of the underlying data generating process or its parameters. In the worst case, an evolving system might just try to track the noise in the data and is unable to learn the actual relationship inherent in the data. But how can we make sure that this will not be the case for a given evolving system? We propose some simple benchmark tests in our paper that can give an idea of how much an evolving system might be misled by noise.

关键词： Stochastic systems

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Product triplets in winning probability relations

Product triplets in winning probability relations

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14th International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems, IPMU 2012

作者： De Loof, Karel De Baets, Bernard De Meyer, Hans Department of Mathematical Modelling Statistics and Bioinformatics Ghent University Coupure links 653 B-9000 Gent Belgium Department of Applied Mathematics and Computer Science Ghent University Krijgslaan 281 S9 B-9000 Gent Belgium

ISBN: (纸本)9783642317231

It is known that the winning probability relation of a dice model, which amounts to the pairwise comparison of a set of independent random variables that are uniformly distributed on finite integer multisets, is dice transitive. The condition of dice transitivity, also called the 3-cycle condition, is, however, not sufficient for an arbitrary rational-valued reciprocal relation to be the winning probability relation of a dice model. An additional necessary condition, called the 4-cycle condition, is introduced in this contribution. Moreover, we reveal a remarkable relationship between the 3-cycle condition and the number of so-called product triplets of a reciprocal relation. Finally, we experimentally count product triplets for several families of winning probability relations. © 2012 Springer-Verlag.

关键词： Random variables

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On a class of variolinear copulas

On a class of variolinear copulas

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14th International Conference on Information Processing and Management of Uncertainty in Knowledge-Based Systems, IPMU 2012

作者： De Meyer, Hans De Baets, Bernard Jwaid, Tarad Department of Applied Mathematics and Computer Science Ghent University Krijgslaan 281 S9 B-9000 Gent Belgium Department of Mathematical Modelling Statistics and Bioinformatics Ghent University Coupure links 653 B-9000 Gent Belgium

ISBN: (纸本)9783642317149

We construct variolinear copulas with a given diagonal section, i.e. copulas that are linear on line segments connecting points on the diagonal to points on the boundary of the unit square. These line segments cover the unit square, two line segments can only intersect at (0,1) or (1,0), and the line segments may have a varying angle w.r.t. the main diagonal. The class of variolinear copulas covers the subclasses of semilinear, ortholinear and biconic copulas, whose construction has been reported before. We restrict the analysis to the case of symmetric variolinear copulas and we focus on the situation where the variability of the line segments is governed by two linear functions. For that subclass we provide the necessary and sufficient conditions on a diagonal function to obtain a variolinear copula. Some examples are provided. © 2012 Springer-Verlag Berlin Heidelberg.

关键词： Information management

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Comparing the transmission potential from sequence and surveillance data of 2009 North American influenza pandemic waves

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Infectious Disease Modelling 2023年第1期8卷 240-252页

作者： Venkata R.Duvvuri Joseph T.Hicks Lambodhar Damodaran Martin Grunnill Thomas Braukmann Jianhong Wu Jonathan B.Gubbay Samir N.Patel Justin Bahl Public Health Ontario TorontoOntarioCanada Department of Laboratory Medicine and Pathobiology Faculty of MedicineUniversity of TorontoTorontoOntarioCanada Laboratory for Industrial and Applied Mathematics Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Center for the Ecology of Infectious Disease Department of Infectious DiseasesInstitute of BioinformaticsUniversity of GeorgiaAthensGeorgia Department of Epidemiology and Biostatistics Institute of BioinformaticsUniversity of GeorgiaAthensGeorgia Duke-NUS Graduate Medical School Singapore

Technological advancements in phylodynamic modeling coupled with the accessibility of real-time pathogen genetic data are increasingly important for understanding the infectious disease transmission *** this study,we compare the transmission potentials of North American influenza A(H1N1)pdm09 derived from sequence data to that derived from surveillance *** impact of the choice of tree-priors,informative epidemiological priors,and evolutionary parameters on the transmission potential estimation is *** American Influenza A(H1N1)pdm09 hemagglutinin(HA)gene sequences are analyzed using the coalescent and birth-death tree prior models to estimate the basic reproduction number(R_(0)).Epidemiological priors gathered from published literature are used to simulate the birth-death skyline ***-sampling marginal likelihood estimation is conducted to assess model fit.A bibliographic search to gather surveillancebased R_(0)values were consistently lower(mean≤1.2)when estimated by coalescent models than by the birth-death models with informative priors on the duration of infectiousness(mean≥1.3 to≤2.88 days).The user-defined informative priors for use in the birth-death model shift the directionality of epidemiological and evolutionary parameters compared to non-informative *** there was no certain impact of clock rate and tree height on the R_(0)estimation,an opposite relationship was observed between coalescent and birth-death tree *** was no significant difference(p=0.46)between the birth-death model and surveillance R0 *** study concludes that treeprior methodological differences may have a substantial impact on the transmission potential estimation as well as the evolutionary *** study also reports a consensus between the sequence-based R_(0)estimation and surveillanceased R_(0)***,these outcomes shed light on the potential role of phylodynamic modeling to augment existing surveillance

关键词： Phylodynamics Pandemic 2009 H1N1 Reproduction number Coalescent growth models Birth-death models Pathogen sequence data Public health

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Robust analysis of related samples under the presence of population substructure

Robust analysis of related samples under the presence of pop...

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IEEE International Conference on bioinformatics and Biomedicine Workshops (BIBMW)

作者： Sungkyoung Choi Sungho Won Bioinformatics Program Seoul National University Seoul South Korea Department of Applied Statistics Chung-Ang University Seoul South Korea

We propose a new method for genome-wide association analysis with a family-based design. The proposed method is robust against population substructure while it is more efficient than the traditional method such as transmission disequilibrium test for related samples. The proposed method estimates the correlation matrix between individuals and then the principal component analysis is applied. To maximize the statistical power, we consider the additive polygenic model and a best linear unbiased predictor is used as offset. We confirmed that the proposed method is always efficient by simulation studies. The method will be applied to Framingham Heart study.

关键词： bioinformatics Genomics Diseases Correlation Robustness Testing

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Statistical Methods for Analyzing EQ-5D in Randomized Clinical Trials: A Systematic Literature Review

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Value in Health 2025年

作者： Yan, Jiajun Humphries, Brittany Xie, Ruinan Yin, Ziran Bo, Zhenyan Diao, Sha Cai, Jing Tse, Preston Li, Meixuan Pullenayegum, Eleanor Lee, Shun Fu Xie, Feng Department of Health Research Methods Evidence and Impact McMaster University Hamilton ON Canada Department of Applied Mathematics Hong Kong Polytechnic University Hong Kong China Department of Biostatistics and Bioinformatics School of Medicine Duke University Chapel Hill NC United States Department of Pharmacy/Evidence-based Pharmacy Center West China Second University Hospital Sichuan University Sichuan China Department of Mathematics and Statistics McMaster University Hamilton ON Canada Evidence-Based Medicine Center School of Basic Medical Sciences Lanzhou University Lanzhou China Health Technology Assessment Centre Evidence-Based Social Science Research Center School of Public Health Lanzhou University Lanzhou China Child Health Evaluative Sciences Hospital for Sick Children Toronto ON Canada Dalla Lana School of Public Health University of Toronto Toronto ON Canada Population Health Research Institute Hamilton Health Sciences Hamilton ON Canada Centre for Health Economics and Policy Analysis McMaster University Hamilton ON Canada

Objectives: We conducted a systematic literature review to summarize the application of statistical methods for analyzing treatment effect on EQ-5D in randomized clinical trials (RCTs). Method: We searched 2 electronic databases (MEDLINE and EMBASE, from inception through 2021) and ***. Eligible studies were RCTs that analyzed postbaseline EQ-5D data by treatment group. Information on trial characteristics, EQ-5D data characteristics, and statistical methods were extracted. Descriptive statistics were used to summarize results by dimension response, EQ visual analog scale (EQ VAS), and EQ-5D utility. Results: A total of 2125 trials met the eligibility criteria. EQ-5D was commonly considered a secondary (n = 1219, 57.4%) or exploratory (n = 775, 36.5%) endpoint in RCTs. EQ-5D utilities were the most analyzed. Both utilities and EQ VAS were primarily analyzed in numerical format. The most common statistical models for analyzing utilities were the linear fixed-effect model for single postbaseline (192/589, 32.6%) and the linear mixed-effect model for multiple post-baselines (338/984, 34.3%). Of the 2054 studies that analyzed numerical EQ-5D, 221 (10.8%) examined model assumptions and 438 (21.3%) adjusted for the baseline score. Missing data were explicitly assessed in 661 trials, among which 347 (52.5% of 661) applied imputations, with the 2 most used imputation methods being multiple imputations (n = 200, 57.6% of 347) and last observation carried forward (n = 106, 30.5% of 347). Conclusions: This review found that health utilities are the most frequently analyzed EQ-5D data collected in clinical trials, followed by EQ VAS. Significant variation was observed in the selection of models, with most trials lacking adjustments for baseline data and appropriate methods for handling missing data. © 2025

关键词： EQ-5D patient-reported outcome randomized clinical trial statistical analysis

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Patient portals: Objectives, acceptance, and effects on health outcome - A scoping review of reviews 66

Patient portals: Objectives, acceptance, and effects on heal...

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Joint Conference of the 66th Annual Meeting of the German Association of Medical Informatics, Biometry, and Epidemiology e.V. (gmds) and the 13th Annual Meeting of the TMF - Technology, Methods, and Infrastructure for Networked Medical Research e.V. 2021

作者： Leb, I. Magnin, S. Prokosch, H.-U. Boeker, M. Friedrich-Alexander-University Erlangen-Nürnberg Germany Medical Data Integration Center Dept. for IT and Applied Medical Informatics University Hospital Tübingen Translational Bioinformatics University of Tübingen Institute for Bioinformatics and Medical Informatics University of Tübingen Germany Technical University of Munich School of Medicine Medical Center Rechts der Isar Institute for Medical Informatics Statistics and Epidemiology-IMedIS Germany

ISBN: (纸本)9781643682068

Patient portals provide patients access to their electronic health record and other functions as secure messaging. For over a decade, more and more patient portals are developed for various settings. The aim of this scoping review of reviews is to systematically search the literature for existing reviews to provide an overview of patient portals' objectives, acceptance and effects on outcome. We followed the PRISMA Statement and its extension for scoping reviews, and searched for articles published in 2011 2021. The 19 included articles were considerably heterogeneous concentrating on health outcome or patient portal facilitators and barriers. © 2021 IOS Press. All rights reserved.

关键词： Records management

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QT-GWAS:A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits

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Molecular Plant 2023年第7期16卷 1212-1227页

作者： Marlies Brouckaert Meng Peng RenéHofer lias El Houari Chiarina Darrah Veronique Storme Yvan Saeys Ruben Vanholme Geert Goeminne Vitaliy I.Timokhin John Ralph Kris Morreel Wout Boerjan Ghent University Department of Plant Biotechnology and Bioinformatics9000 GhentBelgium VIB Center for Plant Systems Biology 9052 GhentBelgium Ghent University Department of Applied MathematicsComputer Science and Statistics9000 GhentBelgium VIB Center for Inflammation Research 9052 GhentBelgium vIB Metabolomics Core 9052 GhentBelgium Department of Biochemistry and US Department of Energy Great Lakes Bioenergy Research CenterWisconsin Energy InstituteUniversity of Wisconsin-MadisonMadisonWI53706USA Ghent University Department of Applied MathematicsComputer Science and StatisticsGhentBelgium ViB Center for Inflammation Research GhentBelgium BioNTech SE MainzRhineland-PalatinateGermany Eunomia Research&Consulting BristolUK VIB Agro-incubator NeveleBelgium Research Institute for Chromatography KortrijkBelgium

Although the plant kingdom provides an enormous diversity of metabolites with potentially beneficial applications for humankind,a large fraction of these metabolites and their biosynthetic pathways remain *** metabolite structures and their biosynthetic pathways is key to gaining biological understanding andto allow metabolic *** orderto retrieve novel biosynthetic genes involved in specialized metabolism,we developed a novel untargeted method designated as qualitative trait GWAs(QT-GWAS)that subjects qualitative metabolic traits to a genome-wide association study,while the conventional metabolite GWAS(mGWAS)mainly considers the quantitative variation of *** a proof of the validity of QT-GWAS,23 and 15of the retrieved associations identified in Arabidopsis thaliana by QTGWAS and mGWAS,respectively,were supported by previous ***,seven genemetabolite associations retrieved by QT-GWAS were confirmed in this study through reverse genetics combined with metabolomics and/or in vitro enzyme *** such,we established that CYTOCHROME P450706A5(CYP706A5)is involved in the biosynthesis of chroman derivatives,UDP-GLYCOSYLTRANSFERASE 76C3(UGT76C3)is able tohexosylate guanine in vitro and in planta,and SULFOTRANSFERASE 202B1(SULT202B1)catalyzes the sulfation of neolignans in ***,our study demonstrates that the untargeted QT-GWAS method can retrieve valid gene-metabolite associations at the level of enzyme-encoding genes,even new associations that cannot be found by the conventional mGwAs,providing a new approach for dissecting qualitative metabolic traits.

关键词： qualitative method proof

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Factors Affecting an Admitted Student's Decision to Enroll

Factors Affecting an Admitted Student's Decision to Enroll

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2016 International Conference on Education, Training and Management Innovation(ETMI 2016)

作者： Bakeerathan GUNARATNAM Harold S.HALLER Wojbor A.WOYCZYNSKI John G.HALLER Department of Bioinformatics and Biostatistics University of Louisville Department of Mathematics Applied Mathematics and Statistics Center for Stochastic and Chaotic Processes in Science and Technology Case Western Reserve University

This paper presents a process for and the development of a "Choice" model for predicting student enrollment in a professional school. Our process emphasizes the importance of using subject-matter experts to identify factors that potentially influence students' enrollment decisions. Our analysis focuses on how to identify the statistically significant factors that impact admitted student decisions to enroll or not to enroll. As a case study, this theory was applied to professional school enrollment at a private law school at a major research university in the Midwest. The research process involved personnel from the Law School's enrollment office and statisticians who developed a model using a logistic multiple regression method by analyzing 2008, 2009 and 2010 enrollment data for admitted students to the Law School in order to predict the probability of students enrolling in the Law School. The model was validated with 2011 enrollment data using a classification table with 71.4 % accuracy.

关键词： Admitted students Enrollment management Logistic regression

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In-silico structural and functional analysis of nonsynonymous single nucleotide polymorphisms in human FOLH1 gene

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In silico pharmacology 2025年第1期13卷 32页

作者： Abtin Tondar Muhammad Irfan Sergio Sánchez-Herrero Hafsa Athar Aleena Haqqi Asim Kumar Bepari Laura Calvet Liñán David Hervás Marin Department of Computer Science Multimedia and Telecommunication Interuniversity Doctoral Program in Bioinformatics Universitat Oberta de Catalunya Barcelona (UOC) Spain. Stanford Deep Data Research Center Stanford University Stanford USA. Atta-Ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences and Technology (NUST) Islamabad Punjab Pakistan. School of Medical Laboratory Technology Minhaj University Lahore (MUL) Lahore Punjab Pakistan. Department of Pharmaceutical Sciences North South University (NSU) Dhaka Bangladesh. Telecommunications and Systems Engineering Department Universitat Autònoma de Barcelona (UAB) Sabadell Spain. Department of Applied Statistics and Operational Research and Quality Alcoy Universitat Politècnica de València (UPV) Alcoy Spain.

Non-synonymous single nucleotide polymorphisms (nsSNPs), also known as missense SNPs, can seriously affect an individual’s vulnerability to numerous diseases, including cancer. In this study, we conducted a comprehensive in-silico analysis to examine the structural and functional implications of nsSNPs within the Folate Hydrolase 1(FOLH1) gene, which encodes the Prostate-Specific Membrane Antigen (PSMA). A total of 504 SNPs were retrieved, and after filtering, 15 pathogenic nsSNPs were identified using five different in-silico tools. Three of these SNPs—R255H (rs375565491), R255C (rs201789325), and G168E (rs267602926)—were consistently predicted to be pathogenic across all in-silico tools. MutPred2 was used to predict the structural and functional consequences of the identified mutations. The analysis revealed multiple alterations in the PSMA protein, including changes in helical conformations, glycosylation patterns, transmembrane properties, and solvent accessibility. Furthermore, I-Mutant 2.0 analysis demonstrated a decrease in protein stability for most nsSNPs, except for rs267602926 (G168E), which was predicted to increase stability. Conservation analysis using ConSurf revealed varying degrees of amino acid conservation, with R255H and R255C identified as highly conserved residues, indicating their potential functional and structural significance. Additionally, post-translational modification (PTM) analysis indicated that while phosphorylation and methylation sites remained unchanged, specific glycosylation sites were lost in two pathogenic mutant variants (R255H and R255C), potentially affecting PSMA function and adversely impacting prostate cancer. Our findings highlight the importance of in silico studies to investigate the structural and functional impacts of FOLH1 nsSNPs on the PSMA protein. Such in silico studies can deepen our understanding of the roles of nsSNPs in prostate cancer onset, progression, and drug resistance.

关键词： FOLH1 In-silico structural and functional analyses PSMA PTM nsSNPs

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