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9th International Conference on Computer science and Computational Intelligence, ICCSCI 2024

作者： Dominic, Nicholas Pardamean, Bens Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta11480 Indonesia Computer Science Department BINUS Graduate Program Computer Science Program Bina Nusantara University Jakarta11480 Indonesia

Preventive strategies should be the utmost priority when dealing with diverse patients suffering from malignant ventricular arrhythmia (MVA) that can lead to sudden cardiac death (SCD). Electrocardiogram (ECG) data is commonly used as a predictor for MVA predictive models. In this study, all ECG signals from MIT-BIH databases were fragmented into five-minute durations with a frequency sampling of 128 Hz. To solve the absence of hybrid optimizations in Machine Learning (ML) models, a novel Variational Quantum Neural Network (VQNN) was invented. Empowered by deep learning capabilities and optimized quantum circuits design, VQNN achieved remarkable performances designated by an accuracy of up to 95.1%, a perfect 100% recall, and a 95.2% score of the area under the Receiver Operating Characteristic curve (AUC ROC) with Conjugate Gradient as an optimizer and EfficientSU2 as a quantum ansatz. Despite the susceptibility to quantum noise, this research settles a new trajectory of utilizing quantum variational algorithms to predict and expand its applicability for MVA cases. © 2024 The Authors.

关键词： Quantum computers

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Enhancing Interoperability of Digital Twin in the Maintenance phase of Lifecycle 6

Enhancing Interoperability of Digital Twin in the Maintenanc...

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6th International Conference on Information Technology, Information Systems and Electrical Engineering, ICITISEE 2022

作者： Ariansyah, Dedy Pardamean, Bens Bina Nusantara University Bioinformatics and Data Science Research Centre Jakarta11480 Indonesia Bina Nusantara University BINUS Graduate Program Computer Science Program Computer Science Department Jakarta11480 Indonesia

ISBN: (纸本)9798350399615

In today's digitalization era, asset management has evolved following the rapid adoption of information systems and digital technologies. In the maintenance phase of the asset, Digital Twin (DT) emerges as an effective approach to improve failure recognition and structural damage prediction through DT-driven Prognostic and Health Monitoring (PHM). As a result, DT allows asset manager to proactively plan maintenance strategy to improve the availability of the assets. However, to reduce asset downtime in a cost-effective and time efficient manner, DT for maintenance phase needs to be integrated with other software systems that manage the provision of maintenance service and spare part such as computerized maintenance management system (CMMS) or Enterprise Resource Planning (ERP). Nevertheless, many of the developed DT in PHM were not equipped with semantic data model and hence, lacks interoperability with other systems (e.g., other DT or non-DT system) and limits the effective use of the DT. To qualify as an effective DT, it needs a semantical-enabled interface to connect with data and models from various domain to enable DT-driven decision-making. This paper leverages a rule-based ontology reasoning model to enhance DT interoperability with other maintenance software systems. The results depicts that the developed model paves a way for an effective use of DT-driven system in asset maintenance management. © 2022 IEEE.

关键词： CMMS Digital Twin ERP Maintenance Ontology

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Single-cell transcriptomics uncovers EGFR signaling-mediated gastric progenitor cell differentiation in stomach homeostasis (vol 14, 3750, 2023)

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NATURE COMMUNICATIONS 2023年第1期14卷 1-16页

作者： Takada, Hitomi Sasagawa, Yohei Yoshimura, Mika Tanaka, Kaori Iwayama, Yoshimi Hayashi, Tetsutaro Isomura-Matoba, Ayako Nikaido, Itoshi Kurisaki, Akira Laboratory of Stem Cell Technologies Graduate School of Science and Technology Nara Institute of Science and Technology Takayama-cho Ikoma Nara Japan Laboratory for Bioinformatics Research RIKEN Center for Biosystems Dynamics Research Wako Saitama Japan Department of Functional Genome Informatics Biological Data Science Medical Research Institute Tokyo Medical and Dental University Bunkyo Tokyo Japan Master’s/Doctoral Program in Life Science Innovation (Bioinformatics) Degree Programs in Systems and Information Engineering Graduate School of Science and Technology University of Tsukuba Tsukuba Ibaraki Japan

Defects in gastric progenitor cell differentiation are associated with various gastric disorders, including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the mechanisms underlying the multilineage differentiation of gastric progenitor cells during healthy homeostasis remain poorly understood. Here, using a single-cell RNA sequencing method, Quartz-Seq2, we analyzed the gene expression dynamics of progenitor cell differentiation toward pit cell, neck cell, and parietal cell lineages in healthy adult mouse corpus tissues. Enrichment analysis of pseudotime-dependent genes and a gastric organoid assay revealed that EGFR-ERK signaling promotes pit cell differentiation, whereas NF-κB signaling maintains gastric progenitor cells in an undifferentiated state. In addition, pharmacological inhibition of EGFR in vivo resulted in a decreased number of pit cells. Although activation of EGFR signaling in gastric progenitor cells has been suggested as one of the major inducers of gastric cancers, our findings unexpectedly identified that EGFR signaling exerts a differentiation-promoting function, not a mitogenic function, in normal gastric homeostasis.

关键词： Adult stem cells Stem-cell differentiation Stem-cell niche

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How can mathematics be used to improve burn care?

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Burns Open 2025年 9卷 100390-100390页

作者： Egberts, Ginger Vermolen, Fred Peng, Qiyao Korkmaz, H.Ibrahim van Zuijlen, Paul Computational Mathematics Group Department of Mathematics and Statistics University of Hasselt Diepenbeek Belgium Dutch Burn Foundation Beverwijk Netherlands Data Science Institute (DSI) University of Hasselt Hasselt Belgium Mathematical Institute University of Leiden Leiden Netherlands Burn Center Department of Plastic Reconstructive and Hand Surgery Red Cross Hospital Beverwijk Netherlands Department of Plastic Reconstructive and Hand Surgery Amsterdam UMC Location VUmc Amsterdam Movement Sciences Amsterdam Netherlands Department of Molecular Cell Biology and Immunology Amsterdam UMC Location VUmc Amsterdam Netherlands Pediatric Surgical Centre Emma Children's Hospital Amsterdam UMC Location AMC and VUmc Amsterdam Netherlands Bioinformatics Department of Computer Science Vrije Universiteit Amsterdam Amsterdam Netherlands

Severe second-degree ‘partial thickness’ and third-degree ‘full thickness’ burns are characterized by damage to the dermal layer of the skin. In the dermis, specialized cells called fibroblasts play a crucial role in wound healing. These cells produce collagen, a protein that provides strength and structure to the skin. After burn injury, fibroblasts migrate to the injured area and start producing and depositing collagen to help repair the damaged tissue. While contraction is essential for closing the wound, it can also result in scar contraction (contractures), especially in more severe burns. This contraction creates stresses on the skin, which can deteriorate the mobility of joints near the burn. This article overviews the most recent research results in computer simulations of scar contraction after burns. © 2024 The Authors

关键词： Agent-based models Artificial intelligence Continuum models Mathematical models Mathematics in the clinic Parameter uncertainty Post-burn contraction

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Exploring Recurrent Neural Network Models for Depression Detection Through Facial Expressions: A Systematic Literature Review 6

Exploring Recurrent Neural Network Models for Depression Det...

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6th International Conference on Computer and Informatics Engineering, IC2IE 2023

作者： Rumahorbo, Brilyan Nathanael Pardamean, Bens Elwirehardja, Gregorius Natanael Bina Nusantara University Binus Graduate Program - Master of Computer Science Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia

ISBN: (纸本)9798350345162

Major Depressive Disorder (MDD) is a prevalent mental disorder, affecting a significant number of individuals, with estimates reaching 300 million cases worldwide. Currently, the diagnosis of this condition relies heavily on subjective assessments based on the experience of medical professionals. Therefore, researchers have turned to deep learning models to explore the detection of depression. The objective of this review is to gather information on detecting depression based on facial expressions in videos using deep learning techniques. Overall, this research found that RNN models achieved 7.22 MAE for AVEC2014. LSTM models produced 4.83 MAE for DAIC-WOZ, while GRU models achieved an accuracy of 89.77% for DAIC-WOZ. Features like Facial Action Units (FAU), eye gaze, and landmarks show great potential and need to be further analyzed to improve results. Analysis can include applying feature engineering techniques. Aggregation methods, such as mean calculation, are recommended as effective approaches for data processing. This Systematic Literature Review found that facial expressions do have relevant patterns related to MDD. © 2023 IEEE.

关键词： deep learning facial expression GRU LSTM major depressive disorder

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Sequence to Sequence Deep Learning Architecture for Forecasting Temperature and Humidity inside Closed Space 10

Sequence to Sequence Deep Learning Architecture for Forecast...

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10th International Conference on Cyber and IT Service Management, CITSM 2022

作者： Setiawan, Karli Eka Elwirehardja, Gregorius Natanael Pardamean, Bens Bina Nusantara University Binus Graduate Program Computer Science Program Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia

ISBN: (数字)9781665460743

ISBN: (纸本)9781665460743

Solar Dryer Dome (SDD), an agricultural facility for drying and preserving agricultural products, needs a smart ability to predict the future indoor climate accurately, including indoor temperature and indoor humidity, in order to optimize electricity usage. To overcome these challenges, deep learning has been a widely adopted method. This research aims to forecast the future indoor climate using time series data by implementing a sequence-to-sequence (seq2seq) architecture, which is mostly used in Natural Language Processing (NLP) tasks. The two proposed seq2seq models, Long Short-Term Memory (LSTM) seq2seq and Gated Recurrent Unit (GRU) seq2seq, have proven to be superior to the adapted LSTM and GRU. The results show that the seq2seq GRU model outperforms the adapted GRU baseline model by an average difference of 0.03013 in MAE and the seq2seq LSTM model outperforms the adapted LSTM baseline model by an average difference of 0.00941 in MAE. To the best of our knowledge, this is the first implementation of seq2seq models for indoor climate forecasting on the Room Climate dataset. © 2022 IEEE.

关键词： Long short-term memory

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Web Information System Design for Fast Protein Post-Translational Modification Site Prediction 7

Web Information System Design for Fast Protein Post-Translat...

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7th International Conference on Information Management and Technology, ICIMTech 2022

作者： Elwirehardja, Gregorius Natanael Dominic, Nicholas Pardamean, Bens BINUS Graduate Program - Master of Computer Science Bina Nusantara University Computer Science Department Jakarta11480 Indonesia Research Center Bina Nusantara University Bioinformatics and Data Science Jakarta11480 Indonesia

ISBN: (数字)9781665450904

ISBN: (纸本)9781665450904

In the field of bioinformatics, the protein Post-Translational Modification (PTM) site prediction has been widely studied and Web Information Systems (WIS) has been deployed by researchers for this task. Through a literature review and benchmarking process, we identified the requirements which included quick predictions, efficient memory usage, and input validations. However, no detailed designs have been proposed so far, which may have contributed to some requirements not being implemented in some of the websites. Therefore, we propose a detailed WIS conceptual design, which can be used for predicting the sites of multiple PTM types, equipped with a validation algorithm and compared the usage of various string searching algorithms as well as file storage formats. Experiment results showed that the linear search algorithm is the fastest for this task and storing the protein data in npz format when performing multi-PTMs site prediction can assist in reducing memory usage. The proposed design can be implemented into user-friendly web tools that are both efficient in speed and memory usage in future studies. © 2022 IEEE.

关键词： Forecasting

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Artificial intelligence for modelling infectious disease epidemics

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Nature 2025年第8051期638卷 623-635页

作者： Kraemer, Moritz U. G. Tsui, Joseph L.-H. Chang, Serina Y. Lytras, Spyros Khurana, Mark P. Vanderslott, Samantha Bajaj, Sumali Scheidwasser, Neil Curran-Sebastian, Jacob Liam Semenova, Elizaveta Zhang, Mengyan Unwin, H. Juliette T. Watson, Oliver J. Mills, Cathal Dasgupta, Abhishek Ferretti, Luca Scarpino, Samuel V. Koua, Etien Morgan, Oliver Tegally, Houriiyah Paquet, Ulrich Moutsianas, Loukas Fraser, Christophe Ferguson, Neil M. Topol, Eric J. Duchêne, David A. Stadler, Tanja Kingori, Patricia Parker, Michael J. Dominici, Francesca Shadbolt, Nigel Suchard, Marc A. Ratmann, Oliver Flaxman, Seth Holmes, Edward C. Gomez-Rodriguez, Manuel Schölkopf, Bernhard Donnelly, Christl A. Pybus, Oliver G. Cauchemez, Simon Bhatt, Samir Pandemic Sciences Institute University of Oxford Oxford United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Electrical Engineering and Computer Science University of California Berkeley Berkeley CA United States UCSF UC Berkeley Joint Program in Computational Precision Health Berkeley CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Section of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark Oxford Vaccine Group University of Oxford and NIHR Oxford Biomedical Research Centre Oxford United Kingdom Department of Epidemiology and Biostatistics Imperial College London London United Kingdom Department of Computer Science University of Oxford Oxford United Kingdom School of Mathematics University of Bristol Bristol United Kingdom MRC Centre for Global Infectious Disease Analysis School of Public Health Imperial College London London United Kingdom Department of Statistics University of Oxford Oxford United Kingdom Doctoral Training Centre University of Oxford Oxford United Kingdom Institute for Experiential AI Northeastern University MA Boston Thailand Santa Fe Institute Santa Fe NM United States World Health Organization Regional Office for Africa Brazzaville Congo WHO Hub for Pandemic and Epidemic Intelligence Health Emergencies Programme World Health Organization Berlin Germany Centre for Epidemic Response and Innovation (CERI) School for Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa African Institute for Mathematical Sciences (AIMS) South Africa Muizenberg Cape Town South Africa Genomics England London United Kingdom Scripps Research La Jolla CA United States Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland The Ethox Centre Nuffield

Infectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in economics, medicine and social science, have the potential to transform the scope and power of infectious disease epidemiology. Here we consider the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science. We first outline how recent advances in AI can accelerate breakthroughs in answering key epidemiological questions and we discuss specific AI methods that can be applied to routinely collected infectious disease surveillance data. Second, we elaborate on the social context of AI for infectious disease epidemiology, including issues such as explainability, safety, accountability and ethics. Finally, we summarize some limitations of AI applications in this field and provide recommendations for how infectious disease epidemiology can harness most effectively current and future developments in AI. © Springer Nature Limited 2025.

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Corrigendum to "Transit functions and pyramid-like binary clustering systems" [Discrete Appl. Math. 357 (2024) 365–384, (S0166218X24002786), (10.1016/***.2024.06.032)]

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Discrete Applied Mathematics 2025年 371卷 280-280页

作者： Changat, Manoj Shanavas, Ameera Vaheeda Stadler, Peter F. Department of Futures Studies University of Kerala TrivandrumIN 695 581 India Bioinformatics Group Department of Computer Science Härtelstraße 16-18 LeipzigD-04107 Germany Halle-Jena-Leipzig & Competence Center for Scalable Data Services and Solutions Dresden-Leipzig & Centre for Biotechnology and Biomedicine at Leipzig University Leipzig Germany Max Planck Institute for Mathematics in the Sciences Inselstraße 22 LeipzigD-04103 Germany Institute for Theoretical Chemistry University of Vienna Währingerstrasse 17 WienA-1090 Austria Facultad de Ciencias Universidad National de Colombia Bogotá Colombia Santa Fe Institute 1399 Hyde Park Rd. Santa Fe NM87501 United States

In [1], axiom (P3), p. 378, and its transit-function counterpart (p3), was designed to rule out Tucker's third forbidden configuration. However, (P3) does not achieve this goal completely, see [2] for a counterexample. This mistake does not affect the correctness of any of the following results. However, it requires a modification in the proof of Theorem 8.6, the main result of [1]. There, the statement "Axioms (p2) and (p3) imply that [Formula presented] satisfies (P2) and (P3), which by construction exclude the second and third forbidden configuration, respectively" must be replaced by the following short argument: (P2) by construction excludes the second forbidden configuration, while (P3) rules out the third forbidden configuration in all cases where the sets [Formula presented], then the sets [Formula presented]. The remainder of the proof and all subsequent results in [1] remain unchanged. © 2025 The Author(s)

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Systematic Literature Review on Machine Learning Predictive Models for Indoor Climate in Smart Solar Dryer Dome 4

Systematic Literature Review on Machine Learning Predictive ...

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4th International Conference on Cybernetics and Intelligent System, ICORIS 2022

作者： Setiawan, Karli Eka Elwirehardja, Gregorius Natanael Pardamean, Bens Bina Nusantara University BINUS Graduate Program Master of Computer Science Program Computer Science Department Jakarta11480 Indonesia Bina Nusantara University Bioinformatics and Data Science Research Center Jakarta11480 Indonesia

ISBN: (纸本)9781665453950

Precise predictions of indoor climate conditions are required in the implementation of Smart Solar Dryer Dome (SDD). Trend development of prediction models is discussed in this review from 15 selected research papers (2018-2022) on indoor climate prediction which was obtained from research paper databases The output shows that the most used model for predicting indoor climate is Artificial Neural Network (ANN), especially Recurrent Neural Network (RNN) such as LSTM and GRU. However, there are some potential methods such as Transformer, Combined Support Vector Machines (SVM)-Deep Learning, and sequence-to-sequence which could outperform other commonly used models. Based on findings various opportunities exist to improve the precision of indoor climate prediction, which can bring power consumption efficiency and others benefit to Smart SDD users. Such studies may further be explored to produce more accurate machine learning models. © 2022 IEEE.

关键词： Domes

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