检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

669 篇 期刊文献
270 篇 会议

馆藏范围

939 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

395 篇 工学
- 235 篇 计算机科学与技术...
- 181 篇 软件工程
- 123 篇 生物医学工程（可授...
- 109 篇 生物工程
- 63 篇 信息与通信工程
- 39 篇 化学工程与技术
- 35 篇 电气工程
- 32 篇 控制科学与工程
- 26 篇 光学工程
- 21 篇 安全科学与工程
- 14 篇 农业工程
- 13 篇 网络空间安全
- 11 篇 环境科学与工程（可...
- 11 篇 食品科学与工程（可...
- 10 篇 电子科学与技术（可...
357 篇 理学
- 202 篇 生物学
- 98 篇 数学
- 50 篇 化学
- 44 篇 物理学
- 38 篇 统计学（可授理学、...
- 19 篇 系统科学
236 篇 医学
- 170 篇 临床医学
- 108 篇 基础医学(可授医学...
- 43 篇 公共卫生与预防医...
- 43 篇 药学(可授医学、理...
99 篇 管理学
- 53 篇 图书情报与档案管...
- 40 篇 管理科学与工程(可...
- 18 篇 工商管理
- 16 篇 公共管理
70 篇 农学
- 35 篇 作物学
8 篇 法学
8 篇 教育学
6 篇 经济学
2 篇 文学

主题

31 篇 deep learning
31 篇 machine learning
21 篇 bioinformatics
13 篇 data mining
12 篇 predictive model...
10 篇 genome
10 篇 diseases
10 篇 accuracy
10 篇 forecasting
9 篇 covid-19
9 篇 cancer
9 篇 genomics
8 篇 transfer learnin...
8 篇 data models
7 篇 svm
7 篇 breast cancer
7 篇 twitter
7 篇 databases
7 篇 proteins
7 篇 classification

机构

75 篇 bioinformatics a...
51 篇 bioinformatics a...
42 篇 bioinformatics a...
38 篇 computer science...
33 篇 computer science...
25 篇 computer science...
25 篇 computer science...
21 篇 bioinformatics &...
17 篇 max planck insti...
17 篇 computer science...
15 篇 computer science...
15 篇 computer science...
15 篇 bina nusantara u...
10 篇 department of in...
10 篇 facultad de cien...
9 篇 department of me...
9 篇 computer science...
9 篇 bina nusantara u...
8 篇 santa fe insitut...
8 篇 bioinformatics a...

作者

124 篇 bens pardamean
108 篇 pardamean bens
31 篇 tjeng wawan ceng...
29 篇 alam ahmad hiday...
26 篇 stadler peter f.
23 篇 hidayat alam ahm...
23 篇 cenggoro tjeng w...
22 篇 arif budiarto
21 篇 rahutomo reza
21 篇 reza rahutomo
20 篇 elwirehardja gre...
19 篇 teddy suparyanto
17 篇 suparyanto teddy
15 篇 gregorius natana...
14 篇 hellmuth marc
14 篇 isnan mahmud
14 篇 mukherjee sayan
13 篇 mahmud isnan
12 篇 rudi nirwantono
12 篇 joko pebrianto t...

语言

903 篇 英文
21 篇 其他
12 篇 中文
1 篇 德文
1 篇 法文
1 篇 俄文

检索条件"机构=Bioinformatics and Data Center"

共 939 条记录，以下是901-910 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Challenges in DNA sequence analysis on a production grid 2

Challenges in DNA sequence analysis on a production grid

引用

2012 EGI Community Forum / EMI 2nd Technical Conference, EGICF-EMITC 2012

作者： Van Schaik, Barbera D.C. Santcroos, Mark Korkhov, Vladimir Jongejan, Aldo Willemsen, Marcel Van Kampen, Antoine H.C. Olabarriaga, S lvia D. Bioinformatics Laboratory Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Center Amsterdam Netherlands Faculty of Applied Math and Control Processes St. Petersburg State University Russia Biosystems Data Analysis Swammerdam Institute for Life Science University of Amsterdam Amsterdam Netherlands

Modern DNA sequencing machines produce data in the range of 1-100 GB per experiment and with ongoing technological developments this amount is rapidly increasing. The majority of experiments involve re-sequencing of human genomes and exomes to find genomic regions that are associated with disease. There are many sequence analysis tools freely available, e.g. for sequence alignment, quality control and variant detection, and frequently new tools are developed to address new biological questions. Since 2008 we use workflow technology to allow easy incorporation of such software in our data analysis pipelines, as well as to leverage grid infrastructures for the analysis of large datasets in parallel. The size of the datasets has grown from 1 GB to 70 GB in 3 years, therefore adjustments were needed to optimize these workflows. Procedures have been implemented for faster data transfer to and from grid resources, and for fault recovery at run time. A split-and-merge procedure for a frequently used sequence alignment tool, BWA, resulted in a three-fold reduction of the total time needed to complete an experiment and increased efficiency by a reduction in number of failures. The success rate was increased from 10% to 70%. In addition, steps to resubmit workflows for partly failed workflows were automated, which saved user intervention. Here we present our current procedure of analyzing data from DNA sequencing experiments, comment on the experiences and focus on the improvements needed to scale up the analysis of genomics data at our hospital. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.

关键词： data transfer

来源：评论

学校读者我要写书评

暂无评论

Legal constraints on genetic data processing in European grids

引用

10th HealthGrid Conference and the 4th International Workshop on Science Gateways for Life Sciences, IWSG-Life 2012

作者： Mouw, Evert Van't Noordende, Guido Van Kampen, Antoine H.C. Louter, Baas Santcroos, Mark Olabarriaga, Silvia D. Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Center University of Amsterdam Netherlands Department of Medical Informatics Academic Medical Center University of Amsterdam Netherlands Informatics Institute University of Amsterdam Netherlands Biosystems Data Analysis Swammerdam Institute for Life Science University of Amsterdam Netherlands

ISBN: (纸本)9781614990536

European laws on privacy and data security are not explicit about the storage and processing of genetic data. Especially whole-genome data is identifying and contains a lot of personal information. Is processing of such data allowed in computing grids? To find out, we looked at legal precedents in related fields, current literature, and interviews with legal experts. We found that processing of genetic data is only allowed on distributed systems with specific security measures, both technical and organizational. Informed consent, although important, offers no substitute for such requirements. © 2012 The authors and IOS Press. All rights reserved.

关键词： Digital storage

来源：评论

学校读者我要写书评

暂无评论

Crowd-sourcing design: Sketch minimization using crowds for feedback

Crowd-sourcing design: Sketch minimization using crowds for ...

引用

2012 AAAI Workshop

作者： Engel, David Kottler, Verena A. Malisi, Christoph Roettig, Marc Willing, Eva-Maria Schultheiss, Sebastian J. Massachusetts Institute of Technology Center for Collective Intelligence Cambridge MA United States Max Planck Institute for Developmental Biology Tuebingen Germany University of Tuebingen Center for Bioinformatics Tuebingen Germany Max Planck Institute for Plant Breeding Research Cologne Germany *** Molecular Data Analysis Tuebingen Germany

ISBN: (纸本)9781577355731

Design tasks are notoriously difficult, because success is defined by the perception of the target audience, whose feedback is usually not available during design stages. Commonly, design is performed by professionals who have specific domain knowledge (i.e., an intuitive understanding of the implicit requirements of the task) and do not need the feedback of the perception of the viewers during the process. In this paper, we present a novel design methodology for creating minimal sketches of objects that uses an iterative optimization scheme. We define minimality for a sketch via the minimal number of straight line segments required for correct recognition by 75% of naïve viewers. Crowd-sourcing techniques allow us to directly include the perception of the audience in the design process. By joining designers and crowds, we are able to create a human computation system that can efficiently optimize sketches without requiring high levels of domain knowledge (i.e., design skills) from any worker. Copyright © 2012, Association for the Advancement of Artificial Intelligence (***). All rights reserved.

关键词： Domain Knowledge

来源：评论

学校读者我要写书评

暂无评论

Integrated support for neuroscience research: From study design to publication

引用

10th HealthGrid Conference and the 4th International Workshop on Science Gateways for Life Sciences, IWSG-Life 2012

作者： Shahand, Shayan Caan, Matthan W.A. Van Kampen, Antoine H.C. Olabarriaga, Sílvia D. Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Center University of Amsterdam PO Box 22700 1100 DE Amsterdam Netherlands Dept. of Radiology Brain Imaging Center University of Amsterdam Netherlands Biosystems Data Analysis Swammerdam Institute for Life Science University of Amsterdam Netherlands

ISBN: (纸本)9781614990536

Computational neuroscience is a new field of research in which neurodegenerative diseases are studied with the aid of new imaging techniques and computation facilities. Researchers with different expertise collaborate in these studies. A study requires scalable computational and storage capacity and information management facilities to succeed. Many virtual laboratories are proposed and developed to facilitate these studies, however most of them cover only the parts related to the computational data processing. In this paper we describe and analyse the phases of the computational neuroscience studies including the actors, the tasks they perform, and the characteristics of each phase. Based on these we identify the required properties and functionalities of a virtual laboratory that supports the actors and their tasks throughout the complete study. © 2012 The authors and IOS Press. All rights reserved.

关键词： Neurodegenerative diseases

来源：评论

学校读者我要写书评

暂无评论

Integrating epigenetic and transcriptome data to identify consensus gene modules and signatures of paclitaxel responsiveness across multiple cancer types

Integrating epigenetic and transcriptome data to identify co...

引用

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Xu Li Fengji Liang Xingyi Hang Ling Yin Yinghui Li Shanguang Chen 熊江辉 Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application(SMFA)China Astronaut Research and Training Center(ACC)

Background:Paclitaxel(Taxol) is a widely used anti-cancer chemotherapeutic drug for many cancer ***,multiple studies focused on identifying cancer-specific paclitaxel responsive regulatory elements and signatures in particular type of *** we integrated DNA Methylation and gene expression profiling data to test whether there are shared gene modules and signatures across multiple types of cancer. Methods and Results:The promoter CGI methylation and mRNA expression profiles of multiple types of cancer were integrated to identify the epigenetically regulated genes, by selecting genes which show significant negative correlation between its expression level and promoter CGI *** Cox multivariate regression analysis was adopted to screen genes which are significantly associated with survival times of Paclitaxel treated *** overlap signature genes across multiple types of cancers were investigated in human protein-protein interaction *** demonstrated that these shared gene modules enriched in gene networks related to cell adhesion,tight junction pathways,synthesis of methionine adenosyltransferase,cell cycle progression and ***,by combining above features and constructing an SVM classifier,we demonstrated that the consensus gene modules could be used to classify the patient outcomes in various types of cancer. Conclusions:We demonstrated that epigenetically regulated genes and pathways is a common feature related to clinical outcome of paclitaxel treatment in multiple types of cancer.

关键词： Paclitaxel DNA methylation Regression analysis SVM

来源：评论

学校读者我要写书评

暂无评论

Integrating epigenetic and transcriptome data to identify consensus gene modules and signatures of paclitaxel responsiveness across multiple cancer types

Integrating epigenetic and transcriptome data to identify co...

引用

第五届全国生物信息学与系统生物学学术大会

作者： Xu Li Fengji Liang Xingyi Hang Ling Yin Yinghui Li Shanguang Chen Jianghui Xiong Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application (SMFA) China Astronaut Research and Training Center (ACC) Beijing China National Scientific Data Sharing Platform for Population and Health Beijing China

Background: Paclitaxel (Taxol) is a widely used anti-cancer chemotherapeutic drug for many cancer ***, multiple studies focused on identifying cancer-specific paclitaxel responsive regulatory elements and signatures in particular type of *** we integrated DNA Methylation and gene expression profiling data to test whether there are shared gene modules and signatures across multiple types of *** and Results: The promoter CGI methylation and mRNA expression profiles of multiple types of cancer were integrated to identify the epigenetically regulated genes, by selecting genes which show significant negative correlation between its expression level and promoter CGI *** Cox multivariate regression analysis was adopted to screen genes which are significantly associated with survival times of Paclitaxel treated *** overlap signature genes across multiple types of cancers were investigated in human protein-protein interaction *** demonstrated that these shared gene modules enriched in gene networks related to cell adhesion, tight junction pathways, synthesis of methionine adenosyltransferase, cell cycle progression and ***, by combining above features and constructing an SVM classifier, we demonstrated that the consensus gene modules could be used to classify the patient outcomes in various types of ***: We demonstrated that epigenetically regulated genes and pathways is a common feature related to clinical outcome of paclitaxel treatment in multiple types of cancer .

关键词： Paclitaxel DNA methylation Regression analysis SVM

来源：评论

学校读者我要写书评

暂无评论

In silico cancer drug screening based on microRNAs regulationnetworks

In silico cancer drug screening based on microRNAs regulatio...

引用

第五届全国生物信息学与系统生物学学术大会

作者： Lida Zhu Fengji Liang Juan Liu Yinghui Li Jianghui Xiong Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application (SMFA) China Astronaut Research and Training Center (ACC) Beijing China Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application (SMFA) China Astronaut Research and Training Center (ACC) Beijing China Computer School Wuhan University China Computer School Wuhan University China

Background: Severalstudies, such as the Connectivity Map (CMAP), showed that gene expression profiles could reflect drug perturbationeffects, and can be used in drug screening and drug *** we introduced a concept CoMi (Context-Specific miRNA Activity), and provide a novel perspective on drug mechanisms of *** this work, we intend to construct a virtual drug screening system and test whether CoMi could be used to capture the common features of approved cancer drugs and discriminate them from other candidate *** & Results: (1)We used correlation analysisby integrating the drugsensitive data (GI50) with gene expression datafrom diverse cancer cell lines in NCI60 datasets, and generated the drug sensitivity gene *** calculating the overlap rate between the drug sensitivity gene sets with disregulated gene set in breast cancer, we defined a drug-disease association index andgenerated a pool of 445 breast cancer associated compounds, including 61 positive drugs (approved breast cancer drugs) and 384 negative drugs.(2)Using the most significant differential CoMi features in positive *** drugs, a Na(i)veBayesian classifier could accurately predict the successful breast cancer drugs (AUC 0.86), and its performance was significantly exceed the mRNA signature based drug screening system (AUC 0.75), far superior to naive CMAP screening system (AUC0.56).(3)Further analysis of the network consisted of CoMi with good classification performance,highlighted some high connected miRNA nodes,including important cancer-related miRNAs (mir-495) and tumor suppressormiRNA (mir-520d) ; In addition, a number of high connectivity functional gene setsare also closely related with the biological processes of cancer (for example, cell differentiation).(4)Integrating differential expressed CoMi induced by Paclitaxel with breast cancer specific CoMi, weexaminedits application on classifying drug responsiveness in a breast cancer cohort using

关键词：

来源：评论

学校读者我要写书评

暂无评论

Predicting distant metastasis in breast cancer using ensemble classifier based on context-specific miRNA regulation modules

Predicting distant metastasis in breast cancer using ensembl...

引用

IEEE International Conference on bioinformatics and Biomedicine (BIBM)

作者： Xionghui Zhou Juan Liu Jianghui Xiong School of Computer Wuhan University Wuhan China Bioinformatics Group and Data Coordination Center State key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training Center Beijing China

Many methods based on building classifiers by selecting gene markers have been proposed to predict breast cancer patient's outcome However, most of them suffer from the problem of poor robustness, which are mainly due to the fact that the overlap degree of gene markers derived by different methods is not high, hading that few of them are generalized and can be widely used for clinical practice. In this paper, we present a method based on context-specific miRNA regulation modules to predict distant metastasis in breast cancer. First, we describe the regulation activity of a miRNA on a specific context by using CoMi (Context-specific miRNA activity) score, based on which, several miRNAs regulate on the same context are regarded as a miRNA regulation module; then the discriminate regulation modules are selected and each is used to construct a classification model separately; finally, an ensemble classifier is established by combining all the models with a majority voting strategy. The evaluation experiment results show that our method performs better than previous works. In addition, the obtained discriminate modules show great stability across different data sets (withp-value of 1.119e-06).

关键词： Breast cancer Metastasis Context Robustness Tumors

来源：评论

学校读者我要写书评

暂无评论

Predicting bone metastasis of breast cancer using context-specific miRNA regulation modules

Predicting bone metastasis of breast cancer using context-sp...

引用

第五届全国生物信息学与系统生物学学术大会

作者： Xionghui Zhou Fengji Liang Juan Liu Yinghui Li Shanguang Chen Jianghui Xiong Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application (SMFA) China Astronaut Research and Training Center (ACC) Beijing China Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application (SMFA) China Astronaut Research and Training Center (ACC) Beijing China School of Computer Science Wuhan University Wuhan China School of Computer Science Wuhan University Wuhan China

Background: The bone is the most frequent target of metastatic breast ***, the underlying molecular mechanisms are *** many microarray studies have reported gene signatures that can predict metastasis in breast cancer, predicting cancer metastasis to a specific organ, such as to bone, remains a challenge in cancer ***: Previously we proposed a concept CoMi (Context Specific miRNA activity), which could quantify the regulation activity of miRNA on specific context (CoMi activity) by calculating the statistical difference of the expression level between the miRNAtargets and non-targets in a given context (GO term biological process), and demonstrated its application on predicting *** we extend this concept to CoMi module and use it to predict whether the cancer will metastasize to ***, CoMi features which are significant associated with the bone metastasis are identified by Cox proportional hazards *** on the significant CoMi features, miRNAs regulate on the same context are regarded as a significant miRNA regulation *** each significant CoMi module is used to predict bone metastasis of breast cancer patients by sum up all the risk scores (Cox proportional hazards regression) of CoMi features in the ***: We tested the proposed method on a breast cancer cohort contain 855 samples' gene expression profiles together with bone metastasis *** bone metastasis specific CoMi modules are identified, such as module 'hemopoiesis', which has a log rank p value of 9.05e-07 in train dataset, 0.0075 in test dataset and 0.0031 in independent test *** the hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors, our results might facilitate to identify the miRNAs regulation modules involved in hematopoietic stem cell ***: We proposed the concept of CoMi activity module, and identified some CoMi activity modules which

关键词： Context specific miRNA activity metastasis organ prediction miRNA regulation network

来源：评论

学校读者我要写书评

暂无评论

In silico cancer drug screening based on microRNAs regulationnetworks

In silico cancer drug screening based on microRNAs regulatio...

引用

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Lida Zhu Fengji Liang Juan Liu Yinghui Li Jianghui Xiong Computer School Wuhan University Bioinformatics Group and Data Coordination Center State Key Lab of Space Medicine Fundamentals and Application(SMFA)China Astronaut Research and Training Center(ACC) Computer School Wuhan UniversityChina

Background:Severalstudies,such as the Connectivity Map(CMAP),showed that gene expression profiles could reflect drug perturbationeffects,and can be used in drug screening and drug *** we introduced a concept CoMi(Context-Specific miRNA Activity),and provide a novel perspective on drug mechanisms of *** this work,we intend to construct a virtual drug screening system and test whether CoMi could be used to capture the common features of approved cancer drugs and discriminate them from other candidate chemicals. Methods & Results:(l)We used correlation analysisby integrating the drugsensitive data(GI50) with gene expression datafrom diverse cancer cell lines in NCI60 datasets,and generated the drug sensitivity gene *** calculating the overlap rate between the drug sensitivity gene sets with disregulated gene set in breast cancer,we defined a drug-disease association index andgenerated a pool of 445 breast cancer associated compounds,including 61 positive drugs(approved breast cancer drugs) and 384 negative drugs.(2)Using the most significant differential CoMi features in positive *** drugs,a NaiveBayesian classifier could accurately predict the successful breast cancer drugs(AUC 0.86),and its performance was significantly exceed the mRNA signature based drug screening system (AUC 0.75),far superior to naive CMAP screening system(AUC0.56).(3)Further analysis of the network consisted of CoMi with good classification performance,highlighted some high connected miRNA nodes,including important cancer-related miRNAs(mir-495) and tumor suppressormiRNA(mir-520d);In addition,a number of high connectivity functional gene setsare also closely related with the biological processes of cancer(for example,cell differentiation).(4)Integrating differential expressed CoMi induced by Paclitaxel with breast cancer specific CoMi,weexaminedits application on classifying drug responsiveness in a breast cancer cohort using paclitaxel as neoadjuvant thera

关键词： microRNAs In silico cancer drug screening based on microRNAs regulationnetworks

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共94页 << < 85 86 87 88 89 90 91 92 93 94 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：