检索结果-内蒙古大学图书馆

2022-RA-685-ESGO What is beyond brca mutational status in high grade serous ovarian cancer? The role of hormone receptors expression

引用

International Journal of Gynecological Cancer 2022年 32卷 A254-A254页

作者： Emanuele Perrone Riccardo Tudisco Pia Clara Pafundi Davide Guido Alessandra Ciucci Enrica Martinelli Gian Franco Zannoni Alessia Piermattei Claudia Marchetti Camilla Nero Daniela Gallo Giovanni Scambia Anna Fagotti Gynecologic Oncology Unit Dipartimento per le Scienze della Salute della Donna del Bambino e di Sa Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Dipartimento per le Scienze della Salute della Donna del Bambino e di Sa Universita’ Cattolica del Sacro Cuore Fondazione Policlinico Universitario A. Gemelli IRCCS. Rome Italy. Rome Italy Facility of Epidemiology and Biostatistics Gemelli Generator Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Bioinformatics Facility Core Research Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italy. Rome Italy Unit of Translational Medicine for Woman and Child Health Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Rome Italy Gynecopathology and Breast Pathology Unit Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy

来源：评论

学校读者我要写书评

暂无评论

DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study

引用

Clinical epigenetics 2024年第1期16卷 80页

作者： Po-Lung Yang Tai-Shuan Lai Yu-Hsiang Chou Liang-Chuan Lai Shuei-Liong Lin Yung-Ming Chen Department of Geriatrics and Gerontology National Taiwan University Hospital College of Medicine National Taiwan University Taipei Taiwan. Renal Division Department of Internal Medicine National Taiwan University College of Medicine No. 1 Jen-Ai Road Section 1 Taipei 100 Taiwan. Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan. Renal Division Department of Internal Medicine National Taiwan University College of Medicine No. 1 Jen-Ai Road Section 1 Taipei 100 Taiwan. chouyuhsiang@ntuh.gov.tw. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine National Taiwan University Taipei Taiwan. Research Center for Developmental Biology and Regenerative Medicine National Taiwan University Taipei Taiwan. Department of Internal Medicine National Taiwan University Hospital Bei-Hu Branch Taipei Taiwan.

BACKGROUND:Older patients are at risk for acute kidney injury and chronic kidney disease. Age-related increases in DNA methylation at CpG islands have been linked to aging-related diseases like cancer and cardiovascular disease, but the exact causal relationship between methylation in renal aging and other kidney diseases remains unclear. This study aimed to elucidate the methylation status of peripheral blood mononuclear cells (PBMCs) in the Asian population. Using human whole blood DNA methylation analysis from the Taiwan Biobank, we included participants with both whole blood genome-wide methylation data and follow-up data on serum creatinine. We investigated hyper- and hypomethylated genes in comparison of participants with higher and lower estimated glomerular filtration (eGFR) decline rate in overall cohort as well as in comparison of old and young participants in subgroup of participants with higher eGFR decline rate. Common genes and signaling pathways in both comparative analyses were identified. RESULTS:Among 1587 participants in the analysis, 187 participants had higher eGFR decline rate. According to the comparison of methylation in participants with different eGFR declines and at different ages, respectively, we identified common hypermethylated genes, including DNMT3A and GGACT, as well as hypomethylated genes such as ARL6IP5, CYB5D1, BCL6, RPRD2, ZNF451, and MIAT in both participants with higher eGFR decline and those of older age. We observed associations between the methylation status of signaling pathways and aging as well as renal function decline. These pathways notably included autophagy, p38 mitogen-activated protein kinases, and sirtuins, which were associated with autophagy process and cytokine production. CONCLUSIONS:Through methylation analysis of PBMCs, we identified genes and signaling pathways which could play crucial roles in the interplay of renal aging and renal function decline. These findings contribute to the development of novel b

关键词： Chronic kidney disease DNA methylation Estimated glomerular filtration rate Peripheral blood mononuclear cell Renal aging

来源：评论

学校读者我要写书评

暂无评论

#1. Acid ceramidase (ASAH1) is a key mediator of drug resistance in relapsed/refractory multiple myeloma

引用

Journal of Bone Oncology 2024年 45卷 100539-100539页

作者： Ryan T. Bishop Tao Li Raghunandan R. Alugubelli Mostafa Nasr Karl J. Nyman Praneeth Sudalagunta Mark Meads Jeremy Frieling Niveditha Nerlakanti Marilena Tauro Oliver Hampton Bin Fang Steven Grant John Koomen Ariosto Siqueira Silva Kenneth H. Shain Conor C. Lynch Tumor Biology Dept. H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA Collaborative Data Services Core H. Lee Moffitt Cancer Center & Research Institute Tampa FL 33612 USA Cancer Biology Ph.D. Program University of South Florida Tampa FL USA Department of Metabolism and Physiology H. Lee Moffitt Cancer Center and Research Institute Tampa Florida Bioinformatics and Biostatistics Department M2GEN Tampa FL USA Chemical Biology & Molecular Medicine H. Lee Moffitt Cancer Center & Research Institute Tampa FL USA Virginia Commonwealth University (VCU) Massey Cancer Center Richmond VA 23298 USA Department of Molecular Oncology H. Lee Moffitt Cancer Center & Research Institute Tampa FL 33612 USA Department of Malignant Hematology H. Lee Moffitt Cancer Center & Research Institute Tampa FL 33612 USA

来源：评论

学校读者我要写书评

暂无评论

Inhibition of DNMTs increases neoantigen-reactive T-cell toxicity against microsatellite-stable colorectal cancer in combination with radiotherapy

引用

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024年 177卷 116958页

作者： Kevin Chih-Yang Huang Tao-Wei Ke Chia-Ying Lai Wei-Ze Hong Hsin-Yu Chang Chien-Yueh Lee Chia-Hsin Wu Shu-Fen Chiang Ji-An Liang Jhen-Yu Chen Pei-Chen Yang William Tzu-Liang Chen Eric Y Chuang K S Clifford Chao Department of Biomedical Imaging and Radiological Science China Medical University Taiwan Translation Research Core China Medical University Hospital China Medical University Taichung 40402 Taiwan Cancer Biology and Precision Therapeutics Center China Medical University Taichung 40402 Taiwan. Electronic address: chihyang0425@mail.cmu.edu.tw. School of Chinese Medicine China Medical University Taichung 40402 Taiwan Department of Colorectal Surgery China Medical University Hospital China Medical University Taichung 40402 Taiwan. Center of Proton therapy and Science China Medical University Hospital China Medical University Taichung 40402 Taiwan. Innovation Frontier Institute of Research for Science and Technology National Taipei University of Technology Taipei 106344 Taiwan Department of Electrical Engineering National Taipei University of Technology Taipei 106344 Taiwan. Center of Proton therapy and Science China Medical University Hospital China Medical University Taichung 40402 Taiwan Bioinformatics and Biostatistics Core Centers of Genomic and Precision Medicine National Taiwan University Taipei 10055 Taiwan. Lab of Precision Medicine Feng-Yuan Hospital Taichung 42055 Taiwan. Department of Radiation Oncology School of Medicine China Medical University Taichung 40402 Taiwan Department of Radiation Oncology China Medical University Hospital China Medical University Taichung Taiwan. Translation Research Core China Medical University Hospital China Medical University Taichung 40402 Taiwan. Department of Colorectal Surgery China Medical University Hospital China Medical University Taichung 40402 Taiwan Department of Surgery School of Medicine China Medical University Taichung 40402 Taiwan Department of Colorectal Surgery China Medical University HsinChu Hospital China Medical University Hsinchu 302 Taiwan. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Biomedical Technology and Device Research La

The therapeutic efficacy of immunotherapy is limited in the majority of colorectal cancer patients due to the low mutational and neoantigen burdens in this immunogenically "cold" microsatellite stability-colorectal cancer (MSS-CRC) cohort. Here, we showed that DNA methyltransferase (DNMT) inhibition upregulated neoantigen-bearing gene expression in MSS-CRC, resulting in increased neoantigen presentation by MHC class I in tumor cells and leading to increased neoantigen-specific T-cell activation in combination with radiotherapy. The cytotoxicity of neoantigen-reactive T cells (NRTs) to DNMTi-treated cancer cells was highly cytotoxic, and these cells secreted high IFNγ levels targeting MSS-CRC cells after ex vivo expansion of NRTs with DNMTi-treated tumor antigens. Moreover, the therapeutic efficacy of NRTs further increased when NRTs were combined with radiotherapy in vivo. Administration of DNMTi-augmented NRTs and radiotherapy achieved an ∼50 % complete response and extended survival time in an immunocompetent MSS-CRC animal model. Moreover, remarkably, splenocytes from these mice exhibited neoantigen-specific T-cell responses, indicating that radiotherapy in combination with DNMTi-augmented NRTs prolonged and increased neoantigen-specific T-cell toxicity in MSS-CRC patients. In addition, these DNMTi-augmented NRTs markedly increase the therapeutic efficacy of cancer vaccines and immune checkpoint inhibitors (ICIs). These data suggest that a combination of radiotherapy and epi-immunotherapeutic agents improves the function of ex vivo-expanded neoantigen-reactive T cells and increases the tumor-specific cytotoxic effector population to enhance therapeutic efficacy in MSS-CRC.

关键词： DNMT1 Immune checkpoint inhibitor MSS-CRC Neoantigen-reactive T cells

来源：评论

学校读者我要写书评

暂无评论

Correction to: A Multi-Omic Mosaic Model of Acetaminophen Induced Alanine Aminotransferase Elevation

引用

Journal of medical toxicology : official journal of the American College of Medical Toxicology 2023年第4期19卷 416页

作者： Andrew A Monte Alexis Vest Julie A Reisz Danielle Berninzoni Claire Hart Layne Dylla Angelo D'Alessandro Kennon J Heard Cheyret Wood Jack Pattee Department of Emergency Medicine University of Colorado School of Medicine Leprino Building 7Th Floor Campus Box B-215 12401 E. 17Th Avenue Aurora CO 80045 USA. Andrew.monte@cuanschutz.edu. Center for Bioinformatics & Personalized Medicine University of Colorado School of Medicine Aurora CO USA. Andrew.monte@cuanschutz.edu. Skaggs School of Pharmacy University of Colorado Aurora CO USA. Andrew.monte@cuanschutz.edu. Rocky Mountain Poison & Drug Safety Denver Health & Hospital Authority Denver CO USA. Andrew.monte@cuanschutz.edu. Department of Emergency Medicine University of Colorado School of Medicine Leprino Building 7Th Floor Campus Box B-215 12401 E. 17Th Avenue Aurora CO 80045 USA. Metabolomics Core Department of Biochemistry and Molecular Genetics University of Colorado-Denver Anschutz Medical Campus Aurora CO USA. Center for Bioinformatics & Personalized Medicine University of Colorado School of Medicine Aurora CO USA. Rocky Mountain Poison & Drug Safety Denver Health & Hospital Authority Denver CO USA. Department of Biostatistics & Informatics Colorado School of Public Health University of Colorado-Denver Anschutz Medical Campus Aurora CO USA.

来源：评论

学校读者我要写书评

暂无评论

Proceedings of the 15th Annual UT-KBRIN bioinformatics Summit 2016 : Cadiz, KY, USA. 8-10 April 2016

引用

BMC bioinformatics 2016年第SUPPL 10期17卷 297页

作者： Eric C. Rouchka Julia H. Chariker Benjamin J. Harrison Juw Won Park Xueyuan Cao Stanley Pounds Susana Raimondi James Downing Raul Ribeiro Jeffery Rubnitz Jatinder Lamba Bernie J. Daigle Deborah Burgess Stephanie Gehrlich John C. Carmen Nicholas Johnson Chandrakanth Emani Kalpani De Silva Michael P. Heaton Theodore S. Kalbfleisch Teeradache Viangteeravat Rahul Mudunuri Oluwaseun Ajayi Fatih Şen Eunice Y. Huang Mohammad Mohebbi Luaire Florian Douglas J. Jackson John F. Naber AKM Sabbir Sally R. Ellingson Yuping Lu Charles A Phillips Michael A. Langston Rahul K. Sevakula Raghuveer Thirukovalluru Nishchal K. Verma Yan Cui Mohammed Sayed Jing Wang Qi Liu Yu Shyr Xiaofei Zhang Naresh Prodduturi Gavin R. Oliver Diane Grill Jie Na Jeanette Eckel-Passow Eric W. Klee Michael M. Goodin Mark Farman Harrison Inocencio Chanyong Jang Jerzy W. Jaromczyk Neil Moore Kelly Sovacool Leon Dent Mike Izban Sammed Mandape Shruti Sakhare Siddharth Pratap Dana Marshall M Scotty DePriest James N. MacLeod Hanady Adam Ethan Blandford Joel Campbell Joshua Castlen Brittany Dixon Ginger Gilbert Aaron Hall Philip Kreisle Jessica Lasher Bethany Oakes Allison Speer Maximilian Valentine Naga Satya V. Rao Nagisetty Rony Jose Robert Rooney David Hains Department of Computer Engineering and Computer Science University of Louisville Duthie Center for Engineering Louisville USA Kentucky Biomedical Research Infrastructure (KBRIN) Bioinformatics Core Louisville USA Department of Psychological and Brain Sciences University of Louisville Louisville USA Department of Anatomical Sciences and Neurobiology University of Louisville Louisville USA Department of Biostatistics St. Jude Children’s Research Hospital Memphis USA Department of Pathology St. Jude Children’s Research Hospital Memphis USA Department of Oncology St. Jude Children’s Research Hospital Memphis USA Department of Pharmacotherapy and Translational Research College of Pharmacy University of Florida Gainesville USA Department of Biological Sciences University of Memphis Memphis USA Department of Computer Science University of Memphis Memphis USA Department of Computer Science Northern Kentucky University Highland Heights USA Department of Biological Sciences Northern Kentucky University Highland Heights USA Department of Biology Western Kentucky University Bowling Green USA Interdisciplinary Studies Program: Specialization in Bioinformatics University of Louisville Louisville USA United States Department of Agriculture Agricultural Research Service United States Meat Animal Research Center Clay Center USA Department of Biochemistry and Molecular Genetics School of Medicine University of Louisville Louisville USA Biomedical Informatics Core Children’s Foundation Research Institute Memphis USA Department of Pediatrics University of Tennessee Health Science Center Memphis USA Department of Electrical and Computer Engineering University of Louisville Louisville USA Department of Computer Science University of Kentucky Lexington USA Division of Biomedical Informatics College of Medicine University of Kentucky Lexington USA Department of Electrical Engineering and Computer Science University of Tennessee Knoxville USA Department of Electrical E

I1 Proceedings of the Fifteenth Annual UT- KBRIN bioinformatics Summit 2016 Eric C. Rouchka, Julia H. Chariker, Benjamin J. Harrison, Juw Won Park P1 CC-PROMISE: Projection onto the Most Interesting Statistical Evidence (PROMISE) with Canonical Correlation to integrate gene expression and methylation data with multiple pharmacologic and clinical endpoints Xueyuan Cao, Stanley Pounds, Susana Raimondi, James Downing, Raul Ribeiro, Jeffery Rubnitz, Jatinder Lamba P2 Integration of microRNA-mRNA interaction networks with gene expression data to increase experimental power Bernie J Daigle, Jr. P3 Designing and writing software for in silico subtractive hybridization of large eukaryotic genomes Deborah Burgess, Stephanie Gehrlich, John C Carmen P4 Tracking the molecular evolution of Pax gene Nicholas Johnson; Chandrakanth Emani P5 Identifying genetic differences in thermally dimorphic and state specific fungi using in silico genomic comparison Stephanie Gehrlich, Deborah Burgess, John C Carmen P6 Identification of conserved genomic regions and variation therein amongst Cetartiodactyla species using next generation sequencing Kalpani De Silva, Michael P Heaton, Theodore S Kalbfleisch P7 Mining physiological data to identify patients with similar medical events and phenotypes Teeradache Viangteeravat, Rahul Mudunuri, Oluwaseun Ajayi, Fatih Şen, Eunice Y Huang P8 Smart brief for home health monitoring Mohammad Mohebbi, Luaire Florian, Douglas J Jackson, John F Naber P9 Side-effect term matching for computational adverse drug reaction predictions AKM Sabbir, Sally R Ellingson P10 Enrichment vs robustness: A comparison of transcriptomic data clustering metrics Yuping Lu, Charles A Phillips, Michael A Langston P11 Deep neural networks for transcriptome-based cancer classification Rahul K Sevakula, Raghuveer Thirukovalluru, Nishchal K. Verma, Yan Cui P12 Motif discovery using K-means clustering Mohammed Sayed, Juw Won Park P13 Large scale discovery of active enhancers from nasce

关键词： True Negative Differential Expression UCSC Genome Browser Laboratory Information Management System Biomedical Informatics

来源：评论

学校读者我要写书评

暂无评论

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women

引用

Gynecologic oncology 2019年第2期153卷 343-355页

作者： Kate Lawrenson Fengju Song Dennis J Hazelett Siddhartha P Kar Jonathan Tyrer Catherine M Phelan Rosario I Corona Norma I Rodríguez-Malavé Ji-Hei Seo Emily Adler Simon G Coetzee Felipe Segato Marcos A S Fonseca Christopher I Amos Michael E Carney Georgia Chenevix-Trench Jiyeob Choi Jennifer A Doherty Weihua Jia Gang J Jin Byoung-Gie Kim Nhu D Le Juyeon Lee Lian Li Boon K Lim Noor A Adenan Mika Mizuno Boyoung Park Celeste L Pearce Kang Shan Yongyong Shi Xiao-Ou Shu Weiva Sieh Pamela J Thompson Lynne R Wilkens Qingyi Wei Yin L Woo Li Yan Beth Y Karlan Matthew L Freedman Houtan Noushmehr Ellen L Goode Andrew Berchuck Thomas A Sellers Soo-Hwang Teo Wei Zheng Keitaro Matsuo Sue Park Kexin Chen Paul D P Pharoah Simon A Gayther Marc T Goodman Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center 8700 Beverly Boulevard Suite 290W Los Angeles CA USA Center for Bioinformatics and Functional Genomics Cedars Sinai Genomics Core Cedars-Sinai Medical Center Los Angeles CA USA. Electronic address: kate.lawrenson@***. National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China Department of Epidemiology and Biostatistics Key Laboratory of Cancer Prevention and Therapy Tianjin China. Center for Bioinformatics and Functional Genomics Cedars Sinai Genomics Core Cedars-Sinai Medical Center Los Angeles CA USA. Department of Oncology Centre for Cancer Genetic Epidemiology University of Cambridge Strangeways Research Laboratory Cambridge UK. Department of Gynecologic Oncology Moffitt Cancer Center Tampa FL USA Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL USA. Center for Bioinformatics and Functional Genomics Cedars Sinai Genomics Core Cedars-Sinai Medical Center Los Angeles CA USA. Department of Medical Oncology Dana-Farber Cancer Institute Boston MA USA. Department of Preventive Medicine University of Southern California Keck School of Medicine 1450 Biggy Street Los Angeles CA USA. Department of Genetics Ribeirão Preto Medical School University of São Paulo 14049-900 Brazil. Institute for Clinical and Translational Research Department of Medicine Baylor School of Medicine HoustonTX USA. Department of Obstetrics and Gynecology John A. Burns School of Medicine University of Hawaii Honolulu HI USA. Genetics and Computational Biology Department QIMR Berghofer Medical Research Institute 300 Herston Road Herston QLD 4006 Australia. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea Cancer Research Institute Seoul National University Seoul Republic of Korea Department of Biomedical Science Graduate School Seoul National Un

OBJECTIVE:Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. METHODS:Genotyping was performed as part of the OncoArray project. Samples with >60% Asian ancestry were included in the analysis. Genotyping was performed on 533,631 SNPs in 3238 Asian subjects diagnosed with invasive or borderline EOC and 4083 unaffected controls. After imputation, genotypes were available for 11,595,112 SNPs to identify associations. RESULTS:At chromosome 6p25.2, SNP rs7748275 was associated with risk of serous EOC (odds ratio [OR] = 1.34, P = 8.7 × 10) and high-grade serous EOC (HGSOC) (OR = 1.34, P = 4.3 × 10). SNP rs6902488 at 6p25.2 (r = 0.97 with rs7748275) lies in an active enhancer and is predicted to impact binding of STAT3, P300 and ELF1. We identified additional risk loci with low Bayesian false discovery probability (BFDP) scores, indicating they are likely to be true risk associations (BFDP <10%). At chromosome 20q11.22, rs74272064 was associated with HGSOC risk (OR = 1.27, P = 9.0 × 10). Overall EOC risk was associated with rs10260419 at chromosome 7p21.3 (OR = 1.33, P = 1.2 × 10) and rs74917072 at chromosome 2q37.3 (OR = 1.25, P = 4.7 × 10). At 2q37.3, expression quantitative trait locus analysis in 404 HGSOC tissues identified ESPNL as a putative candidate susceptibility gene (P = 1.2 × 10). CONCLUSION:While some risk loci were shared between East Asian and European populations, others were population-specific, indicating that the landscape of EOC risk in Asian women has both shared and unique features compared to women of European ancestry.

关键词： Asian ancestry Enhancer Epithelial ovarian cancer Gene regulation Genome-wide association study eQTL

来源：评论

学校读者我要写书评

暂无评论

Daratumumab Based Response Adapted Therapy for Older Adults with Newly Diagnosed Multiple Myeloma: Final Results of a Phase II Study

引用

Blood 2024年 144卷 1995-1995页

作者： Rachid Baz Mark B. Meads Jongphil Kim Ariel F. Grajales-Cruz Brandon Blue Sonila Toska Xiaohong Zhao Xiaofei Song Praneeth Reddy Sudalagunta Alexandra Achille David R. Noyes Samer Sansil Sean J. Yoder Ariosto Siqueira Silva Omar Castaneda Jose L. Ochoa-Bayona Chaomei H. Zhang Ciara Louise Freeman Hien Liu Doris K. Hansen Kenneth H. Shain Department of Malignant Hematology H. Lee Moffitt Cancer Center & Research Institute Tampa FL H. Lee Moffitt Cancer Center Tampa FL Department of Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center and Research Institute Tampa FL H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Metabolism and Physiology H. Lee Moffitt Cancer Center & Research Institute Tampa FL H. Lee Moffitt Cancer Center & Research Institute Tampa FL Molecular Genomics Core Facility H. Lee Moffitt Cancer Center & Research Institute Tampa FL Department of Metabolism and Physiology H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Blood and Marrow Transplantation and Cellular Immunotherapy H. Lee Moffitt Cancer Center and Research Institute Tampa FL Moffitt Cancer Center Tampa FL Department of Blood and Marrow Transplant and Cellular Immunotherapy H. Lee Moffitt Cancer Center Tampa FL

Introduction The combination of daratumumab (DARA), lenalidomide (Len) and dexamethasone (Dex) is an accepted therapy for older adults with newly diagnosed multiple myeloma (NDMM). A less intense bortezomib (Bort) lenalidomide dexamethasone combination (RVD lite) is also used. We thought to investigate a personalized daratumumab-based response adapted therapy for older adults with NDMM. Methods NDMM patients over age 65 and not deemed candidates for transplant received DARA Dex for 2 cycles: in the event of PR or better, patients continued DARA Dex per usual dose and schedule, in the event of less than a PR, frailty adjusted dosing of Len or Bort was added to the DARA Dex. The choice of Len or Bort was per the treating physician and informed by Ex Vivo drug sensitivity assay. Modified geriatric assessment (IMWG frailty, timed up and go) and bone marrow biopsy (for correlatives) were performed at screening as well as on C2D22. The primary endpoint was best response per IMWG criteria. Secondary endpoints included PFS, ORR after 2 cycles of DARA Dex. Results Between 11/2019 and 3/2023, 32 patients were enrolled. The median age was 77.5 years (range 66-88) and 11 (34%) were older than 80 years. The proportion of patients with R-ISS stage I, II and III was 15%, 66% and 19%, respectively and 5 patients (15.6%) had high risk cytogenetics (del17p, or t(4;14) or t(14;16)). Using the IMWG frailty score, 6 (19%), 12 (37%) and 14 (44%) were considered fit, unfit and frail (including 22% of patients with a IMWG score of 3 and greater). After 2 cycles of DARA Dex, 12 patients (37.5%) had a PR or better, 1 patient discontinued therapy after 1 dose of study therapy. Of the remaining 19 patients, 12 patients were treated on arm B (addition of Len) and 7 on arm C (addition of Bort). Using this response adapted approach, the ORR was 94% with 12 patients with CR/sCR and 65% in VGPR. After a median of 31 months of follow up, the median PFS for the response adapted approach was 42.5 mont

关键词：

来源：评论

学校读者我要写书评

暂无评论

Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h

引用

Cancer cell international 2023年第1期23卷 45页

作者： Kuan-Yi Lee Chia-Ming Liu Li-Han Chen Chien-Yueh Lee Tzu-Pin Lu Li-Ling Chuang Liang-Chuan Lai Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. Institute of Fisheries Science College of Life Science National Taiwan University Taipei Taiwan. Department of Life Science College of Life Science National Taiwan University Taipei Taiwan. Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung Taiwan. Institute of Epidemiology and Preventive Medicine Department of Public Health National Taiwan University Taipei Taiwan. School of Physical Therapy and Graduate Institute of Rehabilitation Science College of Medicine Chang Gung University Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan. lchuang@gap.cgu.edu.tw. Graduate Institute of Physiology College of Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw. Bioinformatics and Biostatistics Core Center of Genomic and Precision Medicine National Taiwan University Taipei Taiwan. llai@ntu.edu.tw.

BACKGROUND:Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor. METHODS:Firstly, circAAGAB was identified from expression profiling by next generation sequencing. Next, the stability of circAAGAB increased by interacting with the RNA binding protein FUS. Moreover, cellular and nuclear fractionation showed that most circAAGAB resided in the cytoplasm and that it up-regulated KIAA1522, NKX3-1, and JADE3 by sponging miR-378 h. Lastly, the functions of circAAGAB were explored by identifying its down-stream genes using Affymetrix microarrays and validated by in vitro assays. RESULTS:The results showed that circAAGAB reduced cell colony formation, cell migration, and signaling through p38 MAPK pathway, as well as increased radiosensitivity. CONCLUSION:These findings suggest that the oxygen-responsive circAAGAB acts as a tumor suppressor in breast cancer, and may contribute to the development of a more specific therapeutic regimen for breast cancer.

关键词： Breast cancer Hypoxia Radiosensitivity Tumor suppressor circAAGAB miRNA sponge p38 MAPK

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

引用

Nature immunology 2024年第11期25卷 2166页

作者： Martina Musella Andrea Guarracino Nicoletta Manduca Claudia Galassi Eliana Ruggiero Alessia Potenza Ester Maccafeo Gwenola Manic Luca Mattiello Sara Soliman Abdel Rehim Michele Signore Marco Pietrosanto Manuela Helmer-Citterich Matteo Pallocca Maurizio Fanciulli Tiziana Bruno Francesca De Nicola Giacomo Corleone Anna Di Benedetto Cristiana Ercolani Edoardo Pescarmona Laura Pizzuti Francesco Guidi Francesca Sperati Sara Vitale Daniele Macchia Massimo Spada Giovanna Schiavoni Fabrizio Mattei Adele De Ninno Luca Businaro Valeria Lucarini Laura Bracci Eleonora Aricò Giovanna Ziccheddu Francesco Facchiano Stefania Rossi Massimo Sanchez Alessandra Boe Mauro Biffoni Ruggero De Maria Ilio Vitale Antonella Sistigu Dipartimento di Medicina e Chirurgia Traslazionale Università Cattolica del Sacro Cuore Rome Italy. Department of Biology University of Rome 'Tor Vergata' Rome Italy. Genomics Research Centre Human Technopole Milan Italy. Department of Radiation Oncology Weill Cornell Medical College New York NY USA. Experimental Hematology Unit IRCCS San Raffaele Scientific Institute Milan Italy. Italian Institute for Genomic Medicine (IIGM) Candiolo Italy. Candiolo Cancer Institute FPO - IRCCS Candiolo Italy. RPPA Unit Proteomics Area Core Facilities Istituto Superiore di Sanità Rome Italy. UOSD Clinical Trial Center Biostatistics and Bioinformatics IRCCS Regina Elena National Cancer Institute Rome Italy. SAFU Unit IRCCS Regina Elena National Cancer Institute Rome Italy. Pathology Unit IRCCS Regina Elena National Cancer Institute Rome Italy. Division of Medical Oncology 2 IRCCS Regina Elena National Cancer Institute Rome Italy. Fondazione Policlinico Universitario 'A. Gemelli' - IRCCS Rome Italy. UOSD Clinical Trial Center Biostatistics and Bioinformatics IRCCS San Gallicano Dermatological Institute Rome Italy. Center of Animal Research and Welfare Istituto Superiore di Sanità Rome Italy. Department of Oncology and Molecular Medicine Istituto Superiore di Sanità Rome Italy. Institute for Photonics and Nanotechnologies Italian National Research Council Rome Italy. Department of Paediatric Haematology/Oncology and of Cell and Gene Therapy Ospedale Pediatrico Bambino Gesù IRCCS Rome Italy. FaBioCell Core Facilities Istituto Superiore di Sanità Rome Italy. Oncogenomics and Epigenetics IRCCS Regina Elena National Cancer Institute Rome Italy. Cytometry Unit Core Facilities Istituto Superiore di Sanità Rome Italy. Dipartimento di Medicina e Chirurgia Traslazionale Università Cattolica del Sacro Cuore Rome Italy. ruggero.demaria@unicatt.it. Fondazione Policlinico Universitario 'A. Gemelli' - IRCCS Rome Italy. ruggero.demaria@unicatt.it. Italian Institute for Geno

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：