检索结果-内蒙古大学图书馆

Digital is the New Blood: Enabling the Present and the Future

Alzheimer's & Dementia 2023年第S21期19卷

作者： Rhoda Au Zachary T Popp Spencer Low Phillip H Hwang Ileana De Anda-Duran Stephanie Li Salman Rahman Huitong Ding Akwaugo Igwe Cody Karjadi Ting Fang Alvin Ang Sherral A. Devine Ashita S Gurnani Jesse B. Mez Lindsay A. Farrer Preeti Sunderaraman Honghuang Lin Vijaya B. Kolachalama Boston University School of Public Health Boston MA USA Framingham Heart Study Boston University School of Medicine Boston MA USA Davos Alzheimer’s Collaborative Philadelphia PA USA Department of Epidemiology Boston University School of Public Health Boston MA USA Boston University Chobanian & Avedisian School of Medicine Boston MA USA Department of Neurology Boston University Chobanian & Avedisian School of Medicine Boston MA USA Boston University Alzheimer’s Disease Research Center Boston University Chobanian & Avedisian School of Medicine Boston MA USA Department of Anatomy and Neurobiology Boston University Chobanian & Avedisian School of Medicine Boston MA USA Framingham Heart Study Boston University Chobanian & Avedisian School of Medicine Boston MA USA Boston University School of Public Heatlh Boston MA USA Tulane School of Public Health and Tropical Medicine New Orleans LA USA Slone Epidemiology Center Boston University Chobanian & Avedisian School of Medicine Boston MA USA Framigham Heart Study - Boston University Framingham MA USA Boston University Bioinformatics Program Boston MA USA Departments of Medicine (Biomedical Genetics) Neurology Ophthalmology Biostatistics and Epidemiology Boston University Schools of Medicine and Public Health Boston MA USA Department of Neurology - Boston University Chobanian & Avedisian School of Medicine Boston MA USA University of Massachusetts Medical School Worcester MA USA Framingham Heart Study/Boston University BOSTON MA USA Hariri Institute for Computing and Computational Science & Engineering Boston University Boston MA USA College of Arts & Sciences Boston University Boston MA USA Faculty of Computing & Data Sciences Boston University Boston MA USA Boston University Alzheimer’s Disease Center Boston University Chobanian & Avedisian School of Medicine Boston MA USA Whitaker Cardiovascular Institute Boston University Chobanian & Avedisian School of Medicine Boston MA USA

Background Digital is the new blood, where collection, use, and storage of raw digital data streams enabled by technology-embedded sensors are replacing analog methods. Analyses of digital data extend beyond current applications, analogous to previously stored blood currently be used for omics/biomarker research. Today digital technologies are used to measure Alzheimer’s disease (AD)-related clinical symptoms (e.g., cognition, function, and behavior), but future possibilities remain to be determined. Importantly, digital data collection can go beyond current intermittent sampling by employing internet-connected applications and devices that allow real-time monitoring and accurate detection of changes, even within a widely heterogeneous spectrum. Method Beginning in 2005, the Framingham Heart Study (FHS) began digitally recording participants’ spoken responses to neuropsychological (NP) test questions, and in 2011 extended to a digital pen to record written responses. The emergence of wearable devices and smartphone applications has led to an expanded use of digital technologies beyond recordings during NP assessments. The Boston University Alzheimer’s Disease Research Center (BU ADRC) leverages digital sensors in multiple internet-connected devices that longitudinally collect digital data, in both in-person and remote settings. Result The first publication involving FHS digital data was in 2016; the remaining (n> 17) have been from 2020-current. Digital data measuring cognition, function and behavior are being collected through the BU ADRC, where results to date indicate nearly 100% and 75% uptake of active and passive engagement applications, respectively, and 95% uptake for wearable devices (n = 60). Longitudinal assessments include > 3 months for ∼50 participants; > 1 year for n∼21 participants. Conclusion Opportunities for improved trial outcome measurement are evident in the broad range of outcomes digital sensors capture beyond traditional research methodologi

关键词：

来源：评论

学校读者我要写书评

暂无评论

Variant interpretation using population databases: lessons from gnomAD

arXiv

引用

arXiv 2021年

作者： Gudmundsson, Sanna Singer-Berk, Moriel Watts, Nicholas A. Phu, William Goodrich, Julia K. Solomonson, Matthew Rehm, Heidi L. MacArthur, Daniel G. O'Donnell-Luria, Anne Abreu, Maria Aguilar Salinas, Carlos A. Ahmad, Tariq Albert, Christine M. Alföldi, Jessica Ardissino, Diego Armean, Irina M. Atzmon, Gil Banks, Eric Barnard, John Baxter, Samantha M. Beaugerie, Laurent Benjamin, Emelia J. Benjamin, David Bergelson, Louis Boehnke, Michael Bonnycastle, Lori L. Bottinger, Erwin P. Bowden, Donald W. Bown, Matthew J. Brant, Steven Calvo, Sarah E. Campos, Hannia Chambers, John C. Chan, Juliana C. Chao, Katherine R. Chapman, Sinéad Chasman, Daniel Chisholm, Rex Cho, Judy Chowdhury, Rajiv Chung, Mina K. Chung, Wendy Cibulskis, Kristian Cohen, Bruce Collins, Ryan L. Connolly, Kristen M. Correa, Adolfo Covarrubias, Miguel Cummings, Beryl Dabelea, Dana Daly, Mark J. Danesh, John Darbar, Dawood Denny, Joshua Donnelly, Stacey Duggirala, Ravindranath Dupuis, Josée Ellinor, Patrick T. Elosua, Roberto Emery, James England, Eleina Erdmann, Jeanette Esko, Tõnu Evangelista, Emily Farjoun, Yossi Fatkin, Diane Ferriera, Steven Florez, Jose Francioli, Laurent Franke, Andre Färkkilä, Martti Gabriel, Stacey Garimella, Kiran Gauthier, Laura D. Gentry, Jeff Getz, Gad Glahn, David C. Glaser, Benjamin Glatt, Stephen J. Goldstein, David Gonzalez, Clicerio Goodrich, Julia Groop, Leif Gudmundsson, Sanna Gupta, Namrata Haessly, Andrea Haiman, Christopher Hall, Ira Hanis, Craig Harms, Matthew Hiltunen, Mikko Holi, Matti M. Hultman, Christina M. Jalas, Chaim Jeandet, Thibault Kallela, Mikko Kaplan, Diane Kaprio, Jaakko Karczewski, Konrad J. Kathiresan, Sekar Kenny, Eimear Kim, Bong-Jo Kim, Young Jin Kirov, George Kooner, Jaspal Koskinen, Seppo Krumholz, Harlan M. Kugathasan, Subra Kwak, Soo Heon Laakso, Markku Lake, Nicole Langsford, Trevyn Laricchia, Kristen M. Lehtimäki, Terho Lek, Monkol Lipscomb, Emily Llanwarne, Christopher Loos, Ruth J.F. Lubitz, Steven A. Luna, Teresa Tusie Ma, Ronald C.W. MacArthur, Daniel G. Marcus, Gregory M. Marrugat, Ja University of Miami Miller School of Medicine Gastroenterology Miami United States Unidad de Investigacion de Enfermedades Metabolicas Instituto Nacional de Ciencias Medicas y Nutricion Mexico City Mexico Peninsula College of Medicine and Dentistry Exeter United Kingdom Division of Preventive Medicine Brigham and Women's Hospital BostonMA United States Division of Cardiovascular Medicine Brigham and Women's Hospital Harvard Medical School BostonMA United States Program in Medical and Population Genetics Broad Institute of MIT and Harvard CambridgeMA United States Analytic and Translational Genetics Unit Massachusetts General Hospital BostonMA United States Department of Cardiology University Hospital Parma Italy European Molecular Biology Laboratory European Bioinformatics Institute Wellcome Genome Campus Hinxton Cambridge United Kingdom Department of Biology Faculty of Natural Sciences University of Haifa Haifa Israel Department of Medicine and Genetics Albert Einstein College of Medicine BronxNY United States Data Science Platform Broad Institute of MIT and Harvard CambridgeMA United States Department of Quantitative Health Sciences Lerner Research Institute Cleveland Clinic ClevelandOH United States Sorbonne Université APHP Gastroenterology Department Saint Antoine Hospital Paris France NHLBI Boston University's Framingham Heart Study FraminghamMA United States Department of Medicine Boston University School of Medicine BostonMA United States Department of Epidemiology Boston University School of Public Health BostonMA United States Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann ArborMS United States National Human Genome Research Institute National Institutes of Health BethesdaMD United States The Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New YorkNY United States Department of Biochemistry Wake Forest School of Medicine Winston-SalemNC

Reference population databases are an essential tool in variant and gene interpretation. Their use guides the identification of pathogenic variants amidst the sea of benign variation present in every human genome, and supports the discovery of new disease-gene relationships. The Genome Aggregation database (gnomAD) is currently the largest and most widely used publicly available collection of population variation from harmonized sequencing data. The data is available through the online gnomAD browser (https://***/) that enables rapid and intuitive variant analysis. This review provides guidance on the content of the gnomAD browser, and its usage for variant and gene interpretation. We introduce key features including allele frequency, per-base expression levels, constraint scores, and variant co-occurrence, alongside guidance on how to use these in analysis, with a focus on the interpretation of candidate variants and novel genes in rare disease. © 2021, CC BY.

关键词： Genes

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data

引用

npj Parkinson's Disease 2023年第1期9卷 1页

作者： Hampton L. Leonard Anni Moore Dan Vitale Francis P. Grenn Hirotaka Iwaki Jonggeol Jeff Kim Julie Lake Mary B. Makarious Michael Ta Pilar Alvarez Jerez Tarek Antar Yeajin Song Andrew Singleton Mike A. Nalls Sara Bandres-Ciga Cornelis Blauwendraat Ruqaya Murtadha Anastasia Illarionova Alejandro Martinez-Carrasco Catherine Storm Clodagh Towns Lesley Wu Manuela M. X. Tan Raquel Real Alina Jama Devina Chetty Zuné Jansen van Rensburg Shameemah Abrahams Amica Corda Müller-Nedebock Regina H. Reynolds William J. Scotton Ana-Luisa Gil-Martinez Bernabe I. Bustos Bharati Jadhav Brook Huxford Isabelle Francesca Foote Sumit Dey Alastair J. Noyce Eric Yu Konstantin Senkevich Prabhjyot Saini Gabriela Salazar Geoffrey Rateau Inas Elsayed Jie Yuan Ruifneg Hu Kajsa Brolin María Teresa Periñán Nikita Simone Pillay Oswaldo Lorenzo Betancor Paula R. Reyes-Pérez Rami al-Ouran Ramiya Sivakumar Shilpa C. Rao Thiago Peixoto Leal Vassilena Iankova Laboratory of Neurogenetics National Institute on Aging National Institutes of Health Bethesda MD USA Center for Alzheimer’s and Related Dementias (CARD) National Institute on Aging and National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD USA Data Tecnica International LLC Washington DC USA German Center for Neurodegenerative Diseases (DZNE) Tübingen Germany Preventive Neurology Unit Wolfson Institute of Population Health Queen Mary University of London London UK Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology University College London London UK Department of Neurology Oslo University Hospital Oslo Norway Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology University College London London UK Division of Molecular Biology and Human Genetics Department of Biomedical Sciences Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South Africa South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit Stellenbosch University Cape Town South Africa Department of Neurodegenerative Disease University College London London UK Great Ormond Street Institute of Child Health Genetics and Genomic Medicine University College London London UK The Ken & Ruth Davee Department of Neurology and Simpson Querrey Center of Neurogenetics Feinberg Feinberg School of Medicine Northwestern University Chicago IL 60611 USA Department of Genetics and Genomic Sciences and Mindich Child Health and Development Institute Icahn School of Medicine at Mount Hess Center for Science and Medicine New York NY 10029 USA Unit for Psychological Medicine Wolfson Institute of Population Health Queen Mary University of London London UK Department of Human Genetics McGill University Montreal QC Canada The Neuro (Montreal Neurological Institute-Hospital) McGill University Montreal QC Canada Department of Neurology and

来源：评论

学校读者我要写书评

暂无评论

Polygenic risk modeling for prediction of epithelial ovarian cancer risk (vol 30, pg 349, 2021)

引用

EUROPEAN JOURNAL OF HUMAN GENETICS 2022年第5期30卷 630-631页

作者： Dareng, Eileen O. Tyrer, Jonathan P. Barnes, Daniel R. Jones, Michelle R. Yang, Xin Aben, Katja K. H. Adank, Muriel A. Agata, Simona Andrulis, Irene L. Anton-Culver, Hoda Antonenkova, Natalia N. Aravantinos, Gerasimos Arun, Banu K. Augustinsson, Annelie Balmana, Judith Bandera, Elisa V. Barkardottir, Rosa B. Barrowdale, Daniel Beckmann, Matthias W. Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina Bernardini, Marcus Q. Bjorge, Line Black, Amanda Bogdanova, Natalia V. Bonanni, Bernardo Borg, Ake Brenton, James D. Budzilowska, Agnieszka Butzow, Ralf Buys, Saundra S. Cai, Hui Caligo, Maria A. Campbell, Ian Cannioto, Rikki Cassingham, Hayley Chang-Claude, Jenny Chanock, Stephen J. Chen, Kexin Chiew, Yoke-Eng Chung, Wendy K. Claes, Kathleen B. M. Colonna, Sarah Cook, Linda S. Couch, Fergus J. Daly, Mary B. Dao, Fanny Davies, Eleanor de la Hoya, Miguel de Putter, Robin Dennis, Joe DePersia, Allison Devilee, Peter Diez, Orland Ding, Yuan Chun Doherty, Jennifer A. Domchek, Susan M. Dork, Thilo du Bois, Andreas Durst, Matthias Eccles, Diana M. Eliassen, Heather A. Engel, Christoph Evans, Gareth D. Fasching, Peter A. Flanagan, James M. Fortner, Renee T. Machackova, Eva Friedman, Eitan Ganz, Patricia A. Garber, Judy Gensini, Francesca Giles, Graham G. Glendon, Gord Godwin, Andrew K. Goodman, Marc T. Greene, Mark H. Gronwald, Jacek Hahnen, Eric Haiman, Christopher A. Hakansson, Niclas Hamann, Ute Hansen, Thomas V. O. Harris, Holly R. Hartman, Mikael Heitz, Florian Hildebrandt, Michelle A. T. Hogdall, Estrid Hogdall, Claus K. Hopper, John L. Huang, Ruea-Yea Huff, Chad Hulick, Peter J. Huntsman, David G. Imyanitov, Evgeny N. Isaacs, Claudine Jakubowska, Anna James, Paul A. Janavicius, Ramunas Jensen, Allan Johannsson, Oskar Th. John, Esther M. Jones, Michael E. Kang, Daehee Karlan, Beth Y. Karnezis, Anthony Kelemen, Linda E. Khusnutdinova, Elza Kiemeney, Lambertus A. Kim, Byoung-Gie Kjaer, Susanne K. Komenaka, Ian Kupryjanczyk, Jolanta Kurian, Allison W. Kwong, Ava Lambrechts, Diether Larson, Melissa C. Lazaro, Conxi L University of Cambridge Centre for Cancer Genetic Epidemiology Department of Public Health and Primary Care Cambridge UK University of Cambridge Centre for Cancer Genetic Epidemiology Department of Oncology Cambridge UK Center for Bioinformatics and Functional Genomics Cedars-Sinai Medical Center Los Angeles CA USA Radboud University Medical Center Radboud Institute for Health Sciences Nijmegen The Netherlands Netherlands Comprehensive Cancer Organisation Utrecht The Netherlands The Netherlands Cancer Institute—Antoni van Leeuwenhoek hospital Family Cancer Clinic Amsterdam The Netherlands Veneto Institute of Oncology IOV—IRCCS Immunology and Molecular Oncology Unit Padua Italy Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital Fred A. Litwin Center for Cancer Genetics Toronto ON Canada University of Toronto Department of Molecular Genetics Toronto ON Canada University of California Irvine Department of Epidemiology Genetic Epidemiology Research Institute Irvine CA USA N.N. Alexandrov Research Institute of Oncology and Medical Radiology Minsk Belarus ‘Agii Anargiri’ Cancer Hospital Athens Greece University of Texas MD Anderson Cancer Center Department of Breast Medical Oncology Houston TX USA Lund University Department of Cancer Epidemiology Clinical Sciences Lund Sweden Vall d’Hebron Institute of Oncology Hereditary cancer Genetics Group Barcelona Spain University Hospital of Vall d’Hebron Department of Medical Oncology Barcelona Spain Rutgers Cancer Institute of New Jersey Cancer Prevention and Control Program New Brunswick NJ USA Landspitali University Hospital Department of Pathology Reykjavik Iceland University of Iceland BMC (Biomedical Centre) Faculty of Medicine Reykjavik Iceland University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg Department of Gynecology and Obstetrics Comprehensive Cancer Center ER-EMN Erlangen Germany Vanderbilt University School of Medicine Division of Epidemiology Department

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individual level genotype data and a Bayesian framework with continuous shrinkage, “select and shrink for summary statistics” (S4), to summary level data for epithelial non-mucinous ovarian cancer risk prediction. We developed the models in a dataset consisting of 23,564 non-mucinous EOC cases and 40,138 controls participating in the Ovarian Cancer Association Consortium (OCAC) and validated the best models in three populations of different ancestries: prospective data from 198,101 women of European ancestries; 7,669 women of East Asian ancestries; 1,072 women of African ancestries, and in 18,915 BRCA1 and 12,337 BRCA2 pathogenic variant carriers of European ancestries. In the external validation data, the model with the strongest association for non-mucinous EOC risk derived from the OCAC model development data was the S4 model (27,240 SNPs) with odds ratios (OR) of 1.38 (95% CI: 1.28–1.48, AUC: 0.588) per unit standard deviation, in women of European ancestries; 1.14 (95% CI: 1.08–1.19, AUC: 0.538) in women of East Asian ancestries; 1.38 (95% CI: 1.21–1.58, AUC: 0.593) in women of African ancestries; hazard ratios of 1.36 (95% CI: 1.29–1.43, AUC: 0.592) in BRCA1 pathogenic variant carriers and 1.49 (95% CI: 1.35–1.64, AUC: 0.624) in BRCA2 pathogenic variant carriers. Incorporation of the S4 PRS in risk prediction models for ovarian cancer may have clinical utility in ovarian cancer prevention programs.

关键词： Clinical genetics Genetic markers Risk factors Biomedicine general Human Genetics bioinformatics Gene Expression Cytogenetics

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The SEQC2 epigenomics quality control (EpiQC) study

引用

Genome biology 2021年第1期22卷 350页

作者： Jonathan Foox Jessica Nordlund Claudia Lalancette Ting Gong Michelle Lacey Samantha Lent Bradley W Langhorst V K Chaithanya Ponnaluri Louise Williams Karthik Ramaswamy Padmanabhan Raymond Cavalcante Anders Lundmark Daniel Butler Christopher Mozsary Justin Gurvitch John M Greally Masako Suzuki Mark Menor Masaki Nasu Alicia Alonso Caroline Sheridan Andreas Scherer Stephen Bruinsma Gosia Golda Agata Muszynska Paweł P Łabaj Matthew A Campbell Frank Wos Amanda Raine Ulrika Liljedahl Tomas Axelsson Charles Wang Zhong Chen Zhaowei Yang Jing Li Xiaopeng Yang Hongwei Wang Ari Melnick Shang Guo Alexander Blume Vedran Franke Inmaculada Ibanez de Caceres Carlos Rodriguez-Antolin Rocio Rosas Justin Wade Davis Jennifer Ishii Dalila B Megherbi Wenming Xiao Will Liao Joshua Xu Huixiao Hong Baitang Ning Weida Tong Altuna Akalin Yunliang Wang Youping Deng Christopher E Mason Department of Physiology and Biophysics Weill Cornell Medicine New York NY USA. The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell Medicine New York NY USA. Department of Medical Sciences and Science for Life Laboratory Uppsala University Uppsala Sweden. EATRIS ERIC- European Infrastructure for Translational Medicine De Boelelaan 1118 1081 HZ Amsterdam The Netherlands. BRCF Epigenomics Core University of Michigan Medicine Ann Arbor MI 48109 USA. Department of Quantitative Health Sciences University of Hawaii John A. Burns School of Medicine Honolulu HI 96813 USA. Tulane University New Orleans LA 70118 USA. AbbVie Genomics Research Center 1 N. Waukegan Rd North Chicago IL 60036 USA. New England Biolabs Ipswich MA 01938 USA. Albert Einstein College of Medicine Bronx NY 10461 USA. Division of Hematology/Oncology Department of Medicine Epigenomics Core Facility Weill Cornell Medicine New York NY USA. Institute for Molecular Medicine Finland (FIMM) University of Helsinki Helsinki Finland. Illumina Inc Madison WI 53705 USA. Faculty of Biochemistry Biophysics and Biotechnology Jagiellonian University Krakow Poland. Małopolska Centre of Biotechnology Jagiellonian University Krakow Poland. New York Genome Center New York NY 10013 USA. Center for Genomics School of Medicine Loma Linda University Loma Linda CA 92350 USA. Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health the First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China. Department of Neurology The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450014 China. Development of Medicine the University of Chicago Chicago IL 60637 USA. Department of Neurology the Second Affiliated Hospital of Zhengzhou University Zhengzhou 450014 China. Bioinformatics and Omics Data Science Platform Berlin Institute f

来源：评论

学校读者我要写书评

暂无评论

Dense sampling of bird diversity increases power of comparative genomics (vol 587, pg 252, 2020)

引用

NATURE 2021年第7856期592卷 E24-E24页

作者： Feng, Shaohong Stiller, Josefin Deng, Yuan Armstrong, Joel Fang, Qi Reeve, Andrew Hart Xie, Duo Chen, Guangji Guo, Chunxue Faircloth, Brant C. Petersen, Bent Wang, Zongji Zhou, Qi Diekhans, Mark Chen, Wanjun Andreu-Sanchez, Sergio Margaryan, Ashot Howard, Jason Travis Parent, Carole Pacheco, George Sinding, Mikkel-Holger S. Puetz, Lara Cavill, Emily Ribeiro, Angela M. Eckhart, Leopold Fjeldsa, Jon Hosner, Peter A. Brumfield, Robb T. Christidis, Les Bertelsen, Mads F. Sicheritz-Ponten, Thomas Tietze, Dieter Thomas Robertson, Bruce C. Song, Gang Borgia, Gerald Claramunt, Santiago Lovette, Irby J. Cowen, Saul J. Njoroge, Peter Dumbacher, John Philip Ryder, Oliver A. Fuchs, Jerome Bunce, Michael Burt, David W. Cracraft, Joel Meng, Guanliang Hackett, Shannon J. Ryan, Peter G. Jonsson, Knud Andreas Jamieson, Ian G. da Fonseca, Rute R. Braun, Edward L. Houde, Peter Mirarab, Siavash Suh, Alexander Hansson, Bengt Ponnikas, Suvi Sigeman, Hanna Stervander, Martin Frandsen, Paul B. van der Zwan, Henriette van der Sluis, Rencia Visser, Carina Balakrishnan, Christopher N. Clark, Andrew G. Fitzpatrick, John W. Bowman, Reed Chen, Nancy Cloutier, Alison Sackton, Timothy B. Edwards, Scott V. Foote, Dustin J. Shakya, Subir B. Sheldon, Frederick H. Vignal, Alain Soares, Andre E. R. Shapiro, Beth Gonzalez-Solis, Jacob Ferrer-Obiol, Joan Rozas, Julio Riutort, Marta Tigano, Anna Friesen, Vicki Dalen, Love Urrutia, Araxi O. Szekely, Tamas Liu, Yang Campana, Michael G. Corvelo, Andre Fleischer, Robert C. Rutherford, Kim M. Gemmell, Neil J. Dussex, Nicolas Mouritsen, Henrik Thiele, Nadine Delmore, Kira Liedvogel, Miriam Franke, Andre Hoeppner, Marc P. Krone, Oliver Fudickar, Adam M. Mila, Borja Ketterson, Ellen D. Fidler, Andrew Eric Friis, Guillermo Parody-Merino, Angela M. Battley, Phil F. Cox, Murray P. Lima, Nicholas Costa Barroso Prosdocimi, Francisco Parchman, Thomas Lee Schlinger, Barney A. Loiselle, Bette A. Blake, John G. Lim, Haw Chuan Day, Lainy B. Fuxjager, Matthew J. Baldwin, Maude W. Braun, Michael J. Wirthlin, Morgan Dikow, China National GeneBank BGI-Shenzhen Shenzhen China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming China BGI-Shenzhen Shenzhen China Villum Centre for Biodiversity Genomics Section for Ecology and Evolution Department of Biology University of Copenhagen Copenhagen Denmark BGI Education Center University of Chinese Academy of Sciences Shenzhen China MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute Zhejiang University Hangzhou China Department of Neuroscience and Developmental Biology University of Vienna Vienna Austria Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China James D. Watson Institute of Genome Sciences Hangzhou China UC Santa Cruz Genomics Institute UC Santa Cruz Santa Cruz CA USA Natural History Museum of Denmark University of Copenhagen Copenhagen Denmark Center for Macroecology Evolution and Climate GLOBE Institute University of Copenhagen Copenhagen Denmark Department of Biological Sciences Louisiana State University Baton Rouge LA USA Museum of Natural Science Louisiana State University Baton Rouge LA USA Centre of Excellence for Omics-Driven Computational Biodiscovery (COMBio) Faculty of Applied Sciences AIMST University Kedah Malaysia Section for Evolutionary Genomics The GLOBE Institute Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark Institute of Molecular Biology National Academy of Sciences Yerevan Armenia University Museum Norwegian University of Science and Technology Trondheim Norway Center for Reproductive Medicine The 2nd Affiliated Hospital School of Medicine Zhejiang University Hangzhou China Novogene Durham NC USA Duke University Medical Center Durham NC USA The Rockefeller University New York NY USA Howard Hughes Medical Institute Chevy Chase MD USA Department of Dermatology Medical University of Vienna Vienna Austria

来源：评论

学校读者我要写书评

暂无评论

Author Correction: High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

引用

Nature Communications 2022年第1期13卷 1页

作者： Marta Palafox Laia Monserrat Andreu Òdena Mònica Sánchez-Guixé Olga Rodríguez Marta Guzmán Judit Grueso Violeta Serra Meritxell Bellet Mafalda Oliveira Marta Capelán Analía Azaro Cristina Saura Guillermo Villacampa Cristina Viaplana Rodrigo Dienstmann Abel Gonzalez-Perez Nuria Lopez-Bigas Fara Brasó-Maristany Aleix Prat Nusaibah Ibrahimi Stefan Michiels Srinivasaraghavan Kannan Chandra S. Verma Leonardo Mina Alicia García-Sanz Maria Teresa Herrera-Abreu Nicholas C. Turner Alejandra Bruna Javier Hernández Faye Su Kui Lin Robert B. Clarke Carlos Caldas Joaquín Arribas Paolo Nuciforo Maurizio Scaltriti Monica Arnedos Experimental Therapeutics Group Vall d’Hebron Institute of Oncology Barcelona Spain CIBERONC Vall d’Hebron Institute of Oncology Barcelona Spain Breast Cancer and Melanoma Group Vall d’Hebron Institute of Oncology Barcelona Spain Department of Medical Oncology Hospital Vall d’Hebron Barcelona Spain Oncology Data Science Group Vall d’Hebron Institute of Oncology Barcelona Spain Institute for Research in Biomedicine (IRB Barcelona) Barcelona Spain Research Program on Biomedical Informatics Universitat Pompeu Fabra Barcelona Spain Institució Catalana de Recerca i Estudis Avançats (ICREA) Barcelona Spain Translational Genomics and Targeted Therapies in Solid Tumors August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Barcelona Spain University of Barcelona Barcelona Spain Department of Medical Oncology Hospital Clinic Barcelona Spain SOLTI Breast Cancer Research Group Barcelona Spain Department of Oncology IOB Institute of Oncology Barcelona Spain Service de Biostatistique et d’Epidémiologie Gustave Roussy Villejuif France Oncostat U1018 Inserm University Paris-Saclay Villejuif France Bioinformatics Institute (A*STAR) Singapore Singapore School of Biological Sciences Nanyang Technological University Singapore Singapore Department of Biological Sciences National University of Singapore Singapore Singapore Medica Scientia Innovation Research (MedSIR) Barcelona Spain The Breast Cancer Now Research Centre London UK Preclinical Modelling of Pediatric Cancer Evolution Group The Institute of Cancer Research London UK Translational Molecular Pathology Vall d’Hebron Institute of Research (VHIR) Barcelona Spain Novartis Pharmaceuticals East Hanover NJ USA Genentech Inc. South San Francisco California USA Breast Biology Group Manchester Breast Centre Manchester UK Cancer Research UK Cambridge UK Growth Factors Laboratory Vall d’Hebron Institute of Oncology Barcelona Spain Department of Biochemistry and Molecular Biology Universitat Autònoma de Bar

来源：评论

学校读者我要写书评

暂无评论

Publisher Correction: Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral infection

引用

Nature immunology 2020年第9期21卷 1135页

作者： Marc Beyer Zeinab Abdullah Jens M Chemnitz Daniela Maisel Jil Sander Clara Lehmann Yasser Thabet Prashant V Shinde Lisa Schmidleithner Maren Köhne Jonel Trebicka Robert Schierwagen Andrea Hofmann Alexey Popov Karl S Lang Annette Oxenius Thorsten Buch Christian Kurts Mathias Heikenwalder Gerd Fätkenheuer Philipp A Lang Pia Hartmann Percy A Knolle Joachim L Schultze Life and Medical Sciences Bonn Genomics & Immunoregulation University of Bonn Bonn Germany. marc.beyer@uni-bonn.de. Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn Bonn Germany. marc.beyer@uni-bonn.de. Institute of Experimental Immunology University Hospital Bonn Bonn Germany. Department of Internal Medicine I University Hospital Cologne Cologne Germany. Bioinformatics and Exploratory Data Analysis Pharma Research and Early Development Roche Diagnostics Penzberg Germany. Life and Medical Sciences Bonn Genomics & Immunoregulation University of Bonn Bonn Germany. German Center for Infection Research partner site Bonn-Cologne Cologne Germany. Department of Gastroenterology Hepatology and Infectious Diseases Heinrich-Heine-University Düsseldorf Düsseldorf Germany. Department of Internal Medicine I University Hospital Bonn Bonn Germany. Institute of Human Genetics Department of Genomics Life & Brain Center University of Bonn Bonn Germany. Institute of Immunology Faculty of Medicine University of Duisburg-Essen Essen Germany. Institute of Microbiology Swiss Federal Institute of Technology Zürich Zürich Switzerland. Institute of Laboratory Animal Science University of Zürich Schlieren Switzerland. Institute of Virology Technische Universität /Helmholtz Zentrum München München Germany. Division of Chronic Inflammation and Cancer German Cancer Research Center Heidelberg Germany. Department of Molecular Medicine II Heinrich-Heine-University Düsseldorf Düsseldorf Germany. Institute for Medical Microbiology Immunology and Hygiene University of Cologne Cologne Germany. Institute of Experimental Immunology University Hospital Bonn Bonn Germany. percy.knolle@tum.de. Institute of Molecular Immunology Klinikum rechts der Isar Technische Universität München München Germany. percy.knolle@tum.de. Life and Medical Sciences Bonn Genomics & Immunoregulation University of Bonn Bonn Germany

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight

引用

Nature genetics 2023年第7期55卷 1250页

作者： Pol Solé-Navais Christopher Flatley Valgerdur Steinthorsdottir Marc Vaudel Julius Juodakis Jing Chen Triin Laisk Abigail L LaBella David Westergaard Jonas Bacelis Ben Brumpton Line Skotte Maria C Borges Øyvind Helgeland Anubha Mahajan Matthias Wielscher Frederick Lin Catherine Briggs Carol A Wang Gunn-Helen Moen Robin N Beaumont Jonathan P Bradfield Abin Abraham Gudmar Thorleifsson Maiken E Gabrielsen Sisse R Ostrowski Dominika Modzelewska Ellen A Nohr Elina Hypponen Amit Srivastava Octavious Talbot Catherine Allard Scott M Williams Ramkumar Menon Beverley M Shields Gardar Sveinbjornsson Huan Xu Mads Melbye William Lowe Luigi Bouchard Emily Oken Ole B Pedersen Daniel F Gudbjartsson Christian Erikstrup Erik Sørensen Rolv T Lie Kari Teramo Mikko Hallman Thorhildur Juliusdottir Hakon Hakonarson Henrik Ullum Andrew T Hattersley Line Sletner Mario Merialdi Sheryl L Rifas-Shiman Thora Steingrimsdottir Denise Scholtens Christine Power Jane West Mette Nyegaard John A Capra Anne H Skogholt Per Magnus Ole A Andreassen Unnur Thorsteinsdottir Struan F A Grant Elisabeth Qvigstad Craig E Pennell Marie-France Hivert Geoffrey M Hayes Marjo-Riitta Jarvelin Mark I McCarthy Deborah A Lawlor Henriette S Nielsen Reedik Mägi Antonis Rokas Kristian Hveem Kari Stefansson Bjarke Feenstra Pål Njolstad Louis J Muglia Rachel M Freathy Stefan Johansson Ge Zhang Bo Jacobsson Department of Obstetrics and Gynaecology Sahlgrenska Academy Institute of Clinical Science University of Gothenburg Gothenburg Sweden. pol.sole.navais@gu.se. Department of Obstetrics and Gynaecology Sahlgrenska Academy Institute of Clinical Science University of Gothenburg Gothenburg Sweden. deCODE genetics/Amgen Reykjavik Iceland. Center for Diabetes Research Department of Clinical Science University of Bergen Bergen Norway. Division of Biomedical Informatics Cincinnati Children's Hospital Medical Center Cincinnati OH USA. Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA. Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia. Department of Biological Sciences Vanderbilt University Nashville TN USA. Novo Nordisk Foundation Center for Protein Research University of Copenhagen Copenhagen Denmark. Department of Obstetrics and Gynaecology Copenhagen University Hospital Hvidovre Hvidovre Denmark. Methods and Analysis Statistics Denmark Copenhagen Denmark. K.G. Jebsen Center for Genetic Epidemiology Department of Public Health and Nursing Norwegian University of Science and Technology Trondheim Norway. Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark. MRC Integrative Epidemiology Unit University of Bristol Bristol UK. Population Health Sciences Bristol Medical School University of Bristol Bristol UK. Department of Genetics and Bioinformatics Health Data and Digitalization Norwegian Institute of Public Health Oslo Norway. Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK. Genentech South San Francisco CA USA. Department of Epidemiology and Biostatistics MRC-PHE Centre for Environment and Health School of Public Health Imperial College London London UK. Department of Dermatology Medical University of Vienna Vienna Austria. Northwestern University Feinberg School of Medicine Chicago IL USA. Department of Population Medicine Harvard M

来源：评论

学校读者我要写书评

暂无评论

Erratum to: Making sense of big data in health research: towards an EU action plan

引用

Genome medicine 2016年第1期8卷 118页

作者： Charles Auffray Rudi Balling Inês Barroso László Bencze Mikael Benson Jay Bergeron Enrique Bernal-Delgado Niklas Blomberg Christoph Bock Ana Conesa Susanna Del Signore Christophe Delogne Peter Devilee Alberto Di Meglio Marinus Eijkemans Paul Flicek Norbert Graf Vera Grimm Henk-Jan Guchelaar Yi-Ke Guo Ivo Glynne Gut Allan Hanbury Shahid Hanif Ralf-Dieter Hilgers Ángel Honrado D Rod Hose Jeanine Houwing-Duistermaat Tim Hubbard Sophie Helen Janacek Haralampos Karanikas Tim Kievits Manfred Kohler Andreas Kremer Jerry Lanfear Thomas Lengauer Edith Maes Theo Meert Werner Müller Dörthe Nickel Peter Oledzki Bertrand Pedersen Milan Petkovic Konstantinos Pliakos Magnus Rattray Josep Redón I Màs Reinhard Schneider Thierry Sengstag Xavier Serra-Picamal Wouter Spek Lea A I Vaas Okker van Batenburg Marc Vandelaer Peter Varnai Pablo Villoslada Juan Antonio Vizcaíno John Peter Mary Wubbe Gianluigi Zanetti European Institute for Systems Biology and Medicine 1 avenue Claude Vellefaux 75010 Paris France. cauffray@***. CIRI-UMR5308 CNRS-ENS-INSERM-UCBL Université de Lyon 50 avenue Tony Garnier 69007 Lyon France. cauffray@***. Luxembourg Centre for Systems Biomedicine University of Luxembourg 7 Avenue des Hauts Fourneaux 4362 Esch-sur-Alzette Luxembourg. rudi.balling@uni.lu. Wellcome Trust Sanger Institute Wellcome Genome Campus Hinxton Cambridge CB10 1SA UK. Health Services Management Training Centre Faculty of Health and Public Services Semmelweis University Kútvölgyi út 2 1125 Budapest Hungary. Centre for Personalised Medicine Linköping University 581 85 Linköping Sweden. Translational & Bioinformatics Pfizer Inc. 300 Technology Square Cambridge MA 02139 USA. Institute for Health Sciences IACS - IIS Aragon San Juan Bosco 13 50009 Zaragoza Spain. ELIXIR Wellcome Genome Campus Hinxton Cambridge CB10 1SD UK. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14 AKH BT25.2 1090 Vienna Austria. Department of Laboratory Medicine Medical University of Vienna Lazarettgasse 14 AKH BT25.2 1090 Vienna Austria. Max Planck Institute for Informatics Campus E1 4 66123 Saarbrücken Germany. Príncipe Felipe Research Center C/Eduardo Primo Yúfera 3 46012 Valencia Spain. University of Florida Institute of Food and Agricultural Sciences (IFAS) 2033 Mowry Road Gainesville FL 32610 USA. Bluecompanion Ltd 6 London Street (second floor) London W2 1HR UK. Technology Data & Analytics KPMG Luxembourg Société Coopérative 39 Avenue John F. Kennedy 1855 Luxembourg Luxembourg. Department of Human Genetics Department of Pathology Leiden University Medical Centre Einthovenweg 20 2333 ZC Leiden The Netherlands. Information Technology Department European Organization for Nuclear Research (CERN) 385 Route de Meyrin 1211 Geneva 23 Switzerland. Julius Center for Health Sciences and Primary Care University Medical Center

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：