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1128P Preliminary results of first-in-human study of 225-Actinium MTI-201 (225Ac-MTI-201) in metastatic uveal melanoma

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Annals of Oncology 2024年 35卷 S742-S742页

作者： N.I. Khushalani G. El-Haddad K. Gage M. Budzevich M. Schell E.G. Moros C. Tichacek W. Gibbons R. Rogers M. Nickels L. Tetteh Z. Eroglu L. Karapetyan A.S. Brohl J. Markowitz A. Tarhini K. Hayes L. Hazlehurst M. McLaughlin D. Morse Cutaneous Oncology H. Lee Moffitt Cancer Center Tampa FL USA Diagnostic Imaging and Interventional Radiology H. Lee Moffitt Cancer Center Tampa FL USA Core Facility H. Lee Moffitt Cancer Center Tampa FL USA Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center Tampa FL USA Radiation Oncology H. Lee Moffitt Cancer Center Tampa FL USA Mallinckrodt Institute of Radiology Washington University School of Medicine St. Louis MO USA Modulation Therapeutics Morgantown WV USA Metabolism and Physiology H. Lee Moffitt Cancer Center Tampa FL USA

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Correction: Improvements in lung function following vitamin C supplementation to pregnant smokers are associated with buccal DNA methylation at 5 years of age

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Clinical epigenetics 2024年第1期16卷 59页

作者： Lyndsey E Shorey-Kendrick Cindy T McEvoy Kristin Milner Julia Harris Julie Brownsberger Robert S Tepper Byung Park Lina Gao Annette Vu Cynthia D Morris Eliot R Spindel Division of Neuroscience Oregon National Primate Research Center Oregon Health and Science University Beaverton OR 97006 USA. shorey@ohsu.edu. Department of Pediatrics Pape Pediatric Research Institute Oregon Health and Science University Portland OR USA. Department of Pediatrics Oregon Health and Science University Portland OR USA. Department of Pediatrics Herman B Wells Center for Pediatric Research Indiana University School of Medicine Indianapolis IN USA. Biostatistics Shared Resources Knight Cancer Institute Bioinformatics and Biostatistics Core Oregon National Primate Research Center Oregon Health and Science University Portland State University School of Public Health Portland OR USA. Oregon Clinical and Translational Research Institute Oregon Health and Science Department of Medical Informatics and Clinical Epidemiology Oregon Health and Science University Portland OR USA. Division of Neuroscience Oregon National Primate Research Center Oregon Health and Science University Beaverton OR 97006 USA.

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#1056 Multi-omic characterization of naïve treatment samples of epithelial ovarian cancer addressed to neoadjuvant chemotherapy: an hypothesis-generating study on biomarkers of response to platinum-based chemotherapy

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International Journal of Gynecological Cancer 2024年 34卷 A577-A578页

作者： Rita Trozzi Luca Mastrantoni Camilla Nero Simona Duranti Valentina Iacobelli Angelo Minucci Tina Pasciuto Luciano Giacò Gian Franco Zannoni Diana Giannarelli Domenica Lorusso Maria De Bonis Claudia Marchetti Anna Fagotti Giovanni Scambia Department of Women Children and Public Health Sciences Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy UOC Oncologia medica Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Università Cattolica del Sacro Cuore Rome Italy Facoltà di Medicina e Chirurgia Università Cattolica del Sacro Cuore Rome Italy Scientific Directorate Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Departmental Unit of Molecular and Genomic Diagnostics Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Data Collection Research Core Facility Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Bioinformatics Research Core Facility Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy Biostatistics Unit Gemelli Science and Technology Park (GSTeP) Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Rome Italy

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OP 2.7 – 00057 The latency reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific CD8+ T-cells

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Journal of Virus Eradication 2022年 8卷

作者： D.C. Copertino C.S. Holmberg A.R. Ward J. Weiler J.N. Howard C. Levinger A.P.S. Pang M.J. Corley F. Dündar P. Zumbo D. Betel R.T. Gandhi D.K. McMahon R.J. Bosch B.J. Macatangay J.C. Cyktor J.J. Eron J.W. Mellors A. Bosque R. Brad Jones Weill Cornell Medicine Department of Infectious Diseases Division of Medicine NewYork NY George Washington University Department of Microbiology Immunology and Tropical Medicine Washington DC Weill Cornell Medicine Applied Bioinformatics Core New York NY Catenion GmbH Berlin Germany Weill Cornell Medicine Department of Physiology and Biophysics New York NY WeillCornellMedicine Institute for Computational Biomedicine New York NY Division of Infectious Diseases Massachusetts General Hospital Boston MA USA Department of Medicine University of Pittsburgh School of Medicine Pittsburgh PA USA Center for Biostatistics in AIDS Research Harvard T.H. Chan School of Public Health Boston MA USA Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA

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Sexual Health in Young Adult Patients after Chimeric Antigen Receptor T-Cell Therapy

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Transplantation and Cellular Therapy 2024年第2期30卷 S337-S337页

作者： Gatell, Vivian Michelle Irizarry, MD Buro, Acadia, PhD Fulton, Hayden J, MA Blackwell, Rebecca, PhD Zambrano, Kellie, BS Rodriguez, Yvelise, MS Li, Xiaoyin, PhD Wang, Xuefeng, PhD Faramand, Rawan G, MD Oswald, Laura, PhD Department of Blood and Marrow Transplantation and Cellular Immunotherapy H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Hematology/Oncology University of Texas Southwestern Dallas TX College of Population Health University of New Mexico Health Sciences Center Albuquerque NM Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center and Research Institute Tampa FL Participant Research Interventions and Measurement (PRISM) Core H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Blood and Marrow Transplant and Cellular Immunotherapy H. Lee Moffitt Cancer Center and Research Institute Tampa FL

BackgroundChimeric antigen receptor T-cell therapy (CAR T) shows promise for treating relapsed/refractory hematologic malignancies. Despite known immune mediated toxicities, studies on late effects and survivorship concerns are limited. Sexual health is crucial for health-related quality of life (HRQOL), particularly for young adults (YAs) aged 18-39 years. No prior studies have evaluated sexual health in YAs post-CAR T. We conducted a mixed methods study to examine sexual health and HRQOL and explore sexual health communication with healthcare providers (HCPs) in YAs post-CAR T. MethodsThis cross-sectional study recruited YAs aged 18-39 years treated with CAR T to complete a survey and semi-structured interview. The survey included PROMIS short form measures assessing sexual health and HRQOL and study-specific items on patient-provider sexual health communication. PROMIS scores were calculated as T-scores with a normative M=50, SD=10, and minimally important difference (MID)=5. The interview explored the impact of cancer and CAR T on sexual health and HRQOL, sexual health communication with HCPs, and support systems during and post-treatment. Preliminary analysis included descriptive statistics for quantitative data compared to evidence-based thresholds and thematic analysis of qualitative data. ResultsIn total, 13 YAs completed the survey and 10 completed an interview. Median age was 35 years (range: 21-39), 61.5% identified as male, 92.3% identified as heterosexual, and median time since CAR T was 30 months (Table 1). Survey results are summarized in Table 2. Average interest in sexual activity was low for females (M=35.1, SD=10.0) but not males (M=48.7, SD=10.3). Other average scores were within normal ranges. Several differences in average scores by gender exceeded the MID; females reported less interest in sexual activity, worse fatigue, more impaired social function, and worse emotional impact. Most YAs had not discussed (46.2%) or did not recall discussing (

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Phase I Trial of Ex Vivo Expanded Donor Gamma Delta T Cell Immunotherapy to Prevent Acute Myeloid Leukemia Relapse after Allogeneic Transplantation

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Blood 2024年 144卷 4826-4826页

作者： Nelli Bejanyan Hany Elmariah Jongphil Kim Cheryl Cox Melissa Lowden Xiaofei Song Hien Liu Bin Yu Kayla Reid Sean J. Yoder Christopher Cubitt Rawan Faramand Sayeef Mirza Farhad Khimani Lia Perez Jose L. Ochoa-Bayona Justin Boucher Jose Alejandro Guevara David Sallman Jeffrey E Lancet Marco Davila Department of Blood and Marrow Transplantation and Cellular Immunotherapy H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Biostatistics and Bioinformatics H. Lee Moffitt Cancer Center and Research Institute Tampa FL Cell Therapy Facility Moffitt Cancer Center Tampa FL Department of Blood and Marrow Transplantation and Cellular Immunotherapy Moffitt Cancer Center Tampa FL Moffitt Cancer Center Tampa FL Immune Monitoring Core Moffitt Cancer Center Tampa FL Department of Clinical Science Moffitt Cancer Center Tampa FL Molecular Genomics Core Facility H. Lee Moffitt Cancer Center & Research Institute Tampa FL Immuno-Oncology Program Moffitt Cancer Center Tampa FL Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa FL Department of Malignant Hematology Moffitt Cancer Center Tampa FL Department of Medicine Roswell Park Comprehensive Cancer Center Buffalo NY

Background Patients with adverse risk acute myeloid leukemia (AML) by European LeukemiaNet (ELN) risk stratification are at high risk (~50%) of relapse after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT). We developed a novel cellular therapy using ex vivo expanded donor-derived gamma delta T (GDT) cells to prevent post-HCT relapse and cure more patients with adverse risk AML. GDT cells that are rare in circulating blood have MHC-independent potent antitumor cytotoxicity against AML. They cause no graft-versus-host-disease (GVHD) in preclinical studies, which allows the potential for a healthy donor-derived cellular immunotherapy for AML. Methods This first-in-human trial enrolled patients with ELN adverse risk AML who received either HLA-identical sibling donor (MSD) or haploidentical donor RIC alloHCT. The same donor used for HCT underwent non-mobilized leukapheresis for large scale expansion of GDT cells with use of artificial antigen presented cells (Boucher J. Immunother. 2023). Expanded GDT cells were infused to patients between days 60-100 after alloHCT in the absence of uncontrolled infection and/or GVHD requiring systemic steroids. The trial followed a 3+3 design to study the primary endpoint of maximum-tolerated dose (MTD) of donor GDT cell infusion. Three dose levels (DL) of GDT cells were studied where DL1 was 6.25 x 10 6 cells/kg, DL2 was 3.13 x 10 7 cells/kg and DL3 was 1.10 x 10 8 cells/kg. Dose-limiting toxicities (DLT) were evaluated for 42 days following GDT cell infusion and were defined as grade 3-4 cytokine release syndrome (CRS), grade 3-4 immune effector cell-associated neurotoxicity syndrome (ICANS), or any grade 4 organ toxicity by CTCAE 5.0. Results We treated 9 patients with ELN adverse risk AML in morphological complete remission (CR), including 5 patients who had detectable measurable residual disease (MRD) prior to HCT. Median age was 63 years, and all patients received RIC alloHCT prior to

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Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants

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Science (New York, N.Y.) 2025年第6734期387卷 eadp4753页

作者： Liu, Hongbo Abedini, Amin Ha, Eunji Ma, Ziyuan Sheng, Xin Dumoulin, Bernhard Qiu, Chengxiang Aranyi, Tamas Li, Shen Dittrich, Nicole Chen, Hua-Chang Tao, Ran Tarng, Der-Cherng Hsieh, Feng-Jen Chen, Shih-Ann Yang, Shun-Fa Lee, Mei-Yueh Kwok, Pui-Yan Wu, Jer-Yuarn Chen, Chien-Hsiun Khan, Atlas Limdi, Nita A. Wei, Wei-Qi Walunas, Theresa L. Karlson, Elizabeth W. Kenny, Eimear E. Luo, Yuan Kottyan, Leah Connolly, John J. Jarvik, Gail P. Weng, Chunhua Shang, Ning Cole, Joanne B. Mercader, Josep M. Mandla, Ravi Majarian, Timothy D. Florez, Jose C. Haas, Mary E. Lotta, Luca A. Drivas, Theodore G. Vy, Ha My T Nadkarni, Girish N. Wiley, Laura K. Wilson, Melissa P. Gignoux, Christopher R. Rasheed, Humaira Thomas, Laurent F. Åsvold, Bjørn Olav Brumpton, Ben M. Hallan, Stein I. Hveem, Kristian Zheng, Jie Hellwege, Jacklyn N. Zawistowski, Matthew Zöllner, Sebastian Franceschini, Nora Hu, Hailong Zhou, Jianfu Kiryluk, Krzysztof Ritchie, Marylyn D. Palmer, Matthew Edwards, Todd L. Voight, Benjamin F. Hung, Adriana M. Susztak, Katalin Department of Medicine Renal Electrolyte and Hypertension Division University of Pennsylvania Philadelphia PA United States Institute of Diabetes Obesity and Metabolism University of Pennsylvania Philadelphia PA United States Department of Genetics University of Pennsylvania Philadelphia PA United States Penn-CHOP Kidney Innovation Center University of Pennsylvania Philadelphia PA United States Liangzhu Laboratory Zhejiang University 1369 West Wenyi Road Hangzhou Zhejiang China Department of Nephrology Children' Hospital Zhejiang University School of Medicine National Clinical Research Center for Child Health Hangzhou Zhejiang China Institute of Molecular Life Sciences HUN-REN Research Center for Natural Sciences Budapest Hungary Department of Molecular Biology Semmelweis University Budapest Hungary Department of Medicine Federal University of São Paulo São Paulo Brazil Department of Biostatistics Vanderbilt University Medical Center Nashville TN United States Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN United States Institute of Clinical Medicine School of Medicine National Yang Ming Chiao Tung University ROC Taipei Taiwan Division of Nephrology Department of Medicine Taipei Veterans General Hospital ROC Taipei Taiwan Institute of Biomedical Sciences Academia Sinica ROC Taipei Taiwan Cardiovascular Center Taichung Veterans General Hospital Taichung Taiwan ROC National Chung Hsing University Taichung Taiwan ROC Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital ROC Taipei Taiwan Department of Internal Medicine College of Medicine National Yang Ming Chiao Tung University ROC Taipei Taiwan Institute of Medicine Chung Shan Medical University Taichung Taiwan ROC Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan ROC Division of Endocrinology and Metabolism Department of Internal Medicine Kaohsiung Medical Universit

Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation of newly identified signals on common variants in European ancestry populations and the power of population diversity for further discoveries. We defined genotype effects on allele-specific gene expression and regulatory circuitries in more than 700 human kidneys and 237,000 cells. We found 1363 coding variants disrupting 782 genes, with 601 genes also targeted by regulatory variants and convergence in 161 genes. Integrating 32 types of genetic information, we present the "Kidney Disease Genetic Scorecard" for prioritizing potentially causal genes, cell types, and druggable targets for kidney disease.

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Improving ITS sequence data for identification of plant pathogenic fungi

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Fungal Diversity 2014年第4期67卷 11-19页

作者： R.Henrik Nilsson Kevin D.Hyde Julia Pawlowska Martin Ryberg Leho Tedersoo Anders Bjornsgard Aas Siti A.Alias Artur Alves Cajsa Lisa Anderson Alexandre Antonelli A.Elizabeth Arnold Barbara Bahnmann Mohammad Bahram Johan Bengtsson-Palme Anna Berlin Sara Branco Putarak Chomnunti Asha Dissanayake Rein Drenkhan Hanna Friberg Tobias Guldberg Froslev Bettina Halwachs Martin Hartmann Beatrice Henricot Ruvishika Jayawardena Ari Jumpponen Havard Kauserud Sonja Koskela Tomasz Kulik Kare Liimatainen Bjorn D.Lindahl Daniel Lindner Jian-Kui Liu Sajeewa Maharachchikumbura Dimuthu Manamgoda Svante Martinsson Maria Alice Neves Tuula Niskanen Stephan Nylinder Olinto Liparini Pereira Danilo Batista Pinho Teresita M.Porter Valentin Queloz Taavi Riit Marisol Sánchez-García Filipe de Sousa Emil Stefańczyk Mariusz Tadych Susumu Takamatsu Qing Tian Dhanushka Udayanga Martin Unterseher Zheng Wang Saowanee Wikee Jiye Yan Ellen Larsson Karl-Henrik Larsson Urmas Koljalg Kessy Abarenkov Department of Biological and Environmental Sciences University of GothenburgBox 46140530 GothenburgSweden Institute of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Plant Systematics and Geography Faculty of BiologyUniversity of WarsawAl.Ujazdowskie 400-478 WarsawPoland Department of Organismal Biology Uppsala UniversityNorbyvagen 18D75236 UppsalaSweden Institute of Ecology and Earth Sciences University of TartuLai 40Tartu 51005Estonia Microbial Evolution Research Group University of OsloBlindernveien 310371 OsloNorway Institute of Biological Sciences University of Malaya50603 Kuala LumpurMalaysia Department of Biology CESAMUniversity of Aveiro3810-193 AveiroPortugal School of Plant Sciences The University of Arizona1140 E South Campus DriveForbes 303TucsonAZ 85721USA Laboratory of Environmental Microbiology Institute of Microbiology ASCRVídeňská108314220 Prague 4Czech Republic Department of Infectious Diseases Institute of BiomedicineSahlgrenska AcademyUniversity of GothenburgGuldhedsgatan 1041346 GoteborgSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden University of California at Berkeley 321 Koshland Hall University of CaliforniaBerkeleyCA 94720-3102USA Agriculture and Forestry Sciences Beijing 100097China Institute of Forestry and Rural Engineering Estonian University of Life SciencesKreutzwaldi551014 TartuEstonia Natural History Museum of Denmark Øster Voldgade 5-71350 København KDenmark Institute for Genomics and Bioinformatics Graz University of Technology8010 GrazAustria Core Facility Bioinformatics Austrian Centre of Industrial Biotechnology8010 GrazAustria Forest Soils and Biogeochemistry Swiss Federal Research Institute WSLZuercherstrasse 1118903 BirmensdorfSwitzerland Molecular Ecology Institute for Sustainability SciencesAgroscopeReckenholzstrasse 191

Plant pathogenic fungi are a large and diverse assemblage of eukaryotes with substantial impacts on natural ecosystems and human *** taxa often have complex and poorly understood life cycles,lack observable,discriminatory morphological characters,and may not be amenable to in vitro *** a result,species identification is frequently ***(DNA sequence)data have emerged as crucial information for the taxonomic identification of plant pathogenic fungi,with the nuclear ribosomal internal transcribed spacer(ITS)region being the most popular ***,international nucleotide sequence databases are accumulating numerous sequences of compromised or low-resolution taxonomic annotations and substandard technical quality,making their use in the molecular identification of plant pathogenic fungi *** we report on a concerted effort to identify high-quality reference sequences for various plant pathogenic fungi and to re-annotate incorrectly or insufficiently annotated public ITS sequences from these fungal lineages.A third objective was to enrich the sequences with geographical and ecological *** results-a total of 31,954 changes-are incorporated in and made available through the UNITE database for molecular identification of fungi(http://***),including standalone FASTA files of sequence data for local BLAST searches,use in the next-generation sequencing analysis platforms QIIME and mothur,and related *** present initiative is just a beginning to cover the wide spectrum of plant pathogenic fungi,and we invite all researchers with pertinent expertise to join the annotation effort.

关键词： Phytopathogenic fungi Molecular identification ITS Taxonomy Annotation

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Allogeneic Hematopoietic Cell Transplantation Is Effective In Patients With Advanced Systemic Mastocytosis: A Multicenter Retrospective Analysis

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BLOOD 2013年第21期122卷 2145-2145页

作者： Ustun, Celalettin Reiter, Andreas Scott, Bart L. Nakamura, Ryotaro Gandhi, Damaj Kreil, Sebastian Shanley, Ryan Hogan, William J. Perales, Miguel-Angel Shore, Tsiporah B. Baurmann, Herrad Stuart, Robert K. Gruhn, Bernd Doubek, Michael Hsu, Jack W. Tholouli, Eleni Gromke, Tanja Godley, Lucy A. Pagano, Livio Gilman, Andrew Wagner, Eva Maria Shwayder, Tor Bornhaeuser, Martin Papadopoulos, Esperanza B. Boehm, Alexandra Vercellotti, Gregory M. Van Lint, Maria Theresa Schmid, Christoph Rabitsch, Werner Pullarkat, Vinod Barrett, A. John Hermine, Olivier Hagglund, Hans Gustaf Sperr, Wolfgang R. Popat, Uday R. Devine, Steven M. Deeg, H. Joachim Weisdorf, Daniel J. Akin, Cem Valent, Peter Hematology Oncology and Transplantation University of Minnesota Minneapolis MN USA III. Medizinische Universitätsklinik Medizinische Fakultät Mannheim der Universität Heidelberg Mannheim Germany Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA Hematology and Hematopoietic Cell Transplantation City of Hope National Medical Center Duarte CA USA Service d'hematologie Hopital Necker Enfants Malades Paris France Biostatistics and Bioinformatics Core University of Minnesota Masonic Cancer Center Minneapolis MN USA Division of Hematology Mayo Clinic Rochester MN USA Department of Medicine Adult Bone Marrow Transplantation Memorial Sloan-Kettering Cancer Center New York NY USA Divison of Hematology/Oncology Weill Cornell Medical College New York Presbyterian Hospital New York NY USA Stiftung Deutsche Klinik fuer Diagnostik GmbH Wiesbaden Germany Division of Hematology/ Oncology Medical University of South Carolina Charleston SC USA Department of Pediatrics Jena University Hospital Jena Germany Department of Internal Medicine Hematology and Oncology University Hospital Brno Masaryk University Brno Czech Republic Division of Hematology-Oncology University of Florida Gainesville FL USA Department of Paediatric Haematology Royal Manchester Children's Hospital Manchester United Kingdom Department of Bone Marrow Transplantation University Hospitals of Essen Essen Germany Section of Hematology/Oncology The University of Chicago Chicago IL USA Istituto di Ematologia Università Cattolica S. Cuore Rome Italy Pediatric Blood and Marrow Transplantation Levine Children's Hospital Charlotte NC USA Department of Internal Medicine I Division of Hematology and Hemostaseology Medical University of Vienna Vienna Austria

2145

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GENO-33PATIENT DERIVED GLIOBLASTOMA CELL LINES RECAPITULATE PARENTAL TUMORS' MOLECULAR LANDSCAPE

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Neuro-Oncology 2015年第SUPPL_5期17卷 v99–v99页

作者： Rosenberg, Shai Verreault, Maité Schmitt, Charlotte Guegan, Justine Guehennec, Jeremy Levasseur, Camille Marie, Yannick Mokhtari, Karima Hoang-Xuan, Khê Sanson, Marc Delattre, Jean-Yves Idbaih, Ahmed Inserm U 1127 CNRS UMR 7225 Sorbonne Universite's UPMC Univ Paris 06 UMR S 1127 Institut du Cerveau et de la Moelle épinière ICM Paris France Neurooncology Unit Sharette Institute for Oncology and Neurology Department Hadassah Hebrew University Medical Center Jerusalem Israel Bioinformatics/Biostatistics Core Facility IHU-A-ICM Institut du Cerveau et de la Moelle épinière ICM Paris France Genotyping and sequencing platform Institut du Cerveau et de la Moelle épinière Paris France AP-HP Hôpital Universitaire La Pitié Salpêtrière Service de Neuropathologie-Escourolle Paris France AP-HP Hôpital Universitaire La Pitié Salpêtrière Service de Neurologie 2-Mazarin Paris France

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